Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B692_LEIMU

TriTrypDb:

LmxM.34.2130

Length:

505

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B692

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B692

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.564
CLV_MEL_PAP_1	36	42	PF00089	0.627
CLV_NRD_NRD_1	219	221	PF00675	0.689
CLV_NRD_NRD_1	36	38	PF00675	0.545
CLV_PCSK_KEX2_1	219	221	PF00082	0.689
CLV_PCSK_KEX2_1	235	237	PF00082	0.571
CLV_PCSK_KEX2_1	38	40	PF00082	0.553
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.571
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.537
DOC_CKS1_1	249	254	PF01111	0.643
DOC_CKS1_1	3	8	PF01111	0.606
DOC_MAPK_gen_1	377	385	PF00069	0.453
DOC_PP4_FxxP_1	136	139	PF00568	0.606
DOC_USP7_MATH_1	107	111	PF00917	0.642
DOC_USP7_MATH_1	139	143	PF00917	0.620
DOC_USP7_MATH_1	200	204	PF00917	0.637
DOC_USP7_MATH_1	270	274	PF00917	0.619
DOC_USP7_MATH_1	477	481	PF00917	0.580
DOC_USP7_MATH_1	494	498	PF00917	0.586
DOC_WW_Pin1_4	116	121	PF00397	0.502
DOC_WW_Pin1_4	142	147	PF00397	0.546
DOC_WW_Pin1_4	2	7	PF00397	0.713
DOC_WW_Pin1_4	248	253	PF00397	0.597
DOC_WW_Pin1_4	90	95	PF00397	0.581
LIG_14-3-3_CanoR_1	37	45	PF00244	0.552
LIG_14-3-3_CanoR_1	379	384	PF00244	0.466
LIG_APCC_ABBA_1	254	259	PF00400	0.499
LIG_BRCT_BRCA1_1	326	330	PF00533	0.612
LIG_Clathr_ClatBox_1	306	310	PF01394	0.555
LIG_deltaCOP1_diTrp_1	122	128	PF00928	0.563
LIG_deltaCOP1_diTrp_1	335	341	PF00928	0.516
LIG_FHA_1	147	153	PF00498	0.537
LIG_FHA_1	380	386	PF00498	0.501
LIG_FHA_2	112	118	PF00498	0.612
LIG_FHA_2	169	175	PF00498	0.763
LIG_FHA_2	20	26	PF00498	0.488
LIG_FHA_2	30	36	PF00498	0.424
LIG_LIR_Gen_1	145	156	PF02991	0.486
LIG_LIR_Gen_1	228	237	PF02991	0.542
LIG_LIR_Gen_1	335	343	PF02991	0.509
LIG_LIR_Nem_3	145	151	PF02991	0.496
LIG_LIR_Nem_3	228	233	PF02991	0.596
LIG_LIR_Nem_3	335	340	PF02991	0.514
LIG_LIR_Nem_3	351	357	PF02991	0.538
LIG_LIR_Nem_3	448	454	PF02991	0.543
LIG_LYPXL_yS_3	354	357	PF13949	0.509
LIG_MYND_1	9	13	PF01753	0.724
LIG_NRBOX	418	424	PF00104	0.467
LIG_NRBOX	51	57	PF00104	0.526
LIG_Pex14_1	99	103	PF04695	0.529
LIG_Pex14_2	337	341	PF04695	0.508
LIG_Pex14_2	459	463	PF04695	0.483
LIG_PTAP_UEV_1	5	10	PF05743	0.603
LIG_SH2_CRK	230	234	PF00017	0.587
LIG_SH2_NCK_1	230	234	PF00017	0.595
LIG_SH2_STAP1	230	234	PF00017	0.522
LIG_SH2_STAP1	410	414	PF00017	0.482
LIG_SH2_STAT5	31	34	PF00017	0.439
LIG_SH3_3	15	21	PF00018	0.687
LIG_SH3_3	246	252	PF00018	0.481
LIG_SH3_3	3	9	PF00018	0.658
LIG_SH3_3	483	489	PF00018	0.537
LIG_SUMO_SIM_anti_2	47	54	PF11976	0.522
LIG_SUMO_SIM_par_1	47	54	PF11976	0.582
LIG_SUMO_SIM_par_1	80	85	PF11976	0.571
LIG_TRAF2_1	241	244	PF00917	0.657
LIG_TRAF2_1	32	35	PF00917	0.561
MOD_CDK_SPK_2	116	121	PF00069	0.502
MOD_CDK_SPxxK_3	90	97	PF00069	0.515
MOD_CK1_1	111	117	PF00069	0.587
MOD_CK1_1	124	130	PF00069	0.602
MOD_CK1_1	142	148	PF00069	0.482
MOD_CK1_1	326	332	PF00069	0.588
MOD_CK1_1	394	400	PF00069	0.598
MOD_CK1_1	4	10	PF00069	0.692
MOD_CK1_1	41	47	PF00069	0.531
MOD_CK1_1	90	96	PF00069	0.762
MOD_CK2_1	111	117	PF00069	0.613
MOD_CK2_1	162	168	PF00069	0.641
MOD_CK2_1	29	35	PF00069	0.472
MOD_CK2_1	318	324	PF00069	0.667
MOD_CMANNOS	336	339	PF00535	0.508
MOD_CMANNOS	460	463	PF00535	0.493
MOD_GlcNHglycan	164	167	PF01048	0.562
MOD_GlcNHglycan	202	205	PF01048	0.740
MOD_GlcNHglycan	320	323	PF01048	0.787
MOD_GlcNHglycan	326	329	PF01048	0.626
MOD_GlcNHglycan	398	403	PF01048	0.590
MOD_GlcNHglycan	404	407	PF01048	0.594
MOD_GlcNHglycan	411	415	PF01048	0.516
MOD_GlcNHglycan	460	463	PF01048	0.484
MOD_GlcNHglycan	6	9	PF01048	0.629
MOD_GlcNHglycan	89	92	PF01048	0.635
MOD_GSK3_1	107	114	PF00069	0.595
MOD_GSK3_1	142	149	PF00069	0.585
MOD_GSK3_1	259	266	PF00069	0.666
MOD_GSK3_1	297	304	PF00069	0.614
MOD_GSK3_1	318	325	PF00069	0.644
MOD_GSK3_1	394	401	PF00069	0.594
MOD_GSK3_1	454	461	PF00069	0.664
MOD_GSK3_1	50	57	PF00069	0.588
MOD_N-GLC_1	107	112	PF02516	0.560
MOD_N-GLC_2	224	226	PF02516	0.429
MOD_NEK2_1	323	328	PF00069	0.557
MOD_NEK2_1	342	347	PF00069	0.392
MOD_NEK2_1	458	463	PF00069	0.480
MOD_NEK2_2	270	275	PF00069	0.571
MOD_NEK2_2	454	459	PF00069	0.522
MOD_PIKK_1	213	219	PF00454	0.545
MOD_PKA_1	38	44	PF00069	0.622
MOD_PKA_2	11	17	PF00069	0.680
MOD_PKA_2	162	168	PF00069	0.555
MOD_PKA_2	297	303	PF00069	0.479
MOD_PKA_2	318	324	PF00069	0.657
MOD_PKA_2	38	44	PF00069	0.622
MOD_PKB_1	377	385	PF00069	0.453
MOD_Plk_1	185	191	PF00069	0.662
MOD_Plk_1	258	264	PF00069	0.572
MOD_Plk_1	41	47	PF00069	0.561
MOD_Plk_1	445	451	PF00069	0.511
MOD_Plk_2-3	168	174	PF00069	0.604
MOD_Plk_2-3	185	191	PF00069	0.489
MOD_Plk_4	147	153	PF00069	0.566
MOD_Plk_4	264	270	PF00069	0.671
MOD_Plk_4	302	308	PF00069	0.483
MOD_Plk_4	326	332	PF00069	0.685
MOD_Plk_4	418	424	PF00069	0.467
MOD_Plk_4	454	460	PF00069	0.477
MOD_Plk_4	51	57	PF00069	0.560
MOD_ProDKin_1	116	122	PF00069	0.500
MOD_ProDKin_1	142	148	PF00069	0.546
MOD_ProDKin_1	2	8	PF00069	0.713
MOD_ProDKin_1	248	254	PF00069	0.599
MOD_ProDKin_1	90	96	PF00069	0.583
MOD_SUMO_for_1	499	502	PF00179	0.496
MOD_SUMO_rev_2	25	29	PF00179	0.556
TRG_DiLeu_BaLyEn_6	483	488	PF01217	0.533
TRG_ENDOCYTIC_2	230	233	PF00928	0.538
TRG_ENDOCYTIC_2	234	237	PF00928	0.518
TRG_ENDOCYTIC_2	354	357	PF00928	0.509
TRG_ER_diArg_1	218	220	PF00400	0.689
TRG_ER_diArg_1	36	39	PF00400	0.552
TRG_ER_diArg_1	376	379	PF00400	0.465
TRG_ER_diArg_1	59	62	PF00400	0.537
TRG_NLS_MonoExtC_3	36	42	PF00514	0.587
TRG_Pf-PMV_PEXEL_1	219	223	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSZ3	Leptomonas seymouri	47%	99%
A0A3Q8IHZ9	Leishmania donovani	84%	100%
A4HMN5	Leishmania braziliensis	66%	99%
E9AF37	Leishmania major	84%	100%
E9AHV4	Leishmania infantum	84%	100%