Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6E9_LEIMU

TriTrypDb:

LmxM.34.2710

Length:

512

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6E9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6E9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	310	314	PF00656	0.616
CLV_NRD_NRD_1	492	494	PF00675	0.567
CLV_NRD_NRD_1	7	9	PF00675	0.596
CLV_PCSK_KEX2_1	444	446	PF00082	0.748
CLV_PCSK_KEX2_1	491	493	PF00082	0.582
CLV_PCSK_PC1ET2_1	444	446	PF00082	0.748
CLV_PCSK_PC1ET2_1	491	493	PF00082	0.582
CLV_PCSK_SKI1_1	139	143	PF00082	0.593
CLV_PCSK_SKI1_1	221	225	PF00082	0.618
CLV_PCSK_SKI1_1	29	33	PF00082	0.512
CLV_PCSK_SKI1_1	294	298	PF00082	0.516
CLV_PCSK_SKI1_1	482	486	PF00082	0.524
CLV_PCSK_SKI1_1	8	12	PF00082	0.469
CLV_Separin_Metazoa	299	303	PF03568	0.283
DEG_APCC_DBOX_1	293	301	PF00400	0.572
DEG_APCC_DBOX_1	349	357	PF00400	0.578
DEG_APCC_DBOX_1	7	15	PF00400	0.463
DEG_Nend_UBRbox_1	1	4	PF02207	0.649
DEG_SCF_FBW7_1	59	66	PF00400	0.622
DEG_SPOP_SBC_1	208	212	PF00917	0.662
DEG_SPOP_SBC_1	48	52	PF00917	0.777
DOC_CYCLIN_RxL_1	136	146	PF00134	0.551
DOC_MAPK_gen_1	137	144	PF00069	0.552
DOC_MAPK_gen_1	348	356	PF00069	0.347
DOC_MAPK_MEF2A_6	29	36	PF00069	0.489
DOC_MAPK_NFAT4_5	29	37	PF00069	0.496
DOC_MAPK_RevD_3	479	493	PF00069	0.489
DOC_PP1_RVXF_1	137	144	PF00149	0.475
DOC_PP1_RVXF_1	346	352	PF00149	0.529
DOC_PP2B_LxvP_1	32	35	PF13499	0.497
DOC_PP4_FxxP_1	427	430	PF00568	0.675
DOC_USP7_MATH_1	191	195	PF00917	0.536
DOC_USP7_MATH_1	208	212	PF00917	0.759
DOC_USP7_MATH_1	223	227	PF00917	0.546
DOC_USP7_MATH_1	314	318	PF00917	0.555
DOC_USP7_MATH_1	438	442	PF00917	0.759
DOC_USP7_MATH_1	461	465	PF00917	0.609
DOC_USP7_MATH_1	68	72	PF00917	0.804
DOC_USP7_MATH_1	74	78	PF00917	0.698
DOC_USP7_UBL2_3	12	16	PF12436	0.542
DOC_WW_Pin1_4	189	194	PF00397	0.618
DOC_WW_Pin1_4	354	359	PF00397	0.559
DOC_WW_Pin1_4	451	456	PF00397	0.744
DOC_WW_Pin1_4	59	64	PF00397	0.714
LIG_14-3-3_CanoR_1	150	159	PF00244	0.645
LIG_14-3-3_CanoR_1	29	35	PF00244	0.529
LIG_14-3-3_CanoR_1	308	316	PF00244	0.478
LIG_14-3-3_CanoR_1	348	354	PF00244	0.472
LIG_14-3-3_CanoR_1	465	470	PF00244	0.522
LIG_14-3-3_CanoR_1	93	101	PF00244	0.659
LIG_BRCT_BRCA1_1	463	467	PF00533	0.565
LIG_FHA_1	101	107	PF00498	0.547
LIG_FHA_1	154	160	PF00498	0.567
LIG_FHA_1	296	302	PF00498	0.504
LIG_FHA_1	364	370	PF00498	0.478
LIG_FHA_2	281	287	PF00498	0.559
LIG_FHA_2	308	314	PF00498	0.573
LIG_FHA_2	328	334	PF00498	0.288
LIG_FHA_2	359	365	PF00498	0.577
LIG_FHA_2	37	43	PF00498	0.748
LIG_FHA_2	438	444	PF00498	0.762
LIG_FHA_2	64	70	PF00498	0.718
LIG_FHA_2	80	86	PF00498	0.472
LIG_IRF3_LxIS_1	160	167	PF10401	0.684
LIG_LIR_Apic_2	424	430	PF02991	0.676
LIG_LIR_Gen_1	373	383	PF02991	0.422
LIG_LIR_Gen_1	408	418	PF02991	0.684
LIG_LIR_LC3C_4	366	371	PF02991	0.554
LIG_LIR_Nem_3	373	378	PF02991	0.415
LIG_LIR_Nem_3	408	413	PF02991	0.635
LIG_LIR_Nem_3	464	470	PF02991	0.555
LIG_MLH1_MIPbox_1	467	471	PF16413	0.537
LIG_NRBOX	480	486	PF00104	0.516
LIG_PCNA_yPIPBox_3	139	152	PF02747	0.617
LIG_Pex14_2	275	279	PF04695	0.540
LIG_Pex14_2	347	351	PF04695	0.412
LIG_Pex14_2	467	471	PF04695	0.429
LIG_PTB_Apo_2	369	376	PF02174	0.447
LIG_SH2_CRK	138	142	PF00017	0.595
LIG_SH2_CRK	7	11	PF00017	0.458
LIG_SH2_SRC	391	394	PF00017	0.532
LIG_SH2_STAP1	325	329	PF00017	0.628
LIG_SH2_STAT3	325	328	PF00017	0.559
LIG_SH2_STAT5	111	114	PF00017	0.534
LIG_SH2_STAT5	180	183	PF00017	0.624
LIG_SH2_STAT5	24	27	PF00017	0.577
LIG_SH2_STAT5	329	332	PF00017	0.563
LIG_SH2_STAT5	339	342	PF00017	0.517
LIG_SH2_STAT5	374	377	PF00017	0.392
LIG_SH2_STAT5	391	394	PF00017	0.532
LIG_SH2_STAT5	470	473	PF00017	0.502
LIG_SH3_3	352	358	PF00018	0.473
LIG_SUMO_SIM_anti_2	366	373	PF11976	0.528
LIG_SUMO_SIM_par_1	366	373	PF11976	0.554
LIG_TRFH_1	351	355	PF08558	0.437
LIG_TYR_ITIM	136	141	PF00017	0.592
LIG_TYR_ITIM	484	489	PF00017	0.536
MOD_CK1_1	153	159	PF00069	0.539
MOD_CK1_1	185	191	PF00069	0.697
MOD_CK1_1	211	217	PF00069	0.750
MOD_CK1_1	41	47	PF00069	0.739
MOD_CK1_1	450	456	PF00069	0.733
MOD_CK1_1	53	59	PF00069	0.786
MOD_CK2_1	280	286	PF00069	0.577
MOD_CK2_1	327	333	PF00069	0.595
MOD_CK2_1	358	364	PF00069	0.677
MOD_CK2_1	36	42	PF00069	0.701
MOD_CK2_1	443	449	PF00069	0.744
MOD_Cter_Amidation	489	492	PF01082	0.544
MOD_Cter_Amidation	78	81	PF01082	0.498
MOD_GlcNHglycan	120	123	PF01048	0.641
MOD_GlcNHglycan	189	192	PF01048	0.742
MOD_GlcNHglycan	193	196	PF01048	0.736
MOD_GlcNHglycan	215	218	PF01048	0.785
MOD_GlcNHglycan	249	252	PF01048	0.550
MOD_GlcNHglycan	415	418	PF01048	0.651
MOD_GlcNHglycan	440	443	PF01048	0.669
MOD_GlcNHglycan	449	453	PF01048	0.727
MOD_GlcNHglycan	53	56	PF01048	0.733
MOD_GSK3_1	160	167	PF00069	0.685
MOD_GSK3_1	185	192	PF00069	0.708
MOD_GSK3_1	204	211	PF00069	0.698
MOD_GSK3_1	213	220	PF00069	0.668
MOD_GSK3_1	314	321	PF00069	0.434
MOD_GSK3_1	354	361	PF00069	0.640
MOD_GSK3_1	38	45	PF00069	0.676
MOD_GSK3_1	443	450	PF00069	0.760
MOD_GSK3_1	461	468	PF00069	0.557
MOD_GSK3_1	47	54	PF00069	0.679
MOD_GSK3_1	59	66	PF00069	0.722
MOD_N-GLC_1	182	187	PF02516	0.641
MOD_N-GLC_1	314	319	PF02516	0.529
MOD_N-GLC_1	472	477	PF02516	0.561
MOD_NEK2_1	159	164	PF00069	0.617
MOD_NEK2_1	30	35	PF00069	0.532
MOD_NEK2_1	36	41	PF00069	0.612
MOD_NEK2_1	413	418	PF00069	0.709
MOD_PIKK_1	153	159	PF00454	0.573
MOD_PIKK_1	182	188	PF00454	0.687
MOD_PKA_1	80	86	PF00069	0.566
MOD_PKA_2	118	124	PF00069	0.502
MOD_PKA_2	212	218	PF00069	0.747
MOD_PKA_2	265	271	PF00069	0.570
MOD_PKA_2	307	313	PF00069	0.409
MOD_PKA_2	349	355	PF00069	0.530
MOD_PKA_2	42	48	PF00069	0.527
MOD_PKA_2	92	98	PF00069	0.700
MOD_Plk_1	101	107	PF00069	0.619
MOD_Plk_1	314	320	PF00069	0.421
MOD_Plk_4	102	108	PF00069	0.614
MOD_Plk_4	370	376	PF00069	0.430
MOD_ProDKin_1	189	195	PF00069	0.617
MOD_ProDKin_1	354	360	PF00069	0.565
MOD_ProDKin_1	451	457	PF00069	0.741
MOD_ProDKin_1	59	65	PF00069	0.715
MOD_SUMO_rev_2	178	185	PF00179	0.663
TRG_DiLeu_BaEn_1	381	386	PF01217	0.540
TRG_DiLeu_BaEn_4	387	393	PF01217	0.589
TRG_ENDOCYTIC_2	111	114	PF00928	0.579
TRG_ENDOCYTIC_2	138	141	PF00928	0.593
TRG_ENDOCYTIC_2	486	489	PF00928	0.426
TRG_ENDOCYTIC_2	7	10	PF00928	0.464
TRG_ER_diArg_1	263	266	PF00400	0.583
TRG_ER_diArg_1	347	350	PF00400	0.560
TRG_NLS_MonoExtN_4	488	495	PF00514	0.525
TRG_Pf-PMV_PEXEL_1	399	403	PF00026	0.646
TRG_Pf-PMV_PEXEL_1	493	498	PF00026	0.339

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBR0	Leptomonas seymouri	52%	97%
A0A1X0P6J4	Trypanosomatidae	23%	100%
A0A3S7X9M3	Leishmania donovani	93%	100%
A0A422P2R2	Trypanosoma rangeli	28%	100%
A4HMT7	Leishmania braziliensis	73%	100%
A4IBD8	Leishmania infantum	93%	100%
C9ZZ79	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AF94	Leishmania major	92%	100%
V5BTJ6	Trypanosoma cruzi	28%	100%