FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TFIIF-stimulated CTD phosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9B6E0_LEIMU

TriTrypDb:

LmxM.34.2620

Length:

398

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6E0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6E0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.754
CLV_C14_Caspase3-7	283	287	PF00656	0.498
CLV_NRD_NRD_1	243	245	PF00675	0.665
CLV_NRD_NRD_1	300	302	PF00675	0.590
CLV_NRD_NRD_1	307	309	PF00675	0.734
CLV_NRD_NRD_1	37	39	PF00675	0.528
CLV_PCSK_FUR_1	241	245	PF00082	0.657
CLV_PCSK_FUR_1	298	302	PF00082	0.563
CLV_PCSK_KEX2_1	241	243	PF00082	0.625
CLV_PCSK_KEX2_1	298	300	PF00082	0.545
CLV_PCSK_KEX2_1	36	38	PF00082	0.537
CLV_PCSK_KEX2_1	58	60	PF00082	0.496
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.645
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.530
CLV_PCSK_SKI1_1	109	113	PF00082	0.355
CLV_PCSK_SKI1_1	225	229	PF00082	0.675
CLV_PCSK_SKI1_1	248	252	PF00082	0.450
CLV_PCSK_SKI1_1	254	258	PF00082	0.460
CLV_PCSK_SKI1_1	85	89	PF00082	0.339
DEG_APCC_DBOX_1	253	261	PF00400	0.492
DEG_APCC_DBOX_1	80	88	PF00400	0.323
DEG_SCF_FBW7_1	187	194	PF00400	0.749
DEG_SPOP_SBC_1	336	340	PF00917	0.492
DOC_CKS1_1	188	193	PF01111	0.747
DOC_CYCLIN_RxL_1	248	259	PF00134	0.493
DOC_MAPK_gen_1	36	44	PF00069	0.594
DOC_MAPK_gen_1	58	64	PF00069	0.311
DOC_MAPK_gen_1	89	99	PF00069	0.311
DOC_PP2B_LxvP_1	49	52	PF13499	0.486
DOC_PP2B_LxvP_1	8	11	PF13499	0.546
DOC_USP7_MATH_1	12	16	PF00917	0.600
DOC_USP7_MATH_1	210	214	PF00917	0.746
DOC_USP7_MATH_1	216	220	PF00917	0.775
DOC_USP7_MATH_1	227	231	PF00917	0.776
DOC_USP7_MATH_1	336	340	PF00917	0.719
DOC_WW_Pin1_4	1	6	PF00397	0.671
DOC_WW_Pin1_4	154	159	PF00397	0.298
DOC_WW_Pin1_4	187	192	PF00397	0.724
DOC_WW_Pin1_4	212	217	PF00397	0.755
DOC_WW_Pin1_4	235	240	PF00397	0.757
LIG_14-3-3_CanoR_1	241	251	PF00244	0.530
LIG_14-3-3_CanoR_1	269	277	PF00244	0.513
LIG_14-3-3_CanoR_1	279	283	PF00244	0.415
LIG_14-3-3_CanoR_1	59	63	PF00244	0.383
LIG_APCC_ABBAyCdc20_2	19	25	PF00400	0.606
LIG_EH1_1	118	126	PF00400	0.380
LIG_FHA_1	136	142	PF00498	0.333
LIG_FHA_1	149	155	PF00498	0.361
LIG_FHA_1	247	253	PF00498	0.457
LIG_FHA_1	39	45	PF00498	0.637
LIG_FHA_2	178	184	PF00498	0.659
LIG_FHA_2	204	210	PF00498	0.798
LIG_FHA_2	25	31	PF00498	0.664
LIG_FHA_2	281	287	PF00498	0.555
LIG_FHA_2	99	105	PF00498	0.317
LIG_LIR_Gen_1	147	158	PF02991	0.327
LIG_LIR_Gen_1	172	178	PF02991	0.441
LIG_LIR_Gen_1	57	66	PF02991	0.380
LIG_LIR_Gen_1	93	102	PF02991	0.340
LIG_LIR_Nem_3	172	177	PF02991	0.409
LIG_LIR_Nem_3	57	63	PF02991	0.380
LIG_LIR_Nem_3	93	98	PF02991	0.313
LIG_MYND_1	6	10	PF01753	0.647
LIG_NRBOX	252	258	PF00104	0.485
LIG_SH2_CRK	60	64	PF00017	0.321
LIG_SH2_NCK_1	60	64	PF00017	0.428
LIG_SH2_NCK_1	79	83	PF00017	0.152
LIG_SH2_STAP1	107	111	PF00017	0.287
LIG_SH2_STAP1	137	141	PF00017	0.323
LIG_SH2_STAP1	150	154	PF00017	0.323
LIG_SH2_STAP1	60	64	PF00017	0.323
LIG_SH2_STAP1	79	83	PF00017	0.323
LIG_SH2_STAT5	137	140	PF00017	0.333
LIG_SH2_STAT5	150	153	PF00017	0.323
LIG_SH2_STAT5	60	63	PF00017	0.323
LIG_SH2_STAT5	83	86	PF00017	0.331
LIG_SH3_3	185	191	PF00018	0.728
LIG_SH3_3	324	330	PF00018	0.760
LIG_SUMO_SIM_par_1	150	155	PF11976	0.291
LIG_TRAF2_1	180	183	PF00917	0.628
LIG_TRAF2_2	372	377	PF00917	0.662
LIG_UBA3_1	256	262	PF00899	0.509
LIG_UBA3_1	87	92	PF00899	0.323
MOD_CDC14_SPxK_1	238	241	PF00782	0.749
MOD_CDC14_SPxK_1	4	7	PF00782	0.660
MOD_CDK_SPxK_1	1	7	PF00069	0.689
MOD_CDK_SPxK_1	235	241	PF00069	0.754
MOD_CDK_SPxxK_3	235	242	PF00069	0.720
MOD_CK1_1	235	241	PF00069	0.777
MOD_CK1_1	263	269	PF00069	0.407
MOD_CK1_1	278	284	PF00069	0.466
MOD_CK1_1	332	338	PF00069	0.707
MOD_CK1_1	356	362	PF00069	0.759
MOD_CK1_1	54	60	PF00069	0.542
MOD_CK2_1	177	183	PF00069	0.639
MOD_CK2_1	203	209	PF00069	0.800
MOD_CK2_1	336	342	PF00069	0.683
MOD_CK2_1	98	104	PF00069	0.317
MOD_Cter_Amidation	45	48	PF01082	0.596
MOD_GlcNHglycan	14	17	PF01048	0.556
MOD_GlcNHglycan	212	215	PF01048	0.696
MOD_GlcNHglycan	229	232	PF01048	0.786
MOD_GlcNHglycan	262	265	PF01048	0.399
MOD_GlcNHglycan	333	337	PF01048	0.689
MOD_GlcNHglycan	345	348	PF01048	0.681
MOD_GlcNHglycan	355	358	PF01048	0.800
MOD_GlcNHglycan	359	362	PF01048	0.803
MOD_GSK3_1	183	190	PF00069	0.672
MOD_GSK3_1	212	219	PF00069	0.776
MOD_GSK3_1	242	249	PF00069	0.568
MOD_GSK3_1	256	263	PF00069	0.399
MOD_GSK3_1	278	285	PF00069	0.547
MOD_GSK3_1	332	339	PF00069	0.731
MOD_GSK3_1	353	360	PF00069	0.693
MOD_GSK3_1	54	61	PF00069	0.540
MOD_N-GLC_1	12	17	PF02516	0.514
MOD_N-GLC_1	148	153	PF02516	0.436
MOD_N-GLC_1	343	348	PF02516	0.744
MOD_NEK2_1	148	153	PF00069	0.436
MOD_NEK2_1	256	261	PF00069	0.523
MOD_NEK2_1	66	71	PF00069	0.287
MOD_PIKK_1	233	239	PF00454	0.771
MOD_PKA_1	242	248	PF00069	0.634
MOD_PKA_1	58	64	PF00069	0.323
MOD_PKA_2	242	248	PF00069	0.640
MOD_PKA_2	278	284	PF00069	0.464
MOD_PKA_2	58	64	PF00069	0.437
MOD_PKB_1	241	249	PF00069	0.595
MOD_Plk_1	148	154	PF00069	0.421
MOD_Plk_1	246	252	PF00069	0.421
MOD_Plk_1	66	72	PF00069	0.287
MOD_Plk_2-3	24	30	PF00069	0.570
MOD_Plk_4	148	154	PF00069	0.441
MOD_Plk_4	256	262	PF00069	0.522
MOD_Plk_4	38	44	PF00069	0.550
MOD_Plk_4	58	64	PF00069	0.309
MOD_Plk_4	66	72	PF00069	0.271
MOD_ProDKin_1	1	7	PF00069	0.662
MOD_ProDKin_1	154	160	PF00069	0.298
MOD_ProDKin_1	187	193	PF00069	0.724
MOD_ProDKin_1	212	218	PF00069	0.755
MOD_ProDKin_1	235	241	PF00069	0.754
MOD_SUMO_rev_2	20	27	PF00179	0.526
TRG_DiLeu_BaEn_1	39	44	PF01217	0.570
TRG_ENDOCYTIC_2	150	153	PF00928	0.323
TRG_ENDOCYTIC_2	60	63	PF00928	0.323
TRG_ER_diArg_1	240	243	PF00400	0.739
TRG_ER_diArg_1	298	301	PF00400	0.557
TRG_NES_CRM1_1	143	155	PF08389	0.405
TRG_Pf-PMV_PEXEL_1	142	147	PF00026	0.401
TRG_Pf-PMV_PEXEL_1	254	258	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1T4	Leptomonas seymouri	70%	95%
A0A0S4IUQ9	Bodo saltans	48%	100%
A0A0S4JWE2	Bodo saltans	34%	100%
A0A1X0NJT2	Trypanosomatidae	33%	100%
A0A1X0P5T3	Trypanosomatidae	54%	100%
A0A3R7P338	Trypanosoma rangeli	50%	100%
A0A3S7X9F4	Leishmania donovani	95%	99%
A4HMT1	Leishmania braziliensis	82%	100%
A4IBC9	Leishmania infantum	95%	99%
C9ZZ90	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AF85	Leishmania major	93%	100%
V5BSW0	Trypanosoma cruzi	32%	100%
V5BY89	Trypanosoma cruzi	55%	100%