Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6B0_LEIMU

TriTrypDb:

LmxM.34.2300

Length:

406

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6B0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6B0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	271	275	PF00656	0.337
CLV_C14_Caspase3-7	72	76	PF00656	0.707
CLV_NRD_NRD_1	100	102	PF00675	0.541
CLV_NRD_NRD_1	103	105	PF00675	0.531
CLV_NRD_NRD_1	148	150	PF00675	0.516
CLV_NRD_NRD_1	237	239	PF00675	0.535
CLV_NRD_NRD_1	298	300	PF00675	0.366
CLV_NRD_NRD_1	320	322	PF00675	0.360
CLV_NRD_NRD_1	397	399	PF00675	0.428
CLV_NRD_NRD_1	45	47	PF00675	0.642
CLV_PCSK_FUR_1	103	107	PF00082	0.459
CLV_PCSK_FUR_1	395	399	PF00082	0.452
CLV_PCSK_FUR_1	97	101	PF00082	0.522
CLV_PCSK_KEX2_1	103	105	PF00082	0.531
CLV_PCSK_KEX2_1	136	138	PF00082	0.426
CLV_PCSK_KEX2_1	237	239	PF00082	0.533
CLV_PCSK_KEX2_1	298	300	PF00082	0.366
CLV_PCSK_KEX2_1	320	322	PF00082	0.360
CLV_PCSK_KEX2_1	341	343	PF00082	0.447
CLV_PCSK_KEX2_1	397	399	PF00082	0.524
CLV_PCSK_KEX2_1	45	47	PF00082	0.608
CLV_PCSK_KEX2_1	99	101	PF00082	0.546
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.462
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.426
CLV_PCSK_PC1ET2_1	341	343	PF00082	0.447
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.572
CLV_PCSK_PC7_1	99	105	PF00082	0.502
CLV_PCSK_SKI1_1	199	203	PF00082	0.693
CLV_PCSK_SKI1_1	226	230	PF00082	0.392
CLV_PCSK_SKI1_1	250	254	PF00082	0.467
CLV_PCSK_SKI1_1	373	377	PF00082	0.374
DEG_APCC_DBOX_1	297	305	PF00400	0.369
DEG_APCC_KENBOX_2	154	158	PF00400	0.579
DEG_MDM2_SWIB_1	303	311	PF02201	0.473
DEG_SCF_FBW7_1	17	24	PF00400	0.597
DOC_CKS1_1	18	23	PF01111	0.771
DOC_CKS1_1	200	205	PF01111	0.570
DOC_CYCLIN_RxL_1	169	179	PF00134	0.616
DOC_CYCLIN_RxL_1	296	306	PF00134	0.358
DOC_MAPK_gen_1	317	325	PF00069	0.462
DOC_PP2B_LxvP_1	217	220	PF13499	0.608
DOC_USP7_MATH_1	189	193	PF00917	0.643
DOC_USP7_MATH_1	2	6	PF00917	0.701
DOC_USP7_MATH_1	349	353	PF00917	0.504
DOC_USP7_MATH_1	357	361	PF00917	0.329
DOC_USP7_MATH_1	69	73	PF00917	0.618
DOC_USP7_MATH_1	92	96	PF00917	0.552
DOC_USP7_UBL2_3	341	345	PF12436	0.278
DOC_USP7_UBL2_3	43	47	PF12436	0.708
DOC_WW_Pin1_4	17	22	PF00397	0.776
DOC_WW_Pin1_4	199	204	PF00397	0.575
DOC_WW_Pin1_4	226	231	PF00397	0.539
DOC_WW_Pin1_4	64	69	PF00397	0.637
LIG_14-3-3_CanoR_1	103	112	PF00244	0.465
LIG_14-3-3_CanoR_1	298	302	PF00244	0.414
LIG_14-3-3_CanoR_1	359	369	PF00244	0.428
LIG_14-3-3_CanoR_1	370	380	PF00244	0.452
LIG_14-3-3_CanoR_1	381	387	PF00244	0.518
LIG_14-3-3_CanoR_1	397	402	PF00244	0.572
LIG_AP2alpha_2	221	223	PF02296	0.385
LIG_AP2alpha_2	33	35	PF02296	0.444
LIG_APCC_ABBA_1	174	179	PF00400	0.576
LIG_BIR_III_4	27	31	PF00653	0.550
LIG_BRCT_BRCA1_1	299	303	PF00533	0.520
LIG_Dynein_DLC8_1	55	61	PF01221	0.491
LIG_FHA_1	12	18	PF00498	0.609
LIG_FHA_1	212	218	PF00498	0.383
LIG_FHA_1	59	65	PF00498	0.789
LIG_FHA_2	234	240	PF00498	0.581
LIG_FHA_2	381	387	PF00498	0.466
LIG_FHA_2	57	63	PF00498	0.790
LIG_LIR_Gen_1	214	222	PF02991	0.359
LIG_LIR_Gen_1	319	330	PF02991	0.482
LIG_LIR_Nem_3	306	311	PF02991	0.368
LIG_LIR_Nem_3	319	325	PF02991	0.346
LIG_LIR_Nem_3	33	38	PF02991	0.443
LIG_LIR_Nem_3	363	369	PF02991	0.399
LIG_LIR_Nem_3	389	393	PF02991	0.395
LIG_PDZ_Class_3	401	406	PF00595	0.435
LIG_Pex14_2	164	168	PF04695	0.491
LIG_Pex14_2	303	307	PF04695	0.489
LIG_SH2_CRK	308	312	PF00017	0.365
LIG_SH2_CRK	366	370	PF00017	0.368
LIG_SH2_PTP2	322	325	PF00017	0.477
LIG_SH2_SRC	354	357	PF00017	0.419
LIG_SH2_STAP1	143	147	PF00017	0.462
LIG_SH2_STAP1	207	211	PF00017	0.582
LIG_SH2_STAP1	215	219	PF00017	0.362
LIG_SH2_STAP1	70	74	PF00017	0.487
LIG_SH2_STAT5	207	210	PF00017	0.579
LIG_SH2_STAT5	322	325	PF00017	0.404
LIG_SH3_1	160	166	PF00018	0.441
LIG_SH3_3	15	21	PF00018	0.698
LIG_SH3_3	160	166	PF00018	0.428
LIG_SH3_3	197	203	PF00018	0.583
LIG_SH3_3	227	233	PF00018	0.564
LIG_SH3_3	256	262	PF00018	0.395
LIG_TRAF2_1	383	386	PF00917	0.557
LIG_UBA3_1	121	128	PF00899	0.491
MOD_CK1_1	360	366	PF00069	0.432
MOD_CK1_1	76	82	PF00069	0.673
MOD_CK2_1	150	156	PF00069	0.564
MOD_CK2_1	380	386	PF00069	0.374
MOD_CK2_1	56	62	PF00069	0.600
MOD_Cter_Amidation	147	150	PF01082	0.614
MOD_DYRK1A_RPxSP_1	199	203	PF00069	0.579
MOD_DYRK1A_RPxSP_1	226	230	PF00069	0.486
MOD_GlcNHglycan	152	155	PF01048	0.590
MOD_GlcNHglycan	191	194	PF01048	0.796
MOD_GlcNHglycan	362	365	PF01048	0.615
MOD_GlcNHglycan	373	376	PF01048	0.469
MOD_GlcNHglycan	48	51	PF01048	0.619
MOD_GlcNHglycan	54	57	PF01048	0.537
MOD_GlcNHglycan	79	82	PF01048	0.687
MOD_GlcNHglycan	94	97	PF01048	0.558
MOD_GSK3_1	17	24	PF00069	0.778
MOD_GSK3_1	187	194	PF00069	0.662
MOD_GSK3_1	293	300	PF00069	0.507
MOD_GSK3_1	330	337	PF00069	0.519
MOD_GSK3_1	41	48	PF00069	0.622
MOD_GSK3_1	52	59	PF00069	0.705
MOD_GSK3_1	69	76	PF00069	0.643
MOD_GSK3_1	77	84	PF00069	0.523
MOD_NEK2_1	211	216	PF00069	0.481
MOD_NEK2_1	3	8	PF00069	0.614
MOD_NEK2_1	330	335	PF00069	0.453
MOD_NEK2_1	371	376	PF00069	0.410
MOD_PIKK_1	135	141	PF00454	0.470
MOD_PIKK_1	293	299	PF00454	0.489
MOD_PIKK_1	56	62	PF00454	0.620
MOD_PKA_1	104	110	PF00069	0.489
MOD_PKA_1	397	403	PF00069	0.447
MOD_PKA_1	45	51	PF00069	0.608
MOD_PKA_2	297	303	PF00069	0.364
MOD_PKA_2	380	386	PF00069	0.505
MOD_PKA_2	397	403	PF00069	0.585
MOD_PKA_2	45	51	PF00069	0.522
MOD_PKA_2	56	62	PF00069	0.474
MOD_PKB_1	395	403	PF00069	0.487
MOD_Plk_1	38	44	PF00069	0.634
MOD_Plk_1	70	76	PF00069	0.643
MOD_Plk_2-3	58	64	PF00069	0.724
MOD_Plk_4	335	341	PF00069	0.394
MOD_ProDKin_1	17	23	PF00069	0.776
MOD_ProDKin_1	199	205	PF00069	0.572
MOD_ProDKin_1	226	232	PF00069	0.536
MOD_ProDKin_1	64	70	PF00069	0.639
MOD_SUMO_rev_2	384	393	PF00179	0.284
TRG_DiLeu_BaEn_1	306	311	PF01217	0.462
TRG_DiLeu_BaLyEn_6	169	174	PF01217	0.533
TRG_DiLeu_LyEn_5	306	311	PF01217	0.462
TRG_ENDOCYTIC_2	215	218	PF00928	0.680
TRG_ENDOCYTIC_2	308	311	PF00928	0.347
TRG_ENDOCYTIC_2	322	325	PF00928	0.351
TRG_ENDOCYTIC_2	366	369	PF00928	0.355
TRG_ER_diArg_1	101	104	PF00400	0.539
TRG_ER_diArg_1	320	322	PF00400	0.358
TRG_ER_diArg_1	323	326	PF00400	0.377
TRG_ER_diArg_1	395	398	PF00400	0.463
TRG_ER_diArg_1	97	100	PF00400	0.555
TRG_NLS_MonoExtC_3	103	109	PF00514	0.485
TRG_NLS_MonoExtN_4	101	108	PF00514	0.493
TRG_NLS_MonoExtN_4	43	49	PF00514	0.429
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMN6	Leptomonas seymouri	61%	92%
A0A0S4JDE7	Bodo saltans	43%	100%
A0A1X0P5P1	Trypanosomatidae	48%	100%
A0A3S5H7Z4	Leishmania donovani	94%	100%
A0A422NM18	Trypanosoma rangeli	48%	100%
A4HMQ4	Leishmania braziliensis	83%	100%
A4IBC2	Leishmania infantum	94%	100%
C9ZZC6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AF54	Leishmania major	93%	100%
V5BJA6	Trypanosoma cruzi	47%	100%