Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B693_LEIMU

TriTrypDb:

LmxM.34.2140

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B693

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B693

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	8
GO:0008152	metabolic process	1	8
GO:0044238	primary metabolic process	2	8
GO:0071704	organic substance metabolic process	2	8

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	244	248	PF00656	0.565
CLV_MEL_PAP_1	217	223	PF00089	0.396
CLV_MEL_PAP_1	37	43	PF00089	0.570
CLV_NRD_NRD_1	39	41	PF00675	0.453
CLV_NRD_NRD_1	523	525	PF00675	0.557
CLV_NRD_NRD_1	537	539	PF00675	0.603
CLV_NRD_NRD_1	70	72	PF00675	0.602
CLV_PCSK_KEX2_1	39	41	PF00082	0.447
CLV_PCSK_KEX2_1	523	525	PF00082	0.512
CLV_PCSK_KEX2_1	537	539	PF00082	0.508
CLV_PCSK_KEX2_1	69	71	PF00082	0.692
CLV_PCSK_PC1ET2_1	523	525	PF00082	0.572
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.634
CLV_PCSK_SKI1_1	165	169	PF00082	0.467
CLV_PCSK_SKI1_1	177	181	PF00082	0.285
CLV_PCSK_SKI1_1	273	277	PF00082	0.477
CLV_PCSK_SKI1_1	356	360	PF00082	0.281
CLV_PCSK_SKI1_1	496	500	PF00082	0.509
CLV_Separin_Metazoa	476	480	PF03568	0.528
DEG_APCC_DBOX_1	164	172	PF00400	0.510
DEG_SPOP_SBC_1	389	393	PF00917	0.626
DOC_CKS1_1	197	202	PF01111	0.504
DOC_CYCLIN_RxL_1	174	184	PF00134	0.464
DOC_MAPK_DCC_7	347	357	PF00069	0.281
DOC_MAPK_gen_1	220	230	PF00069	0.473
DOC_MAPK_gen_1	496	505	PF00069	0.371
DOC_MAPK_gen_1	523	534	PF00069	0.573
DOC_MAPK_HePTP_8	522	534	PF00069	0.404
DOC_MAPK_MEF2A_6	223	230	PF00069	0.328
DOC_MAPK_MEF2A_6	496	505	PF00069	0.454
DOC_MAPK_MEF2A_6	525	534	PF00069	0.407
DOC_PP2B_LxvP_1	335	338	PF13499	0.360
DOC_USP7_MATH_1	18	22	PF00917	0.421
DOC_USP7_MATH_1	299	303	PF00917	0.308
DOC_USP7_MATH_1	388	392	PF00917	0.663
DOC_USP7_MATH_1	399	403	PF00917	0.725
DOC_USP7_MATH_1	441	445	PF00917	0.774
DOC_USP7_MATH_1	450	454	PF00917	0.658
DOC_WW_Pin1_4	196	201	PF00397	0.516
DOC_WW_Pin1_4	292	297	PF00397	0.325
DOC_WW_Pin1_4	384	389	PF00397	0.472
DOC_WW_Pin1_4	414	419	PF00397	0.661
LIG_14-3-3_CanoR_1	191	196	PF00244	0.538
LIG_14-3-3_CanoR_1	211	221	PF00244	0.378
LIG_14-3-3_CanoR_1	301	305	PF00244	0.301
LIG_14-3-3_CanoR_1	524	532	PF00244	0.644
LIG_APCC_ABBA_1	171	176	PF00400	0.330
LIG_APCC_ABBA_1	8	13	PF00400	0.393
LIG_BIR_II_1	1	5	PF00653	0.467
LIG_BRCT_BRCA1_1	37	41	PF00533	0.451
LIG_BRCT_BRCA1_1	452	456	PF00533	0.602
LIG_BRCT_BRCA1_2	452	458	PF00533	0.602
LIG_DLG_GKlike_1	191	198	PF00625	0.552
LIG_eIF4E_1	174	180	PF01652	0.344
LIG_eIF4E_1	28	34	PF01652	0.446
LIG_eIF4E_1	485	491	PF01652	0.441
LIG_FHA_1	113	119	PF00498	0.356
LIG_FHA_1	202	208	PF00498	0.364
LIG_FHA_1	301	307	PF00498	0.306
LIG_FHA_1	330	336	PF00498	0.413
LIG_FHA_1	473	479	PF00498	0.422
LIG_FHA_2	242	248	PF00498	0.530
LIG_FHA_2	368	374	PF00498	0.422
LIG_FHA_2	504	510	PF00498	0.464
LIG_FHA_2	531	537	PF00498	0.613
LIG_LIR_Apic_2	194	200	PF02991	0.524
LIG_LIR_Gen_1	129	138	PF02991	0.531
LIG_LIR_Gen_1	278	287	PF02991	0.366
LIG_LIR_Gen_1	516	527	PF02991	0.527
LIG_LIR_LC3C_4	224	228	PF02991	0.405
LIG_LIR_Nem_3	516	522	PF02991	0.627
LIG_LRP6_Inhibitor_1	350	356	PF00058	0.299
LIG_NRBOX	317	323	PF00104	0.281
LIG_PCNA_yPIPBox_3	183	196	PF02747	0.467
LIG_PCNA_yPIPBox_3	339	349	PF02747	0.255
LIG_PTB_Apo_2	124	131	PF02174	0.377
LIG_PTB_Phospho_1	124	130	PF10480	0.383
LIG_SH2_CRK	106	110	PF00017	0.467
LIG_SH2_SRC	507	510	PF00017	0.497
LIG_SH2_STAP1	174	178	PF00017	0.454
LIG_SH2_STAT3	234	237	PF00017	0.372
LIG_SH2_STAT5	197	200	PF00017	0.500
LIG_SH2_STAT5	240	243	PF00017	0.328
LIG_SH2_STAT5	280	283	PF00017	0.325
LIG_SH2_STAT5	348	351	PF00017	0.255
LIG_SH2_STAT5	36	39	PF00017	0.368
LIG_SH2_STAT5	494	497	PF00017	0.361
LIG_SH2_STAT5	90	93	PF00017	0.418
LIG_SH3_2	296	301	PF14604	0.362
LIG_SH3_3	293	299	PF00018	0.426
LIG_SH3_3	362	368	PF00018	0.360
LIG_SH3_3	412	418	PF00018	0.666
LIG_SUMO_SIM_anti_2	176	182	PF11976	0.409
LIG_SUMO_SIM_anti_2	382	387	PF11976	0.366
LIG_SUMO_SIM_anti_2	426	432	PF11976	0.577
LIG_SUMO_SIM_par_1	226	233	PF11976	0.337
LIG_SUMO_SIM_par_1	382	387	PF11976	0.497
LIG_TRAF2_1	468	471	PF00917	0.644
LIG_TRAF2_1	533	536	PF00917	0.633
LIG_UBA3_1	138	147	PF00899	0.477
LIG_WRC_WIRS_1	138	143	PF05994	0.514
LIG_WRC_WIRS_1	420	425	PF05994	0.447
MOD_CDK_SPK_2	414	419	PF00069	0.611
MOD_CK1_1	137	143	PF00069	0.523
MOD_CK1_1	212	218	PF00069	0.364
MOD_CK1_1	392	398	PF00069	0.671
MOD_CK2_1	137	143	PF00069	0.482
MOD_CK2_1	147	153	PF00069	0.530
MOD_CK2_1	18	24	PF00069	0.441
MOD_CK2_1	263	269	PF00069	0.450
MOD_CK2_1	367	373	PF00069	0.407
MOD_CK2_1	399	405	PF00069	0.719
MOD_CK2_1	465	471	PF00069	0.676
MOD_CK2_1	503	509	PF00069	0.444
MOD_CK2_1	523	529	PF00069	0.411
MOD_CK2_1	530	536	PF00069	0.619
MOD_GlcNHglycan	121	124	PF01048	0.423
MOD_GlcNHglycan	20	23	PF01048	0.513
MOD_GlcNHglycan	211	214	PF01048	0.402
MOD_GlcNHglycan	250	253	PF01048	0.560
MOD_GlcNHglycan	30	33	PF01048	0.494
MOD_GlcNHglycan	400	404	PF01048	0.650
MOD_GlcNHglycan	443	446	PF01048	0.717
MOD_GlcNHglycan	448	451	PF01048	0.729
MOD_GlcNHglycan	525	528	PF01048	0.575
MOD_GlcNHglycan	71	74	PF01048	0.568
MOD_GSK3_1	133	140	PF00069	0.499
MOD_GSK3_1	203	210	PF00069	0.390
MOD_GSK3_1	271	278	PF00069	0.482
MOD_GSK3_1	316	323	PF00069	0.366
MOD_GSK3_1	327	334	PF00069	0.264
MOD_GSK3_1	337	344	PF00069	0.432
MOD_GSK3_1	384	391	PF00069	0.547
MOD_GSK3_1	399	406	PF00069	0.732
MOD_GSK3_1	409	416	PF00069	0.560
MOD_GSK3_1	446	453	PF00069	0.726
MOD_GSK3_1	499	506	PF00069	0.473
MOD_GSK3_1	65	72	PF00069	0.683
MOD_LATS_1	497	503	PF00433	0.428
MOD_N-GLC_1	126	131	PF02516	0.596
MOD_N-GLC_1	28	33	PF02516	0.452
MOD_N-GLC_1	389	394	PF02516	0.603
MOD_N-GLC_1	441	446	PF02516	0.479
MOD_NEK2_1	133	138	PF00069	0.469
MOD_NEK2_1	27	32	PF00069	0.455
MOD_NEK2_1	275	280	PF00069	0.381
MOD_NEK2_1	282	287	PF00069	0.357
MOD_NEK2_1	316	321	PF00069	0.413
MOD_NEK2_1	327	332	PF00069	0.418
MOD_NEK2_1	89	94	PF00069	0.489
MOD_PIKK_1	241	247	PF00454	0.280
MOD_PIKK_1	275	281	PF00454	0.369
MOD_PIKK_1	320	326	PF00454	0.362
MOD_PIKK_1	44	50	PF00454	0.436
MOD_PK_1	4	10	PF00069	0.498
MOD_PK_1	499	505	PF00069	0.449
MOD_PK_1	528	534	PF00069	0.411
MOD_PKA_1	147	153	PF00069	0.591
MOD_PKA_1	523	529	PF00069	0.641
MOD_PKA_1	69	75	PF00069	0.504
MOD_PKA_2	190	196	PF00069	0.539
MOD_PKA_2	300	306	PF00069	0.291
MOD_PKA_2	523	529	PF00069	0.588
MOD_PKA_2	60	66	PF00069	0.618
MOD_PKA_2	69	75	PF00069	0.646
MOD_Plk_1	126	132	PF00069	0.541
MOD_Plk_1	134	140	PF00069	0.468
MOD_Plk_1	230	236	PF00069	0.369
MOD_Plk_1	528	534	PF00069	0.473
MOD_Plk_2-3	250	256	PF00069	0.540
MOD_Plk_4	113	119	PF00069	0.354
MOD_Plk_4	134	140	PF00069	0.473
MOD_Plk_4	191	197	PF00069	0.561
MOD_Plk_4	203	209	PF00069	0.389
MOD_Plk_4	271	277	PF00069	0.353
MOD_Plk_4	287	293	PF00069	0.281
MOD_Plk_4	300	306	PF00069	0.318
MOD_Plk_4	316	322	PF00069	0.150
MOD_Plk_4	426	432	PF00069	0.577
MOD_Plk_4	499	505	PF00069	0.511
MOD_ProDKin_1	196	202	PF00069	0.513
MOD_ProDKin_1	292	298	PF00069	0.325
MOD_ProDKin_1	384	390	PF00069	0.491
MOD_ProDKin_1	414	420	PF00069	0.659
MOD_SUMO_rev_2	140	149	PF00179	0.442
TRG_DiLeu_BaEn_1	176	181	PF01217	0.462
TRG_DiLeu_BaEn_2	372	378	PF01217	0.409
TRG_DiLeu_BaEn_3	472	478	PF01217	0.367
TRG_DiLeu_BaLyEn_6	174	179	PF01217	0.342
TRG_ENDOCYTIC_2	11	14	PF00928	0.361
TRG_ENDOCYTIC_2	130	133	PF00928	0.473
TRG_ENDOCYTIC_2	280	283	PF00928	0.337
TRG_ENDOCYTIC_2	519	522	PF00928	0.523
TRG_ENDOCYTIC_2	90	93	PF00928	0.396
TRG_ER_diArg_1	39	41	PF00400	0.459
TRG_ER_diArg_1	537	540	PF00400	0.659
TRG_Pf-PMV_PEXEL_1	496	500	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	537	541	PF00026	0.572

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9E6	Leptomonas seymouri	63%	100%
A0A1X0P5Q0	Trypanosomatidae	43%	100%
A0A3R7RFL4	Trypanosoma rangeli	46%	100%
A0A3S7X984	Leishmania donovani	93%	100%
A4HMN6	Leishmania braziliensis	84%	100%
C9ZZF2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AF38	Leishmania major	92%	100%
E9AHV5	Leishmania infantum	93%	100%
V5BTI6	Trypanosoma cruzi	45%	100%