Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B689_LEIMU

TriTrypDb:

LmxM.34.2110

Length:

482

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B689

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B689

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	158	160	PF00675	0.752
CLV_NRD_NRD_1	178	180	PF00675	0.819
CLV_NRD_NRD_1	204	206	PF00675	0.710
CLV_PCSK_KEX2_1	177	179	PF00082	0.825
CLV_PCSK_KEX2_1	204	206	PF00082	0.710
CLV_PCSK_KEX2_1	238	240	PF00082	0.770
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.770
CLV_PCSK_SKI1_1	205	209	PF00082	0.537
CLV_PCSK_SKI1_1	321	325	PF00082	0.503
CLV_PCSK_SKI1_1	361	365	PF00082	0.422
DEG_SPOP_SBC_1	106	110	PF00917	0.691
DEG_SPOP_SBC_1	387	391	PF00917	0.491
DOC_CYCLIN_RxL_1	374	383	PF00134	0.506
DOC_MAPK_gen_1	306	313	PF00069	0.490
DOC_PP1_RVXF_1	109	116	PF00149	0.698
DOC_PP4_FxxP_1	275	278	PF00568	0.651
DOC_USP7_MATH_1	102	106	PF00917	0.644
DOC_USP7_MATH_1	197	201	PF00917	0.698
DOC_USP7_MATH_1	33	37	PF00917	0.647
DOC_USP7_MATH_1	387	391	PF00917	0.527
DOC_USP7_MATH_1	412	416	PF00917	0.725
DOC_USP7_MATH_1	470	474	PF00917	0.761
DOC_USP7_MATH_1	476	480	PF00917	0.711
DOC_WW_Pin1_4	248	253	PF00397	0.743
DOC_WW_Pin1_4	257	262	PF00397	0.617
DOC_WW_Pin1_4	267	272	PF00397	0.491
DOC_WW_Pin1_4	280	285	PF00397	0.519
DOC_WW_Pin1_4	388	393	PF00397	0.697
DOC_WW_Pin1_4	62	67	PF00397	0.569
LIG_14-3-3_CanoR_1	187	197	PF00244	0.694
LIG_14-3-3_CanoR_1	204	208	PF00244	0.542
LIG_14-3-3_CanoR_1	254	262	PF00244	0.605
LIG_14-3-3_CanoR_1	345	354	PF00244	0.477
LIG_14-3-3_CanoR_1	443	448	PF00244	0.452
LIG_14-3-3_CanoR_1	464	472	PF00244	0.661
LIG_14-3-3_CanoR_1	477	481	PF00244	0.517
LIG_14-3-3_CanoR_1	97	106	PF00244	0.540
LIG_Actin_WH2_2	364	382	PF00022	0.487
LIG_BRCT_BRCA1_1	128	132	PF00533	0.567
LIG_BRCT_BRCA1_1	35	39	PF00533	0.599
LIG_Clathr_ClatBox_1	436	440	PF01394	0.540
LIG_DLG_GKlike_1	159	166	PF00625	0.647
LIG_DLG_GKlike_1	443	451	PF00625	0.469
LIG_FHA_1	108	114	PF00498	0.697
LIG_FHA_1	272	278	PF00498	0.648
LIG_FHA_1	32	38	PF00498	0.639
LIG_FHA_1	70	76	PF00498	0.547
LIG_FHA_2	126	132	PF00498	0.687
LIG_FHA_2	261	267	PF00498	0.526
LIG_FHA_2	347	353	PF00498	0.480
LIG_IRF3_LxIS_1	4	10	PF10401	0.482
LIG_LIR_Apic_2	272	278	PF02991	0.648
LIG_LIR_Gen_1	18	29	PF02991	0.602
LIG_LIR_Nem_3	18	24	PF02991	0.589
LIG_LIR_Nem_3	235	240	PF02991	0.524
LIG_LIR_Nem_3	301	305	PF02991	0.505
LIG_LIR_Nem_3	41	47	PF02991	0.584
LIG_LYPXL_yS_3	44	47	PF13949	0.613
LIG_NRBOX	3	9	PF00104	0.548
LIG_Rb_pABgroove_1	161	169	PF01858	0.647
LIG_SH2_NCK_1	455	459	PF00017	0.671
LIG_SH2_STAP1	455	459	PF00017	0.671
LIG_SH2_STAT5	418	421	PF00017	0.503
LIG_SH2_STAT5	68	71	PF00017	0.524
LIG_SH2_STAT5	89	92	PF00017	0.543
LIG_SH3_2	249	254	PF14604	0.538
LIG_SH3_3	10	16	PF00018	0.562
LIG_SH3_3	246	252	PF00018	0.534
LIG_SH3_3	396	402	PF00018	0.586
LIG_SH3_3	43	49	PF00018	0.610
LIG_SH3_3	80	86	PF00018	0.498
LIG_SUMO_SIM_anti_2	426	431	PF11976	0.543
LIG_SUMO_SIM_anti_2	53	60	PF11976	0.643
LIG_SUMO_SIM_par_1	260	266	PF11976	0.651
LIG_TRAF2_1	349	352	PF00917	0.511
LIG_TRAF2_1	353	356	PF00917	0.438
LIG_UBA3_1	74	82	PF00899	0.519
MOD_CDC14_SPxK_1	251	254	PF00782	0.679
MOD_CDC14_SPxK_1	270	273	PF00782	0.483
MOD_CDK_SPxK_1	248	254	PF00069	0.677
MOD_CDK_SPxK_1	267	273	PF00069	0.490
MOD_CK1_1	105	111	PF00069	0.692
MOD_CK1_1	126	132	PF00069	0.687
MOD_CK1_1	162	168	PF00069	0.646
MOD_CK1_1	180	186	PF00069	0.682
MOD_CK1_1	199	205	PF00069	0.520
MOD_CK1_1	214	220	PF00069	0.603
MOD_CK1_1	260	266	PF00069	0.693
MOD_CK1_1	283	289	PF00069	0.467
MOD_CK1_1	391	397	PF00069	0.615
MOD_CK1_1	466	472	PF00069	0.592
MOD_CK2_1	125	131	PF00069	0.690
MOD_CK2_1	25	31	PF00069	0.676
MOD_CK2_1	346	352	PF00069	0.482
MOD_GlcNHglycan	100	103	PF01048	0.654
MOD_GlcNHglycan	168	171	PF01048	0.519
MOD_GlcNHglycan	192	195	PF01048	0.627
MOD_GlcNHglycan	199	202	PF01048	0.645
MOD_GlcNHglycan	216	220	PF01048	0.580
MOD_GlcNHglycan	230	233	PF01048	0.561
MOD_GlcNHglycan	240	243	PF01048	0.536
MOD_GlcNHglycan	393	396	PF01048	0.704
MOD_GlcNHglycan	405	408	PF01048	0.629
MOD_GlcNHglycan	468	471	PF01048	0.785
MOD_GlcNHglycan	472	475	PF01048	0.724
MOD_GlcNHglycan	9	12	PF01048	0.513
MOD_GSK3_1	102	109	PF00069	0.594
MOD_GSK3_1	144	151	PF00069	0.687
MOD_GSK3_1	162	169	PF00069	0.531
MOD_GSK3_1	199	206	PF00069	0.671
MOD_GSK3_1	211	218	PF00069	0.588
MOD_GSK3_1	228	235	PF00069	0.552
MOD_GSK3_1	253	260	PF00069	0.707
MOD_GSK3_1	267	274	PF00069	0.544
MOD_GSK3_1	276	283	PF00069	0.514
MOD_GSK3_1	33	40	PF00069	0.711
MOD_GSK3_1	387	394	PF00069	0.629
MOD_GSK3_1	412	419	PF00069	0.606
MOD_GSK3_1	459	466	PF00069	0.688
MOD_GSK3_1	472	479	PF00069	0.676
MOD_GSK3_1	93	100	PF00069	0.583
MOD_N-GLC_1	336	341	PF02516	0.555
MOD_NEK2_1	166	171	PF00069	0.575
MOD_NEK2_1	190	195	PF00069	0.828
MOD_NEK2_1	203	208	PF00069	0.613
MOD_NEK2_1	230	235	PF00069	0.516
MOD_NEK2_1	253	258	PF00069	0.620
MOD_NEK2_1	386	391	PF00069	0.626
MOD_NEK2_1	465	470	PF00069	0.714
MOD_NEK2_1	7	12	PF00069	0.569
MOD_NEK2_2	102	107	PF00069	0.543
MOD_NEK2_2	271	276	PF00069	0.524
MOD_PIKK_1	188	194	PF00454	0.719
MOD_PIKK_1	380	386	PF00454	0.464
MOD_PIKK_1	418	424	PF00454	0.501
MOD_PIKK_1	50	56	PF00454	0.588
MOD_PKA_1	159	165	PF00069	0.648
MOD_PKA_1	177	183	PF00069	0.745
MOD_PKA_1	238	244	PF00069	0.769
MOD_PKA_2	177	183	PF00069	0.745
MOD_PKA_2	188	194	PF00069	0.626
MOD_PKA_2	197	203	PF00069	0.505
MOD_PKA_2	211	217	PF00069	0.589
MOD_PKA_2	238	244	PF00069	0.832
MOD_PKA_2	253	259	PF00069	0.596
MOD_PKA_2	463	469	PF00069	0.591
MOD_PKA_2	476	482	PF00069	0.575
MOD_PKA_2	98	104	PF00069	0.664
MOD_Plk_1	412	418	PF00069	0.558
MOD_Plk_2-3	25	31	PF00069	0.626
MOD_Plk_4	150	156	PF00069	0.574
MOD_Plk_4	162	168	PF00069	0.694
MOD_Plk_4	33	39	PF00069	0.600
MOD_Plk_4	412	418	PF00069	0.635
MOD_Plk_4	53	59	PF00069	0.414
MOD_ProDKin_1	248	254	PF00069	0.744
MOD_ProDKin_1	257	263	PF00069	0.619
MOD_ProDKin_1	267	273	PF00069	0.492
MOD_ProDKin_1	280	286	PF00069	0.512
MOD_ProDKin_1	388	394	PF00069	0.703
MOD_ProDKin_1	62	68	PF00069	0.558
MOD_SUMO_rev_2	241	249	PF00179	0.669
TRG_DiLeu_BaLyEn_6	377	382	PF01217	0.475
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.507
TRG_ENDOCYTIC_2	360	363	PF00928	0.495
TRG_ENDOCYTIC_2	44	47	PF00928	0.613
TRG_ER_diArg_1	177	179	PF00400	0.823
TRG_ER_diArg_1	187	190	PF00400	0.684
TRG_ER_diArg_1	203	205	PF00400	0.552
TRG_ER_diArg_1	305	308	PF00400	0.489
TRG_NES_CRM1_1	426	440	PF08389	0.544
TRG_Pf-PMV_PEXEL_1	321	326	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	380	384	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X976	Leishmania donovani	89%	100%
A4HMN2	Leishmania braziliensis	75%	100%
A4IBA9	Leishmania infantum	89%	73%
E9AF34	Leishmania major	83%	94%