Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PHD-like zinc-binding domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B6E1_LEIMU

TriTrypDb:

LmxM.34.2630

Length:

743

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B6E1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6E1

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	292	296	PF00656	0.497
CLV_C14_Caspase3-7	738	742	PF00656	0.700
CLV_NRD_NRD_1	165	167	PF00675	0.453
CLV_NRD_NRD_1	236	238	PF00675	0.798
CLV_NRD_NRD_1	324	326	PF00675	0.491
CLV_NRD_NRD_1	336	338	PF00675	0.419
CLV_NRD_NRD_1	446	448	PF00675	0.683
CLV_NRD_NRD_1	525	527	PF00675	0.544
CLV_NRD_NRD_1	531	533	PF00675	0.522
CLV_NRD_NRD_1	586	588	PF00675	0.605
CLV_NRD_NRD_1	88	90	PF00675	0.544
CLV_PCSK_FUR_1	529	533	PF00082	0.499
CLV_PCSK_KEX2_1	324	326	PF00082	0.518
CLV_PCSK_KEX2_1	336	338	PF00082	0.518
CLV_PCSK_KEX2_1	446	448	PF00082	0.681
CLV_PCSK_KEX2_1	531	533	PF00082	0.541
CLV_PCSK_KEX2_1	579	581	PF00082	0.526
CLV_PCSK_KEX2_1	585	587	PF00082	0.603
CLV_PCSK_KEX2_1	88	90	PF00082	0.544
CLV_PCSK_KEX2_1	98	100	PF00082	0.720
CLV_PCSK_PC1ET2_1	579	581	PF00082	0.545
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.792
CLV_PCSK_PC7_1	84	90	PF00082	0.521
CLV_PCSK_PC7_1	94	100	PF00082	0.697
CLV_PCSK_SKI1_1	11	15	PF00082	0.528
CLV_PCSK_SKI1_1	257	261	PF00082	0.563
CLV_PCSK_SKI1_1	325	329	PF00082	0.496
CLV_PCSK_SKI1_1	89	93	PF00082	0.566
CLV_Separin_Metazoa	363	367	PF03568	0.514
DEG_APCC_DBOX_1	198	206	PF00400	0.661
DEG_SPOP_SBC_1	435	439	PF00917	0.692
DOC_CKS1_1	279	284	PF01111	0.516
DOC_CKS1_1	368	373	PF01111	0.580
DOC_CYCLIN_yCln2_LP_2	188	194	PF00134	0.543
DOC_MAPK_gen_1	22	30	PF00069	0.359
DOC_MAPK_gen_1	280	288	PF00069	0.505
DOC_MAPK_gen_1	321	330	PF00069	0.514
DOC_MAPK_gen_1	336	343	PF00069	0.482
DOC_MAPK_gen_1	355	364	PF00069	0.299
DOC_MAPK_gen_1	479	486	PF00069	0.642
DOC_MAPK_gen_1	526	536	PF00069	0.688
DOC_MAPK_MEF2A_6	271	279	PF00069	0.404
DOC_MAPK_MEF2A_6	280	288	PF00069	0.515
DOC_MAPK_MEF2A_6	3	12	PF00069	0.430
DOC_PP1_RVXF_1	46	52	PF00149	0.429
DOC_PP1_RVXF_1	7	13	PF00149	0.476
DOC_PP4_FxxP_1	118	121	PF00568	0.662
DOC_PP4_FxxP_1	279	282	PF00568	0.526
DOC_PP4_FxxP_1	30	33	PF00568	0.510
DOC_USP7_MATH_1	133	137	PF00917	0.515
DOC_USP7_MATH_1	2	6	PF00917	0.278
DOC_USP7_MATH_1	434	438	PF00917	0.617
DOC_USP7_MATH_1	459	463	PF00917	0.698
DOC_USP7_MATH_1	464	468	PF00917	0.644
DOC_USP7_MATH_1	491	495	PF00917	0.585
DOC_USP7_MATH_1	705	709	PF00917	0.759
DOC_USP7_MATH_1	723	727	PF00917	0.585
DOC_WW_Pin1_4	111	116	PF00397	0.759
DOC_WW_Pin1_4	187	192	PF00397	0.772
DOC_WW_Pin1_4	223	228	PF00397	0.698
DOC_WW_Pin1_4	278	283	PF00397	0.500
DOC_WW_Pin1_4	367	372	PF00397	0.528
DOC_WW_Pin1_4	492	497	PF00397	0.580
LIG_14-3-3_CanoR_1	3	7	PF00244	0.275
LIG_14-3-3_CanoR_1	446	451	PF00244	0.650
LIG_14-3-3_CanoR_1	55	62	PF00244	0.308
LIG_14-3-3_CanoR_1	596	604	PF00244	0.562
LIG_14-3-3_CanoR_1	660	668	PF00244	0.504
LIG_14-3-3_CanoR_1	693	700	PF00244	0.643
LIG_AP2alpha_2	683	685	PF02296	0.621
LIG_Clathr_ClatBox_1	353	357	PF01394	0.502
LIG_FHA_1	298	304	PF00498	0.507
LIG_FHA_1	447	453	PF00498	0.557
LIG_FHA_1	461	467	PF00498	0.745
LIG_FHA_1	536	542	PF00498	0.464
LIG_FHA_1	593	599	PF00498	0.542
LIG_FHA_1	606	612	PF00498	0.435
LIG_FHA_1	693	699	PF00498	0.611
LIG_FHA_2	285	291	PF00498	0.458
LIG_FHA_2	305	311	PF00498	0.493
LIG_FHA_2	380	386	PF00498	0.657
LIG_FHA_2	493	499	PF00498	0.662
LIG_FHA_2	503	509	PF00498	0.628
LIG_FHA_2	99	105	PF00498	0.715
LIG_GBD_Chelix_1	635	643	PF00786	0.440
LIG_Integrin_RGD_1	321	323	PF01839	0.552
LIG_LIR_Apic_2	116	121	PF02991	0.653
LIG_LIR_Apic_2	29	33	PF02991	0.514
LIG_LIR_Apic_2	590	594	PF02991	0.406
LIG_LIR_Apic_2	683	689	PF02991	0.622
LIG_LIR_Gen_1	307	316	PF02991	0.506
LIG_LIR_Gen_1	35	45	PF02991	0.459
LIG_LIR_Gen_1	50	59	PF02991	0.485
LIG_LIR_Gen_1	574	582	PF02991	0.480
LIG_LIR_Gen_1	662	672	PF02991	0.447
LIG_LIR_Gen_1	673	684	PF02991	0.530
LIG_LIR_Gen_1	76	87	PF02991	0.557
LIG_LIR_Nem_3	21	27	PF02991	0.547
LIG_LIR_Nem_3	307	311	PF02991	0.511
LIG_LIR_Nem_3	35	41	PF02991	0.359
LIG_LIR_Nem_3	429	435	PF02991	0.751
LIG_LIR_Nem_3	50	54	PF02991	0.475
LIG_LIR_Nem_3	57	62	PF02991	0.461
LIG_LIR_Nem_3	574	578	PF02991	0.481
LIG_LIR_Nem_3	662	668	PF02991	0.446
LIG_LIR_Nem_3	673	679	PF02991	0.508
LIG_LIR_Nem_3	76	82	PF02991	0.406
LIG_LYPXL_yS_3	432	435	PF13949	0.691
LIG_PTAP_UEV_1	99	104	PF05743	0.501
LIG_Rb_LxCxE_1	154	173	PF01857	0.568
LIG_SH2_GRB2like	676	679	PF00017	0.513
LIG_SH2_STAT5	269	272	PF00017	0.462
LIG_SH2_STAT5	334	337	PF00017	0.451
LIG_SH2_STAT5	676	679	PF00017	0.513
LIG_SH2_STAT5	78	81	PF00017	0.467
LIG_SH3_1	94	100	PF00018	0.691
LIG_SH3_3	10	16	PF00018	0.487
LIG_SH3_3	240	246	PF00018	0.565
LIG_SH3_3	493	499	PF00018	0.613
LIG_SH3_3	610	616	PF00018	0.491
LIG_SH3_3	681	687	PF00018	0.585
LIG_SH3_3	94	100	PF00018	0.691
LIG_SUMO_SIM_anti_2	695	701	PF11976	0.661
LIG_SUMO_SIM_par_1	167	173	PF11976	0.726
LIG_SUMO_SIM_par_1	379	385	PF11976	0.711
LIG_SUMO_SIM_par_1	391	396	PF11976	0.708
LIG_SUMO_SIM_par_1	695	701	PF11976	0.563
LIG_UBA3_1	352	361	PF00899	0.516
LIG_WRC_WIRS_1	27	32	PF05994	0.582
LIG_WRC_WIRS_1	572	577	PF05994	0.341
MOD_CDC14_SPxK_1	226	229	PF00782	0.710
MOD_CDK_SPK_2	278	283	PF00069	0.500
MOD_CDK_SPxK_1	223	229	PF00069	0.711
MOD_CK1_1	138	144	PF00069	0.740
MOD_CK1_1	182	188	PF00069	0.567
MOD_CK1_1	437	443	PF00069	0.684
MOD_CK1_1	548	554	PF00069	0.501
MOD_CK1_1	57	63	PF00069	0.503
MOD_CK2_1	26	32	PF00069	0.581
MOD_CK2_1	284	290	PF00069	0.472
MOD_CK2_1	304	310	PF00069	0.482
MOD_CK2_1	357	363	PF00069	0.483
MOD_CK2_1	379	385	PF00069	0.657
MOD_CK2_1	47	53	PF00069	0.436
MOD_CK2_1	492	498	PF00069	0.642
MOD_CK2_1	713	719	PF00069	0.645
MOD_CK2_1	98	104	PF00069	0.709
MOD_GlcNHglycan	128	131	PF01048	0.805
MOD_GlcNHglycan	184	187	PF01048	0.638
MOD_GlcNHglycan	215	218	PF01048	0.715
MOD_GlcNHglycan	376	379	PF01048	0.665
MOD_GlcNHglycan	388	391	PF01048	0.716
MOD_GlcNHglycan	408	411	PF01048	0.787
MOD_GlcNHglycan	412	415	PF01048	0.740
MOD_GlcNHglycan	424	427	PF01048	0.571
MOD_GlcNHglycan	428	431	PF01048	0.467
MOD_GlcNHglycan	442	445	PF01048	0.663
MOD_GlcNHglycan	455	458	PF01048	0.536
MOD_GlcNHglycan	466	469	PF01048	0.604
MOD_GlcNHglycan	549	553	PF01048	0.571
MOD_GlcNHglycan	605	608	PF01048	0.548
MOD_GlcNHglycan	622	625	PF01048	0.525
MOD_GlcNHglycan	672	675	PF01048	0.553
MOD_GlcNHglycan	79	82	PF01048	0.528
MOD_GSK3_1	131	138	PF00069	0.744
MOD_GSK3_1	219	226	PF00069	0.691
MOD_GSK3_1	297	304	PF00069	0.476
MOD_GSK3_1	406	413	PF00069	0.784
MOD_GSK3_1	422	429	PF00069	0.563
MOD_GSK3_1	434	441	PF00069	0.562
MOD_GSK3_1	448	455	PF00069	0.679
MOD_GSK3_1	460	467	PF00069	0.609
MOD_GSK3_1	599	606	PF00069	0.493
MOD_GSK3_1	73	80	PF00069	0.572
MOD_N-GLC_2	642	644	PF02516	0.516
MOD_NEK2_1	180	185	PF00069	0.587
MOD_NEK2_1	213	218	PF00069	0.754
MOD_NEK2_1	356	361	PF00069	0.526
MOD_NEK2_1	561	566	PF00069	0.565
MOD_NEK2_1	597	602	PF00069	0.512
MOD_NEK2_1	603	608	PF00069	0.469
MOD_NEK2_2	379	384	PF00069	0.711
MOD_NEK2_2	607	612	PF00069	0.541
MOD_PIKK_1	297	303	PF00454	0.521
MOD_PIKK_1	393	399	PF00454	0.636
MOD_PIKK_1	535	541	PF00454	0.531
MOD_PIKK_1	692	698	PF00454	0.563
MOD_PKA_1	446	452	PF00069	0.738
MOD_PKA_1	98	104	PF00069	0.754
MOD_PKA_2	2	8	PF00069	0.284
MOD_PKA_2	357	363	PF00069	0.536
MOD_PKA_2	445	451	PF00069	0.677
MOD_PKA_2	54	60	PF00069	0.316
MOD_PKA_2	562	568	PF00069	0.650
MOD_PKA_2	659	665	PF00069	0.529
MOD_PKA_2	692	698	PF00069	0.616
MOD_PKA_2	98	104	PF00069	0.754
MOD_PKB_1	255	263	PF00069	0.510
MOD_Plk_1	34	40	PF00069	0.469
MOD_Plk_1	393	399	PF00069	0.653
MOD_Plk_1	57	63	PF00069	0.450
MOD_Plk_1	637	643	PF00069	0.536
MOD_Plk_1	713	719	PF00069	0.645
MOD_Plk_2-3	139	145	PF00069	0.677
MOD_Plk_2-3	26	32	PF00069	0.510
MOD_Plk_2-3	34	40	PF00069	0.523
MOD_Plk_4	599	605	PF00069	0.532
MOD_ProDKin_1	111	117	PF00069	0.753
MOD_ProDKin_1	187	193	PF00069	0.773
MOD_ProDKin_1	223	229	PF00069	0.701
MOD_ProDKin_1	278	284	PF00069	0.509
MOD_ProDKin_1	367	373	PF00069	0.530
MOD_ProDKin_1	492	498	PF00069	0.582
MOD_SUMO_for_1	121	124	PF00179	0.492
MOD_SUMO_rev_2	40	50	PF00179	0.507
MOD_SUMO_rev_2	584	594	PF00179	0.688
TRG_DiLeu_BaLyEn_6	348	353	PF01217	0.474
TRG_ENDOCYTIC_2	38	41	PF00928	0.451
TRG_ENDOCYTIC_2	432	435	PF00928	0.691
TRG_ENDOCYTIC_2	676	679	PF00928	0.556
TRG_ER_diArg_1	254	257	PF00400	0.510
TRG_ER_diArg_1	335	337	PF00400	0.514
TRG_ER_diArg_1	445	447	PF00400	0.721
TRG_ER_diArg_1	478	481	PF00400	0.547
TRG_ER_diArg_1	528	531	PF00400	0.608
TRG_ER_diArg_1	585	587	PF00400	0.608
TRG_ER_diArg_1	8	11	PF00400	0.486
TRG_ER_diArg_1	88	90	PF00400	0.373
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	580	584	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDF9	Leptomonas seymouri	69%	100%
A0A3S7X9C0	Leishmania donovani	91%	100%
A4HMT2	Leishmania braziliensis	81%	100%
A4IBD0	Leishmania infantum	91%	100%
C9ZZ89	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AF86	Leishmania major	90%	100%