LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

MFS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
MFS domain-containing protein
Gene product:
major facilitator superfamily, putative
Species:
Leishmania mexicana
UniProt:
E9B6G1_LEIMU
TriTrypDb:
LmxM.34.2820
Length:
646

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

E9B6G1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6G1

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 11
GO:0022857 transmembrane transporter activity 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 640 646 PF00089 0.416
CLV_NRD_NRD_1 219 221 PF00675 0.364
CLV_NRD_NRD_1 237 239 PF00675 0.431
CLV_NRD_NRD_1 79 81 PF00675 0.300
CLV_PCSK_FUR_1 235 239 PF00082 0.448
CLV_PCSK_KEX2_1 219 221 PF00082 0.364
CLV_PCSK_KEX2_1 237 239 PF00082 0.431
CLV_PCSK_SKI1_1 435 439 PF00082 0.375
CLV_PCSK_SKI1_1 593 597 PF00082 0.336
DEG_Nend_UBRbox_1 1 4 PF02207 0.634
DEG_SPOP_SBC_1 549 553 PF00917 0.312
DOC_CDC14_PxL_1 625 633 PF14671 0.372
DOC_CKS1_1 529 534 PF01111 0.372
DOC_MAPK_gen_1 400 409 PF00069 0.652
DOC_MAPK_gen_1 472 479 PF00069 0.409
DOC_MAPK_gen_1 80 88 PF00069 0.512
DOC_MAPK_MEF2A_6 444 451 PF00069 0.578
DOC_MAPK_MEF2A_6 514 523 PF00069 0.398
DOC_MAPK_MEF2A_6 77 86 PF00069 0.524
DOC_PP2B_LxvP_1 29 32 PF13499 0.385
DOC_PP2B_LxvP_1 296 299 PF13499 0.725
DOC_PP4_FxxP_1 438 441 PF00568 0.579
DOC_USP7_MATH_1 215 219 PF00917 0.594
DOC_USP7_MATH_1 224 228 PF00917 0.614
DOC_USP7_MATH_1 251 255 PF00917 0.665
DOC_USP7_MATH_1 313 317 PF00917 0.744
DOC_USP7_MATH_1 501 505 PF00917 0.291
DOC_USP7_MATH_1 549 553 PF00917 0.433
DOC_USP7_MATH_1 92 96 PF00917 0.324
DOC_WW_Pin1_4 307 312 PF00397 0.648
DOC_WW_Pin1_4 331 336 PF00397 0.745
DOC_WW_Pin1_4 386 391 PF00397 0.729
DOC_WW_Pin1_4 528 533 PF00397 0.381
DOC_WW_Pin1_4 98 103 PF00397 0.385
LIG_14-3-3_CanoR_1 351 359 PF00244 0.786
LIG_14-3-3_CanoR_1 425 429 PF00244 0.790
LIG_14-3-3_CanoR_1 5 10 PF00244 0.529
LIG_14-3-3_CanoR_1 593 598 PF00244 0.372
LIG_14-3-3_CterR_2 643 646 PF00244 0.639
LIG_BIR_III_4 375 379 PF00653 0.671
LIG_BRCT_BRCA1_1 498 502 PF00533 0.385
LIG_BRCT_BRCA1_1 540 544 PF00533 0.454
LIG_BRCT_BRCA1_1 562 566 PF00533 0.379
LIG_BRCT_BRCA1_1 94 98 PF00533 0.438
LIG_eIF4E_1 51 57 PF01652 0.407
LIG_FHA_1 108 114 PF00498 0.336
LIG_FHA_1 134 140 PF00498 0.492
LIG_FHA_1 16 22 PF00498 0.398
LIG_FHA_1 511 517 PF00498 0.563
LIG_FHA_1 524 530 PF00498 0.313
LIG_FHA_1 551 557 PF00498 0.501
LIG_FHA_1 594 600 PF00498 0.312
LIG_FHA_1 65 71 PF00498 0.478
LIG_FHA_2 130 136 PF00498 0.526
LIG_FHA_2 71 77 PF00498 0.526
LIG_IRF3_LxIS_1 205 211 PF10401 0.295
LIG_IRF3_LxIS_1 484 491 PF10401 0.385
LIG_IRF3_LxIS_1 52 58 PF10401 0.324
LIG_LIR_Apic_2 436 441 PF02991 0.519
LIG_LIR_Gen_1 200 210 PF02991 0.336
LIG_LIR_Gen_1 223 230 PF02991 0.660
LIG_LIR_Gen_1 275 284 PF02991 0.701
LIG_LIR_Gen_1 358 366 PF02991 0.592
LIG_LIR_Gen_1 499 509 PF02991 0.399
LIG_LIR_Gen_1 559 570 PF02991 0.387
LIG_LIR_Gen_1 590 599 PF02991 0.327
LIG_LIR_Gen_1 8 16 PF02991 0.554
LIG_LIR_Nem_3 145 150 PF02991 0.298
LIG_LIR_Nem_3 200 205 PF02991 0.465
LIG_LIR_Nem_3 223 228 PF02991 0.659
LIG_LIR_Nem_3 275 281 PF02991 0.720
LIG_LIR_Nem_3 358 362 PF02991 0.590
LIG_LIR_Nem_3 499 505 PF02991 0.448
LIG_LIR_Nem_3 563 569 PF02991 0.391
LIG_LIR_Nem_3 95 100 PF02991 0.445
LIG_MLH1_MIPbox_1 94 98 PF16413 0.385
LIG_MYND_1 191 195 PF01753 0.395
LIG_NRBOX 518 524 PF00104 0.203
LIG_Pex14_2 225 229 PF04695 0.683
LIG_Pex14_2 33 37 PF04695 0.346
LIG_Pex14_2 617 621 PF04695 0.382
LIG_SH2_CRK 450 454 PF00017 0.326
LIG_SH2_CRK 619 623 PF00017 0.317
LIG_SH2_GRB2like 10 13 PF00017 0.483
LIG_SH2_NCK_1 545 549 PF00017 0.239
LIG_SH2_STAP1 10 14 PF00017 0.526
LIG_SH2_STAP1 352 356 PF00017 0.626
LIG_SH2_STAP1 359 363 PF00017 0.638
LIG_SH2_STAP1 545 549 PF00017 0.350
LIG_SH2_STAP1 562 566 PF00017 0.398
LIG_SH2_STAT5 10 13 PF00017 0.526
LIG_SH2_STAT5 161 164 PF00017 0.336
LIG_SH2_STAT5 309 312 PF00017 0.632
LIG_SH2_STAT5 352 355 PF00017 0.592
LIG_SH2_STAT5 495 498 PF00017 0.428
LIG_SH2_STAT5 51 54 PF00017 0.507
LIG_SH2_STAT5 536 539 PF00017 0.393
LIG_SH2_STAT5 568 571 PF00017 0.517
LIG_SH3_3 150 156 PF00018 0.385
LIG_SH3_3 218 224 PF00018 0.651
LIG_SH3_3 292 298 PF00018 0.654
LIG_SH3_3 384 390 PF00018 0.701
LIG_SH3_3 596 602 PF00018 0.378
LIG_SH3_4 81 88 PF00018 0.526
LIG_SUMO_SIM_anti_2 203 209 PF11976 0.377
LIG_SUMO_SIM_anti_2 258 264 PF11976 0.734
LIG_SUMO_SIM_anti_2 518 523 PF11976 0.259
LIG_SUMO_SIM_par_1 17 24 PF11976 0.360
LIG_SUMO_SIM_par_1 197 203 PF11976 0.295
LIG_SUMO_SIM_par_1 206 211 PF11976 0.288
LIG_SUMO_SIM_par_1 628 633 PF11976 0.372
LIG_SxIP_EBH_1 402 413 PF03271 0.590
LIG_SxIP_EBH_1 593 606 PF03271 0.336
LIG_TRAF2_1 312 315 PF00917 0.686
LIG_TRFH_1 187 191 PF08558 0.340
LIG_TRFH_1 98 102 PF08558 0.336
LIG_TYR_ITIM 448 453 PF00017 0.407
LIG_UBA3_1 96 105 PF00899 0.385
LIG_WRC_WIRS_1 359 364 PF05994 0.591
LIG_WRC_WIRS_1 588 593 PF05994 0.276
LIG_WRC_WIRS_1 631 636 PF05994 0.428
MOD_CDK_SPK_2 331 336 PF00069 0.633
MOD_CDK_SPxxK_3 98 105 PF00069 0.385
MOD_CK1_1 200 206 PF00069 0.343
MOD_CK1_1 301 307 PF00069 0.693
MOD_CK1_1 358 364 PF00069 0.719
MOD_CK1_1 455 461 PF00069 0.293
MOD_CK1_1 528 534 PF00069 0.308
MOD_CK1_1 587 593 PF00069 0.343
MOD_CK1_1 8 14 PF00069 0.596
MOD_CK2_1 309 315 PF00069 0.746
MOD_CK2_1 549 555 PF00069 0.372
MOD_Cter_Amidation 78 81 PF01082 0.300
MOD_GlcNHglycan 177 180 PF01048 0.609
MOD_GlcNHglycan 202 205 PF01048 0.336
MOD_GlcNHglycan 230 233 PF01048 0.439
MOD_GlcNHglycan 25 28 PF01048 0.385
MOD_GlcNHglycan 285 290 PF01048 0.567
MOD_GlcNHglycan 292 295 PF01048 0.515
MOD_GlcNHglycan 311 314 PF01048 0.410
MOD_GlcNHglycan 341 344 PF01048 0.513
MOD_GlcNHglycan 457 460 PF01048 0.408
MOD_GlcNHglycan 52 55 PF01048 0.348
MOD_GlcNHglycan 545 548 PF01048 0.428
MOD_GlcNHglycan 571 574 PF01048 0.382
MOD_GSK3_1 1 8 PF00069 0.599
MOD_GSK3_1 129 136 PF00069 0.526
MOD_GSK3_1 15 22 PF00069 0.355
MOD_GSK3_1 224 231 PF00069 0.685
MOD_GSK3_1 285 292 PF00069 0.692
MOD_GSK3_1 301 308 PF00069 0.766
MOD_GSK3_1 309 316 PF00069 0.716
MOD_GSK3_1 346 353 PF00069 0.822
MOD_GSK3_1 420 427 PF00069 0.698
MOD_GSK3_1 496 503 PF00069 0.490
MOD_GSK3_1 524 531 PF00069 0.434
MOD_GSK3_1 535 542 PF00069 0.368
MOD_GSK3_1 556 563 PF00069 0.373
MOD_GSK3_1 589 596 PF00069 0.372
MOD_GSK3_1 630 637 PF00069 0.437
MOD_NEK2_1 1 6 PF00069 0.554
MOD_NEK2_1 175 180 PF00069 0.372
MOD_NEK2_1 197 202 PF00069 0.412
MOD_NEK2_1 208 213 PF00069 0.448
MOD_NEK2_1 228 233 PF00069 0.746
MOD_NEK2_1 25 30 PF00069 0.346
MOD_NEK2_1 339 344 PF00069 0.694
MOD_NEK2_1 477 482 PF00069 0.355
MOD_NEK2_1 488 493 PF00069 0.350
MOD_NEK2_1 500 505 PF00069 0.409
MOD_NEK2_1 523 528 PF00069 0.348
MOD_NEK2_1 55 60 PF00069 0.339
MOD_NEK2_1 595 600 PF00069 0.369
MOD_NEK2_1 604 609 PF00069 0.388
MOD_NEK2_1 623 628 PF00069 0.345
MOD_NEK2_1 630 635 PF00069 0.345
MOD_NEK2_1 70 75 PF00069 0.595
MOD_NEK2_2 142 147 PF00069 0.336
MOD_NEK2_2 224 229 PF00069 0.678
MOD_NEK2_2 92 97 PF00069 0.425
MOD_PKA_1 237 243 PF00069 0.611
MOD_PKA_2 237 243 PF00069 0.666
MOD_PKA_2 350 356 PF00069 0.770
MOD_PKA_2 424 430 PF00069 0.683
MOD_PKB_1 235 243 PF00069 0.612
MOD_Plk_1 517 523 PF00069 0.514
MOD_Plk_1 538 544 PF00069 0.362
MOD_Plk_4 123 129 PF00069 0.399
MOD_Plk_4 149 155 PF00069 0.411
MOD_Plk_4 15 21 PF00069 0.327
MOD_Plk_4 224 230 PF00069 0.762
MOD_Plk_4 25 31 PF00069 0.326
MOD_Plk_4 358 364 PF00069 0.649
MOD_Plk_4 489 495 PF00069 0.399
MOD_Plk_4 5 11 PF00069 0.641
MOD_Plk_4 501 507 PF00069 0.538
MOD_Plk_4 517 523 PF00069 0.380
MOD_Plk_4 525 531 PF00069 0.387
MOD_Plk_4 539 545 PF00069 0.427
MOD_Plk_4 560 566 PF00069 0.477
MOD_Plk_4 595 601 PF00069 0.444
MOD_Plk_4 630 636 PF00069 0.465
MOD_Plk_4 92 98 PF00069 0.466
MOD_ProDKin_1 307 313 PF00069 0.647
MOD_ProDKin_1 331 337 PF00069 0.745
MOD_ProDKin_1 386 392 PF00069 0.729
MOD_ProDKin_1 528 534 PF00069 0.381
MOD_ProDKin_1 98 104 PF00069 0.385
TRG_DiLeu_BaLyEn_6 626 631 PF01217 0.372
TRG_ENDOCYTIC_2 10 13 PF00928 0.526
TRG_ENDOCYTIC_2 359 362 PF00928 0.592
TRG_ENDOCYTIC_2 450 453 PF00928 0.367
TRG_ENDOCYTIC_2 562 565 PF00928 0.508
TRG_ENDOCYTIC_2 619 622 PF00928 0.317
TRG_ER_diArg_1 219 221 PF00400 0.700
TRG_ER_diArg_1 237 239 PF00400 0.652
TRG_Pf-PMV_PEXEL_1 212 216 PF00026 0.351
TRG_Pf-PMV_PEXEL_1 381 385 PF00026 0.513
TRG_Pf-PMV_PEXEL_1 514 518 PF00026 0.352

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMM8 Leptomonas seymouri 32% 98%
A0A3Q8II42 Leishmania donovani 88% 100%
A4HMU7 Leishmania braziliensis 30% 100%
A4HMU9 Leishmania braziliensis 70% 100%
A4IBH1 Leishmania infantum 88% 100%
C9ZZ72 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
E8NHI2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9AFA6 Leishmania major 84% 100%
E9B6G0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS