SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6B7_LEIMU

TriTrypDb:

LmxM.34.2370

Length:

822

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6B7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6B7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.648
CLV_C14_Caspase3-7	295	299	PF00656	0.492
CLV_C14_Caspase3-7	588	592	PF00656	0.757
CLV_C14_Caspase3-7	765	769	PF00656	0.519
CLV_NRD_NRD_1	13	15	PF00675	0.582
CLV_NRD_NRD_1	136	138	PF00675	0.442
CLV_NRD_NRD_1	643	645	PF00675	0.482
CLV_NRD_NRD_1	650	652	PF00675	0.530
CLV_NRD_NRD_1	673	675	PF00675	0.349
CLV_PCSK_FUR_1	416	420	PF00082	0.739
CLV_PCSK_FUR_1	499	503	PF00082	0.593
CLV_PCSK_KEX2_1	13	15	PF00082	0.582
CLV_PCSK_KEX2_1	136	138	PF00082	0.442
CLV_PCSK_KEX2_1	418	420	PF00082	0.629
CLV_PCSK_KEX2_1	501	503	PF00082	0.729
CLV_PCSK_KEX2_1	642	644	PF00082	0.496
CLV_PCSK_KEX2_1	650	652	PF00082	0.530
CLV_PCSK_KEX2_1	672	674	PF00082	0.326
CLV_PCSK_PC1ET2_1	418	420	PF00082	0.747
CLV_PCSK_PC1ET2_1	501	503	PF00082	0.626
CLV_PCSK_SKI1_1	13	17	PF00082	0.589
CLV_PCSK_SKI1_1	33	37	PF00082	0.283
CLV_PCSK_SKI1_1	502	506	PF00082	0.702
CLV_PCSK_SKI1_1	650	654	PF00082	0.525
CLV_PCSK_SKI1_1	691	695	PF00082	0.391
DEG_APCC_DBOX_1	169	177	PF00400	0.720
DEG_APCC_DBOX_1	598	606	PF00400	0.709
DEG_APCC_DBOX_1	641	649	PF00400	0.487
DEG_Nend_UBRbox_2	1	3	PF02207	0.521
DEG_SCF_FBW7_2	438	445	PF00400	0.613
DEG_SPOP_SBC_1	343	347	PF00917	0.732
DOC_CDC14_PxL_1	524	532	PF14671	0.724
DOC_CKS1_1	439	444	PF01111	0.615
DOC_CKS1_1	519	524	PF01111	0.621
DOC_CKS1_1	59	64	PF01111	0.417
DOC_CYCLIN_RxL_1	644	654	PF00134	0.505
DOC_CYCLIN_yClb1_LxF_4	549	554	PF00134	0.724
DOC_CYCLIN_yCln2_LP_2	686	692	PF00134	0.391
DOC_MAPK_gen_1	170	179	PF00069	0.608
DOC_MAPK_gen_1	730	738	PF00069	0.507
DOC_MAPK_MEF2A_6	730	738	PF00069	0.389
DOC_MAPK_RevD_3	1	14	PF00069	0.495
DOC_PP2B_LxvP_1	257	260	PF13499	0.588
DOC_PP2B_LxvP_1	686	689	PF13499	0.391
DOC_PP4_FxxP_1	692	695	PF00568	0.388
DOC_USP7_MATH_1	132	136	PF00917	0.523
DOC_USP7_MATH_1	178	182	PF00917	0.662
DOC_USP7_MATH_1	220	224	PF00917	0.622
DOC_USP7_MATH_1	226	230	PF00917	0.625
DOC_USP7_MATH_1	344	348	PF00917	0.732
DOC_USP7_MATH_1	394	398	PF00917	0.585
DOC_USP7_MATH_1	444	448	PF00917	0.605
DOC_USP7_MATH_1	493	497	PF00917	0.717
DOC_USP7_MATH_1	542	546	PF00917	0.632
DOC_USP7_MATH_1	583	587	PF00917	0.651
DOC_USP7_MATH_1	621	625	PF00917	0.621
DOC_USP7_MATH_1	630	634	PF00917	0.422
DOC_USP7_MATH_1	770	774	PF00917	0.662
DOC_USP7_MATH_1	783	787	PF00917	0.402
DOC_WW_Pin1_4	155	160	PF00397	0.553
DOC_WW_Pin1_4	194	199	PF00397	0.665
DOC_WW_Pin1_4	305	310	PF00397	0.457
DOC_WW_Pin1_4	319	324	PF00397	0.472
DOC_WW_Pin1_4	345	350	PF00397	0.656
DOC_WW_Pin1_4	438	443	PF00397	0.670
DOC_WW_Pin1_4	518	523	PF00397	0.641
DOC_WW_Pin1_4	535	540	PF00397	0.515
DOC_WW_Pin1_4	545	550	PF00397	0.545
DOC_WW_Pin1_4	58	63	PF00397	0.416
DOC_WW_Pin1_4	624	629	PF00397	0.649
DOC_WW_Pin1_4	632	637	PF00397	0.476
DOC_WW_Pin1_4	797	802	PF00397	0.604
LIG_14-3-3_CanoR_1	154	161	PF00244	0.538
LIG_14-3-3_CanoR_1	315	320	PF00244	0.490
LIG_14-3-3_CanoR_1	33	38	PF00244	0.439
LIG_14-3-3_CanoR_1	419	424	PF00244	0.760
LIG_14-3-3_CanoR_1	451	456	PF00244	0.521
LIG_14-3-3_CanoR_1	599	605	PF00244	0.619
LIG_14-3-3_CanoR_1	680	690	PF00244	0.432
LIG_14-3-3_CanoR_1	733	737	PF00244	0.500
LIG_14-3-3_CanoR_1	77	82	PF00244	0.436
LIG_BIR_III_2	443	447	PF00653	0.541
LIG_BIR_III_4	337	341	PF00653	0.617
LIG_BRCT_BRCA1_1	361	365	PF00533	0.746
LIG_CaM_IQ_9	606	622	PF13499	0.646
LIG_deltaCOP1_diTrp_1	371	378	PF00928	0.592
LIG_DLG_GKlike_1	126	133	PF00625	0.436
LIG_eIF4E_1	24	30	PF01652	0.413
LIG_eIF4E_1	43	49	PF01652	0.418
LIG_FHA_1	129	135	PF00498	0.406
LIG_FHA_1	182	188	PF00498	0.706
LIG_FHA_1	306	312	PF00498	0.471
LIG_FHA_1	519	525	PF00498	0.781
LIG_FHA_1	607	613	PF00498	0.750
LIG_FHA_1	647	653	PF00498	0.515
LIG_FHA_2	606	612	PF00498	0.733
LIG_FHA_2	716	722	PF00498	0.361
LIG_FHA_2	724	730	PF00498	0.532
LIG_FHA_2	751	757	PF00498	0.394
LIG_Integrin_RGD_1	674	676	PF01839	0.432
LIG_LIR_Gen_1	128	134	PF02991	0.415
LIG_LIR_Gen_1	158	168	PF02991	0.531
LIG_LIR_Gen_1	64	71	PF02991	0.432
LIG_LIR_LC3C_4	613	617	PF02991	0.521
LIG_LIR_LC3C_4	735	738	PF02991	0.367
LIG_LIR_Nem_3	128	133	PF02991	0.418
LIG_LIR_Nem_3	158	163	PF02991	0.525
LIG_LIR_Nem_3	18	24	PF02991	0.368
LIG_LIR_Nem_3	61	66	PF02991	0.395
LIG_LIR_Nem_3	80	86	PF02991	0.430
LIG_MYND_3	552	556	PF01753	0.670
LIG_NRBOX	315	321	PF00104	0.482
LIG_Pex14_2	66	70	PF04695	0.431
LIG_RPA_C_Fungi	669	681	PF08784	0.349
LIG_SH2_STAP1	776	780	PF00017	0.531
LIG_SH2_STAP1	90	94	PF00017	0.378
LIG_SH2_STAT3	634	637	PF00017	0.627
LIG_SH2_STAT5	408	411	PF00017	0.606
LIG_SH2_STAT5	604	607	PF00017	0.698
LIG_SH2_STAT5	666	669	PF00017	0.427
LIG_SH2_STAT5	744	747	PF00017	0.411
LIG_SH2_STAT5	79	82	PF00017	0.422
LIG_SH3_3	174	180	PF00018	0.577
LIG_SH3_3	35	41	PF00018	0.446
LIG_SH3_3	374	380	PF00018	0.574
LIG_SH3_3	436	442	PF00018	0.650
LIG_SUMO_SIM_anti_2	513	521	PF11976	0.714
LIG_SUMO_SIM_anti_2	613	619	PF11976	0.566
LIG_SUMO_SIM_anti_2	732	739	PF11976	0.394
LIG_SUMO_SIM_par_1	264	269	PF11976	0.493
LIG_SUMO_SIM_par_1	315	322	PF11976	0.486
LIG_SUMO_SIM_par_1	748	753	PF11976	0.481
LIG_SUMO_SIM_par_1	791	797	PF11976	0.376
LIG_SxIP_EBH_1	51	60	PF03271	0.410
LIG_TRAF2_1	141	144	PF00917	0.535
LIG_TRAF2_1	25	28	PF00917	0.420
LIG_TRAF2_1	446	449	PF00917	0.529
LIG_TRAF2_1	608	611	PF00917	0.586
LIG_TRAF2_1	753	756	PF00917	0.382
LIG_TRAF2_2	380	385	PF00917	0.587
LIG_TRFH_1	692	696	PF08558	0.450
LIG_WRC_WIRS_1	179	184	PF05994	0.724
LIG_WRC_WIRS_1	724	729	PF05994	0.531
LIG_WW_3	694	698	PF00397	0.465
MOD_CDC14_SPxK_1	548	551	PF00782	0.723
MOD_CDK_SPK_2	305	310	PF00069	0.457
MOD_CDK_SPxK_1	545	551	PF00069	0.728
MOD_CK1_1	181	187	PF00069	0.687
MOD_CK1_1	188	194	PF00069	0.593
MOD_CK1_1	205	211	PF00069	0.654
MOD_CK1_1	318	324	PF00069	0.477
MOD_CK1_1	342	348	PF00069	0.647
MOD_CK1_1	355	361	PF00069	0.676
MOD_CK1_1	364	370	PF00069	0.674
MOD_CK1_1	429	435	PF00069	0.659
MOD_CK1_1	447	453	PF00069	0.592
MOD_CK1_1	497	503	PF00069	0.721
MOD_CK1_1	532	538	PF00069	0.623
MOD_CK1_1	545	551	PF00069	0.583
MOD_CK1_1	586	592	PF00069	0.695
MOD_CK1_1	624	630	PF00069	0.579
MOD_CK1_1	711	717	PF00069	0.662
MOD_CK1_1	73	79	PF00069	0.472
MOD_CK2_1	122	128	PF00069	0.349
MOD_CK2_1	235	241	PF00069	0.665
MOD_CK2_1	287	293	PF00069	0.433
MOD_CK2_1	394	400	PF00069	0.586
MOD_CK2_1	565	571	PF00069	0.625
MOD_CK2_1	605	611	PF00069	0.698
MOD_CK2_1	681	687	PF00069	0.471
MOD_CK2_1	723	729	PF00069	0.299
MOD_CK2_1	750	756	PF00069	0.357
MOD_CMANNOS	381	384	PF00535	0.591
MOD_GlcNHglycan	117	120	PF01048	0.420
MOD_GlcNHglycan	155	158	PF01048	0.534
MOD_GlcNHglycan	187	190	PF01048	0.748
MOD_GlcNHglycan	194	197	PF01048	0.648
MOD_GlcNHglycan	207	210	PF01048	0.714
MOD_GlcNHglycan	221	225	PF01048	0.672
MOD_GlcNHglycan	228	231	PF01048	0.761
MOD_GlcNHglycan	235	238	PF01048	0.589
MOD_GlcNHglycan	245	248	PF01048	0.538
MOD_GlcNHglycan	311	314	PF01048	0.524
MOD_GlcNHglycan	341	344	PF01048	0.660
MOD_GlcNHglycan	354	357	PF01048	0.758
MOD_GlcNHglycan	428	431	PF01048	0.651
MOD_GlcNHglycan	491	494	PF01048	0.668
MOD_GlcNHglycan	496	499	PF01048	0.745
MOD_GlcNHglycan	534	537	PF01048	0.686
MOD_GlcNHglycan	544	547	PF01048	0.640
MOD_GlcNHglycan	559	562	PF01048	0.590
MOD_GlcNHglycan	623	626	PF01048	0.597
MOD_GlcNHglycan	63	66	PF01048	0.406
MOD_GlcNHglycan	710	713	PF01048	0.710
MOD_GlcNHglycan	768	771	PF01048	0.651
MOD_GlcNHglycan	772	775	PF01048	0.575
MOD_GSK3_1	122	129	PF00069	0.432
MOD_GSK3_1	181	188	PF00069	0.741
MOD_GSK3_1	190	197	PF00069	0.670
MOD_GSK3_1	226	233	PF00069	0.741
MOD_GSK3_1	305	312	PF00069	0.481
MOD_GSK3_1	315	322	PF00069	0.544
MOD_GSK3_1	339	346	PF00069	0.734
MOD_GSK3_1	355	362	PF00069	0.704
MOD_GSK3_1	363	370	PF00069	0.642
MOD_GSK3_1	394	401	PF00069	0.589
MOD_GSK3_1	447	454	PF00069	0.652
MOD_GSK3_1	485	492	PF00069	0.599
MOD_GSK3_1	49	56	PF00069	0.441
MOD_GSK3_1	493	500	PF00069	0.515
MOD_GSK3_1	528	535	PF00069	0.609
MOD_GSK3_1	555	562	PF00069	0.747
MOD_GSK3_1	579	586	PF00069	0.724
MOD_GSK3_1	600	607	PF00069	0.602
MOD_GSK3_1	69	76	PF00069	0.325
MOD_GSK3_1	711	718	PF00069	0.438
MOD_GSK3_1	732	739	PF00069	0.397
MOD_GSK3_1	764	771	PF00069	0.599
MOD_LATS_1	396	402	PF00433	0.591
MOD_N-GLC_1	115	120	PF02516	0.417
MOD_N-GLC_1	485	490	PF02516	0.642
MOD_N-GLC_2	683	685	PF02516	0.601
MOD_NEK2_1	200	205	PF00069	0.697
MOD_NEK2_1	359	364	PF00069	0.666
MOD_NEK2_1	49	54	PF00069	0.521
MOD_NEK2_1	529	534	PF00069	0.586
MOD_NEK2_1	555	560	PF00069	0.685
MOD_NEK2_1	605	610	PF00069	0.724
MOD_NEK2_1	70	75	PF00069	0.480
MOD_OFUCOSY	679	685	PF10250	0.503
MOD_PIKK_1	202	208	PF00454	0.510
MOD_PIKK_1	281	287	PF00454	0.425
MOD_PIKK_1	323	329	PF00454	0.464
MOD_PIKK_1	349	355	PF00454	0.629
MOD_PIKK_1	398	404	PF00454	0.597
MOD_PIKK_1	444	450	PF00454	0.709
MOD_PIKK_1	606	612	PF00454	0.575
MOD_PIKK_1	711	717	PF00454	0.404
MOD_PIKK_1	750	756	PF00454	0.376
MOD_PK_1	183	189	PF00069	0.593
MOD_PK_1	419	425	PF00069	0.761
MOD_PKA_2	153	159	PF00069	0.555
MOD_PKA_2	450	456	PF00069	0.554
MOD_PKA_2	679	685	PF00069	0.474
MOD_PKA_2	732	738	PF00069	0.504
MOD_PKB_1	672	680	PF00069	0.452
MOD_Plk_1	466	472	PF00069	0.707
MOD_Plk_1	720	726	PF00069	0.373
MOD_Plk_2-3	511	517	PF00069	0.660
MOD_Plk_4	315	321	PF00069	0.537
MOD_Plk_4	388	394	PF00069	0.569
MOD_Plk_4	55	61	PF00069	0.433
MOD_Plk_4	600	606	PF00069	0.587
MOD_Plk_4	662	668	PF00069	0.428
MOD_Plk_4	732	738	PF00069	0.400
MOD_ProDKin_1	155	161	PF00069	0.550
MOD_ProDKin_1	194	200	PF00069	0.668
MOD_ProDKin_1	305	311	PF00069	0.462
MOD_ProDKin_1	319	325	PF00069	0.466
MOD_ProDKin_1	345	351	PF00069	0.651
MOD_ProDKin_1	438	444	PF00069	0.673
MOD_ProDKin_1	518	524	PF00069	0.642
MOD_ProDKin_1	535	541	PF00069	0.518
MOD_ProDKin_1	545	551	PF00069	0.546
MOD_ProDKin_1	58	64	PF00069	0.421
MOD_ProDKin_1	624	630	PF00069	0.651
MOD_ProDKin_1	632	638	PF00069	0.465
MOD_ProDKin_1	797	803	PF00069	0.597
MOD_SUMO_for_1	212	215	PF00179	0.621
TRG_AP2beta_CARGO_1	128	137	PF09066	0.418
TRG_DiLeu_BaEn_1	515	520	PF01217	0.718
TRG_DiLeu_BaEn_1	611	616	PF01217	0.507
TRG_DiLeu_BaEn_4	515	521	PF01217	0.720
TRG_DiLeu_BaLyEn_6	525	530	PF01217	0.720
TRG_DiLeu_BaLyEn_6	757	762	PF01217	0.429
TRG_DiLeu_BaLyEn_6	813	818	PF01217	0.429
TRG_ENDOCYTIC_2	100	103	PF00928	0.520
TRG_ENDOCYTIC_2	63	66	PF00928	0.406
TRG_ER_diArg_1	13	15	PF00400	0.582
TRG_ER_diArg_1	169	172	PF00400	0.594
TRG_ER_diArg_1	473	476	PF00400	0.693
TRG_ER_diArg_1	641	644	PF00400	0.486
TRG_ER_diArg_1	650	652	PF00400	0.530
TRG_ER_diArg_1	671	674	PF00400	0.416
TRG_ER_diArg_1	678	681	PF00400	0.488
TRG_ER_diArg_1	696	699	PF00400	0.562
TRG_Pf-PMV_PEXEL_1	14	18	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	270	274	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.296

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P946	Leptomonas seymouri	52%	88%
A0A3Q8IMA4	Leishmania donovani	88%	100%
A4HMR1	Leishmania braziliensis	77%	98%
A4IBE7	Leishmania infantum	89%	100%
E9AF61	Leishmania major	87%	100%