Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6C9_LEIMU

TriTrypDb:

LmxM.35.2500

Length:

557

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6C9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6C9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	453	457	PF00656	0.797
CLV_NRD_NRD_1	211	213	PF00675	0.642
CLV_NRD_NRD_1	247	249	PF00675	0.593
CLV_NRD_NRD_1	99	101	PF00675	0.740
CLV_PCSK_KEX2_1	213	215	PF00082	0.625
CLV_PCSK_KEX2_1	247	249	PF00082	0.488
CLV_PCSK_KEX2_1	443	445	PF00082	0.738
CLV_PCSK_KEX2_1	470	472	PF00082	0.558
CLV_PCSK_KEX2_1	99	101	PF00082	0.773
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.678
CLV_PCSK_PC1ET2_1	443	445	PF00082	0.770
CLV_PCSK_PC1ET2_1	470	472	PF00082	0.558
CLV_PCSK_SKI1_1	128	132	PF00082	0.564
CLV_PCSK_SKI1_1	500	504	PF00082	0.300
DEG_APCC_DBOX_1	365	373	PF00400	0.567
DOC_CKS1_1	14	19	PF01111	0.436
DOC_CKS1_1	48	53	PF01111	0.677
DOC_CYCLIN_yCln2_LP_2	174	180	PF00134	0.528
DOC_CYCLIN_yCln2_LP_2	310	316	PF00134	0.553
DOC_CYCLIN_yCln2_LP_2	42	45	PF00134	0.698
DOC_MAPK_gen_1	500	510	PF00069	0.292
DOC_MAPK_gen_1	99	107	PF00069	0.612
DOC_PP2B_LxvP_1	42	45	PF13499	0.668
DOC_PP4_FxxP_1	287	290	PF00568	0.640
DOC_USP7_MATH_1	130	134	PF00917	0.612
DOC_USP7_MATH_1	156	160	PF00917	0.529
DOC_USP7_MATH_1	181	185	PF00917	0.746
DOC_USP7_MATH_1	195	199	PF00917	0.678
DOC_USP7_MATH_1	233	237	PF00917	0.463
DOC_USP7_MATH_1	301	305	PF00917	0.665
DOC_USP7_MATH_1	452	456	PF00917	0.774
DOC_USP7_MATH_1	530	534	PF00917	0.627
DOC_USP7_MATH_1	540	544	PF00917	0.722
DOC_USP7_MATH_1	66	70	PF00917	0.665
DOC_USP7_MATH_1	86	90	PF00917	0.381
DOC_WW_Pin1_4	199	204	PF00397	0.763
DOC_WW_Pin1_4	205	210	PF00397	0.587
DOC_WW_Pin1_4	227	232	PF00397	0.631
DOC_WW_Pin1_4	295	300	PF00397	0.613
DOC_WW_Pin1_4	323	328	PF00397	0.587
DOC_WW_Pin1_4	391	396	PF00397	0.657
DOC_WW_Pin1_4	47	52	PF00397	0.618
DOC_WW_Pin1_4	9	14	PF00397	0.489
LIG_14-3-3_CanoR_1	273	279	PF00244	0.516
LIG_14-3-3_CanoR_1	28	33	PF00244	0.601
LIG_14-3-3_CanoR_1	281	291	PF00244	0.596
LIG_14-3-3_CanoR_1	336	346	PF00244	0.498
LIG_APCC_ABBA_1	36	41	PF00400	0.511
LIG_BRCT_BRCA1_1	158	162	PF00533	0.469
LIG_BRCT_BRCA1_1	197	201	PF00533	0.649
LIG_BRCT_BRCA1_1	245	249	PF00533	0.565
LIG_CSL_BTD_1	226	229	PF09270	0.592
LIG_deltaCOP1_diTrp_1	225	234	PF00928	0.594
LIG_eIF4E_1	37	43	PF01652	0.516
LIG_EVH1_1	43	47	PF00568	0.589
LIG_FHA_1	106	112	PF00498	0.626
LIG_FHA_1	13	19	PF00498	0.547
LIG_FHA_1	283	289	PF00498	0.648
LIG_FHA_1	291	297	PF00498	0.609
LIG_FHA_1	395	401	PF00498	0.583
LIG_FHA_1	474	480	PF00498	0.483
LIG_FHA_1	48	54	PF00498	0.582
LIG_FHA_1	537	543	PF00498	0.634
LIG_FHA_1	74	80	PF00498	0.672
LIG_FHA_2	122	128	PF00498	0.689
LIG_FHA_2	253	259	PF00498	0.522
LIG_FHA_2	264	270	PF00498	0.515
LIG_FHA_2	28	34	PF00498	0.565
LIG_FHA_2	403	409	PF00498	0.588
LIG_FHA_2	93	99	PF00498	0.588
LIG_LIR_Apic_2	269	274	PF02991	0.550
LIG_LIR_Apic_2	285	290	PF02991	0.616
LIG_LIR_Apic_2	29	35	PF02991	0.538
LIG_LIR_Gen_1	159	167	PF02991	0.457
LIG_LIR_Nem_3	159	165	PF02991	0.466
LIG_LIR_Nem_3	329	335	PF02991	0.612
LIG_LIR_Nem_3	340	346	PF02991	0.518
LIG_MYND_1	40	44	PF01753	0.537
LIG_PCNA_PIPBox_1	515	524	PF02747	0.494
LIG_Pex14_1	478	482	PF04695	0.409
LIG_SH2_CRK	344	348	PF00017	0.482
LIG_SH2_SRC	32	35	PF00017	0.537
LIG_SH2_STAP1	344	348	PF00017	0.482
LIG_SH2_STAP1	423	427	PF00017	0.626
LIG_SH2_STAP1	475	479	PF00017	0.517
LIG_SH2_STAT5	331	334	PF00017	0.560
LIG_SH2_STAT5	37	40	PF00017	0.513
LIG_SH2_STAT5	375	378	PF00017	0.581
LIG_SH2_STAT5	403	406	PF00017	0.575
LIG_SH2_STAT5	475	478	PF00017	0.519
LIG_SH3_3	223	229	PF00018	0.556
LIG_SH3_3	285	291	PF00018	0.701
LIG_SH3_3	293	299	PF00018	0.696
LIG_SH3_3	41	47	PF00018	0.569
LIG_SH3_3	415	421	PF00018	0.523
LIG_SH3_3	48	54	PF00018	0.603
LIG_SH3_5	327	331	PF00018	0.527
LIG_SUMO_SIM_anti_2	506	513	PF11976	0.536
LIG_SUMO_SIM_par_1	103	109	PF11976	0.642
LIG_SUMO_SIM_par_1	506	513	PF11976	0.536
LIG_TRAF2_1	150	153	PF00917	0.648
LIG_TRAF2_1	368	371	PF00917	0.399
LIG_WW_1	34	37	PF00397	0.489
LIG_WW_2	51	54	PF00397	0.672
MOD_CDK_SPxxK_3	205	212	PF00069	0.473
MOD_CK1_1	12	18	PF00069	0.589
MOD_CK1_1	208	214	PF00069	0.608
MOD_CK1_1	243	249	PF00069	0.585
MOD_CK1_1	27	33	PF00069	0.714
MOD_CK1_1	326	332	PF00069	0.571
MOD_CK1_1	355	361	PF00069	0.421
MOD_CK1_1	533	539	PF00069	0.648
MOD_CK1_1	541	547	PF00069	0.774
MOD_CK2_1	121	127	PF00069	0.606
MOD_CK2_1	147	153	PF00069	0.636
MOD_CK2_1	181	187	PF00069	0.600
MOD_CK2_1	188	194	PF00069	0.706
MOD_CK2_1	233	239	PF00069	0.647
MOD_CK2_1	252	258	PF00069	0.589
MOD_CK2_1	263	269	PF00069	0.650
MOD_CK2_1	27	33	PF00069	0.567
MOD_CK2_1	402	408	PF00069	0.591
MOD_CK2_1	92	98	PF00069	0.585
MOD_Cter_Amidation	441	444	PF01082	0.645
MOD_GlcNHglycan	132	135	PF01048	0.527
MOD_GlcNHglycan	197	200	PF01048	0.685
MOD_GlcNHglycan	354	357	PF01048	0.676
MOD_GlcNHglycan	379	382	PF01048	0.551
MOD_GlcNHglycan	522	525	PF01048	0.589
MOD_GlcNHglycan	88	91	PF01048	0.582
MOD_GSK3_1	195	202	PF00069	0.701
MOD_GSK3_1	208	215	PF00069	0.708
MOD_GSK3_1	24	31	PF00069	0.718
MOD_GSK3_1	290	297	PF00069	0.600
MOD_GSK3_1	319	326	PF00069	0.689
MOD_GSK3_1	432	439	PF00069	0.634
MOD_GSK3_1	536	543	PF00069	0.742
MOD_GSK3_1	9	16	PF00069	0.516
MOD_N-GLC_1	294	299	PF02516	0.539
MOD_NEK2_1	121	126	PF00069	0.536
MOD_NEK2_1	24	29	PF00069	0.645
MOD_NEK2_1	263	268	PF00069	0.508
MOD_PIKK_1	542	548	PF00454	0.715
MOD_PIKK_1	73	79	PF00454	0.585
MOD_PKA_1	212	218	PF00069	0.670
MOD_PKA_2	27	33	PF00069	0.602
MOD_PKA_2	377	383	PF00069	0.577
MOD_Plk_1	121	127	PF00069	0.590
MOD_Plk_1	370	376	PF00069	0.519
MOD_Plk_1	533	539	PF00069	0.715
MOD_Plk_1	73	79	PF00069	0.520
MOD_Plk_2-3	450	456	PF00069	0.671
MOD_Plk_4	106	112	PF00069	0.507
MOD_Plk_4	121	127	PF00069	0.466
MOD_Plk_4	371	377	PF00069	0.598
MOD_Plk_4	473	479	PF00069	0.486
MOD_ProDKin_1	199	205	PF00069	0.764
MOD_ProDKin_1	227	233	PF00069	0.627
MOD_ProDKin_1	295	301	PF00069	0.609
MOD_ProDKin_1	323	329	PF00069	0.578
MOD_ProDKin_1	391	397	PF00069	0.651
MOD_ProDKin_1	47	53	PF00069	0.621
MOD_ProDKin_1	9	15	PF00069	0.488
MOD_SUMO_for_1	547	550	PF00179	0.614
MOD_SUMO_rev_2	184	191	PF00179	0.627
TRG_DiLeu_BaEn_3	152	158	PF01217	0.598
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.620
TRG_ENDOCYTIC_2	344	347	PF00928	0.482
TRG_ER_diArg_1	247	249	PF00400	0.443
TRG_ER_diArg_1	99	101	PF00400	0.679
TRG_NLS_MonoExtC_3	211	216	PF00514	0.733
TRG_NLS_MonoExtN_4	209	216	PF00514	0.733

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEG0	Leptomonas seymouri	60%	100%
A0A1X0P5K7	Trypanosomatidae	34%	100%
A0A3Q8IJ29	Leishmania donovani	92%	100%
A0A3R7KY71	Trypanosoma rangeli	36%	100%
A4HMS3	Leishmania braziliensis	80%	100%
A4IBF9	Leishmania infantum	92%	100%
C9ZZA5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AF73	Leishmania major	90%	100%
V5DK90	Trypanosoma cruzi	35%	100%