MFS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

major facilitator superfamily, putative

Species:

Leishmania mexicana

UniProt:

E9B6G1_LEIMU

TriTrypDb:

LmxM.34.2820

Length:

646

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9B6G1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6G1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	11
GO:0022857	transmembrane transporter activity	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	640	646	PF00089	0.416
CLV_NRD_NRD_1	219	221	PF00675	0.364
CLV_NRD_NRD_1	237	239	PF00675	0.431
CLV_NRD_NRD_1	79	81	PF00675	0.300
CLV_PCSK_FUR_1	235	239	PF00082	0.448
CLV_PCSK_KEX2_1	219	221	PF00082	0.364
CLV_PCSK_KEX2_1	237	239	PF00082	0.431
CLV_PCSK_SKI1_1	435	439	PF00082	0.375
CLV_PCSK_SKI1_1	593	597	PF00082	0.336
DEG_Nend_UBRbox_1	1	4	PF02207	0.634
DEG_SPOP_SBC_1	549	553	PF00917	0.312
DOC_CDC14_PxL_1	625	633	PF14671	0.372
DOC_CKS1_1	529	534	PF01111	0.372
DOC_MAPK_gen_1	400	409	PF00069	0.652
DOC_MAPK_gen_1	472	479	PF00069	0.409
DOC_MAPK_gen_1	80	88	PF00069	0.512
DOC_MAPK_MEF2A_6	444	451	PF00069	0.578
DOC_MAPK_MEF2A_6	514	523	PF00069	0.398
DOC_MAPK_MEF2A_6	77	86	PF00069	0.524
DOC_PP2B_LxvP_1	29	32	PF13499	0.385
DOC_PP2B_LxvP_1	296	299	PF13499	0.725
DOC_PP4_FxxP_1	438	441	PF00568	0.579
DOC_USP7_MATH_1	215	219	PF00917	0.594
DOC_USP7_MATH_1	224	228	PF00917	0.614
DOC_USP7_MATH_1	251	255	PF00917	0.665
DOC_USP7_MATH_1	313	317	PF00917	0.744
DOC_USP7_MATH_1	501	505	PF00917	0.291
DOC_USP7_MATH_1	549	553	PF00917	0.433
DOC_USP7_MATH_1	92	96	PF00917	0.324
DOC_WW_Pin1_4	307	312	PF00397	0.648
DOC_WW_Pin1_4	331	336	PF00397	0.745
DOC_WW_Pin1_4	386	391	PF00397	0.729
DOC_WW_Pin1_4	528	533	PF00397	0.381
DOC_WW_Pin1_4	98	103	PF00397	0.385
LIG_14-3-3_CanoR_1	351	359	PF00244	0.786
LIG_14-3-3_CanoR_1	425	429	PF00244	0.790
LIG_14-3-3_CanoR_1	5	10	PF00244	0.529
LIG_14-3-3_CanoR_1	593	598	PF00244	0.372
LIG_14-3-3_CterR_2	643	646	PF00244	0.639
LIG_BIR_III_4	375	379	PF00653	0.671
LIG_BRCT_BRCA1_1	498	502	PF00533	0.385
LIG_BRCT_BRCA1_1	540	544	PF00533	0.454
LIG_BRCT_BRCA1_1	562	566	PF00533	0.379
LIG_BRCT_BRCA1_1	94	98	PF00533	0.438
LIG_eIF4E_1	51	57	PF01652	0.407
LIG_FHA_1	108	114	PF00498	0.336
LIG_FHA_1	134	140	PF00498	0.492
LIG_FHA_1	16	22	PF00498	0.398
LIG_FHA_1	511	517	PF00498	0.563
LIG_FHA_1	524	530	PF00498	0.313
LIG_FHA_1	551	557	PF00498	0.501
LIG_FHA_1	594	600	PF00498	0.312
LIG_FHA_1	65	71	PF00498	0.478
LIG_FHA_2	130	136	PF00498	0.526
LIG_FHA_2	71	77	PF00498	0.526
LIG_IRF3_LxIS_1	205	211	PF10401	0.295
LIG_IRF3_LxIS_1	484	491	PF10401	0.385
LIG_IRF3_LxIS_1	52	58	PF10401	0.324
LIG_LIR_Apic_2	436	441	PF02991	0.519
LIG_LIR_Gen_1	200	210	PF02991	0.336
LIG_LIR_Gen_1	223	230	PF02991	0.660
LIG_LIR_Gen_1	275	284	PF02991	0.701
LIG_LIR_Gen_1	358	366	PF02991	0.592
LIG_LIR_Gen_1	499	509	PF02991	0.399
LIG_LIR_Gen_1	559	570	PF02991	0.387
LIG_LIR_Gen_1	590	599	PF02991	0.327
LIG_LIR_Gen_1	8	16	PF02991	0.554
LIG_LIR_Nem_3	145	150	PF02991	0.298
LIG_LIR_Nem_3	200	205	PF02991	0.465
LIG_LIR_Nem_3	223	228	PF02991	0.659
LIG_LIR_Nem_3	275	281	PF02991	0.720
LIG_LIR_Nem_3	358	362	PF02991	0.590
LIG_LIR_Nem_3	499	505	PF02991	0.448
LIG_LIR_Nem_3	563	569	PF02991	0.391
LIG_LIR_Nem_3	95	100	PF02991	0.445
LIG_MLH1_MIPbox_1	94	98	PF16413	0.385
LIG_MYND_1	191	195	PF01753	0.395
LIG_NRBOX	518	524	PF00104	0.203
LIG_Pex14_2	225	229	PF04695	0.683
LIG_Pex14_2	33	37	PF04695	0.346
LIG_Pex14_2	617	621	PF04695	0.382
LIG_SH2_CRK	450	454	PF00017	0.326
LIG_SH2_CRK	619	623	PF00017	0.317
LIG_SH2_GRB2like	10	13	PF00017	0.483
LIG_SH2_NCK_1	545	549	PF00017	0.239
LIG_SH2_STAP1	10	14	PF00017	0.526
LIG_SH2_STAP1	352	356	PF00017	0.626
LIG_SH2_STAP1	359	363	PF00017	0.638
LIG_SH2_STAP1	545	549	PF00017	0.350
LIG_SH2_STAP1	562	566	PF00017	0.398
LIG_SH2_STAT5	10	13	PF00017	0.526
LIG_SH2_STAT5	161	164	PF00017	0.336
LIG_SH2_STAT5	309	312	PF00017	0.632
LIG_SH2_STAT5	352	355	PF00017	0.592
LIG_SH2_STAT5	495	498	PF00017	0.428
LIG_SH2_STAT5	51	54	PF00017	0.507
LIG_SH2_STAT5	536	539	PF00017	0.393
LIG_SH2_STAT5	568	571	PF00017	0.517
LIG_SH3_3	150	156	PF00018	0.385
LIG_SH3_3	218	224	PF00018	0.651
LIG_SH3_3	292	298	PF00018	0.654
LIG_SH3_3	384	390	PF00018	0.701
LIG_SH3_3	596	602	PF00018	0.378
LIG_SH3_4	81	88	PF00018	0.526
LIG_SUMO_SIM_anti_2	203	209	PF11976	0.377
LIG_SUMO_SIM_anti_2	258	264	PF11976	0.734
LIG_SUMO_SIM_anti_2	518	523	PF11976	0.259
LIG_SUMO_SIM_par_1	17	24	PF11976	0.360
LIG_SUMO_SIM_par_1	197	203	PF11976	0.295
LIG_SUMO_SIM_par_1	206	211	PF11976	0.288
LIG_SUMO_SIM_par_1	628	633	PF11976	0.372
LIG_SxIP_EBH_1	402	413	PF03271	0.590
LIG_SxIP_EBH_1	593	606	PF03271	0.336
LIG_TRAF2_1	312	315	PF00917	0.686
LIG_TRFH_1	187	191	PF08558	0.340
LIG_TRFH_1	98	102	PF08558	0.336
LIG_TYR_ITIM	448	453	PF00017	0.407
LIG_UBA3_1	96	105	PF00899	0.385
LIG_WRC_WIRS_1	359	364	PF05994	0.591
LIG_WRC_WIRS_1	588	593	PF05994	0.276
LIG_WRC_WIRS_1	631	636	PF05994	0.428
MOD_CDK_SPK_2	331	336	PF00069	0.633
MOD_CDK_SPxxK_3	98	105	PF00069	0.385
MOD_CK1_1	200	206	PF00069	0.343
MOD_CK1_1	301	307	PF00069	0.693
MOD_CK1_1	358	364	PF00069	0.719
MOD_CK1_1	455	461	PF00069	0.293
MOD_CK1_1	528	534	PF00069	0.308
MOD_CK1_1	587	593	PF00069	0.343
MOD_CK1_1	8	14	PF00069	0.596
MOD_CK2_1	309	315	PF00069	0.746
MOD_CK2_1	549	555	PF00069	0.372
MOD_Cter_Amidation	78	81	PF01082	0.300
MOD_GlcNHglycan	177	180	PF01048	0.609
MOD_GlcNHglycan	202	205	PF01048	0.336
MOD_GlcNHglycan	230	233	PF01048	0.439
MOD_GlcNHglycan	25	28	PF01048	0.385
MOD_GlcNHglycan	285	290	PF01048	0.567
MOD_GlcNHglycan	292	295	PF01048	0.515
MOD_GlcNHglycan	311	314	PF01048	0.410
MOD_GlcNHglycan	341	344	PF01048	0.513
MOD_GlcNHglycan	457	460	PF01048	0.408
MOD_GlcNHglycan	52	55	PF01048	0.348
MOD_GlcNHglycan	545	548	PF01048	0.428
MOD_GlcNHglycan	571	574	PF01048	0.382
MOD_GSK3_1	1	8	PF00069	0.599
MOD_GSK3_1	129	136	PF00069	0.526
MOD_GSK3_1	15	22	PF00069	0.355
MOD_GSK3_1	224	231	PF00069	0.685
MOD_GSK3_1	285	292	PF00069	0.692
MOD_GSK3_1	301	308	PF00069	0.766
MOD_GSK3_1	309	316	PF00069	0.716
MOD_GSK3_1	346	353	PF00069	0.822
MOD_GSK3_1	420	427	PF00069	0.698
MOD_GSK3_1	496	503	PF00069	0.490
MOD_GSK3_1	524	531	PF00069	0.434
MOD_GSK3_1	535	542	PF00069	0.368
MOD_GSK3_1	556	563	PF00069	0.373
MOD_GSK3_1	589	596	PF00069	0.372
MOD_GSK3_1	630	637	PF00069	0.437
MOD_NEK2_1	1	6	PF00069	0.554
MOD_NEK2_1	175	180	PF00069	0.372
MOD_NEK2_1	197	202	PF00069	0.412
MOD_NEK2_1	208	213	PF00069	0.448
MOD_NEK2_1	228	233	PF00069	0.746
MOD_NEK2_1	25	30	PF00069	0.346
MOD_NEK2_1	339	344	PF00069	0.694
MOD_NEK2_1	477	482	PF00069	0.355
MOD_NEK2_1	488	493	PF00069	0.350
MOD_NEK2_1	500	505	PF00069	0.409
MOD_NEK2_1	523	528	PF00069	0.348
MOD_NEK2_1	55	60	PF00069	0.339
MOD_NEK2_1	595	600	PF00069	0.369
MOD_NEK2_1	604	609	PF00069	0.388
MOD_NEK2_1	623	628	PF00069	0.345
MOD_NEK2_1	630	635	PF00069	0.345
MOD_NEK2_1	70	75	PF00069	0.595
MOD_NEK2_2	142	147	PF00069	0.336
MOD_NEK2_2	224	229	PF00069	0.678
MOD_NEK2_2	92	97	PF00069	0.425
MOD_PKA_1	237	243	PF00069	0.611
MOD_PKA_2	237	243	PF00069	0.666
MOD_PKA_2	350	356	PF00069	0.770
MOD_PKA_2	424	430	PF00069	0.683
MOD_PKB_1	235	243	PF00069	0.612
MOD_Plk_1	517	523	PF00069	0.514
MOD_Plk_1	538	544	PF00069	0.362
MOD_Plk_4	123	129	PF00069	0.399
MOD_Plk_4	149	155	PF00069	0.411
MOD_Plk_4	15	21	PF00069	0.327
MOD_Plk_4	224	230	PF00069	0.762
MOD_Plk_4	25	31	PF00069	0.326
MOD_Plk_4	358	364	PF00069	0.649
MOD_Plk_4	489	495	PF00069	0.399
MOD_Plk_4	5	11	PF00069	0.641
MOD_Plk_4	501	507	PF00069	0.538
MOD_Plk_4	517	523	PF00069	0.380
MOD_Plk_4	525	531	PF00069	0.387
MOD_Plk_4	539	545	PF00069	0.427
MOD_Plk_4	560	566	PF00069	0.477
MOD_Plk_4	595	601	PF00069	0.444
MOD_Plk_4	630	636	PF00069	0.465
MOD_Plk_4	92	98	PF00069	0.466
MOD_ProDKin_1	307	313	PF00069	0.647
MOD_ProDKin_1	331	337	PF00069	0.745
MOD_ProDKin_1	386	392	PF00069	0.729
MOD_ProDKin_1	528	534	PF00069	0.381
MOD_ProDKin_1	98	104	PF00069	0.385
TRG_DiLeu_BaLyEn_6	626	631	PF01217	0.372
TRG_ENDOCYTIC_2	10	13	PF00928	0.526
TRG_ENDOCYTIC_2	359	362	PF00928	0.592
TRG_ENDOCYTIC_2	450	453	PF00928	0.367
TRG_ENDOCYTIC_2	562	565	PF00928	0.508
TRG_ENDOCYTIC_2	619	622	PF00928	0.317
TRG_ER_diArg_1	219	221	PF00400	0.700
TRG_ER_diArg_1	237	239	PF00400	0.652
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.351
TRG_Pf-PMV_PEXEL_1	381	385	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	514	518	PF00026	0.352

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMM8	Leptomonas seymouri	32%	98%
A0A3Q8II42	Leishmania donovani	88%	100%
A4HMU7	Leishmania braziliensis	30%	100%
A4HMU9	Leishmania braziliensis	70%	100%
A4IBH1	Leishmania infantum	88%	100%
C9ZZ72	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E8NHI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AFA6	Leishmania major	84%	100%
E9B6G0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%