LeishMANIAdb
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Heat shock factor-binding protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Heat shock factor-binding protein 1
Gene product:
heat shock factor binding protein 1, putative
Species:
Leishmania mexicana
UniProt:
E9B6E6_LEIMU
TriTrypDb:
LmxM.34.2680
Length:
75

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005829 cytosol 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9B6E6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6E6

Function

Biological processes
Term Name Level Count
GO:0006950 response to stress 2 1
GO:0009266 response to temperature stimulus 3 1
GO:0009408 response to heat 3 1
GO:0009628 response to abiotic stimulus 2 1
GO:0009987 cellular process 1 1
GO:0010286 heat acclimation 4 1
GO:0033554 cellular response to stress 3 1
GO:0034605 cellular response to heat 4 1
GO:0050896 response to stimulus 1 1
GO:0051716 cellular response to stimulus 2 1
GO:0070370 cellular heat acclimation 5 1
Molecular functions
Term Name Level Count
GO:0003712 transcription coregulator activity 2 8
GO:0003714 transcription corepressor activity 3 8
GO:0140110 transcription regulator activity 1 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
DOC_USP7_MATH_1 70 74 PF00917 0.521
LIG_FHA_1 9 15 PF00498 0.203
LIG_FHA_2 36 42 PF00498 0.214
MOD_GlcNHglycan 60 63 PF01048 0.260
MOD_GSK3_1 8 15 PF00069 0.400
MOD_NEK2_1 1 6 PF00069 0.511
MOD_NEK2_1 58 63 PF00069 0.293
MOD_PIKK_1 8 14 PF00454 0.434
MOD_Plk_1 50 56 PF00069 0.225

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8R1 Leptomonas seymouri 65% 71%
A0A3Q8IPM3 Leishmania donovani 84% 100%
A0A422P2Q0 Trypanosoma rangeli 50% 76%
A4IBD5 Leishmania infantum 84% 100%
C9ZZ83 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 59% 91%
E9AF91 Leishmania major 83% 100%
O75506 Homo sapiens 54% 99%
Q3ZC22 Bos taurus 57% 99%
Q5RDI2 Pongo abelii 54% 99%
Q8GW48 Arabidopsis thaliana 49% 87%
Q8K3X8 Rattus norvegicus 53% 99%
Q9CQZ1 Mus musculus 53% 99%
V5C320 Trypanosoma cruzi 58% 79%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS