Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6D7_LEIMU

TriTrypDb:

LmxM.34.2580

Length:

191

Annotations

LeishMANIAdb annotations

Might be an organellar (mitochondrial) protein with transit signal. Localization: Mitochondrial (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9B6D7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6D7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.783
CLV_NRD_NRD_1	35	37	PF00675	0.817
CLV_PCSK_KEX2_1	10	12	PF00082	0.783
CLV_PCSK_KEX2_1	124	126	PF00082	0.376
CLV_PCSK_KEX2_1	35	37	PF00082	0.817
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.376
CLV_PCSK_SKI1_1	176	180	PF00082	0.374
DEG_Nend_UBRbox_3	1	3	PF02207	0.522
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.471
DOC_MAPK_gen_1	122	132	PF00069	0.545
DOC_PP1_RVXF_1	157	164	PF00149	0.576
DOC_PP2B_LxvP_1	20	23	PF13499	0.471
DOC_PP2B_LxvP_1	31	34	PF13499	0.519
DOC_USP7_MATH_1	45	49	PF00917	0.585
DOC_USP7_MATH_1	56	60	PF00917	0.475
DOC_WW_Pin1_4	25	30	PF00397	0.512
DOC_WW_Pin1_4	40	45	PF00397	0.445
DOC_WW_Pin1_4	51	56	PF00397	0.527
LIG_14-3-3_CanoR_1	10	17	PF00244	0.528
LIG_14-3-3_CterR_2	189	191	PF00244	0.609
LIG_Actin_WH2_2	81	99	PF00022	0.340
LIG_FHA_1	91	97	PF00498	0.412
LIG_FHA_2	165	171	PF00498	0.578
LIG_LIR_LC3C_4	28	33	PF02991	0.472
LIG_SH2_STAT5	154	157	PF00017	0.582
LIG_SH3_3	133	139	PF00018	0.692
LIG_SH3_3	52	58	PF00018	0.589
LIG_TRAF2_1	167	170	PF00917	0.582
MOD_CDC14_SPxK_1	54	57	PF00782	0.642
MOD_CDK_SPxK_1	51	57	PF00069	0.642
MOD_CK1_1	25	31	PF00069	0.587
MOD_CK1_1	40	46	PF00069	0.534
MOD_CK1_1	90	96	PF00069	0.533
MOD_CK2_1	164	170	PF00069	0.455
MOD_CK2_1	36	42	PF00069	0.774
MOD_GlcNHglycan	12	15	PF01048	0.529
MOD_GlcNHglycan	140	143	PF01048	0.592
MOD_GlcNHglycan	47	50	PF01048	0.634
MOD_GlcNHglycan	58	61	PF01048	0.670
MOD_GSK3_1	36	43	PF00069	0.650
MOD_N-GLC_1	45	50	PF02516	0.559
MOD_N-GLC_1	51	56	PF02516	0.524
MOD_PIKK_1	148	154	PF00454	0.507
MOD_PIKK_1	180	186	PF00454	0.503
MOD_PIKK_1	61	67	PF00454	0.680
MOD_PKA_1	10	16	PF00069	0.640
MOD_PKA_2	10	16	PF00069	0.606
MOD_Plk_1	36	42	PF00069	0.743
MOD_Plk_2-3	164	170	PF00069	0.453
MOD_Plk_2-3	37	43	PF00069	0.563
MOD_ProDKin_1	25	31	PF00069	0.647
MOD_ProDKin_1	40	46	PF00069	0.554
MOD_ProDKin_1	51	57	PF00069	0.665
TRG_ER_diArg_1	34	36	PF00400	0.758
TRG_ER_diArg_1	9	11	PF00400	0.744
TRG_NLS_MonoCore_2	121	126	PF00514	0.475
TRG_NLS_MonoExtC_3	121	127	PF00514	0.479
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	159	164	PF00026	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8R4	Leptomonas seymouri	53%	100%
A0A3Q8IMC4	Leishmania donovani	87%	100%
A4IBG7	Leishmania infantum	87%	100%
E9AF81	Leishmania major	84%	100%
E9AIW4	Leishmania braziliensis	63%	100%