LeishMANIAdb
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Kinetoplastid membrane protein-11

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Kinetoplastid membrane protein-11
Gene product:
kinetoplastid membrane protein-11
Species:
Leishmania mexicana
UniProt:
E9B6A1_LEIMU
TriTrypDb:
LmxM.34.2220
Length:
92

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 6
Forrest at al. (procyclic) no yes: 6
Silverman et al. no yes: 0
Pissara et al. yes yes: 24
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 15
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 10
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 12
GO:0005874 microtubule 6 13
GO:0099080 supramolecular complex 2 13
GO:0099081 supramolecular polymer 3 13
GO:0099512 supramolecular fiber 4 13
GO:0099513 polymeric cytoskeletal fiber 5 13
GO:0110165 cellular anatomical entity 1 13
GO:0005815 microtubule organizing center 2 1
GO:0005930 axoneme 2 1
GO:0036064 ciliary basal body 3 1
GO:0051286 cell tip 3 1
GO:0060187 cell pole 2 1

Expansion

Sequence features

E9B6A1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6A1

Function

Biological processes
Term Name Level Count
GO:0006950 response to stress 2 13
GO:0006952 defense response 3 13
GO:0008284 positive regulation of cell population proliferation 5 13
GO:0042127 regulation of cell population proliferation 4 13
GO:0048518 positive regulation of biological process 3 13
GO:0048522 positive regulation of cellular process 4 13
GO:0050789 regulation of biological process 2 13
GO:0050794 regulation of cellular process 3 13
GO:0050896 response to stimulus 1 13
GO:0065007 biological regulation 1 13
GO:0006996 organelle organization 4 1
GO:0007017 microtubule-based process 2 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0030030 cell projection organization 4 1
GO:0031023 microtubule organizing center organization 3 1
GO:0032053 ciliary basal body organization 4 1
GO:0044782 cilium organization 5 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0120036 plasma membrane bounded cell projection organization 5 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 20 22 PF00675 0.402
DOC_USP7_MATH_1 35 39 PF00917 0.570
DOC_USP7_UBL2_3 61 65 PF12436 0.544
DOC_WW_Pin1_4 38 43 PF00397 0.544
LIG_BIR_II_1 1 5 PF00653 0.570
LIG_BRCT_BRCA1_1 69 73 PF00533 0.544
LIG_FHA_2 1 7 PF00498 0.571
LIG_LIR_Gen_1 3 12 PF02991 0.608
LIG_LIR_Gen_1 46 54 PF02991 0.544
LIG_LIR_Nem_3 3 8 PF02991 0.608
LIG_LIR_Nem_3 46 51 PF02991 0.544
LIG_Pex14_2 73 77 PF04695 0.544
LIG_REV1ctd_RIR_1 28 34 PF16727 0.544
LIG_TRAF2_1 4 7 PF00917 0.570
MOD_CDK_SPxxK_3 38 45 PF00069 0.544
MOD_CK1_1 38 44 PF00069 0.570
MOD_CK2_1 1 7 PF00069 0.570
MOD_GlcNHglycan 6 11 PF01048 0.402
MOD_GSK3_1 52 59 PF00069 0.438
MOD_PKA_2 52 58 PF00069 0.438
MOD_Plk_1 35 41 PF00069 0.545
MOD_ProDKin_1 38 44 PF00069 0.544
TRG_ENDOCYTIC_2 48 51 PF00928 0.544
TRG_ENDOCYTIC_2 5 8 PF00928 0.608

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4JAE0 Bodo saltans 84% 100%
A0A3Q8IJE8 Leishmania donovani 98% 100%
A0A3S7X9H1 Leishmania donovani 95% 100%
A4HMP3 Leishmania braziliensis 93% 100%
A4IBB2 Leishmania infantum 95% 100%
A4IBB3 Leishmania infantum 98% 100%
C9ZZD9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 83% 100%
E9AF45 Leishmania major 98% 100%
E9B6A0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
E9B6A2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 99% 100%
O21436 Leishmania tropica 98% 100%
P69300 Trypanosoma brucei brucei 83% 100%
P69301 Trypanosoma brucei rhodesiense 83% 100%
Q25297 Leishmania infantum 97% 100%
Q25298 Leishmania infantum 97% 100%
Q36736 Leishmania donovani 96% 100%
Q9U6Z1 Trypanosoma cruzi 86% 100%
V5B3U8 Trypanosoma cruzi 87% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS