LeishMANIAdb
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Putative phosphoinositide-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative phosphoinositide-binding protein
Gene product:
Autophagy-related protein 24
Species:
Leishmania mexicana
UniProt:
E9B6C2_LEIMU
TriTrypDb:
LmxM.34.2420
Length:
418

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 4
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005768 endosome 7 1
GO:0012506 vesicle membrane 4 1
GO:0016020 membrane 2 1
GO:0030659 cytoplasmic vesicle membrane 5 1
GO:0030666 endocytic vesicle membrane 5 1
GO:0031090 organelle membrane 3 1
GO:0031410 cytoplasmic vesicle 6 1
GO:0031982 vesicle 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0097708 intracellular vesicle 5 1
GO:0098588 bounding membrane of organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9B6C2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6C2

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0006897 endocytosis 5 1
GO:0006898 receptor-mediated endocytosis 6 1
GO:0006914 autophagy 3 1
GO:0008152 metabolic process 1 1
GO:0009056 catabolic process 2 1
GO:0009987 cellular process 1 1
GO:0016192 vesicle-mediated transport 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044248 cellular catabolic process 3 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0061919 process utilizing autophagic mechanism 2 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 12
GO:0005543 phospholipid binding 3 12
GO:0008289 lipid binding 2 12
GO:0035091 phosphatidylinositol binding 4 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 105 107 PF00675 0.338
CLV_NRD_NRD_1 110 112 PF00675 0.307
CLV_NRD_NRD_1 237 239 PF00675 0.279
CLV_NRD_NRD_1 273 275 PF00675 0.415
CLV_NRD_NRD_1 47 49 PF00675 0.312
CLV_PCSK_FUR_1 235 239 PF00082 0.410
CLV_PCSK_KEX2_1 105 107 PF00082 0.418
CLV_PCSK_KEX2_1 110 112 PF00082 0.417
CLV_PCSK_KEX2_1 237 239 PF00082 0.283
CLV_PCSK_KEX2_1 47 49 PF00082 0.280
CLV_PCSK_PC7_1 106 112 PF00082 0.410
CLV_PCSK_SKI1_1 110 114 PF00082 0.285
CLV_PCSK_SKI1_1 226 230 PF00082 0.392
CLV_PCSK_SKI1_1 385 389 PF00082 0.274
CLV_PCSK_SKI1_1 410 414 PF00082 0.532
DEG_APCC_DBOX_1 109 117 PF00400 0.291
DEG_APCC_DBOX_1 225 233 PF00400 0.310
DEG_APCC_DBOX_1 305 313 PF00400 0.291
DEG_APCC_DBOX_1 315 323 PF00400 0.291
DEG_APCC_DBOX_1 409 417 PF00400 0.532
DEG_SPOP_SBC_1 164 168 PF00917 0.694
DOC_CYCLIN_yClb1_LxF_4 345 351 PF00134 0.154
DOC_CYCLIN_yClb5_NLxxxL_5 226 232 PF00134 0.392
DOC_MAPK_gen_1 389 396 PF00069 0.389
DOC_MAPK_MEF2A_6 389 398 PF00069 0.384
DOC_SPAK_OSR1_1 149 153 PF12202 0.480
DOC_USP7_MATH_1 165 169 PF00917 0.697
DOC_USP7_MATH_1 174 178 PF00917 0.709
DOC_USP7_MATH_1 3 7 PF00917 0.510
DOC_USP7_UBL2_3 385 389 PF12436 0.274
DOC_WW_Pin1_4 151 156 PF00397 0.346
LIG_14-3-3_CanoR_1 105 110 PF00244 0.410
LIG_14-3-3_CanoR_1 149 155 PF00244 0.576
LIG_14-3-3_CanoR_1 237 246 PF00244 0.343
LIG_14-3-3_CanoR_1 290 296 PF00244 0.400
LIG_14-3-3_CanoR_1 47 55 PF00244 0.401
LIG_APCC_ABBA_1 373 378 PF00400 0.386
LIG_BIR_II_1 1 5 PF00653 0.547
LIG_BRCT_BRCA1_1 369 373 PF00533 0.392
LIG_FHA_1 287 293 PF00498 0.329
LIG_FHA_1 31 37 PF00498 0.405
LIG_FHA_2 366 372 PF00498 0.372
LIG_FHA_2 48 54 PF00498 0.392
LIG_FHA_2 93 99 PF00498 0.392
LIG_LIR_Apic_2 26 31 PF02991 0.462
LIG_LIR_Gen_1 370 378 PF02991 0.412
LIG_LIR_Gen_1 405 413 PF02991 0.423
LIG_LIR_Gen_1 50 59 PF02991 0.275
LIG_LIR_Gen_1 62 72 PF02991 0.273
LIG_LIR_Nem_3 103 107 PF02991 0.410
LIG_LIR_Nem_3 24 30 PF02991 0.450
LIG_LIR_Nem_3 249 253 PF02991 0.366
LIG_LIR_Nem_3 370 376 PF02991 0.413
LIG_LIR_Nem_3 405 409 PF02991 0.292
LIG_LIR_Nem_3 50 55 PF02991 0.275
LIG_LIR_Nem_3 62 68 PF02991 0.273
LIG_PDZ_Class_2 413 418 PF00595 0.365
LIG_Pex14_2 246 250 PF04695 0.274
LIG_Pex14_2 369 373 PF04695 0.405
LIG_SH2_CRK 104 108 PF00017 0.410
LIG_SH2_CRK 118 122 PF00017 0.410
LIG_SH2_CRK 65 69 PF00017 0.335
LIG_SH2_PTP2 28 31 PF00017 0.440
LIG_SH2_SRC 28 31 PF00017 0.457
LIG_SH2_STAP1 280 284 PF00017 0.366
LIG_SH2_STAT5 214 217 PF00017 0.274
LIG_SH2_STAT5 28 31 PF00017 0.457
LIG_SH2_STAT5 298 301 PF00017 0.331
LIG_SH2_STAT5 318 321 PF00017 0.122
LIG_SH2_STAT5 49 52 PF00017 0.432
LIG_SH2_STAT5 65 68 PF00017 0.205
LIG_SH3_2 144 149 PF14604 0.537
LIG_SH3_2 69 74 PF14604 0.274
LIG_SH3_3 141 147 PF00018 0.566
LIG_SH3_3 149 155 PF00018 0.574
LIG_SH3_3 66 72 PF00018 0.287
LIG_SH3_3 8 14 PF00018 0.373
LIG_SUMO_SIM_par_1 392 397 PF11976 0.410
LIG_TRAF2_1 155 158 PF00917 0.633
LIG_TYR_ITIM 102 107 PF00017 0.410
LIG_TYR_ITIM 116 121 PF00017 0.410
LIG_WW_3 146 150 PF00397 0.526
MOD_CK1_1 167 173 PF00069 0.717
MOD_CK1_1 185 191 PF00069 0.519
MOD_CK1_1 241 247 PF00069 0.392
MOD_CK1_1 293 299 PF00069 0.411
MOD_CK2_1 151 157 PF00069 0.544
MOD_CK2_1 365 371 PF00069 0.403
MOD_CK2_1 394 400 PF00069 0.390
MOD_CK2_1 47 53 PF00069 0.291
MOD_CK2_1 87 93 PF00069 0.406
MOD_Cter_Amidation 272 275 PF01082 0.410
MOD_GlcNHglycan 167 170 PF01048 0.677
MOD_GlcNHglycan 176 179 PF01048 0.602
MOD_GlcNHglycan 184 187 PF01048 0.558
MOD_GlcNHglycan 240 243 PF01048 0.419
MOD_GlcNHglycan 313 316 PF01048 0.324
MOD_GlcNHglycan 331 334 PF01048 0.321
MOD_GlcNHglycan 89 92 PF01048 0.296
MOD_GSK3_1 159 166 PF00069 0.607
MOD_GSK3_1 19 26 PF00069 0.485
MOD_GSK3_1 204 211 PF00069 0.518
MOD_GSK3_1 217 224 PF00069 0.300
MOD_GSK3_1 286 293 PF00069 0.403
MOD_GSK3_1 394 401 PF00069 0.358
MOD_GSK3_1 47 54 PF00069 0.403
MOD_GSK3_1 87 94 PF00069 0.305
MOD_LATS_1 236 242 PF00433 0.392
MOD_N-GLC_1 285 290 PF02516 0.385
MOD_NEK2_1 150 155 PF00069 0.504
MOD_NEK2_1 228 233 PF00069 0.440
MOD_NEK2_1 23 28 PF00069 0.483
MOD_NEK2_1 246 251 PF00069 0.361
MOD_NEK2_1 291 296 PF00069 0.395
MOD_NEK2_1 329 334 PF00069 0.461
MOD_NEK2_1 394 399 PF00069 0.370
MOD_NEK2_1 412 417 PF00069 0.485
MOD_NEK2_1 59 64 PF00069 0.392
MOD_NEK2_1 87 92 PF00069 0.348
MOD_PIKK_1 12 18 PF00454 0.533
MOD_PIKK_1 185 191 PF00454 0.593
MOD_PIKK_1 196 202 PF00454 0.436
MOD_PKA_1 105 111 PF00069 0.410
MOD_PKA_1 47 53 PF00069 0.291
MOD_PKA_2 105 111 PF00069 0.410
MOD_PKA_2 305 311 PF00069 0.274
MOD_PKA_2 47 53 PF00069 0.366
MOD_Plk_1 204 210 PF00069 0.517
MOD_Plk_1 23 29 PF00069 0.475
MOD_Plk_1 286 292 PF00069 0.410
MOD_Plk_1 365 371 PF00069 0.410
MOD_Plk_1 394 400 PF00069 0.410
MOD_Plk_2-3 73 79 PF00069 0.410
MOD_Plk_4 228 234 PF00069 0.176
MOD_Plk_4 23 29 PF00069 0.520
MOD_Plk_4 293 299 PF00069 0.396
MOD_Plk_4 59 65 PF00069 0.396
MOD_ProDKin_1 151 157 PF00069 0.348
MOD_SUMO_for_1 402 405 PF00179 0.410
MOD_SUMO_rev_2 378 387 PF00179 0.278
TRG_DiLeu_BaEn_1 287 292 PF01217 0.410
TRG_DiLeu_BaEn_4 257 263 PF01217 0.410
TRG_ENDOCYTIC_2 104 107 PF00928 0.410
TRG_ENDOCYTIC_2 118 121 PF00928 0.410
TRG_ENDOCYTIC_2 298 301 PF00928 0.274
TRG_ENDOCYTIC_2 49 52 PF00928 0.274
TRG_ENDOCYTIC_2 65 68 PF00928 0.274
TRG_ER_diArg_1 104 106 PF00400 0.274
TRG_ER_diArg_1 109 111 PF00400 0.274
TRG_ER_diArg_1 235 238 PF00400 0.291
TRG_ER_diArg_1 47 49 PF00400 0.405
TRG_NES_CRM1_1 386 400 PF08389 0.410
TRG_Pf-PMV_PEXEL_1 226 230 PF00026 0.348

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IBS5 Leptomonas seymouri 77% 98%
A0A0S4KLA7 Bodo saltans 34% 100%
A0A1X0P5K9 Trypanosomatidae 34% 100%
A0A3Q8IV97 Leishmania donovani 97% 100%
A0A3R7L2W7 Trypanosoma rangeli 34% 99%
A4HMR6 Leishmania braziliensis 92% 100%
A4IBF2 Leishmania infantum 97% 100%
C9ZZB2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
E9AF66 Leishmania major 97% 100%
O60749 Homo sapiens 24% 81%
P0C220 Macaca fascicularis 23% 80%
Q05B62 Bos taurus 23% 80%
Q13596 Homo sapiens 24% 80%
Q2TBW7 Bos taurus 23% 81%
Q4R503 Macaca fascicularis 24% 80%
Q5R9A9 Pongo abelii 23% 80%
Q5RFP8 Pongo abelii 24% 80%
Q99N27 Rattus norvegicus 24% 80%
Q9CWK8 Mus musculus 24% 81%
Q9WV80 Mus musculus 24% 80%
V5B3T2 Trypanosoma cruzi 34% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS