DUF4200 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6F4_LEIMU

TriTrypDb:

LmxM.34.2750

Length:

429

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6F4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6F4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.447
CLV_C14_Caspase3-7	325	329	PF00656	0.494
CLV_NRD_NRD_1	124	126	PF00675	0.621
CLV_NRD_NRD_1	318	320	PF00675	0.640
CLV_NRD_NRD_1	407	409	PF00675	0.546
CLV_PCSK_FUR_1	122	126	PF00082	0.536
CLV_PCSK_KEX2_1	124	126	PF00082	0.579
CLV_PCSK_KEX2_1	204	206	PF00082	0.653
CLV_PCSK_KEX2_1	229	231	PF00082	0.520
CLV_PCSK_KEX2_1	237	239	PF00082	0.577
CLV_PCSK_KEX2_1	318	320	PF00082	0.640
CLV_PCSK_KEX2_1	407	409	PF00082	0.588
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.599
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.536
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.577
CLV_PCSK_SKI1_1	124	128	PF00082	0.613
CLV_PCSK_SKI1_1	132	136	PF00082	0.650
CLV_PCSK_SKI1_1	219	223	PF00082	0.577
CLV_PCSK_SKI1_1	407	411	PF00082	0.556
CLV_Separin_Metazoa	391	395	PF03568	0.655
DEG_APCC_DBOX_1	131	139	PF00400	0.625
DEG_APCC_DBOX_1	170	178	PF00400	0.474
DEG_APCC_DBOX_1	320	328	PF00400	0.660
DEG_SPOP_SBC_1	157	161	PF00917	0.495
DOC_CYCLIN_RxL_1	127	136	PF00134	0.598
DOC_MAPK_gen_1	318	326	PF00069	0.652
DOC_MAPK_gen_1	407	413	PF00069	0.588
DOC_USP7_MATH_1	13	17	PF00917	0.754
DOC_USP7_MATH_1	186	190	PF00917	0.377
DOC_USP7_MATH_1	276	280	PF00917	0.545
DOC_USP7_MATH_1	32	36	PF00917	0.725
DOC_USP7_MATH_1	339	343	PF00917	0.688
DOC_WW_Pin1_4	149	154	PF00397	0.594
DOC_WW_Pin1_4	17	22	PF00397	0.647
DOC_WW_Pin1_4	26	31	PF00397	0.601
DOC_WW_Pin1_4	415	420	PF00397	0.495
DOC_WW_Pin1_4	9	14	PF00397	0.691
LIG_BIR_III_4	106	110	PF00653	0.636
LIG_BIR_III_4	14	18	PF00653	0.549
LIG_eIF4E_1	372	378	PF01652	0.647
LIG_FHA_1	245	251	PF00498	0.460
LIG_FHA_1	56	62	PF00498	0.812
LIG_NRBOX	134	140	PF00104	0.625
LIG_SH2_STAP1	246	250	PF00017	0.529
LIG_SH2_STAT3	372	375	PF00017	0.647
LIG_SH2_STAT5	246	249	PF00017	0.463
LIG_SH3_3	416	422	PF00018	0.507
LIG_SH3_3	46	52	PF00018	0.811
LIG_SUMO_SIM_par_1	88	94	PF11976	0.554
LIG_TRAF2_1	166	169	PF00917	0.628
LIG_TRAF2_1	176	179	PF00917	0.514
LIG_TRAF2_1	249	252	PF00917	0.523
LIG_TRAF2_1	279	282	PF00917	0.566
LIG_TRAF2_1	82	85	PF00917	0.697
LIG_UBA3_1	398	403	PF00899	0.638
LIG_UBA3_1	89	97	PF00899	0.444
MOD_CK2_1	156	162	PF00069	0.711
MOD_CK2_1	194	200	PF00069	0.634
MOD_CK2_1	276	282	PF00069	0.568
MOD_GlcNHglycan	14	18	PF01048	0.763
MOD_GlcNHglycan	212	216	PF01048	0.646
MOD_GlcNHglycan	34	37	PF01048	0.792
MOD_GlcNHglycan	341	344	PF01048	0.761
MOD_GSK3_1	140	147	PF00069	0.714
MOD_GSK3_1	421	428	PF00069	0.803
MOD_GSK3_1	9	16	PF00069	0.811
MOD_N-GLC_1	302	307	PF02516	0.621
MOD_N-GLC_1	384	389	PF02516	0.579
MOD_NEK2_1	265	270	PF00069	0.394
MOD_NEK2_1	371	376	PF00069	0.647
MOD_PIKK_1	244	250	PF00454	0.585
MOD_PIKK_1	258	264	PF00454	0.510
MOD_PIKK_1	366	372	PF00454	0.661
MOD_PKA_2	186	192	PF00069	0.548
MOD_Plk_1	302	308	PF00069	0.624
MOD_Plk_2-3	194	200	PF00069	0.468
MOD_Plk_2-3	328	334	PF00069	0.689
MOD_ProDKin_1	149	155	PF00069	0.596
MOD_ProDKin_1	17	23	PF00069	0.647
MOD_ProDKin_1	26	32	PF00069	0.600
MOD_ProDKin_1	415	421	PF00069	0.499
MOD_ProDKin_1	9	15	PF00069	0.696
MOD_SUMO_for_1	82	85	PF00179	0.483
TRG_DiLeu_BaEn_1	85	90	PF01217	0.667
TRG_DiLeu_BaLyEn_6	134	139	PF01217	0.623
TRG_ER_diArg_1	122	125	PF00400	0.650
TRG_ER_diArg_1	317	319	PF00400	0.549
TRG_ER_diArg_1	320	323	PF00400	0.537
TRG_ER_diArg_1	406	408	PF00400	0.586
TRG_NES_CRM1_1	400	412	PF08389	0.581
TRG_Pf-PMV_PEXEL_1	116	120	PF00026	0.598
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.717
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.636
TRG_Pf-PMV_PEXEL_1	318	322	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Q8	Leptomonas seymouri	39%	73%
A0A3Q8IJI3	Leishmania donovani	84%	73%
A4IBE3	Leishmania infantum	85%	100%
E9AF99	Leishmania major	86%	100%
E9AIW7	Leishmania braziliensis	62%	100%