LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B6E4_LEIMU
TriTrypDb:
LmxM.34.2660
Length:
653

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6E4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6E4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 302 306 PF00656 0.544
CLV_C14_Caspase3-7 401 405 PF00656 0.620
CLV_C14_Caspase3-7 596 600 PF00656 0.478
CLV_C14_Caspase3-7 78 82 PF00656 0.533
CLV_NRD_NRD_1 207 209 PF00675 0.585
CLV_NRD_NRD_1 225 227 PF00675 0.699
CLV_NRD_NRD_1 228 230 PF00675 0.424
CLV_NRD_NRD_1 250 252 PF00675 0.448
CLV_NRD_NRD_1 444 446 PF00675 0.698
CLV_NRD_NRD_1 480 482 PF00675 0.586
CLV_NRD_NRD_1 501 503 PF00675 0.466
CLV_NRD_NRD_1 622 624 PF00675 0.474
CLV_PCSK_FUR_1 226 230 PF00082 0.513
CLV_PCSK_KEX2_1 206 208 PF00082 0.581
CLV_PCSK_KEX2_1 227 229 PF00082 0.522
CLV_PCSK_KEX2_1 352 354 PF00082 0.512
CLV_PCSK_KEX2_1 444 446 PF00082 0.723
CLV_PCSK_KEX2_1 622 624 PF00082 0.525
CLV_PCSK_PC1ET2_1 206 208 PF00082 0.583
CLV_PCSK_PC1ET2_1 227 229 PF00082 0.739
CLV_PCSK_PC1ET2_1 352 354 PF00082 0.528
CLV_PCSK_SKI1_1 252 256 PF00082 0.478
CLV_PCSK_SKI1_1 260 264 PF00082 0.427
CLV_PCSK_SKI1_1 362 366 PF00082 0.464
CLV_PCSK_SKI1_1 608 612 PF00082 0.478
DEG_COP1_1 3 11 PF00400 0.457
DEG_Nend_UBRbox_4 1 3 PF02207 0.574
DEG_SCF_FBW7_1 541 546 PF00400 0.446
DEG_SIAH_1 536 544 PF03145 0.444
DEG_SPOP_SBC_1 133 137 PF00917 0.581
DEG_SPOP_SBC_1 326 330 PF00917 0.645
DEG_SPOP_SBC_1 433 437 PF00917 0.670
DEG_SPOP_SBC_1 543 547 PF00917 0.541
DOC_ANK_TNKS_1 594 601 PF00023 0.480
DOC_CKS1_1 411 416 PF01111 0.714
DOC_CYCLIN_RxL_1 260 272 PF00134 0.511
DOC_CYCLIN_yCln2_LP_2 113 119 PF00134 0.503
DOC_MAPK_gen_1 512 522 PF00069 0.481
DOC_PP1_RVXF_1 632 639 PF00149 0.542
DOC_PP2B_LxvP_1 113 116 PF13499 0.497
DOC_PP2B_LxvP_1 267 270 PF13499 0.567
DOC_PP4_FxxP_1 411 414 PF00568 0.631
DOC_USP7_MATH_1 133 137 PF00917 0.679
DOC_USP7_MATH_1 177 181 PF00917 0.593
DOC_USP7_MATH_1 189 193 PF00917 0.513
DOC_USP7_MATH_1 279 283 PF00917 0.539
DOC_USP7_MATH_1 326 330 PF00917 0.653
DOC_USP7_MATH_1 432 436 PF00917 0.627
DOC_USP7_MATH_1 462 466 PF00917 0.702
DOC_USP7_MATH_1 477 481 PF00917 0.580
DOC_USP7_MATH_1 543 547 PF00917 0.605
DOC_USP7_MATH_1 561 565 PF00917 0.591
DOC_USP7_MATH_1 590 594 PF00917 0.492
DOC_USP7_MATH_1 604 608 PF00917 0.513
DOC_USP7_MATH_1 82 86 PF00917 0.792
DOC_USP7_UBL2_3 223 227 PF12436 0.589
DOC_USP7_UBL2_3 482 486 PF12436 0.428
DOC_WW_Pin1_4 111 116 PF00397 0.640
DOC_WW_Pin1_4 2 7 PF00397 0.586
DOC_WW_Pin1_4 305 310 PF00397 0.795
DOC_WW_Pin1_4 313 318 PF00397 0.608
DOC_WW_Pin1_4 319 324 PF00397 0.506
DOC_WW_Pin1_4 330 335 PF00397 0.607
DOC_WW_Pin1_4 35 40 PF00397 0.596
DOC_WW_Pin1_4 410 415 PF00397 0.689
DOC_WW_Pin1_4 473 478 PF00397 0.634
DOC_WW_Pin1_4 539 544 PF00397 0.446
DOC_WW_Pin1_4 72 77 PF00397 0.592
DOC_WW_Pin1_4 88 93 PF00397 0.495
LIG_14-3-3_CanoR_1 265 270 PF00244 0.492
LIG_14-3-3_CanoR_1 400 407 PF00244 0.668
LIG_14-3-3_CanoR_1 622 628 PF00244 0.589
LIG_BIR_III_4 278 282 PF00653 0.457
LIG_BRCT_BRCA1_1 178 182 PF00533 0.531
LIG_BRCT_BRCA1_1 282 286 PF00533 0.490
LIG_BRCT_BRCA1_1 571 575 PF00533 0.575
LIG_CaM_IQ_9 345 360 PF13499 0.508
LIG_CSL_BTD_1 331 334 PF09270 0.583
LIG_eIF4E_1 315 321 PF01652 0.488
LIG_EVH1_2 115 119 PF00568 0.619
LIG_FHA_1 133 139 PF00498 0.615
LIG_FHA_1 194 200 PF00498 0.698
LIG_FHA_1 264 270 PF00498 0.560
LIG_FHA_1 275 281 PF00498 0.520
LIG_FHA_1 309 315 PF00498 0.536
LIG_FHA_1 371 377 PF00498 0.601
LIG_FHA_1 533 539 PF00498 0.568
LIG_FHA_1 630 636 PF00498 0.613
LIG_FHA_1 89 95 PF00498 0.710
LIG_FHA_2 399 405 PF00498 0.618
LIG_FHA_2 40 46 PF00498 0.518
LIG_FHA_2 411 417 PF00498 0.504
LIG_FHA_2 474 480 PF00498 0.651
LIG_FHA_2 59 65 PF00498 0.500
LIG_FHA_2 644 650 PF00498 0.578
LIG_Integrin_RGD_1 554 556 PF01839 0.656
LIG_LIR_Apic_2 410 414 PF02991 0.642
LIG_LIR_Nem_3 467 473 PF02991 0.527
LIG_LIR_Nem_3 577 583 PF02991 0.637
LIG_MYND_3 8 12 PF01753 0.467
LIG_Pex14_2 576 580 PF04695 0.633
LIG_SH2_NCK_1 583 587 PF00017 0.525
LIG_SH3_3 13 19 PF00018 0.598
LIG_SH3_3 3 9 PF00018 0.697
LIG_SH3_3 311 317 PF00018 0.709
LIG_SH3_3 320 326 PF00018 0.622
LIG_SH3_3 545 551 PF00018 0.602
LIG_SUMO_SIM_anti_2 29 35 PF11976 0.606
LIG_SUMO_SIM_par_1 194 200 PF11976 0.466
LIG_SUMO_SIM_par_1 264 272 PF11976 0.525
LIG_TRAF2_1 464 467 PF00917 0.594
LIG_WRC_WIRS_1 470 475 PF05994 0.618
LIG_WRC_WIRS_1 624 629 PF05994 0.571
LIG_WW_2 19 22 PF00397 0.544
MOD_CK1_1 165 171 PF00069 0.591
MOD_CK1_1 268 274 PF00069 0.589
MOD_CK1_1 282 288 PF00069 0.720
MOD_CK1_1 299 305 PF00069 0.672
MOD_CK1_1 308 314 PF00069 0.677
MOD_CK1_1 316 322 PF00069 0.704
MOD_CK1_1 324 330 PF00069 0.486
MOD_CK1_1 35 41 PF00069 0.595
MOD_CK1_1 435 441 PF00069 0.674
MOD_CK1_1 472 478 PF00069 0.605
MOD_CK1_1 569 575 PF00069 0.676
MOD_CK1_1 593 599 PF00069 0.608
MOD_CK1_1 643 649 PF00069 0.577
MOD_CK1_1 7 13 PF00069 0.627
MOD_CK2_1 115 121 PF00069 0.629
MOD_CK2_1 460 466 PF00069 0.663
MOD_CK2_1 473 479 PF00069 0.658
MOD_CK2_1 58 64 PF00069 0.422
MOD_CK2_1 643 649 PF00069 0.577
MOD_GlcNHglycan 191 194 PF01048 0.574
MOD_GlcNHglycan 199 202 PF01048 0.619
MOD_GlcNHglycan 329 332 PF01048 0.549
MOD_GlcNHglycan 34 37 PF01048 0.601
MOD_GlcNHglycan 387 390 PF01048 0.705
MOD_GlcNHglycan 404 407 PF01048 0.629
MOD_GlcNHglycan 45 49 PF01048 0.480
MOD_GlcNHglycan 563 566 PF01048 0.765
MOD_GlcNHglycan 568 571 PF01048 0.532
MOD_GlcNHglycan 592 595 PF01048 0.711
MOD_GlcNHglycan 613 616 PF01048 0.530
MOD_GSK3_1 111 118 PF00069 0.667
MOD_GSK3_1 183 190 PF00069 0.598
MOD_GSK3_1 193 200 PF00069 0.595
MOD_GSK3_1 261 268 PF00069 0.522
MOD_GSK3_1 292 299 PF00069 0.673
MOD_GSK3_1 304 311 PF00069 0.588
MOD_GSK3_1 315 322 PF00069 0.591
MOD_GSK3_1 326 333 PF00069 0.669
MOD_GSK3_1 35 42 PF00069 0.655
MOD_GSK3_1 358 365 PF00069 0.522
MOD_GSK3_1 368 375 PF00069 0.556
MOD_GSK3_1 385 392 PF00069 0.739
MOD_GSK3_1 398 405 PF00069 0.619
MOD_GSK3_1 433 440 PF00069 0.636
MOD_GSK3_1 469 476 PF00069 0.656
MOD_GSK3_1 539 546 PF00069 0.567
MOD_GSK3_1 600 607 PF00069 0.531
MOD_GSK3_1 623 630 PF00069 0.712
MOD_N-GLC_1 133 138 PF02516 0.581
MOD_N-GLC_1 299 304 PF02516 0.492
MOD_N-GLC_1 628 633 PF02516 0.581
MOD_NEK2_1 1 6 PF00069 0.613
MOD_NEK2_1 104 109 PF00069 0.617
MOD_NEK2_1 183 188 PF00069 0.630
MOD_NEK2_1 243 248 PF00069 0.440
MOD_NEK2_1 263 268 PF00069 0.339
MOD_NEK2_1 280 285 PF00069 0.565
MOD_NEK2_1 292 297 PF00069 0.595
MOD_NEK2_1 364 369 PF00069 0.460
MOD_NEK2_1 370 375 PF00069 0.507
MOD_NEK2_1 460 465 PF00069 0.678
MOD_NEK2_1 58 63 PF00069 0.466
MOD_NEK2_1 627 632 PF00069 0.589
MOD_NEK2_2 177 182 PF00069 0.529
MOD_PIKK_1 105 111 PF00454 0.644
MOD_PIKK_1 14 20 PF00454 0.611
MOD_PIKK_1 227 233 PF00454 0.406
MOD_PIKK_1 243 249 PF00454 0.437
MOD_PIKK_1 362 368 PF00454 0.466
MOD_PIKK_1 437 443 PF00454 0.616
MOD_PIKK_1 487 493 PF00454 0.643
MOD_PIKK_1 629 635 PF00454 0.614
MOD_PIKK_1 80 86 PF00454 0.609
MOD_PKA_1 227 233 PF00069 0.437
MOD_PKA_2 227 233 PF00069 0.429
MOD_PKB_1 400 408 PF00069 0.592
MOD_Plk_1 133 139 PF00069 0.581
MOD_Plk_1 177 183 PF00069 0.531
MOD_Plk_1 193 199 PF00069 0.454
MOD_Plk_1 29 35 PF00069 0.629
MOD_Plk_1 616 622 PF00069 0.467
MOD_Plk_4 177 183 PF00069 0.603
MOD_Plk_4 193 199 PF00069 0.468
MOD_Plk_4 29 35 PF00069 0.629
MOD_Plk_4 316 322 PF00069 0.556
MOD_ProDKin_1 111 117 PF00069 0.644
MOD_ProDKin_1 2 8 PF00069 0.584
MOD_ProDKin_1 305 311 PF00069 0.796
MOD_ProDKin_1 313 319 PF00069 0.608
MOD_ProDKin_1 322 328 PF00069 0.557
MOD_ProDKin_1 330 336 PF00069 0.601
MOD_ProDKin_1 35 41 PF00069 0.595
MOD_ProDKin_1 410 416 PF00069 0.688
MOD_ProDKin_1 473 479 PF00069 0.632
MOD_ProDKin_1 539 545 PF00069 0.445
MOD_ProDKin_1 72 78 PF00069 0.594
MOD_ProDKin_1 88 94 PF00069 0.494
TRG_DiLeu_BaLyEn_6 287 292 PF01217 0.600
TRG_ENDOCYTIC_2 648 651 PF00928 0.512
TRG_ER_diArg_1 207 210 PF00400 0.659
TRG_ER_diArg_1 226 229 PF00400 0.430
TRG_ER_diArg_1 399 402 PF00400 0.594
TRG_ER_diArg_1 444 446 PF00400 0.723
TRG_ER_diArg_1 621 623 PF00400 0.508
TRG_NLS_MonoExtC_3 205 210 PF00514 0.639
TRG_NLS_MonoExtC_3 226 232 PF00514 0.562
TRG_NLS_MonoExtC_3 351 357 PF00514 0.529
TRG_NLS_MonoExtN_4 205 210 PF00514 0.650
TRG_NLS_MonoExtN_4 226 231 PF00514 0.600
TRG_Pf-PMV_PEXEL_1 248 253 PF00026 0.504
TRG_Pf-PMV_PEXEL_1 290 294 PF00026 0.608
TRG_Pf-PMV_PEXEL_1 362 366 PF00026 0.452
TRG_Pf-PMV_PEXEL_1 374 378 PF00026 0.567
TRG_Pf-PMV_PEXEL_1 512 517 PF00026 0.474

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDR5 Leptomonas seymouri 42% 100%
A0A3Q8IGC1 Leishmania donovani 80% 98%
A4HMT4 Leishmania braziliensis 62% 100%
A4IBD3 Leishmania infantum 80% 98%
C9ZZ86 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
E9AF89 Leishmania major 82% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS