DUF4801 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic protein of unknown function (DUF1764), putative

Species:

Leishmania mexicana

UniProt:

E9B6B6_LEIMU

TriTrypDb:

LmxM.34.2360

Length:

199

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6B6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6B6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	87	91	PF00656	0.759
CLV_NRD_NRD_1	162	164	PF00675	0.622
CLV_PCSK_KEX2_1	162	164	PF00082	0.635
CLV_PCSK_KEX2_1	85	87	PF00082	0.692
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.692
CLV_PCSK_SKI1_1	27	31	PF00082	0.717
CLV_Separin_Metazoa	159	163	PF03568	0.622
DEG_Nend_UBRbox_1	1	4	PF02207	0.709
DEG_SPOP_SBC_1	28	32	PF00917	0.673
DOC_USP7_MATH_1	115	119	PF00917	0.628
DOC_USP7_MATH_1	147	151	PF00917	0.682
DOC_USP7_MATH_1	154	158	PF00917	0.476
DOC_USP7_MATH_1	34	38	PF00917	0.745
DOC_USP7_MATH_1	7	11	PF00917	0.707
DOC_WW_Pin1_4	150	155	PF00397	0.742
DOC_WW_Pin1_4	185	190	PF00397	0.351
DOC_WW_Pin1_4	32	37	PF00397	0.678
DOC_WW_Pin1_4	96	101	PF00397	0.669
LIG_14-3-3_CanoR_1	168	173	PF00244	0.324
LIG_14-3-3_CanoR_1	86	94	PF00244	0.689
LIG_14-3-3_CanoR_1	95	100	PF00244	0.516
LIG_DLG_GKlike_1	168	175	PF00625	0.414
LIG_FHA_1	12	18	PF00498	0.772
LIG_FHA_1	138	144	PF00498	0.657
LIG_FHA_1	23	29	PF00498	0.692
LIG_FHA_1	36	42	PF00498	0.649
LIG_LIR_Apic_2	109	115	PF02991	0.565
LIG_LIR_Gen_1	46	56	PF02991	0.606
LIG_LIR_Nem_3	46	51	PF02991	0.501
LIG_Pex14_2	127	131	PF04695	0.609
LIG_SH3_3	186	192	PF00018	0.326
LIG_TRAF2_1	156	159	PF00917	0.617
LIG_UBA3_1	47	55	PF00899	0.550
MOD_CK1_1	150	156	PF00069	0.701
MOD_CK1_1	180	186	PF00069	0.306
MOD_CK1_1	32	38	PF00069	0.756
MOD_CK2_1	168	174	PF00069	0.351
MOD_GlcNHglycan	127	130	PF01048	0.604
MOD_GlcNHglycan	145	148	PF01048	0.450
MOD_GlcNHglycan	62	65	PF01048	0.688
MOD_GlcNHglycan	87	90	PF01048	0.709
MOD_GlcNHglycan	9	12	PF01048	0.739
MOD_GSK3_1	115	122	PF00069	0.529
MOD_GSK3_1	134	141	PF00069	0.736
MOD_GSK3_1	143	150	PF00069	0.678
MOD_GSK3_1	173	180	PF00069	0.414
MOD_GSK3_1	23	30	PF00069	0.679
MOD_GSK3_1	32	39	PF00069	0.486
MOD_GSK3_1	43	50	PF00069	0.611
MOD_GSK3_1	7	14	PF00069	0.670
MOD_N-GLC_1	60	65	PF02516	0.485
MOD_NEK2_1	127	132	PF00069	0.566
MOD_NEK2_1	47	52	PF00069	0.590
MOD_NEK2_2	75	80	PF00069	0.667
MOD_PKA_1	85	91	PF00069	0.691
MOD_PKA_2	7	13	PF00069	0.755
MOD_PKA_2	85	91	PF00069	0.781
MOD_PKA_2	94	100	PF00069	0.516
MOD_Plk_1	115	121	PF00069	0.569
MOD_Plk_4	127	133	PF00069	0.594
MOD_Plk_4	43	49	PF00069	0.596
MOD_ProDKin_1	150	156	PF00069	0.740
MOD_ProDKin_1	185	191	PF00069	0.351
MOD_ProDKin_1	32	38	PF00069	0.673
MOD_ProDKin_1	96	102	PF00069	0.667
TRG_ER_diArg_1	161	163	PF00400	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8J3	Leptomonas seymouri	51%	100%
A0A1X0P736	Trypanosomatidae	33%	100%
A0A3S7X9A2	Leishmania donovani	82%	100%
A4HMR0	Leishmania braziliensis	69%	99%
C9ZZB9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AF60	Leishmania major	83%	100%
E9AHW2	Leishmania infantum	82%	100%