LeishMANIAdb
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Putative cytochrome P450 reductase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative cytochrome P450 reductase
Gene product:
cytochrome P450 reductase, putative
Species:
Leishmania mexicana
UniProt:
E9B6D5_LEIMU
TriTrypDb:
LmxM.34.2560
Length:
833

Annotations

LeishMANIAdb annotations

Homologous to other eukaryotic CYP450 reductases.. For some reason, these proteins duplicated in Kinetoplastids. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 16
NetGPI no yes: 0, no: 16
Cellular components
Term Name Level Count
GO:0005829 cytosol 2 2
GO:0110165 cellular anatomical entity 1 4
GO:0016020 membrane 2 2

Expansion

Sequence features

E9B6D5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6D5

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 17
GO:0003824 catalytic activity 1 17
GO:0005488 binding 1 17
GO:0010181 FMN binding 4 17
GO:0016491 oxidoreductase activity 2 17
GO:0032553 ribonucleotide binding 3 17
GO:0036094 small molecule binding 2 17
GO:0043167 ion binding 2 17
GO:0043168 anion binding 3 17
GO:0097159 organic cyclic compound binding 2 17
GO:0097367 carbohydrate derivative binding 2 17
GO:1901265 nucleoside phosphate binding 3 17
GO:1901363 heterocyclic compound binding 2 17
GO:0003958 NADPH-hemoprotein reductase activity 5 5
GO:0016651 oxidoreductase activity, acting on NAD(P)H 3 5
GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 4 5
GO:0050660 flavin adenine dinucleotide binding 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 66 70 PF00656 0.763
CLV_NRD_NRD_1 150 152 PF00675 0.444
CLV_NRD_NRD_1 194 196 PF00675 0.312
CLV_NRD_NRD_1 33 35 PF00675 0.389
CLV_NRD_NRD_1 663 665 PF00675 0.274
CLV_NRD_NRD_1 669 671 PF00675 0.291
CLV_NRD_NRD_1 688 690 PF00675 0.301
CLV_NRD_NRD_1 726 728 PF00675 0.352
CLV_NRD_NRD_1 820 822 PF00675 0.339
CLV_PCSK_FUR_1 31 35 PF00082 0.350
CLV_PCSK_KEX2_1 127 129 PF00082 0.433
CLV_PCSK_KEX2_1 194 196 PF00082 0.312
CLV_PCSK_KEX2_1 33 35 PF00082 0.467
CLV_PCSK_KEX2_1 4 6 PF00082 0.616
CLV_PCSK_KEX2_1 643 645 PF00082 0.273
CLV_PCSK_KEX2_1 688 690 PF00082 0.335
CLV_PCSK_KEX2_1 726 728 PF00082 0.352
CLV_PCSK_KEX2_1 755 757 PF00082 0.293
CLV_PCSK_KEX2_1 820 822 PF00082 0.342
CLV_PCSK_PC1ET2_1 127 129 PF00082 0.426
CLV_PCSK_PC1ET2_1 4 6 PF00082 0.574
CLV_PCSK_PC1ET2_1 643 645 PF00082 0.273
CLV_PCSK_PC1ET2_1 755 757 PF00082 0.293
CLV_PCSK_PC7_1 639 645 PF00082 0.291
CLV_PCSK_SKI1_1 194 198 PF00082 0.338
CLV_PCSK_SKI1_1 243 247 PF00082 0.304
CLV_PCSK_SKI1_1 283 287 PF00082 0.378
CLV_PCSK_SKI1_1 355 359 PF00082 0.431
CLV_PCSK_SKI1_1 360 364 PF00082 0.412
CLV_PCSK_SKI1_1 39 43 PF00082 0.522
CLV_PCSK_SKI1_1 400 404 PF00082 0.308
CLV_PCSK_SKI1_1 451 455 PF00082 0.233
CLV_PCSK_SKI1_1 476 480 PF00082 0.286
CLV_PCSK_SKI1_1 490 494 PF00082 0.210
CLV_PCSK_SKI1_1 644 648 PF00082 0.312
CLV_PCSK_SKI1_1 665 669 PF00082 0.261
CLV_PCSK_SKI1_1 756 760 PF00082 0.403
CLV_PCSK_SKI1_1 827 831 PF00082 0.284
CLV_Separin_Metazoa 526 530 PF03568 0.485
DEG_APCC_DBOX_1 160 168 PF00400 0.581
DEG_APCC_DBOX_1 475 483 PF00400 0.445
DEG_APCC_DBOX_1 485 493 PF00400 0.415
DEG_SPOP_SBC_1 321 325 PF00917 0.664
DEG_SPOP_SBC_1 370 374 PF00917 0.642
DOC_ANK_TNKS_1 603 610 PF00023 0.410
DOC_CKS1_1 463 468 PF01111 0.497
DOC_CYCLIN_yCln2_LP_2 463 469 PF00134 0.464
DOC_MAPK_DCC_7 159 167 PF00069 0.552
DOC_MAPK_gen_1 159 167 PF00069 0.501
DOC_MAPK_gen_1 253 260 PF00069 0.430
DOC_MAPK_gen_1 502 510 PF00069 0.428
DOC_MAPK_gen_1 643 649 PF00069 0.577
DOC_MAPK_MEF2A_6 159 167 PF00069 0.530
DOC_MAPK_MEF2A_6 301 310 PF00069 0.633
DOC_MAPK_MEF2A_6 486 493 PF00069 0.409
DOC_MAPK_MEF2A_6 598 605 PF00069 0.512
DOC_PP1_RVXF_1 260 266 PF00149 0.512
DOC_PP1_SILK_1 476 481 PF00149 0.399
DOC_PP2B_LxvP_1 456 459 PF13499 0.471
DOC_PP2B_LxvP_1 528 531 PF13499 0.430
DOC_PP4_FxxP_1 382 385 PF00568 0.738
DOC_PP4_FxxP_1 634 637 PF00568 0.484
DOC_USP7_MATH_1 157 161 PF00917 0.561
DOC_USP7_MATH_1 202 206 PF00917 0.571
DOC_USP7_MATH_1 212 216 PF00917 0.376
DOC_USP7_MATH_1 322 326 PF00917 0.744
DOC_USP7_MATH_1 340 344 PF00917 0.759
DOC_USP7_MATH_1 353 357 PF00917 0.678
DOC_USP7_MATH_1 362 366 PF00917 0.763
DOC_USP7_MATH_1 369 373 PF00917 0.697
DOC_USP7_MATH_1 410 414 PF00917 0.533
DOC_USP7_MATH_1 503 507 PF00917 0.417
DOC_USP7_MATH_1 541 545 PF00917 0.533
DOC_USP7_MATH_1 725 729 PF00917 0.639
DOC_USP7_MATH_1 730 734 PF00917 0.648
DOC_USP7_UBL2_3 148 152 PF12436 0.665
DOC_WW_Pin1_4 360 365 PF00397 0.633
DOC_WW_Pin1_4 406 411 PF00397 0.497
DOC_WW_Pin1_4 462 467 PF00397 0.464
LIG_14-3-3_CanoR_1 194 204 PF00244 0.430
LIG_14-3-3_CanoR_1 243 252 PF00244 0.502
LIG_14-3-3_CanoR_1 502 511 PF00244 0.461
LIG_14-3-3_CanoR_1 592 599 PF00244 0.512
LIG_14-3-3_CanoR_1 630 635 PF00244 0.489
LIG_14-3-3_CanoR_1 688 695 PF00244 0.478
LIG_14-3-3_CanoR_1 756 762 PF00244 0.462
LIG_Actin_WH2_2 465 482 PF00022 0.505
LIG_Actin_WH2_2 815 832 PF00022 0.523
LIG_APCC_ABBA_1 183 188 PF00400 0.471
LIG_BIR_II_1 1 5 PF00653 0.495
LIG_BRCT_BRCA1_1 378 382 PF00533 0.679
LIG_CtBP_PxDLS_1 445 449 PF00389 0.512
LIG_eIF4E_1 663 669 PF01652 0.451
LIG_EVH1_1 380 384 PF00568 0.716
LIG_FHA_1 16 22 PF00498 0.326
LIG_FHA_1 246 252 PF00498 0.471
LIG_FHA_1 322 328 PF00498 0.628
LIG_FHA_1 505 511 PF00498 0.546
LIG_FHA_1 631 637 PF00498 0.493
LIG_FHA_1 678 684 PF00498 0.537
LIG_FHA_1 736 742 PF00498 0.543
LIG_FHA_1 757 763 PF00498 0.480
LIG_FHA_1 76 82 PF00498 0.512
LIG_FHA_2 151 157 PF00498 0.776
LIG_FHA_2 170 176 PF00498 0.419
LIG_FHA_2 463 469 PF00498 0.481
LIG_FHA_2 553 559 PF00498 0.428
LIG_FHA_2 595 601 PF00498 0.445
LIG_FHA_2 740 746 PF00498 0.501
LIG_FHA_2 98 104 PF00498 0.522
LIG_GBD_Chelix_1 602 610 PF00786 0.312
LIG_HCF-1_HBM_1 825 828 PF13415 0.564
LIG_LIR_Apic_2 379 385 PF02991 0.737
LIG_LIR_Apic_2 632 637 PF02991 0.495
LIG_LIR_Gen_1 114 124 PF02991 0.550
LIG_LIR_Gen_1 179 189 PF02991 0.512
LIG_LIR_Gen_1 522 532 PF02991 0.510
LIG_LIR_Gen_1 623 634 PF02991 0.479
LIG_LIR_Gen_1 767 777 PF02991 0.589
LIG_LIR_Nem_3 179 185 PF02991 0.512
LIG_LIR_Nem_3 235 241 PF02991 0.451
LIG_LIR_Nem_3 307 313 PF02991 0.594
LIG_LIR_Nem_3 522 527 PF02991 0.498
LIG_LIR_Nem_3 623 629 PF02991 0.550
LIG_LIR_Nem_3 767 773 PF02991 0.507
LIG_NRBOX 799 805 PF00104 0.488
LIG_Pex14_2 182 186 PF04695 0.445
LIG_PTB_Apo_2 222 229 PF02174 0.512
LIG_PTB_Phospho_1 222 228 PF10480 0.512
LIG_SH2_GRB2like 124 127 PF00017 0.564
LIG_SH2_NCK_1 586 590 PF00017 0.444
LIG_SH2_PTP2 166 169 PF00017 0.512
LIG_SH2_PTP2 496 499 PF00017 0.488
LIG_SH2_PTP2 6 9 PF00017 0.363
LIG_SH2_PTP2 628 631 PF00017 0.566
LIG_SH2_SRC 122 125 PF00017 0.532
LIG_SH2_STAP1 40 44 PF00017 0.579
LIG_SH2_STAT3 270 273 PF00017 0.383
LIG_SH2_STAT3 40 43 PF00017 0.673
LIG_SH2_STAT5 122 125 PF00017 0.584
LIG_SH2_STAT5 166 169 PF00017 0.512
LIG_SH2_STAT5 241 244 PF00017 0.460
LIG_SH2_STAT5 496 499 PF00017 0.445
LIG_SH2_STAT5 514 517 PF00017 0.445
LIG_SH2_STAT5 559 562 PF00017 0.439
LIG_SH2_STAT5 6 9 PF00017 0.420
LIG_SH2_STAT5 614 617 PF00017 0.484
LIG_SH2_STAT5 628 631 PF00017 0.500
LIG_SH2_STAT5 693 696 PF00017 0.494
LIG_SH2_STAT5 757 760 PF00017 0.510
LIG_SH2_STAT5 828 831 PF00017 0.499
LIG_SH3_3 300 306 PF00018 0.571
LIG_SH3_3 378 384 PF00018 0.674
LIG_SH3_3 439 445 PF00018 0.467
LIG_SH3_4 305 312 PF00018 0.627
LIG_Sin3_3 10 17 PF02671 0.219
LIG_SUMO_SIM_anti_2 18 25 PF11976 0.301
LIG_SUMO_SIM_anti_2 597 603 PF11976 0.479
LIG_SUMO_SIM_par_1 284 290 PF11976 0.495
LIG_SUMO_SIM_par_1 385 390 PF11976 0.671
LIG_SUMO_SIM_par_1 464 471 PF11976 0.407
LIG_TRAF2_1 153 156 PF00917 0.640
LIG_TRAF2_1 287 290 PF00917 0.562
LIG_TYR_ITIM 164 169 PF00017 0.516
LIG_TYR_ITIM 768 773 PF00017 0.470
LIG_UBA3_1 285 291 PF00899 0.504
LIG_UBA3_1 527 534 PF00899 0.404
LIG_WRC_WIRS_1 631 636 PF05994 0.550
MOD_CDK_SPK_2 406 411 PF00069 0.352
MOD_CK1_1 140 146 PF00069 0.740
MOD_CK1_1 150 156 PF00069 0.761
MOD_CK1_1 206 212 PF00069 0.584
MOD_CK1_1 215 221 PF00069 0.532
MOD_CK1_1 413 419 PF00069 0.482
MOD_CK1_1 587 593 PF00069 0.445
MOD_CK1_1 594 600 PF00069 0.445
MOD_CK1_1 61 67 PF00069 0.722
MOD_CK1_1 739 745 PF00069 0.548
MOD_CK2_1 150 156 PF00069 0.783
MOD_CK2_1 169 175 PF00069 0.430
MOD_CK2_1 213 219 PF00069 0.461
MOD_CK2_1 462 468 PF00069 0.522
MOD_CK2_1 594 600 PF00069 0.445
MOD_GlcNHglycan 143 146 PF01048 0.493
MOD_GlcNHglycan 18 21 PF01048 0.364
MOD_GlcNHglycan 190 193 PF01048 0.300
MOD_GlcNHglycan 205 208 PF01048 0.295
MOD_GlcNHglycan 215 218 PF01048 0.280
MOD_GlcNHglycan 243 246 PF01048 0.230
MOD_GlcNHglycan 342 345 PF01048 0.463
MOD_GlcNHglycan 373 376 PF01048 0.533
MOD_GlcNHglycan 58 61 PF01048 0.547
MOD_GlcNHglycan 63 66 PF01048 0.561
MOD_GlcNHglycan 785 788 PF01048 0.281
MOD_GlcNHglycan 789 792 PF01048 0.291
MOD_GlcNHglycan 86 89 PF01048 0.317
MOD_GSK3_1 137 144 PF00069 0.613
MOD_GSK3_1 147 154 PF00069 0.603
MOD_GSK3_1 202 209 PF00069 0.585
MOD_GSK3_1 241 248 PF00069 0.517
MOD_GSK3_1 312 319 PF00069 0.635
MOD_GSK3_1 336 343 PF00069 0.767
MOD_GSK3_1 358 365 PF00069 0.664
MOD_GSK3_1 402 409 PF00069 0.465
MOD_GSK3_1 410 417 PF00069 0.479
MOD_GSK3_1 587 594 PF00069 0.434
MOD_GSK3_1 61 68 PF00069 0.717
MOD_GSK3_1 725 732 PF00069 0.658
MOD_GSK3_1 735 742 PF00069 0.552
MOD_GSK3_1 783 790 PF00069 0.488
MOD_N-GLC_1 141 146 PF02516 0.404
MOD_N-GLC_1 157 162 PF02516 0.327
MOD_N-GLC_1 353 358 PF02516 0.424
MOD_NEK2_1 15 20 PF00069 0.337
MOD_NEK2_1 233 238 PF00069 0.445
MOD_NEK2_1 294 299 PF00069 0.645
MOD_NEK2_1 312 317 PF00069 0.662
MOD_NEK2_1 358 363 PF00069 0.655
MOD_NEK2_1 610 615 PF00069 0.517
MOD_NEK2_1 772 777 PF00069 0.503
MOD_NEK2_1 97 102 PF00069 0.517
MOD_PIKK_1 402 408 PF00454 0.499
MOD_PIKK_1 578 584 PF00454 0.430
MOD_PIKK_1 58 64 PF00454 0.664
MOD_PK_1 454 460 PF00069 0.430
MOD_PK_1 584 590 PF00069 0.445
MOD_PKA_1 151 157 PF00069 0.593
MOD_PKA_1 194 200 PF00069 0.430
MOD_PKA_1 504 510 PF00069 0.503
MOD_PKA_1 688 694 PF00069 0.508
MOD_PKA_2 150 156 PF00069 0.608
MOD_PKA_2 194 200 PF00069 0.430
MOD_PKA_2 410 416 PF00069 0.478
MOD_PKA_2 591 597 PF00069 0.512
MOD_PKA_2 629 635 PF00069 0.506
MOD_PKA_2 687 693 PF00069 0.483
MOD_PKA_2 725 731 PF00069 0.666
MOD_PKB_1 398 406 PF00069 0.492
MOD_Plk_1 234 240 PF00069 0.456
MOD_Plk_1 353 359 PF00069 0.625
MOD_Plk_1 787 793 PF00069 0.525
MOD_Plk_4 247 253 PF00069 0.517
MOD_Plk_4 342 348 PF00069 0.574
MOD_Plk_4 389 395 PF00069 0.579
MOD_Plk_4 414 420 PF00069 0.446
MOD_Plk_4 610 616 PF00069 0.484
MOD_Plk_4 677 683 PF00069 0.567
MOD_Plk_4 736 742 PF00069 0.496
MOD_Plk_4 757 763 PF00069 0.622
MOD_ProDKin_1 360 366 PF00069 0.632
MOD_ProDKin_1 406 412 PF00069 0.497
MOD_ProDKin_1 462 468 PF00069 0.464
MOD_SUMO_for_1 304 307 PF00179 0.610
TRG_DiLeu_BaEn_4 289 295 PF01217 0.531
TRG_ENDOCYTIC_2 166 169 PF00928 0.494
TRG_ENDOCYTIC_2 227 230 PF00928 0.447
TRG_ENDOCYTIC_2 496 499 PF00928 0.445
TRG_ENDOCYTIC_2 585 588 PF00928 0.471
TRG_ENDOCYTIC_2 6 9 PF00928 0.384
TRG_ENDOCYTIC_2 628 631 PF00928 0.566
TRG_ENDOCYTIC_2 770 773 PF00928 0.554
TRG_ER_diArg_1 159 162 PF00400 0.518
TRG_ER_diArg_1 193 195 PF00400 0.512
TRG_ER_diArg_1 398 401 PF00400 0.518
TRG_ER_diArg_1 819 821 PF00400 0.542
TRG_NLS_MonoExtN_4 549 555 PF00514 0.511
TRG_Pf-PMV_PEXEL_1 604 608 PF00026 0.245
TRG_Pf-PMV_PEXEL_1 827 831 PF00026 0.303

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7X2 Leptomonas seymouri 31% 100%
A0A0N1IBR8 Leptomonas seymouri 67% 100%
A0A1X0P5U2 Trypanosomatidae 41% 100%
A0A3Q8II21 Leishmania donovani 95% 100%
A0A3R7K908 Trypanosoma rangeli 42% 100%
A0A3S7X1H9 Leishmania donovani 31% 100%
A1JJS2 Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081) 23% 100%
A2AI05 Mus musculus 23% 100%
A4HAY4 Leishmania braziliensis 24% 93%
A4HGH1 Leishmania braziliensis 29% 100%
A4HMS7 Leishmania braziliensis 85% 100%
A4I3K3 Leishmania infantum 32% 100%
A4IBG5 Leishmania infantum 95% 100%
C9ZZA0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
D0A835 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
E9AF79 Leishmania major 94% 100%
E9AZU3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B557 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 96%
O08336 Bacillus subtilis (strain 168) 24% 79%
O62699 Canis lupus familiaris 25% 72%
P04175 Sus scrofa 23% 100%
P16603 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 100%
P29473 Bos taurus 24% 69%
P29477 Mus musculus 24% 73%
P35228 Homo sapiens 24% 72%
P37116 Vigna radiata var. radiata 23% 100%
P70313 Mus musculus 23% 69%
Q05001 Catharanthus roseus 26% 100%
Q0CMM0 Aspergillus terreus (strain NIH 2624 / FGSC A1156) 23% 100%
Q1JPJ0 Bos taurus 24% 100%
Q28969 Sus scrofa 23% 69%
Q2UHA7 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 22% 100%
Q3SYT8 Bos taurus 23% 100%
Q4JIJ2 Bos taurus 25% 100%
Q4Q2S8 Leishmania major 24% 96%
Q4Q8E2 Leishmania major 38% 100%
Q4WM67 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 22% 100%
Q4WU59 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 22% 100%
Q55CT1 Dictyostelium discoideum 25% 100%
Q5AD27 Candida albicans (strain SC5314 / ATCC MYA-2876) 20% 100%
Q6NRG5 Xenopus laevis 23% 100%
Q6PFP6 Danio rerio 23% 100%
Q7X7K8 Oryza sativa subsp. japonica 24% 100%
Q8C1A3 Mus musculus 23% 100%
Q90703 Gallus gallus 22% 73%
Q9HDG2 Phanerodontia chrysosporium 22% 100%
Q9SB48 Arabidopsis thaliana 22% 100%
Q9UBK8 Homo sapiens 23% 100%
Q9UHB4 Homo sapiens 24% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS