LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B6F8_LEIMU
TriTrypDb:
LmxM.34.2790
Length:
402

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26167471
Might belong to a Kinetoplastid-specific lectin domain protein family. Experiments of homologues indicate them to localize to ER (PMID: 26167471). Extensively duplicated gene family.. Localization: ER (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. yes yes: 16
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 11, no: 2
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12

Expansion

Sequence features

E9B6F8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6F8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 207 211 PF00656 0.374
CLV_C14_Caspase3-7 221 225 PF00656 0.558
CLV_PCSK_SKI1_1 261 265 PF00082 0.681
DEG_APCC_DBOX_1 145 153 PF00400 0.444
DEG_COP1_1 111 121 PF00400 0.428
DEG_Nend_UBRbox_2 1 3 PF02207 0.622
DEG_SCF_FBW7_2 294 301 PF00400 0.656
DEG_SPOP_SBC_1 5 9 PF00917 0.477
DOC_CKS1_1 48 53 PF01111 0.461
DOC_MAPK_DCC_7 300 310 PF00069 0.634
DOC_PP1_RVXF_1 259 266 PF00149 0.491
DOC_USP7_MATH_1 117 121 PF00917 0.499
DOC_USP7_MATH_1 130 134 PF00917 0.403
DOC_USP7_MATH_1 19 23 PF00917 0.507
DOC_USP7_MATH_1 218 222 PF00917 0.455
DOC_USP7_MATH_1 246 250 PF00917 0.393
DOC_USP7_MATH_1 333 337 PF00917 0.694
DOC_USP7_MATH_1 368 372 PF00917 0.696
DOC_WW_Pin1_4 132 137 PF00397 0.466
DOC_WW_Pin1_4 294 299 PF00397 0.647
DOC_WW_Pin1_4 352 357 PF00397 0.661
DOC_WW_Pin1_4 47 52 PF00397 0.544
LIG_APCC_ABBA_1 232 237 PF00400 0.407
LIG_APCC_ABBAyCdc20_2 231 237 PF00400 0.412
LIG_BRCT_BRCA1_1 237 241 PF00533 0.422
LIG_deltaCOP1_diTrp_1 262 271 PF00928 0.424
LIG_EH1_1 273 281 PF00400 0.368
LIG_FHA_1 153 159 PF00498 0.576
LIG_FHA_2 149 155 PF00498 0.448
LIG_FHA_2 205 211 PF00498 0.394
LIG_GBD_Chelix_1 286 294 PF00786 0.381
LIG_IRF3_LxIS_1 272 278 PF10401 0.235
LIG_LIR_Gen_1 120 128 PF02991 0.535
LIG_LIR_Gen_1 22 30 PF02991 0.422
LIG_LIR_Gen_1 268 279 PF02991 0.383
LIG_LIR_Gen_1 316 322 PF02991 0.682
LIG_LIR_Nem_3 105 110 PF02991 0.536
LIG_LIR_Nem_3 120 124 PF02991 0.526
LIG_LIR_Nem_3 144 150 PF02991 0.489
LIG_LIR_Nem_3 169 174 PF02991 0.507
LIG_LIR_Nem_3 22 27 PF02991 0.517
LIG_LIR_Nem_3 230 235 PF02991 0.516
LIG_LIR_Nem_3 238 244 PF02991 0.488
LIG_LIR_Nem_3 268 274 PF02991 0.383
LIG_LIR_Nem_3 316 321 PF02991 0.680
LIG_LIR_Nem_3 40 46 PF02991 0.452
LIG_LIR_Nem_3 50 56 PF02991 0.494
LIG_LYPXL_S_1 170 174 PF13949 0.649
LIG_LYPXL_yS_3 171 174 PF13949 0.450
LIG_NRBOX 25 31 PF00104 0.555
LIG_PCNA_PIPBox_1 161 170 PF02747 0.453
LIG_Pex14_1 20 24 PF04695 0.535
LIG_Pex14_1 270 274 PF04695 0.364
LIG_Pex14_2 143 147 PF04695 0.510
LIG_SH2_CRK 291 295 PF00017 0.433
LIG_SH2_CRK 48 52 PF00017 0.462
LIG_SH2_GRB2like 318 321 PF00017 0.765
LIG_SH2_NCK_1 48 52 PF00017 0.533
LIG_SH2_PTP2 244 247 PF00017 0.443
LIG_SH2_PTP2 318 321 PF00017 0.687
LIG_SH2_SRC 244 247 PF00017 0.464
LIG_SH2_SRC 318 321 PF00017 0.736
LIG_SH2_STAP1 184 188 PF00017 0.535
LIG_SH2_STAT3 56 59 PF00017 0.455
LIG_SH2_STAT3 74 77 PF00017 0.417
LIG_SH2_STAT5 107 110 PF00017 0.577
LIG_SH2_STAT5 199 202 PF00017 0.501
LIG_SH2_STAT5 226 229 PF00017 0.497
LIG_SH2_STAT5 235 238 PF00017 0.484
LIG_SH2_STAT5 244 247 PF00017 0.375
LIG_SH2_STAT5 291 294 PF00017 0.490
LIG_SH2_STAT5 318 321 PF00017 0.741
LIG_SH2_STAT5 53 56 PF00017 0.445
LIG_SH2_STAT5 74 77 PF00017 0.522
LIG_SH3_3 242 248 PF00018 0.537
LIG_SH3_3 301 307 PF00018 0.772
LIG_SH3_3 356 362 PF00018 0.715
LIG_SH3_3 36 42 PF00018 0.661
LIG_SUMO_SIM_anti_2 278 284 PF11976 0.235
LIG_SUMO_SIM_par_1 148 155 PF11976 0.444
LIG_SUMO_SIM_par_1 306 312 PF11976 0.613
LIG_TRAF2_1 374 377 PF00917 0.661
LIG_TRFH_1 168 172 PF08558 0.441
LIG_TYR_ITIM 242 247 PF00017 0.595
LIG_TYR_ITIM 289 294 PF00017 0.433
LIG_WRC_WIRS_1 118 123 PF05994 0.439
MOD_CDK_SPK_2 352 357 PF00069 0.630
MOD_CDK_SPxK_1 294 300 PF00069 0.652
MOD_CK1_1 225 231 PF00069 0.484
MOD_CK1_1 81 87 PF00069 0.510
MOD_CK1_1 9 15 PF00069 0.472
MOD_CK2_1 110 116 PF00069 0.452
MOD_CK2_1 338 344 PF00069 0.730
MOD_GlcNHglycan 113 116 PF01048 0.709
MOD_GlcNHglycan 21 24 PF01048 0.640
MOD_GlcNHglycan 220 223 PF01048 0.649
MOD_GlcNHglycan 31 34 PF01048 0.703
MOD_GlcNHglycan 315 318 PF01048 0.522
MOD_GlcNHglycan 349 352 PF01048 0.579
MOD_GlcNHglycan 83 86 PF01048 0.731
MOD_GSK3_1 102 109 PF00069 0.541
MOD_GSK3_1 131 138 PF00069 0.523
MOD_GSK3_1 148 155 PF00069 0.445
MOD_GSK3_1 216 223 PF00069 0.471
MOD_GSK3_1 25 32 PF00069 0.535
MOD_GSK3_1 333 340 PF00069 0.663
MOD_GSK3_1 5 12 PF00069 0.602
MOD_N-GLC_1 313 318 PF02516 0.570
MOD_NEK2_1 102 107 PF00069 0.510
MOD_NEK2_1 108 113 PF00069 0.497
MOD_NEK2_1 201 206 PF00069 0.486
MOD_NEK2_1 275 280 PF00069 0.235
MOD_NEK2_1 29 34 PF00069 0.614
MOD_NEK2_2 141 146 PF00069 0.422
MOD_PIKK_1 123 129 PF00454 0.483
MOD_PIKK_1 235 241 PF00454 0.547
MOD_PKA_2 9 15 PF00069 0.552
MOD_Plk_1 216 222 PF00069 0.453
MOD_Plk_1 261 267 PF00069 0.476
MOD_Plk_1 375 381 PF00069 0.759
MOD_Plk_4 148 154 PF00069 0.505
MOD_Plk_4 166 172 PF00069 0.434
MOD_Plk_4 222 228 PF00069 0.445
MOD_Plk_4 237 243 PF00069 0.407
MOD_Plk_4 246 252 PF00069 0.437
MOD_Plk_4 25 31 PF00069 0.494
MOD_Plk_4 368 374 PF00069 0.691
MOD_Plk_4 78 84 PF00069 0.495
MOD_Plk_4 9 15 PF00069 0.552
MOD_ProDKin_1 132 138 PF00069 0.461
MOD_ProDKin_1 294 300 PF00069 0.652
MOD_ProDKin_1 352 358 PF00069 0.659
MOD_ProDKin_1 47 53 PF00069 0.544
MOD_SUMO_rev_2 392 401 PF00179 0.672
TRG_DiLeu_BaEn_2 236 242 PF01217 0.420
TRG_ENDOCYTIC_2 167 170 PF00928 0.452
TRG_ENDOCYTIC_2 171 174 PF00928 0.451
TRG_ENDOCYTIC_2 198 201 PF00928 0.461
TRG_ENDOCYTIC_2 244 247 PF00928 0.559
TRG_ENDOCYTIC_2 260 263 PF00928 0.413
TRG_ENDOCYTIC_2 291 294 PF00928 0.433
TRG_ENDOCYTIC_2 318 321 PF00928 0.799

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2I6 Leptomonas seymouri 33% 85%
A0A0N1I9Y8 Leptomonas seymouri 37% 100%
A0A1X0NK39 Trypanosomatidae 25% 100%
A0A1X0NVE8 Trypanosomatidae 22% 100%
A0A3S7WSM6 Leishmania donovani 34% 86%
A0A3S7X9E7 Leishmania donovani 90% 100%
A4HMU5 Leishmania braziliensis 75% 99%
A4HVR0 Leishmania infantum 34% 86%
E9AFA3 Leishmania major 88% 100%
E9AHW4 Leishmania infantum 91% 100%
E9APF6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 86%
Q4QG22 Leishmania major 30% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS