Short-chain dehydrogenase/reductase SDR

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

short chain dehydrogenase, putative

Species:

Leishmania mexicana

UniProt:

E9B696_LEIMU

TriTrypDb:

LmxM.34.2170

Length:

484

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 28
NetGPI	no	yes: 0, no: 28

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	13
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9B696

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B696

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0006633	fatty acid biosynthetic process	5	1
GO:0008152	metabolic process	1	1
GO:0008610	lipid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0016053	organic acid biosynthetic process	4	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0030497	fatty acid elongation	6	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046394	carboxylic acid biosynthetic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0072330	monocarboxylic acid biosynthetic process	6	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0008667	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity	5	1
GO:0016491	oxidoreductase activity	2	3
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	1
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	4	1
GO:0004312	fatty acid synthase activity	5	2
GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	5	2
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	2
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	2
GO:0016740	transferase activity	2	2
GO:0016746	acyltransferase activity	3	2
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	343	347	PF00656	0.609
CLV_PCSK_SKI1_1	107	111	PF00082	0.321
CLV_PCSK_SKI1_1	275	279	PF00082	0.402
CLV_PCSK_SKI1_1	381	385	PF00082	0.334
CLV_PCSK_SKI1_1	72	76	PF00082	0.260
DEG_Nend_Nbox_1	1	3	PF02207	0.530
DEG_SPOP_SBC_1	188	192	PF00917	0.374
DOC_CDC14_PxL_1	392	400	PF14671	0.269
DOC_CYCLIN_RxL_1	167	177	PF00134	0.508
DOC_MAPK_FxFP_2	393	396	PF00069	0.403
DOC_MAPK_MEF2A_6	153	162	PF00069	0.446
DOC_MAPK_MEF2A_6	359	367	PF00069	0.626
DOC_PP1_RVXF_1	105	111	PF00149	0.416
DOC_PP1_RVXF_1	168	175	PF00149	0.500
DOC_PP2B_LxvP_1	215	218	PF13499	0.458
DOC_PP4_FxxP_1	243	246	PF00568	0.478
DOC_PP4_FxxP_1	393	396	PF00568	0.368
DOC_USP7_MATH_1	11	15	PF00917	0.321
DOC_USP7_MATH_1	124	128	PF00917	0.428
DOC_USP7_MATH_1	189	193	PF00917	0.416
DOC_USP7_MATH_1	194	198	PF00917	0.400
DOC_USP7_UBL2_3	121	125	PF12436	0.526
DOC_USP7_UBL2_3	327	331	PF12436	0.712
DOC_USP7_UBL2_3	337	341	PF12436	0.730
DOC_WW_Pin1_4	329	334	PF00397	0.712
DOC_WW_Pin1_4	351	356	PF00397	0.723
DOC_WW_Pin1_4	445	450	PF00397	0.354
DOC_WW_Pin1_4	461	466	PF00397	0.381
LIG_14-3-3_CanoR_1	103	110	PF00244	0.467
LIG_14-3-3_CanoR_1	193	199	PF00244	0.588
LIG_14-3-3_CanoR_1	317	322	PF00244	0.547
LIG_Actin_WH2_2	168	184	PF00022	0.544
LIG_BRCT_BRCA1_1	396	400	PF00533	0.442
LIG_BRCT_BRCA1_1	46	50	PF00533	0.335
LIG_BRCT_BRCA1_2	396	402	PF00533	0.456
LIG_deltaCOP1_diTrp_1	291	297	PF00928	0.642
LIG_eIF4E_1	210	216	PF01652	0.416
LIG_FHA_1	103	109	PF00498	0.524
LIG_FHA_1	131	137	PF00498	0.464
LIG_FHA_1	228	234	PF00498	0.543
LIG_FHA_1	310	316	PF00498	0.448
LIG_FHA_1	374	380	PF00498	0.515
LIG_FHA_1	417	423	PF00498	0.371
LIG_FHA_1	462	468	PF00498	0.400
LIG_FHA_1	68	74	PF00498	0.553
LIG_FHA_1	78	84	PF00498	0.508
LIG_FHA_1	95	101	PF00498	0.425
LIG_FHA_2	181	187	PF00498	0.389
LIG_FHA_2	341	347	PF00498	0.627
LIG_FHA_2	401	407	PF00498	0.338
LIG_FHA_2	448	454	PF00498	0.333
LIG_LIR_Apic_2	242	246	PF02991	0.478
LIG_LIR_Apic_2	390	396	PF02991	0.435
LIG_LIR_Gen_1	291	301	PF02991	0.538
LIG_LIR_Gen_1	93	102	PF02991	0.569
LIG_LIR_Nem_3	291	297	PF02991	0.564
LIG_LIR_Nem_3	377	383	PF02991	0.540
LIG_LIR_Nem_3	390	395	PF02991	0.365
LIG_LIR_Nem_3	93	99	PF02991	0.495
LIG_LYPXL_yS_3	395	398	PF13949	0.264
LIG_PCNA_yPIPBox_3	313	325	PF02747	0.413
LIG_Pex14_1	387	391	PF04695	0.241
LIG_Pex14_2	400	404	PF04695	0.331
LIG_RPA_C_Fungi	48	60	PF08784	0.396
LIG_SH2_GRB2like	27	30	PF00017	0.268
LIG_SH2_SRC	27	30	PF00017	0.268
LIG_SH2_STAP1	85	89	PF00017	0.280
LIG_SH2_STAT5	145	148	PF00017	0.415
LIG_SH2_STAT5	210	213	PF00017	0.370
LIG_SH2_STAT5	27	30	PF00017	0.487
LIG_SH2_STAT5	288	291	PF00017	0.535
LIG_SH2_STAT5	378	381	PF00017	0.497
LIG_SH2_STAT5	391	394	PF00017	0.280
LIG_SH2_STAT5	427	430	PF00017	0.419
LIG_SH3_3	280	286	PF00018	0.531
LIG_SH3_3	332	338	PF00018	0.539
LIG_SH3_4	337	344	PF00018	0.485
LIG_SUMO_SIM_anti_2	40	45	PF11976	0.188
LIG_SUMO_SIM_par_1	132	139	PF11976	0.250
LIG_SUMO_SIM_par_1	40	45	PF11976	0.199
LIG_TYR_ITIM	298	303	PF00017	0.304
LIG_UBA3_1	321	327	PF00899	0.308
MOD_CDK_SPxxK_3	461	468	PF00069	0.301
MOD_CK1_1	138	144	PF00069	0.379
MOD_CK1_1	187	193	PF00069	0.250
MOD_CK1_1	228	234	PF00069	0.309
MOD_CK1_1	239	245	PF00069	0.326
MOD_CK1_1	407	413	PF00069	0.456
MOD_CK2_1	180	186	PF00069	0.174
MOD_CK2_1	400	406	PF00069	0.380
MOD_CK2_1	447	453	PF00069	0.433
MOD_GlcNHglycan	122	125	PF01048	0.273
MOD_GlcNHglycan	346	349	PF01048	0.706
MOD_GlcNHglycan	406	409	PF01048	0.384
MOD_GlcNHglycan	429	432	PF01048	0.443
MOD_GlcNHglycan	436	439	PF01048	0.446
MOD_GlcNHglycan	80	83	PF01048	0.311
MOD_GSK3_1	120	127	PF00069	0.210
MOD_GSK3_1	180	187	PF00069	0.386
MOD_GSK3_1	220	227	PF00069	0.282
MOD_GSK3_1	235	242	PF00069	0.308
MOD_GSK3_1	325	332	PF00069	0.591
MOD_GSK3_1	340	347	PF00069	0.565
MOD_GSK3_1	400	407	PF00069	0.417
MOD_N-GLC_1	349	354	PF02516	0.703
MOD_NEK2_1	108	113	PF00069	0.340
MOD_NEK2_1	309	314	PF00069	0.514
MOD_NEK2_1	400	405	PF00069	0.480
MOD_NEK2_1	42	47	PF00069	0.330
MOD_NEK2_2	124	129	PF00069	0.241
MOD_NEK2_2	408	413	PF00069	0.421
MOD_PIKK_1	210	216	PF00454	0.321
MOD_PKA_2	102	108	PF00069	0.343
MOD_Plk_1	138	144	PF00069	0.334
MOD_Plk_1	224	230	PF00069	0.378
MOD_Plk_1	290	296	PF00069	0.426
MOD_Plk_4	11	17	PF00069	0.348
MOD_Plk_4	239	245	PF00069	0.414
MOD_Plk_4	317	323	PF00069	0.380
MOD_Plk_4	374	380	PF00069	0.484
MOD_Plk_4	394	400	PF00069	0.284
MOD_ProDKin_1	329	335	PF00069	0.657
MOD_ProDKin_1	351	357	PF00069	0.667
MOD_ProDKin_1	445	451	PF00069	0.428
MOD_ProDKin_1	461	467	PF00069	0.474
MOD_SUMO_rev_2	177	183	PF00179	0.417
MOD_SUMO_rev_2	273	283	PF00179	0.661
TRG_DiLeu_BaLyEn_6	104	109	PF01217	0.310
TRG_DiLeu_BaLyEn_6	215	220	PF01217	0.263
TRG_DiLeu_BaLyEn_6	310	315	PF01217	0.440
TRG_ENDOCYTIC_2	22	25	PF00928	0.382
TRG_ENDOCYTIC_2	252	255	PF00928	0.506
TRG_ENDOCYTIC_2	27	30	PF00928	0.509
TRG_ENDOCYTIC_2	300	303	PF00928	0.297
TRG_ENDOCYTIC_2	380	383	PF00928	0.384
TRG_ENDOCYTIC_2	395	398	PF00928	0.280
TRG_Pf-PMV_PEXEL_1	259	263	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	313	318	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ81	Leptomonas seymouri	25%	87%
A0A0N1I1M5	Leptomonas seymouri	63%	98%
A0A0S4IZG2	Bodo saltans	25%	100%
A0A0S4J1I6	Bodo saltans	24%	100%
A0A0S4J9U3	Bodo saltans	28%	100%
A0A1X0P5Q9	Trypanosomatidae	25%	100%
A0A1X0P5W3	Trypanosomatidae	44%	100%
A0A3Q8IM89	Leishmania donovani	26%	100%
A0A3R7K8J6	Trypanosoma rangeli	25%	100%
A0A3R7N7S2	Trypanosoma rangeli	43%	100%
A0A3S5H7D5	Leishmania donovani	24%	100%
A0A3S7X986	Leishmania donovani	91%	100%
A4HDP2	Leishmania braziliensis	24%	100%
A4HMN7	Leishmania braziliensis	25%	100%
A4HMN9	Leishmania braziliensis	83%	100%
C9ZWC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	97%
C9ZZF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AF39	Leishmania major	26%	100%
E9AF41	Leishmania major	89%	100%
E9AH88	Leishmania infantum	23%	97%
E9AHV6	Leishmania infantum	27%	100%
E9AHV8	Leishmania infantum	91%	100%
E9AX26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	99%
E9B694	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q4QAF0	Leishmania major	25%	100%
V5BJC7	Trypanosoma cruzi	27%	100%
V5BNY6	Trypanosoma cruzi	44%	100%