Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B688_LEIMU

TriTrypDb:

LmxM.34.2100

Length:

722

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B688

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B688

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.587
CLV_C14_Caspase3-7	214	218	PF00656	0.544
CLV_NRD_NRD_1	127	129	PF00675	0.539
CLV_NRD_NRD_1	164	166	PF00675	0.760
CLV_NRD_NRD_1	171	173	PF00675	0.776
CLV_NRD_NRD_1	177	179	PF00675	0.578
CLV_NRD_NRD_1	187	189	PF00675	0.774
CLV_NRD_NRD_1	223	225	PF00675	0.639
CLV_NRD_NRD_1	283	285	PF00675	0.608
CLV_NRD_NRD_1	328	330	PF00675	0.595
CLV_NRD_NRD_1	350	352	PF00675	0.606
CLV_NRD_NRD_1	379	381	PF00675	0.621
CLV_NRD_NRD_1	450	452	PF00675	0.514
CLV_NRD_NRD_1	555	557	PF00675	0.498
CLV_NRD_NRD_1	589	591	PF00675	0.684
CLV_PCSK_FUR_1	125	129	PF00082	0.533
CLV_PCSK_FUR_1	169	173	PF00082	0.780
CLV_PCSK_FUR_1	210	214	PF00082	0.779
CLV_PCSK_FUR_1	281	285	PF00082	0.640
CLV_PCSK_KEX2_1	127	129	PF00082	0.539
CLV_PCSK_KEX2_1	169	171	PF00082	0.803
CLV_PCSK_KEX2_1	187	189	PF00082	0.736
CLV_PCSK_KEX2_1	212	214	PF00082	0.784
CLV_PCSK_KEX2_1	283	285	PF00082	0.622
CLV_PCSK_KEX2_1	328	330	PF00082	0.598
CLV_PCSK_KEX2_1	350	352	PF00082	0.606
CLV_PCSK_KEX2_1	379	381	PF00082	0.621
CLV_PCSK_KEX2_1	450	452	PF00082	0.536
CLV_PCSK_KEX2_1	555	557	PF00082	0.498
CLV_PCSK_KEX2_1	589	591	PF00082	0.684
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.784
CLV_PCSK_PC7_1	165	171	PF00082	0.779
CLV_PCSK_SKI1_1	179	183	PF00082	0.836
CLV_PCSK_SKI1_1	338	342	PF00082	0.599
CLV_PCSK_SKI1_1	427	431	PF00082	0.651
CLV_PCSK_SKI1_1	434	438	PF00082	0.504
CLV_PCSK_SKI1_1	46	50	PF00082	0.602
CLV_PCSK_SKI1_1	549	553	PF00082	0.484
CLV_PCSK_SKI1_1	94	98	PF00082	0.714
DEG_APCC_DBOX_1	12	20	PF00400	0.583
DEG_APCC_DBOX_1	264	272	PF00400	0.580
DEG_SPOP_SBC_1	181	185	PF00917	0.837
DEG_SPOP_SBC_1	699	703	PF00917	0.679
DOC_CYCLIN_RxL_1	221	231	PF00134	0.635
DOC_CYCLIN_yCln2_LP_2	641	647	PF00134	0.773
DOC_MAPK_gen_1	221	229	PF00069	0.535
DOC_MAPK_gen_1	281	289	PF00069	0.594
DOC_MAPK_gen_1	291	298	PF00069	0.586
DOC_MAPK_gen_1	46	55	PF00069	0.668
DOC_MAPK_gen_1	473	482	PF00069	0.517
DOC_MAPK_gen_1	604	612	PF00069	0.649
DOC_MAPK_MEF2A_6	49	57	PF00069	0.668
DOC_PP1_RVXF_1	118	125	PF00149	0.581
DOC_PP1_RVXF_1	336	343	PF00149	0.595
DOC_PP1_RVXF_1	457	464	PF00149	0.490
DOC_PP4_FxxP_1	310	313	PF00568	0.624
DOC_PP4_FxxP_1	455	458	PF00568	0.484
DOC_USP7_MATH_1	181	185	PF00917	0.837
DOC_USP7_MATH_1	233	237	PF00917	0.785
DOC_USP7_MATH_1	432	436	PF00917	0.642
DOC_USP7_MATH_1	581	585	PF00917	0.730
DOC_USP7_MATH_1	636	640	PF00917	0.716
DOC_USP7_MATH_1	699	703	PF00917	0.751
DOC_USP7_UBL2_3	59	63	PF12436	0.584
DOC_WW_Pin1_4	132	137	PF00397	0.730
DOC_WW_Pin1_4	171	176	PF00397	0.548
DOC_WW_Pin1_4	566	571	PF00397	0.644
DOC_WW_Pin1_4	648	653	PF00397	0.788
DOC_WW_Pin1_4	679	684	PF00397	0.740
LIG_14-3-3_CanoR_1	128	137	PF00244	0.523
LIG_14-3-3_CanoR_1	13	22	PF00244	0.518
LIG_14-3-3_CanoR_1	224	230	PF00244	0.798
LIG_14-3-3_CanoR_1	235	244	PF00244	0.640
LIG_14-3-3_CanoR_1	265	269	PF00244	0.703
LIG_14-3-3_CanoR_1	414	424	PF00244	0.645
LIG_14-3-3_CanoR_1	427	432	PF00244	0.504
LIG_14-3-3_CanoR_1	604	610	PF00244	0.677
LIG_14-3-3_CanoR_1	693	699	PF00244	0.568
LIG_APCC_ABBA_1	244	249	PF00400	0.506
LIG_APCC_ABBA_1	287	292	PF00400	0.663
LIG_APCC_ABBA_1	53	58	PF00400	0.558
LIG_BIR_II_1	1	5	PF00653	0.584
LIG_BIR_III_3	1	5	PF00653	0.623
LIG_BRCT_BRCA1_1	306	310	PF00533	0.617
LIG_BRCT_BRCA1_1	459	463	PF00533	0.540
LIG_BRCT_BRCA1_1	630	634	PF00533	0.761
LIG_Clathr_ClatBox_1	295	299	PF01394	0.641
LIG_FHA_1	132	138	PF00498	0.508
LIG_FHA_1	246	252	PF00498	0.798
LIG_FHA_1	332	338	PF00498	0.557
LIG_FHA_1	586	592	PF00498	0.746
LIG_FHA_1	675	681	PF00498	0.727
LIG_FHA_2	212	218	PF00498	0.610
LIG_FHA_2	31	37	PF00498	0.592
LIG_FHA_2	416	422	PF00498	0.687
LIG_FHA_2	428	434	PF00498	0.601
LIG_FHA_2	436	442	PF00498	0.569
LIG_FHA_2	467	473	PF00498	0.518
LIG_FHA_2	714	720	PF00498	0.534
LIG_Integrin_RGD_1	240	242	PF01839	0.768
LIG_LIR_Apic_2	307	313	PF02991	0.621
LIG_LIR_Gen_1	304	314	PF02991	0.622
LIG_LIR_Gen_1	84	93	PF02991	0.643
LIG_LIR_Nem_3	304	309	PF02991	0.621
LIG_LIR_Nem_3	611	616	PF02991	0.668
LIG_LIR_Nem_3	80	86	PF02991	0.659
LIG_MLH1_MIPbox_1	306	310	PF16413	0.617
LIG_MYND_1	648	652	PF01753	0.841
LIG_NRBOX	490	496	PF00104	0.601
LIG_PCNA_PIPBox_1	311	320	PF02747	0.586
LIG_PCNA_PIPBox_1	487	496	PF02747	0.395
LIG_PDZ_Class_1	717	722	PF00595	0.764
LIG_Pex14_2	22	26	PF04695	0.547
LIG_Pex14_2	306	310	PF04695	0.617
LIG_Pex14_2	463	467	PF04695	0.477
LIG_Rb_pABgroove_1	607	615	PF01858	0.681
LIG_REV1ctd_RIR_1	307	312	PF16727	0.622
LIG_SH2_CRK	502	506	PF00017	0.517
LIG_SH2_NCK_1	323	327	PF00017	0.595
LIG_SH2_NCK_1	86	90	PF00017	0.656
LIG_SH2_STAP1	44	48	PF00017	0.364
LIG_SH2_STAT5	317	320	PF00017	0.553
LIG_SH2_STAT5	323	326	PF00017	0.554
LIG_SH2_STAT5	44	47	PF00017	0.368
LIG_SH2_STAT5	64	67	PF00017	0.523
LIG_SH2_STAT5	7	10	PF00017	0.656
LIG_SH3_3	250	256	PF00018	0.667
LIG_SH3_3	399	405	PF00018	0.518
LIG_SH3_3	575	581	PF00018	0.822
LIG_SH3_3	641	647	PF00018	0.645
LIG_SH3_3	708	714	PF00018	0.756
LIG_SUMO_SIM_anti_2	248	255	PF11976	0.634
LIG_SUMO_SIM_par_1	435	442	PF11976	0.606
LIG_SUMO_SIM_par_1	608	614	PF11976	0.681
LIG_TRAF2_1	418	421	PF00917	0.644
LIG_TRAF2_1	597	600	PF00917	0.665
LIG_TYR_ITIM	500	505	PF00017	0.573
LIG_UBA3_1	609	617	PF00899	0.714
LIG_WRC_WIRS_1	19	24	PF05994	0.671
LIG_WW_3	91	95	PF00397	0.615
MOD_CDK_SPxxK_3	171	178	PF00069	0.550
MOD_CK1_1	132	138	PF00069	0.775
MOD_CK1_1	142	148	PF00069	0.709
MOD_CK1_1	150	156	PF00069	0.633
MOD_CK1_1	18	24	PF00069	0.568
MOD_CK1_1	219	225	PF00069	0.706
MOD_CK1_1	234	240	PF00069	0.672
MOD_CK1_1	3	9	PF00069	0.562
MOD_CK1_1	416	422	PF00069	0.637
MOD_CK1_1	435	441	PF00069	0.549
MOD_CK1_1	566	572	PF00069	0.586
MOD_CK1_1	584	590	PF00069	0.798
MOD_CK1_1	702	708	PF00069	0.762
MOD_CK2_1	225	231	PF00069	0.800
MOD_CK2_1	298	304	PF00069	0.708
MOD_CK2_1	30	36	PF00069	0.587
MOD_CK2_1	390	396	PF00069	0.715
MOD_CK2_1	415	421	PF00069	0.750
MOD_CK2_1	427	433	PF00069	0.553
MOD_CK2_1	435	441	PF00069	0.549
MOD_CK2_1	713	719	PF00069	0.652
MOD_Cter_Amidation	553	556	PF01082	0.495
MOD_GlcNHglycan	2	5	PF01048	0.545
MOD_GlcNHglycan	237	240	PF01048	0.740
MOD_GlcNHglycan	324	327	PF01048	0.559
MOD_GlcNHglycan	516	519	PF01048	0.587
MOD_GlcNHglycan	564	568	PF01048	0.715
MOD_GlcNHglycan	583	586	PF01048	0.758
MOD_GlcNHglycan	619	623	PF01048	0.675
MOD_GlcNHglycan	630	633	PF01048	0.627
MOD_GlcNHglycan	657	660	PF01048	0.741
MOD_GlcNHglycan	674	677	PF01048	0.585
MOD_GlcNHglycan	696	699	PF01048	0.733
MOD_GlcNHglycan	702	705	PF01048	0.693
MOD_GSK3_1	132	139	PF00069	0.738
MOD_GSK3_1	14	21	PF00069	0.566
MOD_GSK3_1	142	149	PF00069	0.650
MOD_GSK3_1	150	157	PF00069	0.568
MOD_GSK3_1	219	226	PF00069	0.797
MOD_GSK3_1	231	238	PF00069	0.788
MOD_GSK3_1	366	373	PF00069	0.705
MOD_GSK3_1	412	419	PF00069	0.665
MOD_GSK3_1	580	587	PF00069	0.804
MOD_GSK3_1	648	655	PF00069	0.778
MOD_GSK3_1	674	681	PF00069	0.805
MOD_GSK3_1	694	701	PF00069	0.699
MOD_GSK3_1	713	720	PF00069	0.704
MOD_N-GLC_1	146	151	PF02516	0.531
MOD_N-GLC_1	655	660	PF02516	0.692
MOD_NEK2_1	129	134	PF00069	0.474
MOD_NEK2_1	370	375	PF00069	0.642
MOD_NEK2_1	390	395	PF00069	0.716
MOD_NEK2_1	618	623	PF00069	0.704
MOD_NEK2_1	672	677	PF00069	0.545
MOD_NEK2_1	694	699	PF00069	0.705
MOD_PIKK_1	173	179	PF00454	0.838
MOD_PIKK_1	182	188	PF00454	0.685
MOD_PIKK_1	331	337	PF00454	0.591
MOD_PIKK_1	416	422	PF00454	0.699
MOD_PIKK_1	650	656	PF00454	0.791
MOD_PIKK_1	713	719	PF00454	0.762
MOD_PKA_2	223	229	PF00069	0.805
MOD_PKA_2	234	240	PF00069	0.604
MOD_PKA_2	264	270	PF00069	0.699
MOD_PKA_2	413	419	PF00069	0.662
MOD_PKA_2	42	48	PF00069	0.555
MOD_Plk_1	150	156	PF00069	0.823
MOD_Plk_1	219	225	PF00069	0.532
MOD_Plk_1	412	418	PF00069	0.675
MOD_Plk_1	432	438	PF00069	0.636
MOD_Plk_2-3	245	251	PF00069	0.505
MOD_Plk_2-3	84	90	PF00069	0.698
MOD_Plk_4	15	21	PF00069	0.435
MOD_Plk_4	264	270	PF00069	0.646
MOD_Plk_4	3	9	PF00069	0.662
MOD_Plk_4	366	372	PF00069	0.621
MOD_Plk_4	432	438	PF00069	0.512
MOD_Plk_4	457	463	PF00069	0.523
MOD_Plk_4	591	597	PF00069	0.598
MOD_Plk_4	683	689	PF00069	0.677
MOD_Plk_4	84	90	PF00069	0.659
MOD_ProDKin_1	132	138	PF00069	0.734
MOD_ProDKin_1	171	177	PF00069	0.548
MOD_ProDKin_1	566	572	PF00069	0.646
MOD_ProDKin_1	648	654	PF00069	0.789
MOD_ProDKin_1	679	685	PF00069	0.741
MOD_SUMO_for_1	342	345	PF00179	0.693
MOD_SUMO_for_1	616	619	PF00179	0.710
MOD_SUMO_rev_2	31	39	PF00179	0.567
MOD_SUMO_rev_2	58	65	PF00179	0.545
TRG_DiLeu_BaEn_1	356	361	PF01217	0.713
TRG_DiLeu_BaEn_2	76	82	PF01217	0.683
TRG_ENDOCYTIC_2	317	320	PF00928	0.468
TRG_ENDOCYTIC_2	502	505	PF00928	0.513
TRG_ENDOCYTIC_2	86	89	PF00928	0.654
TRG_ER_diArg_1	124	127	PF00400	0.621
TRG_ER_diArg_1	169	172	PF00400	0.791
TRG_ER_diArg_1	187	189	PF00400	0.567
TRG_ER_diArg_1	191	194	PF00400	0.815
TRG_ER_diArg_1	281	284	PF00400	0.578
TRG_ER_diArg_1	328	330	PF00400	0.598
TRG_ER_diArg_1	349	351	PF00400	0.600
TRG_ER_diArg_1	379	381	PF00400	0.621
TRG_ER_diArg_1	589	591	PF00400	0.683
TRG_ER_diArg_1	602	605	PF00400	0.669
TRG_NLS_MonoExtC_3	164	169	PF00514	0.779
TRG_NLS_MonoExtN_4	163	170	PF00514	0.841
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4W4	Leptomonas seymouri	57%	100%
A0A3S5H7Z3	Leishmania donovani	90%	100%
A4HMN1	Leishmania braziliensis	74%	100%
A4IBA8	Leishmania infantum	90%	100%
E9AF33	Leishmania major	89%	100%