BTB domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

btb/poz domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B6E7_LEIMU

TriTrypDb:

LmxM.34.2690

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6E7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6E7

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022607	cellular component assembly	4	11
GO:0043933	protein-containing complex organization	4	11
GO:0051259	protein complex oligomerization	6	11
GO:0051260	protein homooligomerization	7	11
GO:0065003	protein-containing complex assembly	5	11
GO:0071840	cellular component organization or biogenesis	2	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	41	45	PF00656	0.767
CLV_C14_Caspase3-7	70	74	PF00656	0.556
CLV_NRD_NRD_1	225	227	PF00675	0.420
CLV_NRD_NRD_1	336	338	PF00675	0.410
CLV_NRD_NRD_1	379	381	PF00675	0.360
CLV_NRD_NRD_1	403	405	PF00675	0.416
CLV_PCSK_FUR_1	377	381	PF00082	0.523
CLV_PCSK_KEX2_1	225	227	PF00082	0.420
CLV_PCSK_KEX2_1	379	381	PF00082	0.514
CLV_PCSK_KEX2_1	402	404	PF00082	0.509
CLV_PCSK_SKI1_1	225	229	PF00082	0.374
CLV_PCSK_SKI1_1	382	386	PF00082	0.463
CLV_PCSK_SKI1_1	62	66	PF00082	0.617
DEG_APCC_DBOX_1	263	271	PF00400	0.608
DEG_APCC_DBOX_1	401	409	PF00400	0.519
DOC_CDC14_PxL_1	233	241	PF14671	0.420
DOC_CYCLIN_RxL_1	376	386	PF00134	0.497
DOC_MAPK_gen_1	266	275	PF00069	0.479
DOC_MAPK_gen_1	379	389	PF00069	0.324
DOC_MAPK_MEF2A_6	141	150	PF00069	0.523
DOC_PP1_RVXF_1	377	384	PF00149	0.372
DOC_PP4_FxxP_1	155	158	PF00568	0.291
DOC_SPAK_OSR1_1	154	158	PF12202	0.388
DOC_USP7_MATH_1	17	21	PF00917	0.734
DOC_USP7_MATH_1	38	42	PF00917	0.751
DOC_USP7_MATH_1	94	98	PF00917	0.596
DOC_USP7_UBL2_3	367	371	PF12436	0.384
DOC_WW_Pin1_4	22	27	PF00397	0.697
DOC_WW_Pin1_4	252	257	PF00397	0.650
DOC_WW_Pin1_4	258	263	PF00397	0.648
DOC_WW_Pin1_4	403	408	PF00397	0.581
DOC_WW_Pin1_4	63	68	PF00397	0.780
LIG_14-3-3_CanoR_1	154	158	PF00244	0.388
LIG_14-3-3_CanoR_1	285	291	PF00244	0.339
LIG_14-3-3_CanoR_1	382	388	PF00244	0.419
LIG_14-3-3_CanoR_1	62	67	PF00244	0.647
LIG_Actin_WH2_2	368	384	PF00022	0.468
LIG_AP2alpha_2	199	201	PF02296	0.178
LIG_BIR_II_1	1	5	PF00653	0.584
LIG_BIR_III_4	73	77	PF00653	0.680
LIG_BRCT_BRCA1_1	325	329	PF00533	0.455
LIG_BRCT_BRCA1_1	65	69	PF00533	0.780
LIG_deltaCOP1_diTrp_1	178	187	PF00928	0.388
LIG_eIF4E_1	213	219	PF01652	0.370
LIG_eIF4E_1	234	240	PF01652	0.388
LIG_eIF4E_1	297	303	PF01652	0.315
LIG_FHA_1	154	160	PF00498	0.303
LIG_FHA_1	178	184	PF00498	0.388
LIG_FHA_1	191	197	PF00498	0.319
LIG_FHA_1	287	293	PF00498	0.332
LIG_FHA_1	350	356	PF00498	0.438
LIG_FHA_1	384	390	PF00498	0.465
LIG_FHA_2	308	314	PF00498	0.429
LIG_FHA_2	77	83	PF00498	0.561
LIG_LIR_Apic_2	153	158	PF02991	0.294
LIG_LIR_Apic_2	179	185	PF02991	0.388
LIG_LIR_Gen_1	140	150	PF02991	0.441
LIG_LIR_Gen_1	311	322	PF02991	0.484
LIG_LIR_Gen_1	349	357	PF02991	0.326
LIG_LIR_Nem_3	140	145	PF02991	0.497
LIG_LIR_Nem_3	230	236	PF02991	0.291
LIG_LIR_Nem_3	296	300	PF02991	0.351
LIG_LIR_Nem_3	311	317	PF02991	0.383
LIG_LIR_Nem_3	349	353	PF02991	0.341
LIG_LIR_Nem_3	358	364	PF02991	0.334
LIG_NRBOX	115	121	PF00104	0.515
LIG_PTB_Apo_2	329	336	PF02174	0.503
LIG_PTB_Apo_2	344	351	PF02174	0.503
LIG_PTB_Phospho_1	329	335	PF10480	0.498
LIG_RPA_C_Fungi	87	99	PF08784	0.555
LIG_SH2_CRK	234	238	PF00017	0.388
LIG_SH2_GRB2like	215	218	PF00017	0.420
LIG_SH2_GRB2like	330	333	PF00017	0.343
LIG_SH2_STAP1	290	294	PF00017	0.468
LIG_SH2_STAT5	170	173	PF00017	0.291
LIG_SH2_STAT5	205	208	PF00017	0.310
LIG_SH2_STAT5	209	212	PF00017	0.273
LIG_SH2_STAT5	215	218	PF00017	0.264
LIG_SH2_STAT5	297	300	PF00017	0.318
LIG_SH2_STAT5	330	333	PF00017	0.472
LIG_SH2_STAT5	361	364	PF00017	0.357
LIG_SH3_3	2	8	PF00018	0.637
LIG_SH3_3	29	35	PF00018	0.605
LIG_SUMO_SIM_anti_2	278	283	PF11976	0.485
LIG_TRAF2_1	310	313	PF00917	0.397
LIG_TRAF2_1	397	400	PF00917	0.409
LIG_TRAF2_1	411	414	PF00917	0.425
LIG_TRAF2_1	79	82	PF00917	0.559
MOD_CDC14_SPxK_1	261	264	PF00782	0.580
MOD_CDK_SPxK_1	258	264	PF00069	0.579
MOD_CDK_SPxxK_3	22	29	PF00069	0.743
MOD_CK1_1	104	110	PF00069	0.495
MOD_CK1_1	177	183	PF00069	0.398
MOD_CK1_1	20	26	PF00069	0.700
MOD_CK1_1	280	286	PF00069	0.518
MOD_CK1_1	37	43	PF00069	0.635
MOD_CK1_1	55	61	PF00069	0.724
MOD_CK1_1	63	69	PF00069	0.647
MOD_CK2_1	307	313	PF00069	0.408
MOD_CK2_1	408	414	PF00069	0.535
MOD_CK2_1	76	82	PF00069	0.665
MOD_GlcNHglycan	20	23	PF01048	0.641
MOD_GlcNHglycan	325	328	PF01048	0.460
MOD_GlcNHglycan	36	39	PF01048	0.533
MOD_GlcNHglycan	56	60	PF01048	0.464
MOD_GSK3_1	153	160	PF00069	0.403
MOD_GSK3_1	18	25	PF00069	0.670
MOD_GSK3_1	280	287	PF00069	0.459
MOD_GSK3_1	303	310	PF00069	0.436
MOD_GSK3_1	34	41	PF00069	0.634
MOD_GSK3_1	63	70	PF00069	0.703
MOD_GSK3_1	76	83	PF00069	0.548
MOD_NEK2_1	1	6	PF00069	0.628
MOD_NEK2_1	366	371	PF00069	0.374
MOD_NEK2_1	383	388	PF00069	0.343
MOD_NEK2_1	60	65	PF00069	0.725
MOD_NEK2_1	88	93	PF00069	0.608
MOD_NEK2_2	28	33	PF00069	0.595
MOD_PKA_2	153	159	PF00069	0.388
MOD_PKA_2	28	34	PF00069	0.741
MOD_PKA_2	284	290	PF00069	0.369
MOD_PKB_1	380	388	PF00069	0.479
MOD_Plk_1	220	226	PF00069	0.420
MOD_Plk_1	277	283	PF00069	0.489
MOD_Plk_4	115	121	PF00069	0.437
MOD_Plk_4	158	164	PF00069	0.341
MOD_Plk_4	190	196	PF00069	0.475
MOD_Plk_4	277	283	PF00069	0.489
MOD_ProDKin_1	22	28	PF00069	0.697
MOD_ProDKin_1	252	258	PF00069	0.653
MOD_ProDKin_1	403	409	PF00069	0.574
MOD_ProDKin_1	63	69	PF00069	0.781
MOD_SUMO_for_1	128	131	PF00179	0.575
MOD_SUMO_for_1	187	190	PF00179	0.420
MOD_SUMO_rev_2	122	128	PF00179	0.493
TRG_DiLeu_BaEn_2	345	351	PF01217	0.498
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.504
TRG_ENDOCYTIC_2	142	145	PF00928	0.510
TRG_ENDOCYTIC_2	170	173	PF00928	0.291
TRG_ENDOCYTIC_2	213	216	PF00928	0.310
TRG_ENDOCYTIC_2	233	236	PF00928	0.150
TRG_ENDOCYTIC_2	297	300	PF00928	0.318
TRG_ER_diArg_1	224	226	PF00400	0.420
TRG_ER_diArg_1	264	267	PF00400	0.521
TRG_ER_diArg_1	377	380	PF00400	0.519
TRG_ER_diArg_1	392	395	PF00400	0.379
TRG_ER_diArg_1	401	404	PF00400	0.475
TRG_Pf-PMV_PEXEL_1	225	230	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3C7	Leptomonas seymouri	68%	89%
A0A1X0P5J3	Trypanosomatidae	49%	80%
A0A3Q8II33	Leishmania donovani	97%	100%
A0A422P2R6	Trypanosoma rangeli	47%	81%
A4HMT5	Leishmania braziliensis	94%	100%
A4IBD6	Leishmania infantum	97%	100%
C9ZZ82	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	80%
E9AF92	Leishmania major	96%	100%
V5DUU9	Trypanosoma cruzi	49%	81%