G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6F5_LEIMU

TriTrypDb:

LmxM.34.2760

Length:

620

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B6F5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6F5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0017076	purine nucleotide binding	4	12
GO:0019001	guanyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	319	323	PF00656	0.759
CLV_NRD_NRD_1	115	117	PF00675	0.274
CLV_NRD_NRD_1	219	221	PF00675	0.441
CLV_NRD_NRD_1	24	26	PF00675	0.591
CLV_NRD_NRD_1	486	488	PF00675	0.594
CLV_NRD_NRD_1	492	494	PF00675	0.616
CLV_PCSK_KEX2_1	115	117	PF00082	0.276
CLV_PCSK_KEX2_1	23	25	PF00082	0.605
CLV_PCSK_KEX2_1	486	488	PF00082	0.594
CLV_PCSK_KEX2_1	587	589	PF00082	0.636
CLV_PCSK_PC1ET2_1	587	589	PF00082	0.666
CLV_PCSK_PC7_1	19	25	PF00082	0.609
CLV_PCSK_SKI1_1	36	40	PF00082	0.712
CLV_PCSK_SKI1_1	409	413	PF00082	0.523
CLV_PCSK_SKI1_1	419	423	PF00082	0.538
CLV_PCSK_SKI1_1	427	431	PF00082	0.563
CLV_PCSK_SKI1_1	98	102	PF00082	0.276
DEG_APCC_DBOX_1	426	434	PF00400	0.654
DEG_ODPH_VHL_1	380	391	PF01847	0.489
DEG_SPOP_SBC_1	397	401	PF00917	0.721
DOC_CKS1_1	528	533	PF01111	0.696
DOC_CKS1_1	78	83	PF01111	0.476
DOC_CYCLIN_RxL_1	422	434	PF00134	0.658
DOC_CYCLIN_RxL_1	93	103	PF00134	0.500
DOC_CYCLIN_yCln2_LP_2	603	609	PF00134	0.486
DOC_MAPK_DCC_7	279	289	PF00069	0.685
DOC_MAPK_gen_1	112	121	PF00069	0.479
DOC_MAPK_MEF2A_6	158	165	PF00069	0.517
DOC_PP1_RVXF_1	503	510	PF00149	0.597
DOC_PP2B_LxvP_1	380	383	PF13499	0.718
DOC_PP2B_LxvP_1	596	599	PF13499	0.631
DOC_PP2B_LxvP_1	603	606	PF13499	0.637
DOC_PP2B_LxvP_1	610	613	PF13499	0.643
DOC_PP4_FxxP_1	476	479	PF00568	0.537
DOC_PP4_FxxP_1	485	488	PF00568	0.619
DOC_USP7_MATH_1	362	366	PF00917	0.777
DOC_USP7_MATH_1	397	401	PF00917	0.713
DOC_USP7_MATH_1	492	496	PF00917	0.769
DOC_USP7_UBL2_3	494	498	PF12436	0.696
DOC_WW_Pin1_4	434	439	PF00397	0.541
DOC_WW_Pin1_4	527	532	PF00397	0.692
DOC_WW_Pin1_4	566	571	PF00397	0.602
DOC_WW_Pin1_4	612	617	PF00397	0.705
DOC_WW_Pin1_4	77	82	PF00397	0.473
LIG_14-3-3_CanoR_1	209	215	PF00244	0.546
LIG_14-3-3_CanoR_1	262	271	PF00244	0.459
LIG_14-3-3_CanoR_1	274	281	PF00244	0.504
LIG_14-3-3_CanoR_1	419	425	PF00244	0.640
LIG_14-3-3_CanoR_1	493	501	PF00244	0.724
LIG_14-3-3_CanoR_1	62	72	PF00244	0.576
LIG_14-3-3_CanoR_1	90	100	PF00244	0.548
LIG_APCC_ABBAyCdc20_2	221	227	PF00400	0.414
LIG_BRCT_BRCA1_1	348	352	PF00533	0.585
LIG_CaM_IQ_9	5	21	PF13499	0.403
LIG_FHA_1	195	201	PF00498	0.476
LIG_FHA_1	258	264	PF00498	0.480
LIG_FHA_1	445	451	PF00498	0.542
LIG_FHA_1	78	84	PF00498	0.459
LIG_FHA_1	92	98	PF00498	0.446
LIG_FHA_2	199	205	PF00498	0.466
LIG_FHA_2	262	268	PF00498	0.451
LIG_FHA_2	336	342	PF00498	0.648
LIG_IBAR_NPY_1	468	470	PF08397	0.570
LIG_LIR_Apic_2	436	442	PF02991	0.532
LIG_LIR_Apic_2	482	488	PF02991	0.569
LIG_LIR_Apic_2	586	592	PF02991	0.680
LIG_LIR_Gen_1	140	151	PF02991	0.483
LIG_LIR_Gen_1	222	233	PF02991	0.395
LIG_LIR_Gen_1	245	255	PF02991	0.487
LIG_LIR_Gen_1	530	540	PF02991	0.707
LIG_LIR_LC3C_4	330	335	PF02991	0.599
LIG_LIR_Nem_3	140	146	PF02991	0.483
LIG_LIR_Nem_3	222	228	PF02991	0.431
LIG_LIR_Nem_3	245	251	PF02991	0.479
LIG_LIR_Nem_3	530	535	PF02991	0.703
LIG_LYPXL_SIV_4	416	424	PF13949	0.644
LIG_PCNA_yPIPBox_3	419	433	PF02747	0.560
LIG_Pex14_2	472	476	PF04695	0.685
LIG_SH2_CRK	248	252	PF00017	0.524
LIG_SH2_CRK	514	518	PF00017	0.557
LIG_SH2_CRK	589	593	PF00017	0.597
LIG_SH2_NCK_1	344	348	PF00017	0.687
LIG_SH2_NCK_1	514	518	PF00017	0.557
LIG_SH2_NCK_1	557	561	PF00017	0.669
LIG_SH2_SRC	432	435	PF00017	0.656
LIG_SH2_STAP1	248	252	PF00017	0.487
LIG_SH2_STAP1	417	421	PF00017	0.611
LIG_SH2_STAT3	470	473	PF00017	0.578
LIG_SH2_STAT5	168	171	PF00017	0.476
LIG_SH2_STAT5	179	182	PF00017	0.476
LIG_SH2_STAT5	432	435	PF00017	0.551
LIG_SH2_STAT5	470	473	PF00017	0.578
LIG_SH2_STAT5	484	487	PF00017	0.581
LIG_SH2_STAT5	514	517	PF00017	0.540
LIG_SH2_STAT5	518	521	PF00017	0.534
LIG_SH3_1	514	520	PF00018	0.538
LIG_SH3_3	128	134	PF00018	0.487
LIG_SH3_3	384	390	PF00018	0.739
LIG_SH3_3	460	466	PF00018	0.596
LIG_SH3_3	514	520	PF00018	0.522
LIG_SH3_3	603	609	PF00018	0.763
LIG_SH3_3	610	616	PF00018	0.783
LIG_SH3_3	75	81	PF00018	0.459
LIG_SUMO_SIM_anti_2	182	187	PF11976	0.487
LIG_SUMO_SIM_par_1	196	201	PF11976	0.476
LIG_SUMO_SIM_par_1	230	236	PF11976	0.420
LIG_SxIP_EBH_1	397	409	PF03271	0.715
LIG_TRAF2_1	337	340	PF00917	0.745
LIG_TRAF2_1	383	386	PF00917	0.657
LIG_TRAF2_2	291	296	PF00917	0.660
LIG_TYR_ITIM	223	228	PF00017	0.540
LIG_TYR_ITIM	246	251	PF00017	0.507
MOD_CDC14_SPxK_1	437	440	PF00782	0.538
MOD_CDK_SPxK_1	434	440	PF00069	0.540
MOD_CK1_1	254	260	PF00069	0.573
MOD_CK1_1	399	405	PF00069	0.589
MOD_CK1_1	569	575	PF00069	0.463
MOD_CK1_1	614	620	PF00069	0.740
MOD_CK2_1	100	106	PF00069	0.413
MOD_CK2_1	261	267	PF00069	0.466
MOD_CK2_1	274	280	PF00069	0.517
MOD_CK2_1	335	341	PF00069	0.743
MOD_CK2_1	34	40	PF00069	0.698
MOD_CK2_1	342	348	PF00069	0.693
MOD_GlcNHglycan	102	105	PF01048	0.473
MOD_GlcNHglycan	143	146	PF01048	0.247
MOD_GlcNHglycan	235	238	PF01048	0.410
MOD_GlcNHglycan	271	274	PF01048	0.586
MOD_GlcNHglycan	348	351	PF01048	0.657
MOD_GlcNHglycan	359	362	PF01048	0.609
MOD_GlcNHglycan	364	367	PF01048	0.577
MOD_GlcNHglycan	65	68	PF01048	0.535
MOD_GSK3_1	137	144	PF00069	0.328
MOD_GSK3_1	194	201	PF00069	0.328
MOD_GSK3_1	257	264	PF00069	0.465
MOD_GSK3_1	342	349	PF00069	0.613
MOD_GSK3_1	612	619	PF00069	0.739
MOD_GSK3_1	92	99	PF00069	0.316
MOD_N-GLC_1	194	199	PF02516	0.328
MOD_NEK2_1	233	238	PF00069	0.411
MOD_NEK2_1	433	438	PF00069	0.391
MOD_NEK2_1	96	101	PF00069	0.310
MOD_NEK2_2	210	215	PF00069	0.559
MOD_NEK2_2	242	247	PF00069	0.468
MOD_PIKK_1	274	280	PF00454	0.520
MOD_PIKK_1	289	295	PF00454	0.576
MOD_PIKK_1	410	416	PF00454	0.608
MOD_PIKK_1	493	499	PF00454	0.729
MOD_PIKK_1	5	11	PF00454	0.403
MOD_PIKK_1	569	575	PF00454	0.502
MOD_PKA_1	493	499	PF00069	0.643
MOD_PKA_2	261	267	PF00069	0.482
MOD_PKA_2	269	275	PF00069	0.490
MOD_PKA_2	342	348	PF00069	0.746
MOD_PKA_2	492	498	PF00069	0.667
MOD_PKB_1	15	23	PF00069	0.696
MOD_Plk_1	17	23	PF00069	0.699
MOD_Plk_1	194	200	PF00069	0.328
MOD_Plk_1	279	285	PF00069	0.655
MOD_Plk_1	316	322	PF00069	0.644
MOD_Plk_1	372	378	PF00069	0.775
MOD_Plk_2-3	261	267	PF00069	0.466
MOD_Plk_4	372	378	PF00069	0.806
MOD_Plk_4	92	98	PF00069	0.328
MOD_ProDKin_1	434	440	PF00069	0.540
MOD_ProDKin_1	527	533	PF00069	0.692
MOD_ProDKin_1	566	572	PF00069	0.600
MOD_ProDKin_1	612	618	PF00069	0.742
MOD_ProDKin_1	77	83	PF00069	0.468
TRG_DiLeu_BaEn_1	329	334	PF01217	0.698
TRG_DiLeu_BaLyEn_6	425	430	PF01217	0.655
TRG_DiLeu_BaLyEn_6	78	83	PF01217	0.277
TRG_ENDOCYTIC_2	167	170	PF00928	0.328
TRG_ENDOCYTIC_2	225	228	PF00928	0.551
TRG_ENDOCYTIC_2	248	251	PF00928	0.514
TRG_ENDOCYTIC_2	417	420	PF00928	0.571
TRG_ER_diArg_1	114	116	PF00400	0.344
TRG_ER_diArg_1	23	25	PF00400	0.622
TRG_ER_diArg_1	424	427	PF00400	0.665
TRG_ER_diArg_1	485	487	PF00400	0.581
TRG_Pf-PMV_PEXEL_1	112	117	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	36	40	PF00026	0.670
TRG_Pf-PMV_PEXEL_1	427	431	PF00026	0.684

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF63	Leptomonas seymouri	70%	94%
A0A0S4JFQ6	Bodo saltans	48%	94%
A0A1X0P5I3	Trypanosomatidae	58%	98%
A0A3Q8IJ54	Leishmania donovani	93%	100%
A0A3R7RSH5	Trypanosoma rangeli	56%	97%
A4HMU2	Leishmania braziliensis	85%	100%
A4IBE4	Leishmania infantum	93%	100%
C9ZZ76	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	98%
E9AFA0	Leishmania major	92%	100%
V5C303	Trypanosoma cruzi	56%	91%