Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6B1_LEIMU

TriTrypDb:

LmxM.34.2310

Length:

248

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1
GO:0005744	TIM23 mitochondrial import inner membrane translocase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1

Expansion

Sequence features

E9B6B1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6B1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0030150	protein import into mitochondrial matrix	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0044743	protein transmembrane import into intracellular organelle	4	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0055085	transmembrane transport	2	1
GO:0065002	intracellular protein transmembrane transport	4	1
GO:0070585	protein localization to mitochondrion	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071806	protein transmembrane transport	3	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072655	establishment of protein localization to mitochondrion	5	1
GO:1990542	mitochondrial transmembrane transport	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	227	231	PF00656	0.577
CLV_NRD_NRD_1	179	181	PF00675	0.663
CLV_NRD_NRD_1	3	5	PF00675	0.544
CLV_NRD_NRD_1	32	34	PF00675	0.423
CLV_NRD_NRD_1	48	50	PF00675	0.546
CLV_PCSK_KEX2_1	3	5	PF00082	0.544
CLV_PCSK_KEX2_1	31	33	PF00082	0.421
CLV_PCSK_KEX2_1	48	50	PF00082	0.557
CLV_PCSK_SKI1_1	49	53	PF00082	0.554
DOC_CKS1_1	6	11	PF01111	0.739
DOC_SPAK_OSR1_1	87	91	PF12202	0.438
DOC_USP7_MATH_1	120	124	PF00917	0.555
DOC_USP7_MATH_1	166	170	PF00917	0.373
DOC_WW_Pin1_4	5	10	PF00397	0.724
DOC_WW_Pin1_4	53	58	PF00397	0.722
DOC_WW_Pin1_4	66	71	PF00397	0.658
LIG_14-3-3_CanoR_1	134	142	PF00244	0.437
LIG_14-3-3_CanoR_1	164	174	PF00244	0.496
LIG_14-3-3_CanoR_1	180	187	PF00244	0.314
LIG_14-3-3_CanoR_1	3	7	PF00244	0.740
LIG_BRCT_BRCA1_1	55	59	PF00533	0.632
LIG_FHA_1	125	131	PF00498	0.455
LIG_FHA_1	6	12	PF00498	0.740
LIG_FHA_1	74	80	PF00498	0.564
LIG_LIR_Gen_1	153	163	PF02991	0.506
LIG_LIR_Nem_3	148	154	PF02991	0.446
LIG_LIR_Nem_3	168	174	PF02991	0.458
LIG_LIR_Nem_3	22	28	PF02991	0.743
LIG_Pex14_2	187	191	PF04695	0.402
LIG_SH2_CRK	155	159	PF00017	0.455
LIG_SH2_CRK	25	29	PF00017	0.791
LIG_SH2_CRK	60	64	PF00017	0.585
LIG_SH2_NCK_1	155	159	PF00017	0.455
LIG_SH2_STAP1	20	24	PF00017	0.576
LIG_SH2_STAT5	155	158	PF00017	0.496
LIG_SH2_STAT5	25	28	PF00017	0.792
LIG_SH3_2	173	178	PF14604	0.367
LIG_SH3_3	170	176	PF00018	0.448
LIG_SH3_3	3	9	PF00018	0.747
LIG_SH3_3	76	82	PF00018	0.631
LIG_TRAF2_1	112	115	PF00917	0.356
LIG_TRAF2_1	223	226	PF00917	0.455
LIG_UBA3_1	190	196	PF00899	0.442
MOD_CK1_1	16	22	PF00069	0.787
MOD_CK1_1	165	171	PF00069	0.500
MOD_CK2_1	109	115	PF00069	0.347
MOD_CK2_1	134	140	PF00069	0.407
MOD_CK2_1	220	226	PF00069	0.442
MOD_Cter_Amidation	1	4	PF01082	0.563
MOD_DYRK1A_RPxSP_1	53	57	PF00069	0.714
MOD_GlcNHglycan	136	139	PF01048	0.627
MOD_GlcNHglycan	15	18	PF01048	0.514
MOD_GlcNHglycan	164	167	PF01048	0.694
MOD_GlcNHglycan	168	171	PF01048	0.702
MOD_GlcNHglycan	206	209	PF01048	0.566
MOD_GlcNHglycan	21	24	PF01048	0.535
MOD_GlcNHglycan	222	225	PF01048	0.721
MOD_GlcNHglycan	39	42	PF01048	0.495
MOD_GlcNHglycan	92	95	PF01048	0.418
MOD_GSK3_1	105	112	PF00069	0.366
MOD_GSK3_1	120	127	PF00069	0.546
MOD_GSK3_1	162	169	PF00069	0.497
MOD_GSK3_1	19	26	PF00069	0.657
MOD_GSK3_1	230	237	PF00069	0.570
MOD_GSK3_1	62	69	PF00069	0.767
MOD_GSK3_1	7	14	PF00069	0.741
MOD_NEK2_1	147	152	PF00069	0.408
MOD_PIKK_1	105	111	PF00454	0.486
MOD_PKA_2	179	185	PF00069	0.362
MOD_PKA_2	2	8	PF00069	0.786
MOD_PKA_2	233	239	PF00069	0.581
MOD_PKA_2	73	79	PF00069	0.723
MOD_Plk_1	147	153	PF00069	0.358
MOD_ProDKin_1	5	11	PF00069	0.724
MOD_ProDKin_1	53	59	PF00069	0.725
MOD_ProDKin_1	66	72	PF00069	0.656
TRG_DiLeu_BaEn_2	196	202	PF01217	0.453
TRG_ENDOCYTIC_2	155	158	PF00928	0.455
TRG_ENDOCYTIC_2	25	28	PF00928	0.792
TRG_ENDOCYTIC_2	60	63	PF00928	0.586
TRG_ER_diArg_1	31	33	PF00400	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF73	Leptomonas seymouri	56%	100%
A0A3Q8IPJ2	Leishmania donovani	85%	100%
A4HMQ5	Leishmania braziliensis	75%	100%
A4IBC3	Leishmania infantum	85%	100%
C9ZZC5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AF55	Leishmania major	85%	100%