Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6A4_LEIMU

TriTrypDb:

LmxM.34.2240

Length:

519

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6A4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6A4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.319
CLV_C14_Caspase3-7	278	282	PF00656	0.531
CLV_NRD_NRD_1	119	121	PF00675	0.527
CLV_NRD_NRD_1	139	141	PF00675	0.547
CLV_NRD_NRD_1	25	27	PF00675	0.739
CLV_NRD_NRD_1	308	310	PF00675	0.539
CLV_NRD_NRD_1	333	335	PF00675	0.425
CLV_NRD_NRD_1	35	37	PF00675	0.707
CLV_NRD_NRD_1	382	384	PF00675	0.580
CLV_NRD_NRD_1	434	436	PF00675	0.536
CLV_NRD_NRD_1	46	48	PF00675	0.685
CLV_PCSK_FUR_1	432	436	PF00082	0.686
CLV_PCSK_FUR_1	44	48	PF00082	0.721
CLV_PCSK_KEX2_1	119	121	PF00082	0.527
CLV_PCSK_KEX2_1	25	27	PF00082	0.707
CLV_PCSK_KEX2_1	308	310	PF00082	0.505
CLV_PCSK_KEX2_1	332	334	PF00082	0.419
CLV_PCSK_KEX2_1	35	37	PF00082	0.699
CLV_PCSK_KEX2_1	381	383	PF00082	0.510
CLV_PCSK_KEX2_1	432	434	PF00082	0.566
CLV_PCSK_KEX2_1	46	48	PF00082	0.672
CLV_PCSK_KEX2_1	62	64	PF00082	0.419
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.584
CLV_PCSK_SKI1_1	13	17	PF00082	0.780
CLV_PCSK_SKI1_1	334	338	PF00082	0.431
CLV_PCSK_SKI1_1	63	67	PF00082	0.746
DEG_SCF_FBW7_2	480	487	PF00400	0.597
DOC_CYCLIN_yCln2_LP_2	203	209	PF00134	0.521
DOC_CYCLIN_yCln2_LP_2	65	71	PF00134	0.699
DOC_MAPK_FxFP_2	326	329	PF00069	0.462
DOC_MAPK_gen_1	242	252	PF00069	0.435
DOC_MAPK_gen_1	305	313	PF00069	0.544
DOC_MAPK_gen_1	35	43	PF00069	0.545
DOC_MAPK_HePTP_8	431	448	PF00069	0.464
DOC_MAPK_MEF2A_6	461	468	PF00069	0.564
DOC_PP2B_LxvP_1	157	160	PF13499	0.766
DOC_PP2B_LxvP_1	173	176	PF13499	0.476
DOC_PP4_FxxP_1	20	23	PF00568	0.700
DOC_PP4_FxxP_1	231	234	PF00568	0.560
DOC_PP4_FxxP_1	326	329	PF00568	0.462
DOC_PP4_FxxP_1	84	87	PF00568	0.493
DOC_PP4_MxPP_1	175	178	PF00568	0.465
DOC_USP7_MATH_1	178	182	PF00917	0.758
DOC_USP7_MATH_1	327	331	PF00917	0.420
DOC_USP7_MATH_1	453	457	PF00917	0.547
DOC_USP7_MATH_1	514	518	PF00917	0.582
DOC_USP7_MATH_1	57	61	PF00917	0.670
DOC_WW_Pin1_4	135	140	PF00397	0.539
DOC_WW_Pin1_4	202	207	PF00397	0.432
DOC_WW_Pin1_4	208	213	PF00397	0.453
DOC_WW_Pin1_4	351	356	PF00397	0.478
DOC_WW_Pin1_4	36	41	PF00397	0.745
DOC_WW_Pin1_4	424	429	PF00397	0.682
DOC_WW_Pin1_4	480	485	PF00397	0.586
DOC_WW_Pin1_4	64	69	PF00397	0.680
LIG_14-3-3_CanoR_1	13	20	PF00244	0.766
LIG_14-3-3_CanoR_1	25	34	PF00244	0.706
LIG_14-3-3_CanoR_1	333	342	PF00244	0.442
LIG_14-3-3_CanoR_1	381	389	PF00244	0.669
LIG_14-3-3_CanoR_1	503	509	PF00244	0.697
LIG_Actin_WH2_2	304	320	PF00022	0.538
LIG_BIR_II_1	1	5	PF00653	0.461
LIG_BRCT_BRCA1_1	97	101	PF00533	0.540
LIG_BRCT_BRCA1_2	97	103	PF00533	0.515
LIG_CSL_BTD_1	425	428	PF09270	0.675
LIG_CtBP_PxDLS_1	40	44	PF00389	0.487
LIG_EH_1	494	498	PF12763	0.456
LIG_EH1_1	246	254	PF00400	0.396
LIG_EVH1_1	173	177	PF00568	0.468
LIG_FHA_1	166	172	PF00498	0.537
LIG_FHA_1	195	201	PF00498	0.610
LIG_FHA_1	283	289	PF00498	0.604
LIG_FHA_1	362	368	PF00498	0.551
LIG_FHA_1	406	412	PF00498	0.756
LIG_FHA_2	110	116	PF00498	0.523
LIG_FHA_2	276	282	PF00498	0.513
LIG_FHA_2	297	303	PF00498	0.646
LIG_Integrin_RGD_1	185	187	PF01839	0.504
LIG_LIR_Apic_2	228	234	PF02991	0.519
LIG_LIR_Apic_2	323	329	PF02991	0.473
LIG_LIR_Gen_1	354	361	PF02991	0.447
LIG_LIR_Gen_1	366	376	PF02991	0.509
LIG_LIR_Gen_1	394	405	PF02991	0.691
LIG_LIR_Gen_1	89	99	PF02991	0.435
LIG_LIR_Nem_3	202	207	PF02991	0.565
LIG_LIR_Nem_3	323	328	PF02991	0.392
LIG_LIR_Nem_3	354	360	PF02991	0.424
LIG_LIR_Nem_3	394	400	PF02991	0.689
LIG_LIR_Nem_3	67	72	PF02991	0.621
LIG_LIR_Nem_3	89	94	PF02991	0.426
LIG_PCNA_yPIPBox_3	461	472	PF02747	0.515
LIG_PDZ_Class_1	514	519	PF00595	0.589
LIG_Pex14_2	231	235	PF04695	0.547
LIG_RPA_C_Fungi	377	389	PF08784	0.370
LIG_SH2_CRK	142	146	PF00017	0.441
LIG_SH2_CRK	357	361	PF00017	0.430
LIG_SH2_SRC	274	277	PF00017	0.573
LIG_SH2_STAT3	340	343	PF00017	0.554
LIG_SH2_STAT5	274	277	PF00017	0.532
LIG_SH2_STAT5	4	7	PF00017	0.460
LIG_SH3_3	104	110	PF00018	0.443
LIG_SH3_3	168	174	PF00018	0.671
LIG_SH3_3	258	264	PF00018	0.427
LIG_SH3_3	321	327	PF00018	0.536
LIG_SH3_4	461	468	PF00018	0.533
LIG_SUMO_SIM_anti_2	214	219	PF11976	0.399
LIG_TRFH_1	340	344	PF08558	0.523
MOD_CDK_SPK_2	135	140	PF00069	0.533
MOD_CDK_SPxK_1	135	141	PF00069	0.546
MOD_CK1_1	111	117	PF00069	0.487
MOD_CK1_1	194	200	PF00069	0.652
MOD_CK1_1	2	8	PF00069	0.599
MOD_CK1_1	202	208	PF00069	0.530
MOD_CK1_1	211	217	PF00069	0.429
MOD_CK1_1	29	35	PF00069	0.647
MOD_CK1_1	291	297	PF00069	0.442
MOD_CK1_1	363	369	PF00069	0.311
MOD_CK1_1	39	45	PF00069	0.757
MOD_CK1_1	476	482	PF00069	0.488
MOD_CK1_1	51	57	PF00069	0.648
MOD_CK1_1	58	64	PF00069	0.651
MOD_CK2_1	202	208	PF00069	0.425
MOD_CK2_1	296	302	PF00069	0.647
MOD_Cter_Amidation	44	47	PF01082	0.773
MOD_GlcNHglycan	193	196	PF01048	0.715
MOD_GlcNHglycan	318	321	PF01048	0.477
MOD_GlcNHglycan	386	389	PF01048	0.652
MOD_GlcNHglycan	455	458	PF01048	0.571
MOD_GlcNHglycan	475	478	PF01048	0.406
MOD_GlcNHglycan	57	60	PF01048	0.662
MOD_GSK3_1	161	168	PF00069	0.750
MOD_GSK3_1	190	197	PF00069	0.635
MOD_GSK3_1	401	408	PF00069	0.664
MOD_GSK3_1	451	458	PF00069	0.582
MOD_GSK3_1	476	483	PF00069	0.577
MOD_GSK3_1	504	511	PF00069	0.770
MOD_GSK3_1	51	58	PF00069	0.597
MOD_N-GLC_1	160	165	PF02516	0.708
MOD_N-GLC_1	480	485	PF02516	0.586
MOD_N-GLC_2	123	125	PF02516	0.556
MOD_NEK2_1	3	8	PF00069	0.682
MOD_NEK2_1	360	365	PF00069	0.374
MOD_NEK2_1	405	410	PF00069	0.757
MOD_NEK2_1	471	476	PF00069	0.371
MOD_NEK2_1	73	78	PF00069	0.643
MOD_NEK2_1	95	100	PF00069	0.487
MOD_PIKK_1	13	19	PF00454	0.764
MOD_PKA_1	381	387	PF00069	0.378
MOD_PKA_1	46	52	PF00069	0.749
MOD_PKA_2	282	288	PF00069	0.541
MOD_PKA_2	381	387	PF00069	0.625
MOD_PKA_2	46	52	PF00069	0.707
MOD_PKB_1	332	340	PF00069	0.530
MOD_PKB_1	44	52	PF00069	0.627
MOD_Plk_1	275	281	PF00069	0.553
MOD_Plk_1	392	398	PF00069	0.611
MOD_Plk_2-3	296	302	PF00069	0.407
MOD_Plk_4	152	158	PF00069	0.721
MOD_Plk_4	178	184	PF00069	0.770
MOD_Plk_4	199	205	PF00069	0.602
MOD_Plk_4	363	369	PF00069	0.545
MOD_Plk_4	392	398	PF00069	0.652
MOD_Plk_4	90	96	PF00069	0.507
MOD_ProDKin_1	135	141	PF00069	0.552
MOD_ProDKin_1	202	208	PF00069	0.430
MOD_ProDKin_1	351	357	PF00069	0.477
MOD_ProDKin_1	36	42	PF00069	0.745
MOD_ProDKin_1	424	430	PF00069	0.683
MOD_ProDKin_1	480	486	PF00069	0.592
MOD_ProDKin_1	64	70	PF00069	0.676
TRG_DiLeu_BaEn_2	392	398	PF01217	0.652
TRG_ENDOCYTIC_2	142	145	PF00928	0.437
TRG_ENDOCYTIC_2	204	207	PF00928	0.559
TRG_ENDOCYTIC_2	357	360	PF00928	0.424
TRG_ER_diArg_1	118	120	PF00400	0.458
TRG_ER_diArg_1	307	309	PF00400	0.536
TRG_ER_diArg_1	331	334	PF00400	0.410
TRG_ER_diArg_1	34	36	PF00400	0.764
TRG_ER_diArg_1	381	383	PF00400	0.601
TRG_ER_diArg_1	43	46	PF00400	0.717
TRG_ER_diArg_1	431	434	PF00400	0.588
TRG_NLS_MonoExtN_4	139	144	PF00514	0.640
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.700

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3L8	Leptomonas seymouri	47%	95%
A0A0S4JDL6	Bodo saltans	27%	100%
A0A1X0P5V1	Trypanosomatidae	38%	100%
A0A3Q8IJ19	Leishmania donovani	89%	97%
A0A422NLY6	Trypanosoma rangeli	38%	100%
A4HMP7	Leishmania braziliensis	72%	100%
A4IBB6	Leishmania infantum	89%	97%
C9ZZD3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AF48	Leishmania major	88%	100%
V5DKB8	Trypanosoma cruzi	38%	100%