RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B6D1_LEIMU

TriTrypDb:

LmxM.34.2520

Length:

393

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6D1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6D1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.424
CLV_NRD_NRD_1	159	161	PF00675	0.523
CLV_NRD_NRD_1	230	232	PF00675	0.421
CLV_NRD_NRD_1	246	248	PF00675	0.540
CLV_NRD_NRD_1	262	264	PF00675	0.640
CLV_NRD_NRD_1	361	363	PF00675	0.413
CLV_NRD_NRD_1	90	92	PF00675	0.241
CLV_PCSK_KEX2_1	130	132	PF00082	0.421
CLV_PCSK_KEX2_1	235	237	PF00082	0.450
CLV_PCSK_KEX2_1	246	248	PF00082	0.486
CLV_PCSK_KEX2_1	361	363	PF00082	0.413
CLV_PCSK_KEX2_1	62	64	PF00082	0.379
CLV_PCSK_KEX2_1	90	92	PF00082	0.241
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.513
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.373
CLV_PCSK_PC7_1	231	237	PF00082	0.462
CLV_PCSK_PC7_1	357	363	PF00082	0.392
CLV_PCSK_SKI1_1	146	150	PF00082	0.370
CLV_PCSK_SKI1_1	213	217	PF00082	0.496
CLV_PCSK_SKI1_1	232	236	PF00082	0.343
CLV_PCSK_SKI1_1	62	66	PF00082	0.370
CLV_PCSK_SKI1_1	85	89	PF00082	0.238
CLV_Separin_Metazoa	143	147	PF03568	0.258
DEG_APCC_DBOX_1	360	368	PF00400	0.443
DEG_SPOP_SBC_1	166	170	PF00917	0.538
DOC_MAPK_gen_1	243	253	PF00069	0.498
DOC_MAPK_gen_1	90	98	PF00069	0.498
DOC_MAPK_RevD_3	75	91	PF00069	0.441
DOC_USP7_MATH_1	166	170	PF00917	0.575
DOC_USP7_MATH_1	172	176	PF00917	0.554
DOC_USP7_MATH_1	181	185	PF00917	0.343
DOC_USP7_MATH_1	204	208	PF00917	0.460
DOC_USP7_MATH_1	245	249	PF00917	0.596
DOC_USP7_MATH_1	265	269	PF00917	0.490
DOC_USP7_MATH_1	275	279	PF00917	0.557
DOC_USP7_MATH_1	317	321	PF00917	0.694
DOC_USP7_MATH_1	44	48	PF00917	0.387
LIG_14-3-3_CanoR_1	115	123	PF00244	0.364
LIG_14-3-3_CanoR_1	246	253	PF00244	0.612
LIG_14-3-3_CanoR_1	361	365	PF00244	0.471
LIG_14-3-3_CanoR_1	56	61	PF00244	0.470
LIG_AP2alpha_2	165	167	PF02296	0.416
LIG_BIR_II_1	1	5	PF00653	0.531
LIG_BIR_III_4	39	43	PF00653	0.439
LIG_BRCT_BRCA1_1	16	20	PF00533	0.349
LIG_BRCT_BRCA1_1	21	25	PF00533	0.343
LIG_CaM_IQ_9	77	93	PF13499	0.429
LIG_deltaCOP1_diTrp_1	152	159	PF00928	0.480
LIG_FHA_1	104	110	PF00498	0.446
LIG_FHA_1	325	331	PF00498	0.517
LIG_FHA_2	166	172	PF00498	0.697
LIG_FHA_2	214	220	PF00498	0.468
LIG_LIR_Gen_1	117	125	PF02991	0.480
LIG_LIR_Gen_1	152	163	PF02991	0.410
LIG_LIR_Gen_1	313	322	PF02991	0.565
LIG_LIR_Gen_1	353	360	PF02991	0.338
LIG_LIR_Nem_3	117	123	PF02991	0.366
LIG_LIR_Nem_3	152	158	PF02991	0.369
LIG_LIR_Nem_3	22	28	PF02991	0.332
LIG_LIR_Nem_3	353	358	PF02991	0.358
LIG_LIR_Nem_3	59	64	PF02991	0.371
LIG_PCNA_yPIPBox_3	74	88	PF02747	0.524
LIG_Pex14_2	61	65	PF04695	0.278
LIG_PTB_Apo_2	98	105	PF02174	0.378
LIG_SH2_CRK	300	304	PF00017	0.471
LIG_SH2_CRK	93	97	PF00017	0.384
LIG_SH2_STAT5	108	111	PF00017	0.356
LIG_SH2_STAT5	300	303	PF00017	0.473
LIG_SH2_STAT5	31	34	PF00017	0.398
LIG_SH2_STAT5	346	349	PF00017	0.374
LIG_SH2_STAT5	60	63	PF00017	0.263
LIG_SH2_STAT5	93	96	PF00017	0.362
LIG_SH3_3	160	166	PF00018	0.486
LIG_SH3_3	182	188	PF00018	0.520
LIG_SH3_3	267	273	PF00018	0.692
LIG_SH3_3	372	378	PF00018	0.431
LIG_SH3_3	43	49	PF00018	0.428
LIG_TRAF2_1	125	128	PF00917	0.475
LIG_WRC_WIRS_1	237	242	PF05994	0.624
LIG_WRC_WIRS_1	25	30	PF05994	0.380
MOD_CK1_1	2	8	PF00069	0.634
MOD_CK1_1	239	245	PF00069	0.602
MOD_CK2_1	165	171	PF00069	0.685
MOD_CK2_1	307	313	PF00069	0.447
MOD_CK2_1	97	103	PF00069	0.279
MOD_GlcNHglycan	116	119	PF01048	0.431
MOD_GlcNHglycan	174	177	PF01048	0.614
MOD_GlcNHglycan	247	250	PF01048	0.653
MOD_GlcNHglycan	336	339	PF01048	0.353
MOD_GlcNHglycan	385	388	PF01048	0.368
MOD_GlcNHglycan	45	49	PF01048	0.350
MOD_GSK3_1	167	174	PF00069	0.708
MOD_GSK3_1	177	184	PF00069	0.703
MOD_GSK3_1	307	314	PF00069	0.487
MOD_N-GLC_2	379	381	PF02516	0.342
MOD_NEK2_1	1	6	PF00069	0.600
MOD_NEK2_1	14	19	PF00069	0.289
MOD_NEK2_2	275	280	PF00069	0.564
MOD_PIKK_1	19	25	PF00454	0.381
MOD_PIKK_1	298	304	PF00454	0.564
MOD_PIKK_1	54	60	PF00454	0.483
MOD_PKA_2	114	120	PF00069	0.348
MOD_PKA_2	245	251	PF00069	0.608
MOD_PKA_2	360	366	PF00069	0.459
MOD_Plk_2-3	360	366	PF00069	0.407
MOD_Plk_4	56	62	PF00069	0.370
MOD_SUMO_rev_2	239	245	PF00179	0.645
TRG_ENDOCYTIC_2	300	303	PF00928	0.473
TRG_ENDOCYTIC_2	355	358	PF00928	0.418
TRG_ENDOCYTIC_2	93	96	PF00928	0.358
TRG_ER_diArg_1	104	107	PF00400	0.553
TRG_ER_diArg_1	130	132	PF00400	0.300
TRG_Pf-PMV_PEXEL_1	213	218	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8I6	Leptomonas seymouri	47%	71%
A0A1X0P5K1	Trypanosomatidae	34%	88%
A0A3Q8IGA8	Leishmania donovani	82%	99%
A0A3S5IR12	Trypanosoma rangeli	35%	91%
A4IBG1	Leishmania infantum	82%	99%
C9ZZA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	75%
E9AF75	Leishmania major	82%	100%
E9AIW3	Leishmania braziliensis	72%	100%
V5B3S2	Trypanosoma cruzi	32%	90%