Galactokinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

galactokinase-like protein

Species:

Leishmania mexicana

UniProt:

E9B6F3_LEIMU

TriTrypDb:

LmxM.34.2740

Length:

476

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	13
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	14

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Expansion

Sequence features

E9B6F3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6F3

Function

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Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	14
GO:0005996	monosaccharide metabolic process	3	14
GO:0006012	galactose metabolic process	5	14
GO:0008152	metabolic process	1	14
GO:0019318	hexose metabolic process	4	14
GO:0044238	primary metabolic process	2	14
GO:0044281	small molecule metabolic process	2	14
GO:0071704	organic substance metabolic process	2	14

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	14
GO:0003824	catalytic activity	1	14
GO:0004335	galactokinase activity	5	14
GO:0005488	binding	1	14
GO:0005524	ATP binding	5	14
GO:0016301	kinase activity	4	14
GO:0016740	transferase activity	2	14
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	14
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	14
GO:0017076	purine nucleotide binding	4	14

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	9	13	PF00656	0.442
CLV_NRD_NRD_1	184	186	PF00675	0.292
CLV_NRD_NRD_1	351	353	PF00675	0.532
CLV_NRD_NRD_1	424	426	PF00675	0.323
CLV_NRD_NRD_1	435	437	PF00675	0.356
CLV_PCSK_KEX2_1	184	186	PF00082	0.281
CLV_PCSK_KEX2_1	424	426	PF00082	0.267
CLV_PCSK_KEX2_1	453	455	PF00082	0.456
CLV_PCSK_PC1ET2_1	453	455	PF00082	0.456
CLV_PCSK_SKI1_1	231	235	PF00082	0.471

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1S7	Leptomonas seymouri	76%	100%
A0A0N1I4L5	Leptomonas seymouri	45%	100%
A0A0S4IRX8	Bodo saltans	31%	100%
A0A1X0P569	Trypanosomatidae	50%	100%
A0A1X0P5N8	Trypanosomatidae	53%	100%
A0A3Q8IF81	Leishmania donovani	94%	100%
A0A3R7N2Y9	Trypanosoma rangeli	53%	100%
A0KQH8	Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049)	27%	100%
A1A900	Escherichia coli O1:K1 / APEC	27%	100%
A1JRX5	Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)	26%	100%

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