MFS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6G0_LEIMU

TriTrypDb:

LmxM.34.2810

Length:

705

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

E9B6G0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6G0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	13
GO:0022857	transmembrane transporter activity	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	297	301	PF00656	0.658
CLV_C14_Caspase3-7	367	371	PF00656	0.656
CLV_NRD_NRD_1	109	111	PF00675	0.304
CLV_NRD_NRD_1	212	214	PF00675	0.560
CLV_NRD_NRD_1	27	29	PF00675	0.475
CLV_NRD_NRD_1	31	33	PF00675	0.444
CLV_NRD_NRD_1	359	361	PF00675	0.438
CLV_PCSK_KEX2_1	109	111	PF00082	0.266
CLV_PCSK_KEX2_1	31	33	PF00082	0.462
CLV_PCSK_KEX2_1	359	361	PF00082	0.438
CLV_PCSK_KEX2_1	461	463	PF00082	0.383
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.473
CLV_PCSK_PC1ET2_1	461	463	PF00082	0.383
CLV_PCSK_SKI1_1	214	218	PF00082	0.505
CLV_PCSK_SKI1_1	32	36	PF00082	0.404
CLV_PCSK_SKI1_1	338	342	PF00082	0.424
CLV_PCSK_SKI1_1	364	368	PF00082	0.462
CLV_PCSK_SKI1_1	466	470	PF00082	0.366
CLV_PCSK_SKI1_1	471	475	PF00082	0.370
DEG_MDM2_SWIB_1	586	594	PF02201	0.340
DOC_CKS1_1	629	634	PF01111	0.340
DOC_MAPK_DCC_7	213	223	PF00069	0.297
DOC_MAPK_FxFP_2	572	575	PF00069	0.289
DOC_MAPK_gen_1	511	520	PF00069	0.336
DOC_MAPK_MEF2A_6	214	223	PF00069	0.297
DOC_MAPK_MEF2A_6	475	484	PF00069	0.547
DOC_MAPK_NFAT4_5	475	483	PF00069	0.466
DOC_PP4_FxxP_1	266	269	PF00568	0.561
DOC_PP4_FxxP_1	385	388	PF00568	0.657
DOC_PP4_FxxP_1	469	472	PF00568	0.606
DOC_PP4_FxxP_1	572	575	PF00568	0.320
DOC_PP4_FxxP_1	629	632	PF00568	0.270
DOC_USP7_MATH_1	194	198	PF00917	0.270
DOC_USP7_MATH_1	562	566	PF00917	0.365
DOC_USP7_UBL2_3	29	33	PF12436	0.712
DOC_WW_Pin1_4	32	37	PF00397	0.598
DOC_WW_Pin1_4	324	329	PF00397	0.703
DOC_WW_Pin1_4	384	389	PF00397	0.627
DOC_WW_Pin1_4	440	445	PF00397	0.652
DOC_WW_Pin1_4	628	633	PF00397	0.340
LIG_14-3-3_CanoR_1	359	366	PF00244	0.651
LIG_Actin_WH2_2	388	406	PF00022	0.618
LIG_Actin_WH2_2	58	73	PF00022	0.340
LIG_BIR_II_1	1	5	PF00653	0.650
LIG_BRCT_BRCA1_1	114	118	PF00533	0.327
LIG_BRCT_BRCA1_1	361	365	PF00533	0.658
LIG_BRCT_BRCA1_1	405	409	PF00533	0.634
LIG_BRCT_BRCA1_1	568	572	PF00533	0.445
LIG_deltaCOP1_diTrp_1	681	686	PF00928	0.592
LIG_eIF4E_1	80	86	PF01652	0.352
LIG_FHA_1	117	123	PF00498	0.295
LIG_FHA_1	233	239	PF00498	0.394
LIG_FHA_1	272	278	PF00498	0.683
LIG_FHA_1	420	426	PF00498	0.696
LIG_FHA_1	44	50	PF00498	0.340
LIG_FHA_1	474	480	PF00498	0.542
LIG_FHA_1	562	568	PF00498	0.428
LIG_FHA_2	315	321	PF00498	0.634
LIG_FHA_2	365	371	PF00498	0.702
LIG_FHA_2	488	494	PF00498	0.305
LIG_FHA_2	669	675	PF00498	0.576
LIG_LIR_Apic_2	569	575	PF02991	0.334
LIG_LIR_Gen_1	333	341	PF02991	0.666
LIG_LIR_Gen_1	46	54	PF02991	0.379
LIG_LIR_Gen_1	551	561	PF02991	0.314
LIG_LIR_Gen_1	581	592	PF02991	0.292
LIG_LIR_Nem_3	333	339	PF02991	0.670
LIG_LIR_Nem_3	46	50	PF02991	0.305
LIG_LIR_Nem_3	551	556	PF02991	0.493
LIG_LIR_Nem_3	569	574	PF02991	0.275
LIG_LIR_Nem_3	581	587	PF02991	0.362
LIG_LIR_Nem_3	589	595	PF02991	0.328
LIG_LIR_Nem_3	97	103	PF02991	0.433
LIG_LYPXL_S_1	255	259	PF13949	0.332
LIG_MLH1_MIPbox_1	568	572	PF16413	0.355
LIG_MYND_1	215	219	PF01753	0.381
LIG_MYND_1	269	273	PF01753	0.590
LIG_NRBOX	479	485	PF00104	0.261
LIG_NRBOX	649	655	PF00104	0.305
LIG_Pex14_1	134	138	PF04695	0.272
LIG_Pex14_2	586	590	PF04695	0.358
LIG_REV1ctd_RIR_1	136	144	PF16727	0.305
LIG_SH2_CRK	226	230	PF00017	0.295
LIG_SH2_CRK	592	596	PF00017	0.461
LIG_SH2_CRK	698	702	PF00017	0.526
LIG_SH2_GRB2like	226	229	PF00017	0.295
LIG_SH2_GRB2like	540	543	PF00017	0.560
LIG_SH2_NCK_1	192	196	PF00017	0.252
LIG_SH2_NCK_1	226	230	PF00017	0.249
LIG_SH2_PTP2	254	257	PF00017	0.552
LIG_SH2_PTP2	481	484	PF00017	0.261
LIG_SH2_SRC	192	195	PF00017	0.252
LIG_SH2_SRC	254	257	PF00017	0.552
LIG_SH2_SRC	663	666	PF00017	0.305
LIG_SH2_STAP1	665	669	PF00017	0.377
LIG_SH2_STAT5	226	229	PF00017	0.295
LIG_SH2_STAT5	254	257	PF00017	0.525
LIG_SH2_STAT5	481	484	PF00017	0.261
LIG_SH2_STAT5	517	520	PF00017	0.295
LIG_SH2_STAT5	540	543	PF00017	0.550
LIG_SH2_STAT5	566	569	PF00017	0.365
LIG_SH2_STAT5	571	574	PF00017	0.352
LIG_SH2_STAT5	663	666	PF00017	0.340
LIG_SH3_3	13	19	PF00018	0.684
LIG_SH3_3	322	328	PF00018	0.663
LIG_SH3_3	6	12	PF00018	0.740
LIG_SUMO_SIM_anti_2	391	399	PF11976	0.644
LIG_SUMO_SIM_par_1	391	399	PF11976	0.644
LIG_TRAF2_1	490	493	PF00917	0.392
LIG_TRAF2_1	671	674	PF00917	0.570
LIG_TRFH_1	571	575	PF08558	0.329
LIG_TYR_ITIM	479	484	PF00017	0.489
LIG_WRC_WIRS_1	233	238	PF05994	0.373
MOD_CDK_SPxxK_3	440	447	PF00069	0.641
MOD_CK1_1	206	212	PF00069	0.379
MOD_CK1_1	346	352	PF00069	0.756
MOD_CK1_1	53	59	PF00069	0.362
MOD_CK1_1	551	557	PF00069	0.282
MOD_CK2_1	289	295	PF00069	0.722
MOD_CK2_1	314	320	PF00069	0.646
MOD_CK2_1	368	374	PF00069	0.650
MOD_CK2_1	487	493	PF00069	0.305
MOD_CK2_1	668	674	PF00069	0.578
MOD_CK2_1	71	77	PF00069	0.297
MOD_Cter_Amidation	107	110	PF01082	0.306
MOD_GlcNHglycan	114	117	PF01048	0.252
MOD_GlcNHglycan	119	122	PF01048	0.295
MOD_GlcNHglycan	197	200	PF01048	0.583
MOD_GlcNHglycan	312	315	PF01048	0.507
MOD_GlcNHglycan	601	604	PF01048	0.353
MOD_GlcNHglycan	654	657	PF01048	0.408
MOD_GlcNHglycan	660	663	PF01048	0.295
MOD_GlcNHglycan	81	84	PF01048	0.353
MOD_GSK3_1	112	119	PF00069	0.295
MOD_GSK3_1	267	274	PF00069	0.701
MOD_GSK3_1	276	283	PF00069	0.692
MOD_GSK3_1	310	317	PF00069	0.659
MOD_GSK3_1	324	331	PF00069	0.720
MOD_GSK3_1	339	346	PF00069	0.639
MOD_GSK3_1	360	367	PF00069	0.710
MOD_GSK3_1	562	569	PF00069	0.392
MOD_GSK3_1	599	606	PF00069	0.587
MOD_LATS_1	358	364	PF00433	0.636
MOD_LATS_1	69	75	PF00433	0.297
MOD_N-GLC_1	195	200	PF02516	0.568
MOD_N-GLC_1	289	294	PF02516	0.505
MOD_N-GLC_1	346	351	PF02516	0.461
MOD_N-GLC_1	50	55	PF02516	0.295
MOD_NEK2_1	117	122	PF00069	0.318
MOD_NEK2_1	127	132	PF00069	0.312
MOD_NEK2_1	224	229	PF00069	0.430
MOD_NEK2_1	232	237	PF00069	0.485
MOD_NEK2_1	277	282	PF00069	0.705
MOD_NEK2_1	341	346	PF00069	0.667
MOD_NEK2_1	403	408	PF00069	0.692
MOD_NEK2_1	50	55	PF00069	0.343
MOD_NEK2_1	520	525	PF00069	0.408
MOD_NEK2_1	578	583	PF00069	0.360
MOD_NEK2_1	585	590	PF00069	0.449
MOD_NEK2_1	612	617	PF00069	0.516
MOD_NEK2_1	634	639	PF00069	0.394
MOD_NEK2_1	652	657	PF00069	0.349
MOD_NEK2_1	690	695	PF00069	0.513
MOD_NEK2_2	321	326	PF00069	0.648
MOD_NEK2_2	419	424	PF00069	0.646
MOD_PIKK_1	314	320	PF00454	0.689
MOD_PIKK_1	612	618	PF00454	0.489
MOD_PK_1	368	374	PF00069	0.622
MOD_PK_1	548	554	PF00069	0.209
MOD_PK_1	71	77	PF00069	0.297
MOD_PKA_1	359	365	PF00069	0.636
MOD_PKA_2	271	277	PF00069	0.701
MOD_PKA_2	359	365	PF00069	0.673
MOD_PKA_2	403	409	PF00069	0.701
MOD_Plk_1	195	201	PF00069	0.373
MOD_Plk_1	319	325	PF00069	0.630
MOD_Plk_1	487	493	PF00069	0.335
MOD_Plk_1	50	56	PF00069	0.295
MOD_Plk_1	680	686	PF00069	0.594
MOD_Plk_2-3	413	419	PF00069	0.645
MOD_Plk_4	10	16	PF00069	0.664
MOD_Plk_4	129	135	PF00069	0.359
MOD_Plk_4	152	158	PF00069	0.504
MOD_Plk_4	206	212	PF00069	0.388
MOD_Plk_4	217	223	PF00069	0.247
MOD_Plk_4	232	238	PF00069	0.382
MOD_Plk_4	419	425	PF00069	0.646
MOD_Plk_4	43	49	PF00069	0.320
MOD_Plk_4	53	59	PF00069	0.310
MOD_Plk_4	542	548	PF00069	0.565
MOD_Plk_4	562	568	PF00069	0.439
MOD_Plk_4	579	585	PF00069	0.419
MOD_Plk_4	593	599	PF00069	0.358
MOD_Plk_4	607	613	PF00069	0.506
MOD_ProDKin_1	32	38	PF00069	0.587
MOD_ProDKin_1	324	330	PF00069	0.703
MOD_ProDKin_1	384	390	PF00069	0.628
MOD_ProDKin_1	440	446	PF00069	0.653
MOD_ProDKin_1	628	634	PF00069	0.340
MOD_SUMO_rev_2	456	463	PF00179	0.624
MOD_SUMO_rev_2	683	693	PF00179	0.522
TRG_DiLeu_BaEn_2	261	267	PF01217	0.564
TRG_DiLeu_BaLyEn_6	325	330	PF01217	0.688
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.662
TRG_ENDOCYTIC_2	226	229	PF00928	0.295
TRG_ENDOCYTIC_2	256	259	PF00928	0.529
TRG_ENDOCYTIC_2	481	484	PF00928	0.352
TRG_ENDOCYTIC_2	517	520	PF00928	0.296
TRG_ENDOCYTIC_2	571	574	PF00928	0.316
TRG_ENDOCYTIC_2	592	595	PF00928	0.493
TRG_ENDOCYTIC_2	698	701	PF00928	0.584
TRG_ER_diArg_1	109	111	PF00400	0.466
TRG_NES_CRM1_1	41	52	PF08389	0.497
TRG_NLS_MonoExtC_3	27	32	PF00514	0.690
TRG_NLS_MonoExtN_4	28	35	PF00514	0.660

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMM8	Leptomonas seymouri	44%	100%
A0A3Q8II42	Leishmania donovani	30%	98%
A0A3Q8IPN7	Leishmania donovani	81%	100%
A4HMU7	Leishmania braziliensis	63%	100%
A4HMU9	Leishmania braziliensis	29%	99%
A4IBH0	Leishmania infantum	81%	100%
A4IBH1	Leishmania infantum	29%	96%
E8NHI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9AFA5	Leishmania major	79%	100%
E9AFA6	Leishmania major	29%	95%
E9B6G1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%