Putative ribonuclease

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribonuclease, putative

Species:

Leishmania mexicana

UniProt:

E9B6B4_LEIMU

TriTrypDb:

LmxM.34.2340

Length:

677

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9B6B4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6B4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	13
GO:0005488	binding	1	13
GO:0097159	organic cyclic compound binding	2	13
GO:1901363	heterocyclic compound binding	2	13
GO:0000175	3'-5'-RNA exonuclease activity	7	2
GO:0003723	RNA binding	4	2
GO:0003824	catalytic activity	1	2
GO:0004518	nuclease activity	4	2
GO:0004527	exonuclease activity	5	2
GO:0004532	RNA exonuclease activity	5	2
GO:0004540	RNA nuclease activity	4	2
GO:0008408	3'-5' exonuclease activity	6	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	2
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	2
GO:0140098	catalytic activity, acting on RNA	3	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	337	341	PF00656	0.397
CLV_C14_Caspase3-7	388	392	PF00656	0.441
CLV_C14_Caspase3-7	39	43	PF00656	0.385
CLV_NRD_NRD_1	111	113	PF00675	0.241
CLV_NRD_NRD_1	211	213	PF00675	0.365
CLV_NRD_NRD_1	315	317	PF00675	0.382
CLV_NRD_NRD_1	402	404	PF00675	0.329
CLV_NRD_NRD_1	442	444	PF00675	0.342
CLV_NRD_NRD_1	480	482	PF00675	0.256
CLV_NRD_NRD_1	54	56	PF00675	0.261
CLV_PCSK_KEX2_1	211	213	PF00082	0.299
CLV_PCSK_KEX2_1	480	482	PF00082	0.282
CLV_PCSK_SKI1_1	155	159	PF00082	0.189
CLV_PCSK_SKI1_1	212	216	PF00082	0.317
CLV_PCSK_SKI1_1	268	272	PF00082	0.338
CLV_PCSK_SKI1_1	384	388	PF00082	0.317
CLV_PCSK_SKI1_1	537	541	PF00082	0.241
CLV_PCSK_SKI1_1	621	625	PF00082	0.363
CLV_PCSK_SKI1_1	659	663	PF00082	0.486
CLV_PCSK_SKI1_1	90	94	PF00082	0.196
DEG_Nend_UBRbox_2	1	3	PF02207	0.433
DEG_SPOP_SBC_1	171	175	PF00917	0.385
DEG_SPOP_SBC_1	409	413	PF00917	0.441
DOC_CDC14_PxL_1	187	195	PF14671	0.415
DOC_MAPK_gen_1	268	276	PF00069	0.529
DOC_MAPK_gen_1	316	324	PF00069	0.571
DOC_MAPK_gen_1	665	672	PF00069	0.465
DOC_MAPK_MEF2A_6	69	78	PF00069	0.507
DOC_PP1_RVXF_1	442	449	PF00149	0.473
DOC_PP2B_LxvP_1	101	104	PF13499	0.460
DOC_PP2B_LxvP_1	222	225	PF13499	0.560
DOC_SPAK_OSR1_1	333	337	PF12202	0.441
DOC_USP7_MATH_1	172	176	PF00917	0.491
DOC_USP7_MATH_1	206	210	PF00917	0.431
DOC_USP7_MATH_1	242	246	PF00917	0.415
DOC_USP7_MATH_1	409	413	PF00917	0.504
DOC_USP7_MATH_1	49	53	PF00917	0.461
DOC_USP7_MATH_1	523	527	PF00917	0.514
DOC_USP7_MATH_1	531	535	PF00917	0.468
DOC_USP7_MATH_1	569	573	PF00917	0.371
DOC_USP7_MATH_1	610	614	PF00917	0.320
DOC_USP7_UBL2_3	400	404	PF12436	0.522
DOC_WW_Pin1_4	322	327	PF00397	0.441
DOC_WW_Pin1_4	42	47	PF00397	0.485
LIG_14-3-3_CanoR_1	205	211	PF00244	0.534
LIG_14-3-3_CanoR_1	333	339	PF00244	0.470
LIG_14-3-3_CanoR_1	360	366	PF00244	0.468
LIG_14-3-3_CanoR_1	490	498	PF00244	0.511
LIG_14-3-3_CanoR_1	665	673	PF00244	0.501
LIG_APCC_ABBA_1	78	83	PF00400	0.461
LIG_APCC_ABBAyCdc20_2	382	388	PF00400	0.441
LIG_BIR_III_4	88	92	PF00653	0.524
LIG_BRCT_BRCA1_1	401	405	PF00533	0.441
LIG_BRCT_BRCA1_1	525	529	PF00533	0.502
LIG_CtBP_PxDLS_1	469	473	PF00389	0.410
LIG_eIF4E_1	380	386	PF01652	0.441
LIG_FHA_1	130	136	PF00498	0.461
LIG_FHA_1	248	254	PF00498	0.509
LIG_FHA_1	265	271	PF00498	0.564
LIG_FHA_1	487	493	PF00498	0.471
LIG_FHA_1	503	509	PF00498	0.537
LIG_FHA_1	538	544	PF00498	0.441
LIG_FHA_1	553	559	PF00498	0.500
LIG_FHA_1	610	616	PF00498	0.570
LIG_FHA_1	628	634	PF00498	0.370
LIG_FHA_2	126	132	PF00498	0.485
LIG_FHA_2	37	43	PF00498	0.389
LIG_FHA_2	428	434	PF00498	0.398
LIG_FHA_2	617	623	PF00498	0.332
LIG_LIR_Gen_1	233	242	PF02991	0.461
LIG_LIR_Gen_1	454	465	PF02991	0.599
LIG_LIR_Gen_1	582	591	PF02991	0.397
LIG_LIR_Gen_1	79	89	PF02991	0.509
LIG_LIR_Nem_3	151	157	PF02991	0.460
LIG_LIR_Nem_3	21	27	PF02991	0.481
LIG_LIR_Nem_3	233	237	PF02991	0.456
LIG_LIR_Nem_3	28	34	PF02991	0.488
LIG_LIR_Nem_3	454	460	PF02991	0.539
LIG_LIR_Nem_3	473	478	PF02991	0.439
LIG_LIR_Nem_3	526	532	PF02991	0.531
LIG_LIR_Nem_3	582	586	PF02991	0.387
LIG_LIR_Nem_3	79	84	PF02991	0.515
LIG_NRBOX	431	437	PF00104	0.461
LIG_PCNA_PIPBox_1	456	465	PF02747	0.441
LIG_PCNA_yPIPBox_3	592	605	PF02747	0.301
LIG_PDZ_Class_2	672	677	PF00595	0.403
LIG_Pex14_2	150	154	PF04695	0.461
LIG_Pex14_2	483	487	PF04695	0.573
LIG_SH2_CRK	583	587	PF00017	0.381
LIG_SH2_CRK	71	75	PF00017	0.534
LIG_SH2_GRB2like	576	579	PF00017	0.381
LIG_SH2_NCK_1	71	75	PF00017	0.534
LIG_SH2_STAP1	437	441	PF00017	0.461
LIG_SH2_STAP1	452	456	PF00017	0.502
LIG_SH2_STAP1	576	580	PF00017	0.538
LIG_SH2_STAP1	583	587	PF00017	0.399
LIG_SH2_STAT3	463	466	PF00017	0.485
LIG_SH2_STAT3	640	643	PF00017	0.381
LIG_SH2_STAT5	14	17	PF00017	0.528
LIG_SH2_STAT5	156	159	PF00017	0.461
LIG_SH2_STAT5	355	358	PF00017	0.502
LIG_SH2_STAT5	380	383	PF00017	0.458
LIG_SH2_STAT5	452	455	PF00017	0.461
LIG_SH2_STAT5	583	586	PF00017	0.491
LIG_SH2_STAT5	608	611	PF00017	0.339
LIG_SH2_STAT5	640	643	PF00017	0.327
LIG_SH3_3	320	326	PF00018	0.461
LIG_SUMO_SIM_anti_2	167	175	PF11976	0.552
LIG_SUMO_SIM_par_1	334	340	PF11976	0.521
LIG_UBA3_1	654	659	PF00899	0.265
LIG_WRC_WIRS_1	231	236	PF05994	0.502
LIG_WRC_WIRS_1	362	367	PF05994	0.502
LIG_WRC_WIRS_1	472	477	PF05994	0.461
MOD_CK1_1	235	241	PF00069	0.507
MOD_CK1_1	378	384	PF00069	0.499
MOD_CK1_1	413	419	PF00069	0.543
MOD_CK1_1	421	427	PF00069	0.456
MOD_CK1_1	474	480	PF00069	0.461
MOD_CK1_1	594	600	PF00069	0.401
MOD_CK1_1	638	644	PF00069	0.543
MOD_CK1_1	79	85	PF00069	0.485
MOD_CK2_1	125	131	PF00069	0.492
MOD_CK2_1	322	328	PF00069	0.508
MOD_CK2_1	427	433	PF00069	0.385
MOD_CK2_1	616	622	PF00069	0.373
MOD_CK2_1	665	671	PF00069	0.358
MOD_Cter_Amidation	314	317	PF01082	0.236
MOD_GlcNHglycan	105	108	PF01048	0.397
MOD_GlcNHglycan	141	144	PF01048	0.261
MOD_GlcNHglycan	174	177	PF01048	0.190
MOD_GlcNHglycan	234	237	PF01048	0.329
MOD_GlcNHglycan	244	247	PF01048	0.379
MOD_GlcNHglycan	30	34	PF01048	0.338
MOD_GlcNHglycan	342	345	PF01048	0.221
MOD_GlcNHglycan	372	375	PF01048	0.376
MOD_GlcNHglycan	415	418	PF01048	0.210
MOD_GlcNHglycan	494	497	PF01048	0.326
MOD_GlcNHglycan	533	536	PF01048	0.247
MOD_GlcNHglycan	612	615	PF01048	0.395
MOD_GlcNHglycan	637	640	PF01048	0.358
MOD_GlcNHglycan	85	88	PF01048	0.298
MOD_GlcNHglycan	93	96	PF01048	0.288
MOD_GSK3_1	125	132	PF00069	0.567
MOD_GSK3_1	3	10	PF00069	0.411
MOD_GSK3_1	409	416	PF00069	0.515
MOD_GSK3_1	417	424	PF00069	0.461
MOD_GSK3_1	427	434	PF00069	0.401
MOD_GSK3_1	470	477	PF00069	0.600
MOD_GSK3_1	482	489	PF00069	0.452
MOD_GSK3_1	502	509	PF00069	0.533
MOD_GSK3_1	513	520	PF00069	0.500
MOD_GSK3_1	581	588	PF00069	0.377
MOD_GSK3_1	79	86	PF00069	0.425
MOD_GSK3_1	93	100	PF00069	0.505
MOD_N-GLC_1	502	507	PF02516	0.258
MOD_N-GLC_1	569	574	PF02516	0.431
MOD_N-GLC_1	610	615	PF02516	0.317
MOD_NEK2_1	1	6	PF00069	0.371
MOD_NEK2_1	139	144	PF00069	0.556
MOD_NEK2_1	264	269	PF00069	0.576
MOD_NEK2_1	29	34	PF00069	0.444
MOD_NEK2_1	334	339	PF00069	0.518
MOD_NEK2_1	431	436	PF00069	0.548
MOD_NEK2_1	486	491	PF00069	0.473
MOD_NEK2_1	492	497	PF00069	0.465
MOD_NEK2_1	579	584	PF00069	0.409
MOD_PIKK_1	537	543	PF00454	0.461
MOD_PIKK_1	665	671	PF00454	0.408
MOD_PK_1	507	513	PF00069	0.548
MOD_PK_1	517	523	PF00069	0.446
MOD_PKA_1	55	61	PF00069	0.461
MOD_PKA_2	635	641	PF00069	0.498
MOD_Plk_1	130	136	PF00069	0.431
MOD_Plk_1	20	26	PF00069	0.504
MOD_Plk_1	212	218	PF00069	0.400
MOD_Plk_1	247	253	PF00069	0.477
MOD_Plk_1	264	270	PF00069	0.484
MOD_Plk_1	470	476	PF00069	0.478
MOD_Plk_1	569	575	PF00069	0.428
MOD_Plk_4	14	20	PF00069	0.537
MOD_Plk_4	302	308	PF00069	0.559
MOD_Plk_4	375	381	PF00069	0.455
MOD_Plk_4	418	424	PF00069	0.472
MOD_Plk_4	427	433	PF00069	0.457
MOD_Plk_4	474	480	PF00069	0.579
MOD_Plk_4	482	488	PF00069	0.551
MOD_Plk_4	49	55	PF00069	0.511
MOD_Plk_4	507	513	PF00069	0.518
MOD_Plk_4	582	588	PF00069	0.404
MOD_Plk_4	594	600	PF00069	0.461
MOD_Plk_4	69	75	PF00069	0.552
MOD_Plk_4	7	13	PF00069	0.501
MOD_ProDKin_1	322	328	PF00069	0.441
MOD_ProDKin_1	42	48	PF00069	0.485
MOD_SUMO_for_1	386	389	PF00179	0.441
MOD_SUMO_rev_2	289	294	PF00179	0.548
MOD_SUMO_rev_2	83	92	PF00179	0.385
TRG_DiLeu_BaEn_2	113	119	PF01217	0.461
TRG_DiLeu_BaLyEn_6	358	363	PF01217	0.441
TRG_ENDOCYTIC_2	197	200	PF00928	0.479
TRG_ENDOCYTIC_2	452	455	PF00928	0.502
TRG_ENDOCYTIC_2	576	579	PF00928	0.349
TRG_ENDOCYTIC_2	583	586	PF00928	0.344
TRG_ENDOCYTIC_2	71	74	PF00928	0.555
TRG_ER_diArg_1	210	212	PF00400	0.494
TRG_ER_diArg_1	479	481	PF00400	0.441
TRG_NES_CRM1_1	312	328	PF08389	0.584
TRG_Pf-PMV_PEXEL_1	316	320	PF00026	0.215

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGE9	Leptomonas seymouri	41%	96%
A0A3Q8ICI3	Leishmania donovani	25%	100%
A0A3R7LZW8	Trypanosoma rangeli	24%	100%
A0A3S7X9D8	Leishmania donovani	92%	100%
A4HCS6	Leishmania braziliensis	25%	100%
A4HMQ8	Leishmania braziliensis	66%	100%
A4I0A0	Leishmania infantum	25%	100%
A4IBC6	Leishmania infantum	93%	100%
C9ZZC3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AF58	Leishmania major	90%	100%
Q4QBB3	Leishmania major	26%	100%