NAD(P)-binding protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

short chain dehydrogenase, putative

Species:

Leishmania mexicana

UniProt:

E9B694_LEIMU

TriTrypDb:

LmxM.34.2150

Length:

440

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9B694

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B694

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	396	400	PF00656	0.629
CLV_MEL_PAP_1	246	252	PF00089	0.542
CLV_NRD_NRD_1	131	133	PF00675	0.416
CLV_NRD_NRD_1	188	190	PF00675	0.376
CLV_NRD_NRD_1	27	29	PF00675	0.243
CLV_NRD_NRD_1	316	318	PF00675	0.521
CLV_PCSK_KEX2_1	130	132	PF00082	0.429
CLV_PCSK_KEX2_1	27	29	PF00082	0.243
CLV_PCSK_KEX2_1	316	318	PF00082	0.521
CLV_PCSK_KEX2_1	79	81	PF00082	0.600
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.600
CLV_PCSK_SKI1_1	27	31	PF00082	0.386
CLV_PCSK_SKI1_1	319	323	PF00082	0.613
CLV_PCSK_SKI1_1	53	57	PF00082	0.618
DEG_APCC_DBOX_1	380	388	PF00400	0.591
DEG_Nend_UBRbox_1	1	4	PF02207	0.611
DOC_CYCLIN_RxL_1	187	195	PF00134	0.234
DOC_MAPK_MEF2A_6	196	203	PF00069	0.249
DOC_PP1_RVXF_1	188	195	PF00149	0.234
DOC_PP2B_LxvP_1	218	221	PF13499	0.205
DOC_PP2B_LxvP_1	244	247	PF13499	0.367
DOC_PP4_FxxP_1	209	212	PF00568	0.213
DOC_PP4_FxxP_1	23	26	PF00568	0.386
DOC_USP7_MATH_1	281	285	PF00917	0.418
DOC_USP7_MATH_1	394	398	PF00917	0.518
DOC_USP7_UBL2_3	2	6	PF12436	0.646
DOC_WW_Pin1_4	139	144	PF00397	0.288
DOC_WW_Pin1_4	385	390	PF00397	0.577
DOC_WW_Pin1_4	399	404	PF00397	0.432
LIG_14-3-3_CanoR_1	239	245	PF00244	0.364
LIG_14-3-3_CanoR_1	249	253	PF00244	0.403
LIG_14-3-3_CanoR_1	257	266	PF00244	0.292
LIG_Actin_WH2_2	351	366	PF00022	0.196
LIG_BRCT_BRCA1_1	358	362	PF00533	0.358
LIG_BRCT_BRCA1_1	401	405	PF00533	0.478
LIG_BRCT_BRCA1_1	9	13	PF00533	0.540
LIG_BRCT_BRCA1_2	358	364	PF00533	0.358
LIG_EH1_1	299	307	PF00400	0.239
LIG_eIF4E_1	300	306	PF01652	0.260
LIG_FHA_1	214	220	PF00498	0.204
LIG_FHA_1	241	247	PF00498	0.387
LIG_FHA_2	363	369	PF00498	0.490
LIG_FHA_2	380	386	PF00498	0.574
LIG_FHA_2	394	400	PF00498	0.604
LIG_FHA_2	54	60	PF00498	0.323
LIG_GBD_Chelix_1	266	274	PF00786	0.434
LIG_LIR_Gen_1	103	109	PF02991	0.318
LIG_LIR_Gen_1	157	166	PF02991	0.210
LIG_LIR_Gen_1	356	363	PF02991	0.419
LIG_LIR_Nem_3	103	108	PF02991	0.223
LIG_LIR_Nem_3	157	162	PF02991	0.195
LIG_LIR_Nem_3	251	256	PF02991	0.423
LIG_LIR_Nem_3	356	360	PF02991	0.374
LIG_MLH1_MIPbox_1	401	405	PF16413	0.478
LIG_MLH1_MIPbox_1	9	13	PF16413	0.413
LIG_MYND_3	220	224	PF01753	0.288
LIG_NRBOX	214	220	PF00104	0.234
LIG_Pex14_2	19	23	PF04695	0.386
LIG_RPA_C_Fungi	37	49	PF08784	0.367
LIG_SH2_STAP1	105	109	PF00017	0.401
LIG_SH2_STAP1	329	333	PF00017	0.321
LIG_SH2_STAT5	139	142	PF00017	0.309
LIG_SH2_STAT5	232	235	PF00017	0.267
LIG_SH2_STAT5	404	407	PF00017	0.313
LIG_SUMO_SIM_anti_2	356	362	PF11976	0.133
LIG_SUMO_SIM_anti_2	382	388	PF11976	0.402
LIG_SUMO_SIM_par_1	211	217	PF11976	0.245
LIG_SUMO_SIM_par_1	80	86	PF11976	0.294
LIG_TRAF2_1	365	368	PF00917	0.353
LIG_UBA3_1	270	275	PF00899	0.363
LIG_UBA3_1	360	364	PF00899	0.269
LIG_WRC_WIRS_1	339	344	PF05994	0.486
MOD_CK1_1	142	148	PF00069	0.434
MOD_CK1_1	356	362	PF00069	0.254
MOD_CK1_1	7	13	PF00069	0.395
MOD_CK2_1	362	368	PF00069	0.356
MOD_CK2_1	379	385	PF00069	0.482
MOD_GlcNHglycan	112	115	PF01048	0.431
MOD_GlcNHglycan	284	287	PF01048	0.453
MOD_GlcNHglycan	389	392	PF01048	0.552
MOD_GlcNHglycan	396	399	PF01048	0.625
MOD_GSK3_1	110	117	PF00069	0.370
MOD_GSK3_1	248	255	PF00069	0.624
MOD_GSK3_1	4	11	PF00069	0.262
MOD_GSK3_1	53	60	PF00069	0.511
MOD_GSK3_1	83	90	PF00069	0.255
MOD_LATS_1	51	57	PF00433	0.405
MOD_NEK2_1	13	18	PF00069	0.282
MOD_NEK2_1	192	197	PF00069	0.307
MOD_NEK2_1	240	245	PF00069	0.536
MOD_NEK2_1	252	257	PF00069	0.538
MOD_NEK2_1	288	293	PF00069	0.451
MOD_NEK2_1	305	310	PF00069	0.461
MOD_NEK2_2	329	334	PF00069	0.309
MOD_NEK2_2	370	375	PF00069	0.330
MOD_PIKK_1	114	120	PF00454	0.297
MOD_PIKK_1	290	296	PF00454	0.482
MOD_PKA_2	248	254	PF00069	0.581
MOD_Plk_1	409	415	PF00069	0.301
MOD_Plk_1	7	13	PF00069	0.449
MOD_Plk_4	142	148	PF00069	0.297
MOD_Plk_4	240	246	PF00069	0.444
MOD_Plk_4	356	362	PF00069	0.291
MOD_Plk_4	411	417	PF00069	0.487
MOD_Plk_4	8	14	PF00069	0.190
MOD_ProDKin_1	139	145	PF00069	0.358
MOD_ProDKin_1	385	391	PF00069	0.491
MOD_ProDKin_1	399	405	PF00069	0.277
MOD_SUMO_for_1	321	324	PF00179	0.426
TRG_DiLeu_BaLyEn_6	209	214	PF01217	0.228
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.371
TRG_ENDOCYTIC_2	105	108	PF00928	0.302
TRG_ER_diArg_1	130	132	PF00400	0.318
TRG_ER_diArg_1	26	28	PF00400	0.258
TRG_ER_diArg_1	316	318	PF00400	0.405

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A078IS66	Brassica napus	24%	100%
A0A078ISJ6	Brassica napus	24%	100%
A0A0N0P2P0	Leptomonas seymouri	28%	100%
A0A0N0P2S5	Leptomonas seymouri	65%	98%
A0A0N0P2S7	Leptomonas seymouri	26%	86%
A0A0N1HZ81	Leptomonas seymouri	29%	79%
A0A0S4J1I6	Bodo saltans	24%	100%
A0A0S4JBQ4	Bodo saltans	28%	100%
A0A0S4JFU3	Bodo saltans	43%	100%
A0A1X0NVT8	Trypanosomatidae	29%	88%
A0A1X0P5Q9	Trypanosomatidae	47%	96%
A0A1X0P5W3	Trypanosomatidae	30%	99%
A0A3Q8ID46	Leishmania donovani	26%	87%
A0A3Q8IM89	Leishmania donovani	92%	100%
A0A3R7K071	Trypanosoma rangeli	28%	91%
A0A3R7K8J6	Trypanosoma rangeli	52%	100%
A0A3R7N7S2	Trypanosoma rangeli	30%	100%
A0A3S5H7D5	Leishmania donovani	29%	100%
A0A3S7X986	Leishmania donovani	27%	91%
A0A422N2B6	Trypanosoma rangeli	27%	92%
A4HDP2	Leishmania braziliensis	26%	100%
A4HDP3	Leishmania braziliensis	27%	100%
A4HMN7	Leishmania braziliensis	82%	100%
A4HMN9	Leishmania braziliensis	24%	91%
C9ZWC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	93%
C9ZWC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	88%
C9ZZF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
C9ZZF3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	95%
E9AF39	Leishmania major	91%	100%
E9AF41	Leishmania major	24%	100%
E9AH88	Leishmania infantum	29%	88%
E9AH89	Leishmania infantum	26%	87%
E9AHV6	Leishmania infantum	92%	100%
E9AHV8	Leishmania infantum	27%	91%
E9AX27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	87%
E9B696	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	91%
O74959	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
P59837	Bos taurus	29%	100%
Q08651	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
Q17QU7	Bos taurus	30%	100%
Q17QW3	Bos taurus	27%	100%
Q4QAE9	Leishmania major	28%	87%
Q4QHL1	Leishmania major	25%	100%
Q5F389	Gallus gallus	24%	100%
Q5R9W5	Pongo abelii	27%	100%
Q5SS80	Mus musculus	28%	100%
Q6RVV4	Pisum sativum	29%	100%
Q6UX07	Homo sapiens	29%	100%
Q803A8	Danio rerio	29%	100%
Q8BYK4	Mus musculus	29%	100%
Q8N5I4	Homo sapiens	27%	100%
Q8TC12	Homo sapiens	30%	100%
Q91WL8	Mus musculus	24%	100%
Q96NR8	Homo sapiens	30%	100%
Q9ERI6	Mus musculus	27%	100%
Q9HBH5	Homo sapiens	26%	100%
Q9M2E2	Arabidopsis thaliana	24%	100%
Q9NZC7	Homo sapiens	24%	100%
Q9QYF1	Mus musculus	29%	100%
Q9VLU5	Drosophila melanogaster	27%	100%
V5BAF4	Trypanosoma cruzi	31%	92%
V5BJC7	Trypanosoma cruzi	52%	100%
V5BNY6	Trypanosoma cruzi	31%	100%