Putative RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Double RNA binding domain protein 9

Species:

Leishmania mexicana

UniProt:

E9B6D4_LEIMU

TriTrypDb:

LmxM.34.2550

Length:

455

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B6D4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6D4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.526
CLV_C14_Caspase3-7	383	387	PF00656	0.790
CLV_C14_Caspase3-7	67	71	PF00656	0.439
CLV_NRD_NRD_1	112	114	PF00675	0.472
CLV_NRD_NRD_1	137	139	PF00675	0.482
CLV_NRD_NRD_1	360	362	PF00675	0.521
CLV_NRD_NRD_1	364	366	PF00675	0.528
CLV_NRD_NRD_1	377	379	PF00675	0.558
CLV_NRD_NRD_1	420	422	PF00675	0.543
CLV_NRD_NRD_1	447	449	PF00675	0.526
CLV_NRD_NRD_1	45	47	PF00675	0.457
CLV_NRD_NRD_1	75	77	PF00675	0.750
CLV_PCSK_FUR_1	361	365	PF00082	0.524
CLV_PCSK_KEX2_1	137	139	PF00082	0.538
CLV_PCSK_KEX2_1	141	143	PF00082	0.542
CLV_PCSK_KEX2_1	174	176	PF00082	0.204
CLV_PCSK_KEX2_1	299	301	PF00082	0.235
CLV_PCSK_KEX2_1	360	362	PF00082	0.521
CLV_PCSK_KEX2_1	363	365	PF00082	0.527
CLV_PCSK_KEX2_1	379	381	PF00082	0.561
CLV_PCSK_KEX2_1	420	422	PF00082	0.614
CLV_PCSK_KEX2_1	447	449	PF00082	0.549
CLV_PCSK_KEX2_1	45	47	PF00082	0.529
CLV_PCSK_KEX2_1	58	60	PF00082	0.500
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.585
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.204
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.233
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.527
CLV_PCSK_PC1ET2_1	379	381	PF00082	0.561
CLV_PCSK_PC1ET2_1	447	449	PF00082	0.549
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.488
CLV_PCSK_PC7_1	137	143	PF00082	0.470
CLV_PCSK_PC7_1	360	366	PF00082	0.570
CLV_PCSK_PC7_1	443	449	PF00082	0.510
CLV_PCSK_SKI1_1	145	149	PF00082	0.517
CLV_PCSK_SKI1_1	161	165	PF00082	0.209
CLV_PCSK_SKI1_1	179	183	PF00082	0.210
CLV_PCSK_SKI1_1	220	224	PF00082	0.587
CLV_PCSK_SKI1_1	351	355	PF00082	0.548
CLV_PCSK_SKI1_1	41	45	PF00082	0.532
CLV_PCSK_SKI1_1	58	62	PF00082	0.467
CLV_PCSK_SKI1_1	94	98	PF00082	0.603
CLV_Separin_Metazoa	91	95	PF03568	0.604
DEG_SPOP_SBC_1	95	99	PF00917	0.641
DOC_ANK_TNKS_1	381	388	PF00023	0.545
DOC_ANK_TNKS_1	427	434	PF00023	0.523
DOC_MAPK_gen_1	48	57	PF00069	0.428
DOC_PP1_RVXF_1	432	438	PF00149	0.601
DOC_PP2B_LxvP_1	33	36	PF13499	0.390
DOC_PP4_FxxP_1	400	403	PF00568	0.578
DOC_USP7_MATH_1	151	155	PF00917	0.579
DOC_USP7_MATH_1	2	6	PF00917	0.540
DOC_USP7_MATH_1	268	272	PF00917	0.323
DOC_USP7_MATH_1	80	84	PF00917	0.622
DOC_USP7_MATH_1	95	99	PF00917	0.510
DOC_USP7_UBL2_3	110	114	PF12436	0.641
DOC_USP7_UBL2_3	141	145	PF12436	0.488
DOC_USP7_UBL2_3	219	223	PF12436	0.495
DOC_USP7_UBL2_3	354	358	PF12436	0.528
DOC_USP7_UBL2_3	434	438	PF12436	0.614
LIG_BIR_II_1	1	5	PF00653	0.531
LIG_BIR_III_4	103	107	PF00653	0.535
LIG_BIR_III_4	70	74	PF00653	0.433
LIG_deltaCOP1_diTrp_1	283	290	PF00928	0.402
LIG_FHA_1	122	128	PF00498	0.465
LIG_FHA_1	160	166	PF00498	0.245
LIG_FHA_1	225	231	PF00498	0.399
LIG_FHA_1	256	262	PF00498	0.556
LIG_FHA_2	118	124	PF00498	0.588
LIG_FHA_2	255	261	PF00498	0.337
LIG_FHA_2	279	285	PF00498	0.415
LIG_FHA_2	330	336	PF00498	0.449
LIG_FHA_2	42	48	PF00498	0.443
LIG_Integrin_isoDGR_2	338	340	PF01839	0.215
LIG_Integrin_RGD_1	333	335	PF01839	0.249
LIG_LIR_Apic_2	398	403	PF02991	0.577
LIG_LIR_Gen_1	227	235	PF02991	0.364
LIG_LIR_Gen_1	284	295	PF02991	0.423
LIG_LIR_Gen_1	394	403	PF02991	0.693
LIG_LIR_LC3C_4	251	256	PF02991	0.212
LIG_LIR_Nem_3	22	26	PF02991	0.626
LIG_LIR_Nem_3	227	232	PF02991	0.348
LIG_LIR_Nem_3	284	290	PF02991	0.423
LIG_LIR_Nem_3	394	400	PF02991	0.693
LIG_LIR_Nem_3	411	415	PF02991	0.504
LIG_Pex14_2	118	122	PF04695	0.629
LIG_PTB_Apo_2	273	280	PF02174	0.402
LIG_PTB_Phospho_1	273	279	PF10480	0.402
LIG_SH2_GRB2like	397	400	PF00017	0.537
LIG_SH2_STAP1	224	228	PF00017	0.298
LIG_SH2_STAT5	229	232	PF00017	0.327
LIG_SH2_STAT5	317	320	PF00017	0.402
LIG_SH3_2	442	447	PF14604	0.571
LIG_SH3_3	436	442	PF00018	0.554
LIG_TRAF2_1	132	135	PF00917	0.570
LIG_TRAF2_1	154	157	PF00917	0.561
LIG_TRAF2_1	196	199	PF00917	0.473
LIG_TRAF2_1	281	284	PF00917	0.402
LIG_UBA3_1	51	58	PF00899	0.609
LIG_WRC_WIRS_1	286	291	PF05994	0.411
MOD_CK1_1	183	189	PF00069	0.519
MOD_CK1_1	234	240	PF00069	0.469
MOD_CK1_1	391	397	PF00069	0.575
MOD_CK1_1	4	10	PF00069	0.570
MOD_CK1_1	83	89	PF00069	0.758
MOD_CK1_1	98	104	PF00069	0.555
MOD_CK2_1	106	112	PF00069	0.559
MOD_CK2_1	151	157	PF00069	0.565
MOD_CK2_1	237	243	PF00069	0.459
MOD_CK2_1	278	284	PF00069	0.402
MOD_CK2_1	41	47	PF00069	0.452
MOD_Cter_Amidation	74	77	PF01082	0.772
MOD_GlcNHglycan	100	103	PF01048	0.592
MOD_GlcNHglycan	224	227	PF01048	0.294
MOD_GlcNHglycan	233	236	PF01048	0.362
MOD_GlcNHglycan	239	242	PF01048	0.359
MOD_GlcNHglycan	382	385	PF01048	0.770
MOD_GlcNHglycan	406	409	PF01048	0.447
MOD_GlcNHglycan	7	10	PF01048	0.541
MOD_GlcNHglycan	85	88	PF01048	0.689
MOD_GSK3_1	1	8	PF00069	0.507
MOD_GSK3_1	117	124	PF00069	0.511
MOD_GSK3_1	391	398	PF00069	0.671
MOD_GSK3_1	404	411	PF00069	0.548
MOD_GSK3_1	94	101	PF00069	0.649
MOD_N-GLC_1	279	284	PF02516	0.211
MOD_N-GLC_1	347	352	PF02516	0.583
MOD_N-GLC_1	83	88	PF02516	0.447
MOD_NEK2_1	1	6	PF00069	0.592
MOD_NEK2_1	117	122	PF00069	0.629
MOD_NEK2_1	231	236	PF00069	0.385
MOD_NEK2_1	254	259	PF00069	0.377
MOD_NEK2_1	26	31	PF00069	0.631
MOD_NEK2_1	321	326	PF00069	0.467
MOD_NEK2_2	268	273	PF00069	0.324
MOD_PIKK_1	391	397	PF00454	0.467
MOD_PKA_1	140	146	PF00069	0.613
MOD_PKA_1	378	384	PF00069	0.502
MOD_PKA_1	41	47	PF00069	0.464
MOD_PKA_1	447	453	PF00069	0.517
MOD_PKA_2	306	312	PF00069	0.402
MOD_PKA_2	391	397	PF00069	0.535
MOD_PKA_2	447	453	PF00069	0.517
MOD_PKA_2	80	86	PF00069	0.721
MOD_PKB_1	138	146	PF00069	0.604
MOD_PKB_1	378	386	PF00069	0.571
MOD_Plk_1	268	274	PF00069	0.326
MOD_Plk_4	117	123	PF00069	0.517
MOD_Plk_4	268	274	PF00069	0.325
MOD_SUMO_rev_2	119	127	PF00179	0.581
MOD_SUMO_rev_2	217	225	PF00179	0.483
MOD_SUMO_rev_2	292	301	PF00179	0.458
MOD_SUMO_rev_2	306	315	PF00179	0.458
MOD_SUMO_rev_2	350	356	PF00179	0.636
MOD_SUMO_rev_2	376	381	PF00179	0.662
MOD_SUMO_rev_2	426	435	PF00179	0.542
MOD_SUMO_rev_2	54	60	PF00179	0.482
MOD_SUMO_rev_2	62	71	PF00179	0.458
TRG_DiLeu_BaEn_1	243	248	PF01217	0.401
TRG_DiLeu_BaEn_2	268	274	PF01217	0.338
TRG_ENDOCYTIC_2	229	232	PF00928	0.346
TRG_ENDOCYTIC_2	317	320	PF00928	0.402
TRG_ENDOCYTIC_2	397	400	PF00928	0.577
TRG_ER_diArg_1	137	140	PF00400	0.583
TRG_ER_diArg_1	190	193	PF00400	0.425
TRG_ER_diArg_1	300	303	PF00400	0.405
TRG_ER_diArg_1	419	421	PF00400	0.598
TRG_NLS_Bipartite_1	363	383	PF00514	0.644
TRG_NLS_MonoCore_2	400	405	PF00514	0.679
TRG_NLS_MonoExtC_3	139	144	PF00514	0.477
TRG_NLS_MonoExtC_3	400	406	PF00514	0.594
TRG_NLS_MonoExtC_3	446	451	PF00514	0.544
TRG_NLS_MonoExtN_4	137	144	PF00514	0.537
TRG_NLS_MonoExtN_4	378	383	PF00514	0.600
TRG_NLS_MonoExtN_4	445	452	PF00514	0.519
TRG_Pf-PMV_PEXEL_1	212	217	PF00026	0.383
TRG_Pf-PMV_PEXEL_1	428	432	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8R8	Leptomonas seymouri	72%	100%
A0A1X0P6L1	Trypanosomatidae	46%	100%
A0A3Q8IPK7	Leishmania donovani	92%	100%
A0A3R7LUT6	Trypanosoma rangeli	47%	100%
A4HMS6	Leishmania braziliensis	86%	100%
C9ZZA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AF78	Leishmania major	92%	100%
Q5M9F1	Rattus norvegicus	29%	100%
V5BNV3	Trypanosoma cruzi	48%	100%