ATP-grasp domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-grasp domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B6A6_LEIMU

TriTrypDb:

LmxM.34.2260

Length:

526

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6A6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6A6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.309
CLV_C14_Caspase3-7	274	278	PF00656	0.372
CLV_C14_Caspase3-7	307	311	PF00656	0.407
CLV_C14_Caspase3-7	506	510	PF00656	0.458
CLV_NRD_NRD_1	21	23	PF00675	0.543
CLV_NRD_NRD_1	512	514	PF00675	0.508
CLV_PCSK_KEX2_1	21	23	PF00082	0.543
CLV_PCSK_KEX2_1	512	514	PF00082	0.451
CLV_PCSK_SKI1_1	114	118	PF00082	0.365
CLV_PCSK_SKI1_1	164	168	PF00082	0.518
CLV_PCSK_SKI1_1	241	245	PF00082	0.452
CLV_PCSK_SKI1_1	306	310	PF00082	0.412
CLV_PCSK_SKI1_1	370	374	PF00082	0.374
CLV_PCSK_SKI1_1	437	441	PF00082	0.442
CLV_PCSK_SKI1_1	512	516	PF00082	0.514
DEG_APCC_DBOX_1	94	102	PF00400	0.535
DEG_Nend_UBRbox_2	1	3	PF02207	0.506
DEG_SCF_FBW7_2	35	41	PF00400	0.394
DOC_CKS1_1	140	145	PF01111	0.588
DOC_CKS1_1	35	40	PF01111	0.548
DOC_CYCLIN_RxL_1	300	311	PF00134	0.467
DOC_CYCLIN_RxL_1	357	366	PF00134	0.418
DOC_CYCLIN_yClb5_NLxxxL_5	360	368	PF00134	0.508
DOC_CYCLIN_yCln2_LP_2	140	146	PF00134	0.452
DOC_CYCLIN_yCln2_LP_2	180	186	PF00134	0.491
DOC_CYCLIN_yCln2_LP_2	32	38	PF00134	0.429
DOC_MAPK_DCC_7	95	103	PF00069	0.510
DOC_MAPK_gen_1	21	28	PF00069	0.388
DOC_MAPK_gen_1	334	342	PF00069	0.397
DOC_MAPK_MEF2A_6	21	30	PF00069	0.391
DOC_MAPK_MEF2A_6	370	377	PF00069	0.322
DOC_MAPK_NFAT4_5	370	378	PF00069	0.244
DOC_PP1_RVXF_1	2	9	PF00149	0.517
DOC_PP2B_LxvP_1	373	376	PF13499	0.516
DOC_PP4_FxxP_1	439	442	PF00568	0.489
DOC_USP7_MATH_1	77	81	PF00917	0.403
DOC_USP7_MATH_2	143	149	PF00917	0.336
DOC_USP7_MATH_2	465	471	PF00917	0.549
DOC_USP7_UBL2_3	169	173	PF12436	0.473
DOC_WW_Pin1_4	125	130	PF00397	0.391
DOC_WW_Pin1_4	139	144	PF00397	0.471
DOC_WW_Pin1_4	186	191	PF00397	0.385
DOC_WW_Pin1_4	34	39	PF00397	0.485
DOC_WW_Pin1_4	403	408	PF00397	0.684
DOC_WW_Pin1_4	96	101	PF00397	0.469
LIG_14-3-3_CanoR_1	118	127	PF00244	0.503
LIG_14-3-3_CanoR_1	198	204	PF00244	0.543
LIG_14-3-3_CanoR_1	21	27	PF00244	0.424
LIG_14-3-3_CanoR_1	420	428	PF00244	0.468
LIG_BRCT_BRCA1_1	156	160	PF00533	0.574
LIG_BRCT_BRCA1_1	222	226	PF00533	0.280
LIG_BRCT_BRCA1_1	275	279	PF00533	0.381
LIG_BRCT_BRCA1_1	435	439	PF00533	0.529
LIG_BRCT_BRCA1_2	156	162	PF00533	0.580
LIG_EVH1_2	487	491	PF00568	0.446
LIG_FHA_1	27	33	PF00498	0.417
LIG_FHA_1	52	58	PF00498	0.410
LIG_FHA_1	9	15	PF00498	0.362
LIG_FHA_2	140	146	PF00498	0.593
LIG_FHA_2	200	206	PF00498	0.489
LIG_FHA_2	500	506	PF00498	0.431
LIG_LIR_Apic_2	436	442	PF02991	0.527
LIG_LIR_Gen_1	223	234	PF02991	0.560
LIG_LIR_Gen_1	426	435	PF02991	0.573
LIG_LIR_Nem_3	115	120	PF02991	0.437
LIG_LIR_Nem_3	223	229	PF02991	0.524
LIG_LIR_Nem_3	357	362	PF02991	0.431
LIG_LIR_Nem_3	382	388	PF02991	0.485
LIG_LIR_Nem_3	41	45	PF02991	0.395
LIG_LIR_Nem_3	426	432	PF02991	0.586
LIG_LIR_Nem_3	80	84	PF02991	0.367
LIG_NRBOX	304	310	PF00104	0.342
LIG_PCNA_PIPBox_1	110	119	PF02747	0.343
LIG_PCNA_PIPBox_1	378	387	PF02747	0.457
LIG_PCNA_yPIPBox_3	110	118	PF02747	0.435
LIG_PCNA_yPIPBox_3	300	309	PF02747	0.365
LIG_PCNA_yPIPBox_3	345	359	PF02747	0.458
LIG_PDZ_Class_2	521	526	PF00595	0.534
LIG_Pex14_2	42	46	PF04695	0.424
LIG_Rb_LxCxE_1	115	131	PF01857	0.490
LIG_SH2_CRK	20	24	PF00017	0.524
LIG_SH2_CRK	359	363	PF00017	0.454
LIG_SH2_CRK	36	40	PF00017	0.481
LIG_SH2_SRC	330	333	PF00017	0.545
LIG_SH2_STAT3	299	302	PF00017	0.306
LIG_SH2_STAT5	285	288	PF00017	0.406
LIG_SH2_STAT5	312	315	PF00017	0.453
LIG_SH2_STAT5	338	341	PF00017	0.386
LIG_SH2_STAT5	36	39	PF00017	0.490
LIG_SH3_3	129	135	PF00018	0.467
LIG_SH3_3	278	284	PF00018	0.419
LIG_SH3_3	32	38	PF00018	0.398
LIG_SH3_3	395	401	PF00018	0.633
LIG_SH3_3	402	408	PF00018	0.567
LIG_SH3_3	481	487	PF00018	0.410
LIG_SH3_3	519	525	PF00018	0.504
LIG_SH3_3	99	105	PF00018	0.379
LIG_SUMO_SIM_anti_2	29	34	PF11976	0.380
LIG_SxIP_EBH_1	95	107	PF03271	0.458
LIG_TRAF2_1	376	379	PF00917	0.527
LIG_TRAF2_1	502	505	PF00917	0.465
LIG_UBA3_1	384	393	PF00899	0.434
LIG_WRC_WIRS_1	78	83	PF05994	0.355
LIG_WW_3	406	410	PF00397	0.512
MOD_CDK_SPK_2	125	130	PF00069	0.435
MOD_CDK_SPxK_1	403	409	PF00069	0.675
MOD_CK1_1	128	134	PF00069	0.447
MOD_CK1_1	311	317	PF00069	0.333
MOD_CK1_1	348	354	PF00069	0.394
MOD_CK2_1	139	145	PF00069	0.613
MOD_CK2_1	499	505	PF00069	0.432
MOD_CK2_1	77	83	PF00069	0.354
MOD_GlcNHglycan	313	316	PF01048	0.451
MOD_GlcNHglycan	347	350	PF01048	0.398
MOD_GlcNHglycan	421	424	PF01048	0.644
MOD_GlcNHglycan	476	479	PF01048	0.442
MOD_GlcNHglycan	64	67	PF01048	0.506
MOD_GSK3_1	167	174	PF00069	0.447
MOD_GSK3_1	212	219	PF00069	0.429
MOD_GSK3_1	22	29	PF00069	0.357
MOD_GSK3_1	350	357	PF00069	0.321
MOD_GSK3_1	419	426	PF00069	0.654
MOD_LATS_1	239	245	PF00433	0.383
MOD_N-GLC_1	26	31	PF02516	0.319
MOD_N-GLC_1	96	101	PF02516	0.536
MOD_NEK2_1	167	172	PF00069	0.446
MOD_NEK2_1	216	221	PF00069	0.487
MOD_NEK2_1	26	31	PF00069	0.346
MOD_NEK2_1	308	313	PF00069	0.412
MOD_NEK2_1	354	359	PF00069	0.375
MOD_NEK2_1	474	479	PF00069	0.525
MOD_NEK2_1	62	67	PF00069	0.537
MOD_NEK2_1	8	13	PF00069	0.320
MOD_PK_1	10	16	PF00069	0.349
MOD_PK_1	271	277	PF00069	0.424
MOD_PKA_1	21	27	PF00069	0.246
MOD_PKA_1	512	518	PF00069	0.442
MOD_PKA_2	21	27	PF00069	0.372
MOD_PKA_2	408	414	PF00069	0.691
MOD_PKA_2	419	425	PF00069	0.432
MOD_PKA_2	512	518	PF00069	0.512
MOD_Plk_1	26	32	PF00069	0.315
MOD_Plk_1	467	473	PF00069	0.465
MOD_Plk_4	191	197	PF00069	0.401
MOD_Plk_4	212	218	PF00069	0.259
MOD_Plk_4	26	32	PF00069	0.393
MOD_Plk_4	292	298	PF00069	0.327
MOD_Plk_4	308	314	PF00069	0.368
MOD_Plk_4	350	356	PF00069	0.363
MOD_Plk_4	467	473	PF00069	0.456
MOD_ProDKin_1	125	131	PF00069	0.394
MOD_ProDKin_1	139	145	PF00069	0.474
MOD_ProDKin_1	186	192	PF00069	0.391
MOD_ProDKin_1	34	40	PF00069	0.488
MOD_ProDKin_1	403	409	PF00069	0.684
MOD_ProDKin_1	96	102	PF00069	0.464
MOD_SUMO_rev_2	219	226	PF00179	0.305
TRG_DiLeu_BaEn_1	467	472	PF01217	0.553
TRG_ENDOCYTIC_2	20	23	PF00928	0.378
TRG_ENDOCYTIC_2	359	362	PF00928	0.408
TRG_ENDOCYTIC_2	36	39	PF00928	0.406
TRG_ER_diArg_1	20	22	PF00400	0.547
TRG_ER_diArg_1	511	513	PF00400	0.515
TRG_Pf-PMV_PEXEL_1	306	310	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	71	76	PF00026	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P380	Leptomonas seymouri	57%	99%
A0A0S4JCU0	Bodo saltans	44%	100%
A0A1X0P6I8	Trypanosomatidae	48%	100%
A0A3Q8IG99	Leishmania donovani	88%	100%
A0A3R7KHD1	Trypanosoma rangeli	47%	100%
A4HMQ0	Leishmania braziliensis	72%	100%
A4IBB8	Leishmania infantum	88%	100%
E9AF50	Leishmania major	85%	100%
V5BJB2	Trypanosoma cruzi	46%	100%