CS domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6D2_LEIMU

TriTrypDb:

LmxM.34.2530

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6D2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6D2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.573
CLV_C14_Caspase3-7	240	244	PF00656	0.483
CLV_NRD_NRD_1	120	122	PF00675	0.707
CLV_NRD_NRD_1	296	298	PF00675	0.610
CLV_NRD_NRD_1	299	301	PF00675	0.628
CLV_NRD_NRD_1	314	316	PF00675	0.455
CLV_NRD_NRD_1	327	329	PF00675	0.417
CLV_NRD_NRD_1	331	333	PF00675	0.386
CLV_PCSK_FUR_1	297	301	PF00082	0.555
CLV_PCSK_KEX2_1	120	122	PF00082	0.639
CLV_PCSK_KEX2_1	253	255	PF00082	0.519
CLV_PCSK_KEX2_1	298	300	PF00082	0.556
CLV_PCSK_KEX2_1	326	328	PF00082	0.442
CLV_PCSK_KEX2_1	333	335	PF00082	0.467
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.327
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.556
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.523
CLV_PCSK_SKI1_1	175	179	PF00082	0.512
DEG_SCF_TRCP1_1	14	19	PF00400	0.682
DEG_SPOP_SBC_1	185	189	PF00917	0.477
DOC_CKS1_1	302	307	PF01111	0.388
DOC_CYCLIN_yCln2_LP_2	205	208	PF00134	0.486
DOC_MAPK_FxFP_2	231	234	PF00069	0.406
DOC_MAPK_gen_1	253	263	PF00069	0.383
DOC_MAPK_MEF2A_6	253	260	PF00069	0.377
DOC_MAPK_NFAT4_5	253	261	PF00069	0.509
DOC_PP2B_LxvP_1	205	208	PF13499	0.402
DOC_PP4_FxxP_1	166	169	PF00568	0.397
DOC_PP4_FxxP_1	231	234	PF00568	0.406
DOC_USP7_MATH_1	107	111	PF00917	0.553
DOC_USP7_MATH_1	64	68	PF00917	0.649
DOC_WW_Pin1_4	218	223	PF00397	0.549
DOC_WW_Pin1_4	288	293	PF00397	0.600
DOC_WW_Pin1_4	301	306	PF00397	0.621
DOC_WW_Pin1_4	66	71	PF00397	0.611
LIG_14-3-3_CanoR_1	278	288	PF00244	0.452
LIG_14-3-3_CanoR_1	297	307	PF00244	0.539
LIG_14-3-3_CanoR_1	49	53	PF00244	0.547
LIG_APCC_ABBA_1	261	266	PF00400	0.439
LIG_deltaCOP1_diTrp_1	243	250	PF00928	0.498
LIG_FHA_1	159	165	PF00498	0.388
LIG_FHA_1	201	207	PF00498	0.453
LIG_FHA_1	282	288	PF00498	0.439
LIG_FHA_1	289	295	PF00498	0.468
LIG_FHA_1	302	308	PF00498	0.353
LIG_FHA_2	129	135	PF00498	0.597
LIG_FHA_2	154	160	PF00498	0.578
LIG_FHA_2	187	193	PF00498	0.506
LIG_FHA_2	19	25	PF00498	0.610
LIG_FHA_2	40	46	PF00498	0.612
LIG_LIR_Apic_2	163	169	PF02991	0.387
LIG_LIR_Apic_2	229	234	PF02991	0.311
LIG_LIR_Gen_1	136	143	PF02991	0.577
LIG_LIR_Gen_1	7	14	PF02991	0.531
LIG_LIR_Nem_3	136	142	PF02991	0.504
LIG_LIR_Nem_3	178	183	PF02991	0.569
LIG_LIR_Nem_3	243	249	PF02991	0.246
LIG_LIR_Nem_3	312	317	PF02991	0.449
LIG_LIR_Nem_3	7	12	PF02991	0.552
LIG_Pex14_1	246	250	PF04695	0.491
LIG_Pex14_1	276	280	PF04695	0.352
LIG_Pex14_2	166	170	PF04695	0.517
LIG_Pex14_2	314	318	PF04695	0.487
LIG_SH2_STAP1	139	143	PF00017	0.574
LIG_SH2_STAT5	249	252	PF00017	0.240
LIG_SH3_2	292	297	PF14604	0.353
LIG_SH3_3	289	295	PF00018	0.368
LIG_SH3_5	2	6	PF00018	0.603
LIG_SUMO_SIM_anti_2	201	206	PF11976	0.423
LIG_SUMO_SIM_par_1	158	165	PF11976	0.512
LIG_TRAF2_1	321	324	PF00917	0.451
LIG_TYR_ITIM	137	142	PF00017	0.579
MOD_CDC14_SPxK_1	69	72	PF00782	0.521
MOD_CDK_SPxK_1	66	72	PF00069	0.519
MOD_CDK_SPxxK_3	301	308	PF00069	0.635
MOD_CK1_1	110	116	PF00069	0.762
MOD_CK1_1	15	21	PF00069	0.613
MOD_CK1_1	48	54	PF00069	0.496
MOD_CK2_1	153	159	PF00069	0.509
MOD_CK2_1	16	22	PF00069	0.651
MOD_CK2_1	173	179	PF00069	0.518
MOD_CK2_1	186	192	PF00069	0.584
MOD_CK2_1	39	45	PF00069	0.639
MOD_CK2_1	95	101	PF00069	0.697
MOD_Cter_Amidation	118	121	PF01082	0.639
MOD_GlcNHglycan	14	17	PF01048	0.650
MOD_GlcNHglycan	18	21	PF01048	0.651
MOD_GlcNHglycan	212	215	PF01048	0.668
MOD_GlcNHglycan	218	221	PF01048	0.657
MOD_GlcNHglycan	66	69	PF01048	0.700
MOD_GlcNHglycan	73	77	PF01048	0.780
MOD_GSK3_1	10	17	PF00069	0.697
MOD_GSK3_1	107	114	PF00069	0.658
MOD_GSK3_1	158	165	PF00069	0.484
MOD_GSK3_1	169	176	PF00069	0.413
MOD_GSK3_1	186	193	PF00069	0.574
MOD_GSK3_1	212	219	PF00069	0.652
MOD_GSK3_1	279	286	PF00069	0.388
MOD_GSK3_1	62	69	PF00069	0.633
MOD_GSK3_1	78	85	PF00069	0.675
MOD_N-GLC_1	82	87	PF02516	0.649
MOD_NEK2_1	12	17	PF00069	0.675
MOD_NEK2_1	138	143	PF00069	0.504
MOD_NEK2_1	200	205	PF00069	0.455
MOD_NEK2_1	71	76	PF00069	0.535
MOD_PIKK_1	153	159	PF00454	0.401
MOD_PIKK_1	298	304	PF00454	0.568
MOD_PK_1	173	179	PF00069	0.510
MOD_PKA_1	298	304	PF00069	0.383
MOD_PKA_2	114	120	PF00069	0.599
MOD_PKA_2	298	304	PF00069	0.473
MOD_PKA_2	48	54	PF00069	0.572
MOD_PKA_2	71	77	PF00069	0.664
MOD_Plk_1	158	164	PF00069	0.438
MOD_Plk_1	200	206	PF00069	0.439
MOD_Plk_1	282	288	PF00069	0.432
MOD_Plk_4	162	168	PF00069	0.380
MOD_Plk_4	270	276	PF00069	0.426
MOD_Plk_4	283	289	PF00069	0.474
MOD_ProDKin_1	218	224	PF00069	0.539
MOD_ProDKin_1	288	294	PF00069	0.592
MOD_ProDKin_1	301	307	PF00069	0.616
MOD_ProDKin_1	66	72	PF00069	0.615
MOD_SUMO_for_1	93	96	PF00179	0.659
TRG_DiLeu_BaEn_1	201	206	PF01217	0.423
TRG_DiLeu_BaLyEn_6	254	259	PF01217	0.379
TRG_ENDOCYTIC_2	139	142	PF00928	0.457
TRG_ER_diArg_1	297	300	PF00400	0.552
TRG_ER_diArg_1	325	328	PF00400	0.487
TRG_NLS_MonoExtN_4	295	302	PF00514	0.372
TRG_Pf-PMV_PEXEL_1	257	262	PF00026	0.364
TRG_Pf-PMV_PEXEL_1	334	338	PF00026	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE56	Leptomonas seymouri	52%	100%
A0A0S4KNN3	Bodo saltans	32%	100%
A0A1X0P6G0	Trypanosomatidae	40%	100%
A0A3R7NBC1	Trypanosoma rangeli	43%	100%
A0A3S7X9A9	Leishmania donovani	88%	100%
A4HMS4	Leishmania braziliensis	72%	100%
A4IBG2	Leishmania infantum	89%	100%
C9ZZA2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AF76	Leishmania major	86%	100%
V5BJ90	Trypanosoma cruzi	38%	100%