FAA_hydrolase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Fumarylacetoacetate (FAA) hydrolase family, putative

Species:

Leishmania mexicana

UniProt:

E9B6C4_LEIMU

TriTrypDb:

LmxM.34.2440

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B6C4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6C4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016787	hydrolase activity	2	4
GO:0016822	hydrolase activity, acting on acid carbon-carbon bonds	3	1
GO:0016823	hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances	4	1
GO:0018773	acetylpyruvate hydrolase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	143	145	PF00675	0.282
CLV_NRD_NRD_1	254	256	PF00675	0.366
CLV_NRD_NRD_1	28	30	PF00675	0.325
CLV_PCSK_KEX2_1	143	145	PF00082	0.285
CLV_PCSK_KEX2_1	151	153	PF00082	0.223
CLV_PCSK_KEX2_1	254	256	PF00082	0.366
CLV_PCSK_KEX2_1	28	30	PF00082	0.325
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.223
CLV_PCSK_SKI1_1	18	22	PF00082	0.603
CLV_PCSK_SKI1_1	232	236	PF00082	0.320
DEG_APCC_DBOX_1	142	150	PF00400	0.566
DEG_APCC_DBOX_1	212	220	PF00400	0.571
DOC_CKS1_1	186	191	PF01111	0.395
DOC_MAPK_RevD_3	137	152	PF00069	0.451
DOC_PP1_RVXF_1	19	26	PF00149	0.565
DOC_PP4_FxxP_1	186	189	PF00568	0.584
DOC_PP4_FxxP_1	56	59	PF00568	0.482
DOC_USP7_MATH_1	163	167	PF00917	0.451
DOC_USP7_MATH_1	59	63	PF00917	0.481
DOC_USP7_UBL2_3	151	155	PF12436	0.516
DOC_WW_Pin1_4	185	190	PF00397	0.469
DOC_WW_Pin1_4	243	248	PF00397	0.491
DOC_WW_Pin1_4	69	74	PF00397	0.566
LIG_14-3-3_CanoR_1	211	220	PF00244	0.541
LIG_14-3-3_CanoR_1	9	13	PF00244	0.486
LIG_Actin_WH2_2	44	60	PF00022	0.395
LIG_BIR_II_1	1	5	PF00653	0.512
LIG_BRCT_BRCA1_1	2	6	PF00533	0.493
LIG_CtBP_PxDLS_1	138	144	PF00389	0.485
LIG_FHA_1	192	198	PF00498	0.569
LIG_FHA_1	229	235	PF00498	0.602
LIG_FHA_1	266	272	PF00498	0.507
LIG_FHA_1	58	64	PF00498	0.571
LIG_FHA_1	74	80	PF00498	0.571
LIG_FHA_2	105	111	PF00498	0.395
LIG_FHA_2	140	146	PF00498	0.482
LIG_Integrin_RGD_1	255	257	PF01839	0.366
LIG_LIR_Apic_2	184	189	PF02991	0.441
LIG_LIR_Gen_1	117	128	PF02991	0.566
LIG_LIR_Gen_1	201	210	PF02991	0.571
LIG_LIR_Gen_1	231	241	PF02991	0.571
LIG_LIR_LC3C_4	91	96	PF02991	0.474
LIG_LIR_Nem_3	201	206	PF02991	0.571
LIG_LIR_Nem_3	231	236	PF02991	0.571
LIG_LIR_Nem_3	52	57	PF02991	0.557
LIG_LYPXL_yS_3	81	84	PF13949	0.566
LIG_REV1ctd_RIR_1	52	58	PF16727	0.513
LIG_SH2_GRB2like	120	123	PF00017	0.571
LIG_SH2_PTP2	233	236	PF00017	0.571
LIG_SH2_SRC	133	136	PF00017	0.566
LIG_SH2_STAP1	37	41	PF00017	0.482
LIG_SH2_STAT5	233	236	PF00017	0.587
LIG_SH2_STAT5	31	34	PF00017	0.490
LIG_SH3_3	165	171	PF00018	0.542
LIG_SUMO_SIM_anti_2	91	96	PF11976	0.496
LIG_SUMO_SIM_par_1	170	177	PF11976	0.571
LIG_TRFH_1	55	59	PF08558	0.520
LIG_TYR_ITIM	79	84	PF00017	0.566
LIG_UBA3_1	226	232	PF00899	0.537
MOD_CDK_SPxK_1	185	191	PF00069	0.441
MOD_CK1_1	103	109	PF00069	0.616
MOD_CK1_1	198	204	PF00069	0.611
MOD_CK1_1	62	68	PF00069	0.486
MOD_CK2_1	104	110	PF00069	0.515
MOD_CK2_1	219	225	PF00069	0.548
MOD_GlcNHglycan	110	113	PF01048	0.394
MOD_GlcNHglycan	164	168	PF01048	0.236
MOD_GlcNHglycan	247	250	PF01048	0.298
MOD_GSK3_1	191	198	PF00069	0.600
MOD_GSK3_1	228	235	PF00069	0.565
MOD_GSK3_1	241	248	PF00069	0.479
MOD_GSK3_1	4	11	PF00069	0.493
MOD_GSK3_1	69	76	PF00069	0.578
MOD_GSK3_1	99	106	PF00069	0.570
MOD_N-GLC_1	68	73	PF02516	0.311
MOD_NEK2_1	108	113	PF00069	0.569
MOD_NEK2_1	139	144	PF00069	0.497
MOD_NEK2_1	219	224	PF00069	0.567
MOD_NEK2_1	241	246	PF00069	0.513
MOD_NEK2_1	4	9	PF00069	0.575
MOD_NEK2_2	265	270	PF00069	0.566
MOD_PKA_1	104	110	PF00069	0.395
MOD_PKA_2	8	14	PF00069	0.498
MOD_Plk_1	73	79	PF00069	0.520
MOD_Plk_4	198	204	PF00069	0.561
MOD_Plk_4	8	14	PF00069	0.482
MOD_ProDKin_1	185	191	PF00069	0.469
MOD_ProDKin_1	243	249	PF00069	0.491
MOD_ProDKin_1	69	75	PF00069	0.566
MOD_SUMO_for_1	123	126	PF00179	0.534
MOD_SUMO_rev_2	175	181	PF00179	0.554
TRG_DiLeu_BaEn_2	51	57	PF01217	0.520
TRG_DiLeu_BaEn_3	126	132	PF01217	0.509
TRG_ENDOCYTIC_2	120	123	PF00928	0.492
TRG_ENDOCYTIC_2	233	236	PF00928	0.571
TRG_ENDOCYTIC_2	81	84	PF00928	0.566
TRG_ER_diArg_1	253	255	PF00400	0.566
TRG_ER_diArg_1	27	29	PF00400	0.386
TRG_NES_CRM1_1	225	240	PF08389	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8S1	Leptomonas seymouri	62%	100%
A0A0S4IKX8	Bodo saltans	35%	100%
A0A0S4JYH7	Bodo saltans	26%	100%
A0A1X0P5X5	Trypanosomatidae	49%	99%
A0A3R7MDA1	Trypanosoma rangeli	48%	100%
A0A3S7X9E6	Leishmania donovani	93%	100%
A0B3M8	Burkholderia cenocepacia (strain HI2424)	28%	97%
A3AJ77	Oryza sativa subsp. japonica	33%	100%
A4HMR8	Leishmania braziliensis	79%	100%
A4IBF4	Leishmania infantum	93%	100%
A9ALD1	Burkholderia multivorans (strain ATCC 17616 / 249)	29%	97%
B1K3Y3	Burkholderia cenocepacia (strain MC0-3)	28%	97%
B1Z1Y2	Burkholderia ambifaria (strain MC40-6)	29%	97%
B2RYW9	Rattus norvegicus	29%	88%
B4EKX6	Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610)	28%	97%
E9AF68	Leishmania major	93%	100%
I6Y276	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	30%	100%
O06724	Bacillus subtilis (strain 168)	28%	91%
O28058	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	27%	100%
O58377	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	33%	100%
O86042	Ralstonia sp.	33%	100%
P34673	Caenorhabditis elegans	31%	100%
P53889	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
P76004	Escherichia coli (strain K12)	33%	100%
Q0B628	Burkholderia ambifaria (strain ATCC BAA-244 / AMMD)	29%	97%
Q0QFQ3	Pseudomonas alcaligenes	27%	95%
Q10B63	Oryza sativa subsp. japonica	33%	100%
Q1BJJ1	Burkholderia cenocepacia (strain AU 1054)	28%	97%
Q2FIA7	Staphylococcus aureus (strain USA300)	27%	91%
Q2FZT4	Staphylococcus aureus (strain NCTC 8325 / PS 47)	27%	91%
Q2HJ98	Bos taurus	32%	100%
Q2KIB0	Bos taurus	31%	87%
Q2YWW3	Staphylococcus aureus (strain bovine RF122 / ET3-1)	27%	91%
Q39BA7	Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)	29%	97%
Q3TC72	Mus musculus	30%	88%
Q49WA8	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	27%	91%
Q4L4Y4	Staphylococcus haemolyticus (strain JCSC1435)	27%	91%
Q54BF3	Dictyostelium discoideum	30%	90%
Q59050	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	32%	100%
Q5HHB6	Staphylococcus aureus (strain COL)	27%	91%
Q5HQJ3	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	27%	91%
Q5RCX5	Pongo abelii	30%	87%
Q5RDW0	Pongo abelii	33%	100%
Q6AYQ8	Rattus norvegicus	33%	100%
Q6GAV8	Staphylococcus aureus (strain MSSA476)	27%	91%
Q6GIC0	Staphylococcus aureus (strain MRSA252)	27%	91%
Q6GLT8	Xenopus laevis	30%	86%
Q6P2I3	Homo sapiens	29%	87%
Q6P587	Homo sapiens	33%	100%
Q7A1B6	Staphylococcus aureus (strain MW2)	27%	91%
Q7A6H3	Staphylococcus aureus (strain N315)	27%	91%
Q86I22	Dictyostelium discoideum	34%	100%
Q8CPT8	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	27%	91%
Q8R0F8	Mus musculus	33%	100%
Q93ZE5	Arabidopsis thaliana	35%	100%
Q96GK7	Homo sapiens	29%	87%
Q99VC2	Staphylococcus aureus (strain Mu50 / ATCC 700699)	27%	91%
Q9LUR3	Arabidopsis thaliana	33%	100%
Q9P7L4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
Q9UYW0	Pyrococcus abyssi (strain GE5 / Orsay)	34%	100%
V5BTF7	Trypanosoma cruzi	47%	99%