Ribosomal RNA-processing protein 8

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6C6_LEIMU

TriTrypDb:

LmxM.35.2470

Length:

391

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6C6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6C6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.461
CLV_C14_Caspase3-7	55	59	PF00656	0.661
CLV_NRD_NRD_1	113	115	PF00675	0.536
CLV_NRD_NRD_1	276	278	PF00675	0.465
CLV_NRD_NRD_1	339	341	PF00675	0.575
CLV_NRD_NRD_1	344	346	PF00675	0.538
CLV_NRD_NRD_1	49	51	PF00675	0.599
CLV_PCSK_FUR_1	340	344	PF00082	0.563
CLV_PCSK_KEX2_1	255	257	PF00082	0.397
CLV_PCSK_KEX2_1	276	278	PF00082	0.465
CLV_PCSK_KEX2_1	30	32	PF00082	0.534
CLV_PCSK_KEX2_1	339	341	PF00082	0.575
CLV_PCSK_KEX2_1	342	344	PF00082	0.559
CLV_PCSK_KEX2_1	359	361	PF00082	0.313
CLV_PCSK_KEX2_1	370	372	PF00082	0.522
CLV_PCSK_PC1ET2_1	255	257	PF00082	0.397
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.506
CLV_PCSK_PC1ET2_1	359	361	PF00082	0.338
CLV_PCSK_PC1ET2_1	370	372	PF00082	0.483
CLV_PCSK_PC7_1	272	278	PF00082	0.439
CLV_PCSK_PC7_1	339	345	PF00082	0.637
CLV_PCSK_SKI1_1	125	129	PF00082	0.503
CLV_PCSK_SKI1_1	18	22	PF00082	0.662
CLV_PCSK_SKI1_1	184	188	PF00082	0.560
CLV_PCSK_SKI1_1	262	266	PF00082	0.431
CLV_PCSK_SKI1_1	290	294	PF00082	0.436
CLV_PCSK_SKI1_1	297	301	PF00082	0.449
CLV_PCSK_SKI1_1	376	380	PF00082	0.535
CLV_PCSK_SKI1_1	386	390	PF00082	0.528
CLV_PCSK_SKI1_1	8	12	PF00082	0.531
DEG_APCC_DBOX_1	7	15	PF00400	0.523
DOC_CYCLIN_RxL_1	293	301	PF00134	0.397
DOC_CYCLIN_RxL_1	370	380	PF00134	0.486
DOC_CYCLIN_yClb1_LxF_4	374	379	PF00134	0.563
DOC_MAPK_DCC_7	81	91	PF00069	0.669
DOC_MAPK_gen_1	370	379	PF00069	0.548
DOC_MAPK_gen_1	83	91	PF00069	0.600
DOC_MAPK_JIP1_4	373	379	PF00069	0.498
DOC_MAPK_MEF2A_6	83	91	PF00069	0.600
DOC_MAPK_RevD_3	89	105	PF00069	0.688
DOC_PP1_RVXF_1	374	380	PF00149	0.563
DOC_USP7_MATH_1	127	131	PF00917	0.699
DOC_USP7_MATH_1	139	143	PF00917	0.605
DOC_USP7_MATH_1	161	165	PF00917	0.596
DOC_USP7_MATH_1	167	171	PF00917	0.569
DOC_USP7_MATH_1	201	205	PF00917	0.458
DOC_USP7_MATH_1	331	335	PF00917	0.569
DOC_USP7_UBL2_3	117	121	PF12436	0.610
DOC_USP7_UBL2_3	125	129	PF12436	0.550
DOC_USP7_UBL2_3	18	22	PF12436	0.596
DOC_USP7_UBL2_3	23	27	PF12436	0.514
DOC_USP7_UBL2_3	251	255	PF12436	0.413
DOC_USP7_UBL2_3	61	65	PF12436	0.561
DOC_USP7_UBL2_3	79	83	PF12436	0.633
LIG_14-3-3_CanoR_1	344	350	PF00244	0.534
LIG_Actin_WH2_2	246	263	PF00022	0.508
LIG_BIR_II_1	1	5	PF00653	0.530
LIG_FHA_1	135	141	PF00498	0.723
LIG_FHA_1	150	156	PF00498	0.591
LIG_FHA_1	316	322	PF00498	0.559
LIG_FHA_2	1	7	PF00498	0.607
LIG_FHA_2	154	160	PF00498	0.692
LIG_FHA_2	176	182	PF00498	0.558
LIG_FHA_2	346	352	PF00498	0.481
LIG_FHA_2	94	100	PF00498	0.576
LIG_Integrin_RGD_1	192	194	PF01839	0.514
LIG_LIR_Gen_1	346	357	PF02991	0.466
LIG_LIR_Nem_3	282	287	PF02991	0.353
LIG_LIR_Nem_3	346	352	PF02991	0.487
LIG_MYND_1	216	220	PF01753	0.499
LIG_Pex14_2	16	20	PF04695	0.500
LIG_REV1ctd_RIR_1	247	255	PF16727	0.434
LIG_SH2_PTP2	286	289	PF00017	0.429
LIG_SH2_STAP1	349	353	PF00017	0.456
LIG_SH2_STAT3	353	356	PF00017	0.433
LIG_SH2_STAT5	286	289	PF00017	0.433
LIG_UBA3_1	10	18	PF00899	0.592
LIG_WRC_WIRS_1	322	327	PF05994	0.540
MOD_CK2_1	153	159	PF00069	0.672
MOD_CK2_1	166	172	PF00069	0.628
MOD_CK2_1	175	181	PF00069	0.551
MOD_CK2_1	235	241	PF00069	0.603
MOD_CK2_1	251	257	PF00069	0.383
MOD_CK2_1	93	99	PF00069	0.577
MOD_GlcNHglycan	118	121	PF01048	0.551
MOD_GlcNHglycan	163	166	PF01048	0.625
MOD_GlcNHglycan	237	240	PF01048	0.498
MOD_GlcNHglycan	300	303	PF01048	0.453
MOD_GlcNHglycan	54	57	PF01048	0.675
MOD_GlcNHglycan	69	72	PF01048	0.675
MOD_GSK3_1	121	128	PF00069	0.692
MOD_GSK3_1	145	152	PF00069	0.584
MOD_GSK3_1	196	203	PF00069	0.545
MOD_GSK3_1	311	318	PF00069	0.544
MOD_GSK3_1	343	350	PF00069	0.608
MOD_GSK3_1	355	362	PF00069	0.388
MOD_GSK3_1	93	100	PF00069	0.615
MOD_N-GLC_1	251	256	PF02516	0.349
MOD_NEK2_1	145	150	PF00069	0.501
MOD_NEK2_1	321	326	PF00069	0.540
MOD_NEK2_1	355	360	PF00069	0.435
MOD_NEK2_1	369	374	PF00069	0.551
MOD_PIKK_1	175	181	PF00454	0.594
MOD_PKA_1	116	122	PF00069	0.545
MOD_PKA_1	343	349	PF00069	0.633
MOD_PKA_1	359	365	PF00069	0.387
MOD_PKA_2	153	159	PF00069	0.689
MOD_PKA_2	338	344	PF00069	0.564
MOD_PKA_2	359	365	PF00069	0.610
MOD_PKB_1	343	351	PF00069	0.580
MOD_Plk_2-3	311	317	PF00069	0.572
MOD_Plk_4	214	220	PF00069	0.539
MOD_Plk_4	311	317	PF00069	0.570
MOD_SUMO_for_1	120	123	PF00179	0.673
MOD_SUMO_rev_2	119	127	PF00179	0.576
MOD_SUMO_rev_2	169	176	PF00179	0.635
MOD_SUMO_rev_2	226	234	PF00179	0.501
TRG_DiLeu_BaEn_1	6	11	PF01217	0.521
TRG_ENDOCYTIC_2	349	352	PF00928	0.462
TRG_ER_diArg_1	338	340	PF00400	0.578
TRG_ER_diArg_1	342	345	PF00400	0.557
TRG_ER_diArg_1	371	374	PF00400	0.524
TRG_NLS_Bipartite_1	103	119	PF00514	0.538
TRG_NLS_Bipartite_1	359	374	PF00514	0.462
TRG_NLS_MonoCore_2	113	118	PF00514	0.615
TRG_NLS_MonoExtC_3	102	107	PF00514	0.527
TRG_NLS_MonoExtC_3	20	25	PF00514	0.550
TRG_NLS_MonoExtC_3	369	374	PF00514	0.461
TRG_NLS_MonoExtN_4	114	119	PF00514	0.625
TRG_NLS_MonoExtN_4	18	25	PF00514	0.557
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	376	380	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P943	Leptomonas seymouri	66%	100%
A0A3S7X9B6	Leishmania donovani	93%	100%
A4HMS0	Leishmania braziliensis	80%	100%
A4IBF6	Leishmania infantum	93%	100%
E9AF70	Leishmania major	89%	100%