Putative kinesin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative kinesin

Gene product:

kinesin, putative

Species:

Leishmania mexicana

UniProt:

E9B687_LEIMU

TriTrypDb:

LmxM.34.2090

Length:

691

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	9
GO:0099080	supramolecular complex	2	9
GO:0099081	supramolecular polymer	3	9
GO:0099512	supramolecular fiber	4	9
GO:0099513	polymeric cytoskeletal fiber	5	9
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	3
GO:0005871	kinesin complex	3	1
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1

Expansion

Sequence features

E9B687

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B687

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	24
GO:0007018	microtubule-based movement	3	24
GO:0009987	cellular process	1	24
GO:0006810	transport	3	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	24
GO:0003774	cytoskeletal motor activity	1	24
GO:0003777	microtubule motor activity	2	24
GO:0005488	binding	1	24
GO:0005515	protein binding	2	24
GO:0005524	ATP binding	5	24
GO:0008017	microtubule binding	5	24
GO:0008092	cytoskeletal protein binding	3	24
GO:0015631	tubulin binding	4	24
GO:0017076	purine nucleotide binding	4	24
GO:0030554	adenyl nucleotide binding	5	24
GO:0032553	ribonucleotide binding	3	24
GO:0032555	purine ribonucleotide binding	4	24
GO:0032559	adenyl ribonucleotide binding	5	24
GO:0035639	purine ribonucleoside triphosphate binding	4	24
GO:0036094	small molecule binding	2	24
GO:0043167	ion binding	2	24
GO:0043168	anion binding	3	24
GO:0097159	organic cyclic compound binding	2	24
GO:0097367	carbohydrate derivative binding	2	24
GO:0140657	ATP-dependent activity	1	24
GO:1901265	nucleoside phosphate binding	3	24
GO:1901363	heterocyclic compound binding	2	24
GO:0003824	catalytic activity	1	10
GO:0016787	hydrolase activity	2	10
GO:0008574	plus-end-directed microtubule motor activity	3	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	83	87	PF00656	0.271
CLV_MEL_PAP_1	358	364	PF00089	0.212
CLV_NRD_NRD_1	216	218	PF00675	0.287
CLV_NRD_NRD_1	455	457	PF00675	0.480
CLV_NRD_NRD_1	484	486	PF00675	0.503
CLV_PCSK_KEX2_1	216	218	PF00082	0.278
CLV_PCSK_KEX2_1	455	457	PF00082	0.478
CLV_PCSK_KEX2_1	484	486	PF00082	0.505
CLV_PCSK_KEX2_1	645	647	PF00082	0.436
CLV_PCSK_PC1ET2_1	645	647	PF00082	0.436
CLV_PCSK_SKI1_1	106	110	PF00082	0.287
CLV_PCSK_SKI1_1	144	148	PF00082	0.267
CLV_PCSK_SKI1_1	16	20	PF00082	0.238
CLV_PCSK_SKI1_1	167	171	PF00082	0.233
CLV_PCSK_SKI1_1	198	202	PF00082	0.236
CLV_PCSK_SKI1_1	310	314	PF00082	0.247
CLV_PCSK_SKI1_1	367	371	PF00082	0.264
CLV_PCSK_SKI1_1	379	383	PF00082	0.190
CLV_PCSK_SKI1_1	407	411	PF00082	0.366
CLV_PCSK_SKI1_1	475	479	PF00082	0.616
CLV_PCSK_SKI1_1	539	543	PF00082	0.366
CLV_PCSK_SKI1_1	633	637	PF00082	0.459
CLV_PCSK_SKI1_1	645	649	PF00082	0.396
CLV_PCSK_SKI1_1	658	662	PF00082	0.424
DOC_CYCLIN_yClb5_NLxxxL_5	361	369	PF00134	0.268
DOC_MAPK_gen_1	144	154	PF00069	0.275
DOC_MAPK_gen_1	472	481	PF00069	0.679
DOC_MAPK_gen_1	510	518	PF00069	0.524
DOC_MAPK_MEF2A_6	147	156	PF00069	0.224
DOC_MAPK_MEF2A_6	472	481	PF00069	0.596
DOC_MAPK_MEF2A_6	8	15	PF00069	0.309
DOC_PP1_RVXF_1	419	425	PF00149	0.472
DOC_PP4_FxxP_1	297	300	PF00568	0.434
DOC_PP4_FxxP_1	373	376	PF00568	0.253
DOC_USP7_MATH_1	221	225	PF00917	0.314
DOC_USP7_MATH_1	247	251	PF00917	0.473
DOC_USP7_MATH_1	280	284	PF00917	0.464
DOC_USP7_MATH_1	444	448	PF00917	0.536
DOC_USP7_MATH_1	55	59	PF00917	0.268
DOC_USP7_MATH_1	578	582	PF00917	0.350
DOC_USP7_MATH_1	592	596	PF00917	0.407
DOC_USP7_UBL2_3	478	482	PF12436	0.532
DOC_WW_Pin1_4	384	389	PF00397	0.241
DOC_WW_Pin1_4	621	626	PF00397	0.558
LIG_14-3-3_CanoR_1	133	141	PF00244	0.265
LIG_14-3-3_CanoR_1	455	459	PF00244	0.396
LIG_14-3-3_CanoR_1	646	651	PF00244	0.526
LIG_14-3-3_CanoR_1	8	14	PF00244	0.350
LIG_Actin_WH2_2	355	372	PF00022	0.393
LIG_Actin_WH2_2	6	22	PF00022	0.253
LIG_APCC_ABBA_1	159	164	PF00400	0.227
LIG_APCC_ABBA_1	74	79	PF00400	0.240
LIG_APCC_ABBAyCdc20_2	461	467	PF00400	0.443
LIG_BIR_II_1	1	5	PF00653	0.549
LIG_BRCT_BRCA1_1	127	131	PF00533	0.253
LIG_BRCT_BRCA1_1	57	61	PF00533	0.253
LIG_BRCT_BRCA1_1	636	640	PF00533	0.411
LIG_Clathr_ClatBox_1	234	238	PF01394	0.253
LIG_Clathr_ClatBox_1	60	64	PF01394	0.376
LIG_CSK_EPIYA_1	304	308	PF00017	0.324
LIG_deltaCOP1_diTrp_1	287	292	PF00928	0.445
LIG_FHA_1	105	111	PF00498	0.213
LIG_FHA_1	306	312	PF00498	0.415
LIG_FHA_1	364	370	PF00498	0.238
LIG_FHA_1	448	454	PF00498	0.399
LIG_FHA_1	474	480	PF00498	0.570
LIG_FHA_1	533	539	PF00498	0.378
LIG_FHA_1	544	550	PF00498	0.325
LIG_FHA_1	8	14	PF00498	0.340
LIG_FHA_2	184	190	PF00498	0.183
LIG_FHA_2	390	396	PF00498	0.201
LIG_FHA_2	413	419	PF00498	0.445
LIG_FHA_2	70	76	PF00498	0.254
LIG_LIR_Apic_2	287	291	PF02991	0.654
LIG_LIR_Apic_2	295	300	PF02991	0.639
LIG_LIR_Gen_1	107	116	PF02991	0.246
LIG_LIR_Gen_1	128	139	PF02991	0.260
LIG_LIR_Gen_1	577	587	PF02991	0.396
LIG_LIR_Gen_1	62	67	PF02991	0.286
LIG_LIR_Gen_1	637	648	PF02991	0.610
LIG_LIR_Nem_3	107	111	PF02991	0.263
LIG_LIR_Nem_3	128	134	PF02991	0.254
LIG_LIR_Nem_3	354	360	PF02991	0.231
LIG_LIR_Nem_3	62	66	PF02991	0.272
LIG_LIR_Nem_3	637	643	PF02991	0.608
LIG_LIR_Nem_3	656	660	PF02991	0.600
LIG_NRBOX	364	370	PF00104	0.255
LIG_PALB2_WD40_1	635	643	PF16756	0.276
LIG_PCNA_yPIPBox_3	163	173	PF02747	0.389
LIG_Pex14_1	288	292	PF04695	0.460
LIG_Pex14_2	63	67	PF04695	0.240
LIG_SH2_CRK	433	437	PF00017	0.441
LIG_SH2_CRK	657	661	PF00017	0.478
LIG_SH2_GRB2like	534	537	PF00017	0.314
LIG_SH2_SRC	77	80	PF00017	0.278
LIG_SH2_STAP1	307	311	PF00017	0.393
LIG_SH2_STAP1	433	437	PF00017	0.475
LIG_SH2_STAP1	466	470	PF00017	0.540
LIG_SH2_STAP1	534	538	PF00017	0.316
LIG_SH2_STAP1	77	81	PF00017	0.255
LIG_SH2_STAT5	307	310	PF00017	0.189
LIG_SH2_STAT5	534	537	PF00017	0.320
LIG_SH2_STAT5	586	589	PF00017	0.525
LIG_SH2_STAT5	65	68	PF00017	0.346
LIG_SH3_2	52	57	PF14604	0.289
LIG_SH3_3	187	193	PF00018	0.251
LIG_SH3_3	49	55	PF00018	0.280
LIG_SUMO_SIM_anti_2	236	241	PF11976	0.350
LIG_SUMO_SIM_anti_2	250	255	PF11976	0.415
LIG_SUMO_SIM_anti_2	377	384	PF11976	0.240
LIG_SUMO_SIM_anti_2	513	520	PF11976	0.472
LIG_UBA3_1	504	512	PF00899	0.328
LIG_UBA3_1	584	591	PF00899	0.524
LIG_WRC_WIRS_1	60	65	PF05994	0.239
LIG_WRC_WIRS_1	647	652	PF05994	0.337
MOD_CK1_1	104	110	PF00069	0.238
MOD_CK1_1	219	225	PF00069	0.247
MOD_CK1_1	226	232	PF00069	0.219
MOD_CK1_1	325	331	PF00069	0.266
MOD_CK1_1	337	343	PF00069	0.270
MOD_CK1_1	363	369	PF00069	0.245
MOD_CK1_1	374	380	PF00069	0.250
MOD_CK1_1	447	453	PF00069	0.542
MOD_CK1_1	59	65	PF00069	0.254
MOD_CK1_1	599	605	PF00069	0.508
MOD_CK2_1	154	160	PF00069	0.234
MOD_CK2_1	348	354	PF00069	0.231
MOD_CK2_1	389	395	PF00069	0.257
MOD_CK2_1	412	418	PF00069	0.460
MOD_CK2_1	69	75	PF00069	0.279
MOD_GlcNHglycan	103	106	PF01048	0.254
MOD_GlcNHglycan	127	130	PF01048	0.240
MOD_GlcNHglycan	175	178	PF01048	0.459
MOD_GlcNHglycan	244	247	PF01048	0.508
MOD_GlcNHglycan	277	280	PF01048	0.623
MOD_GlcNHglycan	324	327	PF01048	0.255
MOD_GlcNHglycan	428	431	PF01048	0.531
MOD_GlcNHglycan	467	471	PF01048	0.575
MOD_GlcNHglycan	563	566	PF01048	0.441
MOD_GlcNHglycan	601	604	PF01048	0.390
MOD_GSK3_1	219	226	PF00069	0.255
MOD_GSK3_1	333	340	PF00069	0.277
MOD_GSK3_1	356	363	PF00069	0.248
MOD_GSK3_1	371	378	PF00069	0.252
MOD_GSK3_1	389	396	PF00069	0.218
MOD_GSK3_1	473	480	PF00069	0.589
MOD_GSK3_1	510	517	PF00069	0.471
MOD_GSK3_1	543	550	PF00069	0.336
MOD_GSK3_1	55	62	PF00069	0.235
MOD_GSK3_1	592	599	PF00069	0.462
MOD_N-GLC_1	260	265	PF02516	0.600
MOD_N-GLC_1	338	343	PF02516	0.240
MOD_N-GLC_1	363	368	PF02516	0.254
MOD_N-GLC_1	92	97	PF02516	0.239
MOD_N-GLC_2	663	665	PF02516	0.286
MOD_NEK2_1	254	259	PF00069	0.549
MOD_NEK2_1	292	297	PF00069	0.526
MOD_NEK2_1	393	398	PF00069	0.267
MOD_NEK2_1	409	414	PF00069	0.364
MOD_NEK2_1	426	431	PF00069	0.503
MOD_NEK2_1	541	546	PF00069	0.396
MOD_NEK2_1	561	566	PF00069	0.477
MOD_NEK2_1	661	666	PF00069	0.477
MOD_NEK2_2	41	46	PF00069	0.287
MOD_PIKK_1	223	229	PF00454	0.372
MOD_PIKK_1	280	286	PF00454	0.401
MOD_PIKK_1	386	392	PF00454	0.272
MOD_PIKK_1	444	450	PF00454	0.546
MOD_PIKK_1	554	560	PF00454	0.515
MOD_PIKK_1	606	612	PF00454	0.541
MOD_PIKK_1	69	75	PF00454	0.200
MOD_PKA_1	216	222	PF00069	0.309
MOD_PKA_2	216	222	PF00069	0.295
MOD_PKA_2	360	366	PF00069	0.235
MOD_PKA_2	454	460	PF00069	0.413
MOD_PKA_2	615	621	PF00069	0.607
MOD_PKA_2	7	13	PF00069	0.360
MOD_Plk_1	198	204	PF00069	0.243
MOD_Plk_1	333	339	PF00069	0.237
MOD_Plk_1	363	369	PF00069	0.243
MOD_Plk_1	393	399	PF00069	0.220
MOD_Plk_1	41	47	PF00069	0.208
MOD_Plk_1	514	520	PF00069	0.562
MOD_Plk_1	547	553	PF00069	0.389
MOD_Plk_1	596	602	PF00069	0.497
MOD_Plk_1	69	75	PF00069	0.246
MOD_Plk_1	92	98	PF00069	0.232
MOD_Plk_4	191	197	PF00069	0.255
MOD_Plk_4	292	298	PF00069	0.511
MOD_Plk_4	460	466	PF00069	0.579
MOD_Plk_4	514	520	PF00069	0.372
MOD_Plk_4	56	62	PF00069	0.247
MOD_Plk_4	580	586	PF00069	0.449
MOD_Plk_4	635	641	PF00069	0.390
MOD_Plk_4	92	98	PF00069	0.249
MOD_ProDKin_1	384	390	PF00069	0.241
MOD_ProDKin_1	621	627	PF00069	0.554
MOD_SUMO_for_1	45	48	PF00179	0.287
MOD_SUMO_rev_2	136	143	PF00179	0.263
MOD_SUMO_rev_2	533	541	PF00179	0.461
MOD_SUMO_rev_2	626	635	PF00179	0.604
TRG_DiLeu_BaEn_1	500	505	PF01217	0.482
TRG_DiLeu_BaLyEn_6	364	369	PF01217	0.268
TRG_ENDOCYTIC_2	433	436	PF00928	0.425
TRG_ENDOCYTIC_2	657	660	PF00928	0.502
TRG_ER_diArg_1	13	16	PF00400	0.243
TRG_ER_diArg_1	216	218	PF00400	0.425
TRG_ER_diArg_1	454	456	PF00400	0.466
TRG_ER_diArg_1	484	486	PF00400	0.589
TRG_NES_CRM1_1	434	446	PF08389	0.438
TRG_NLS_MonoExtC_3	674	680	PF00514	0.597
TRG_NLS_MonoExtN_4	673	679	PF00514	0.591
TRG_Pf-PMV_PEXEL_1	133	137	PF00026	0.207
TRG_Pf-PMV_PEXEL_1	456	460	PF00026	0.609
TRG_Pf-PMV_PEXEL_1	484	489	PF00026	0.613
TRG_Pf-PMV_PEXEL_1	539	543	PF00026	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P569	Leptomonas seymouri	25%	79%
A0A0N1HVM1	Leptomonas seymouri	29%	74%
A0A0N1IM30	Leptomonas seymouri	72%	99%
A0A0S4IR67	Bodo saltans	24%	88%
A0A0S4IXS6	Bodo saltans	34%	67%
A0A0S4JBC0	Bodo saltans	25%	74%
A0A0S4JN49	Bodo saltans	50%	95%
A0A1X0NJN6	Trypanosomatidae	23%	100%
A0A1X0NQ03	Trypanosomatidae	24%	83%
A0A1X0NWZ8	Trypanosomatidae	25%	93%
A0A1X0NY69	Trypanosomatidae	24%	91%
A0A1X0P5Y8	Trypanosomatidae	59%	100%
A0A3Q8IBS7	Leishmania donovani	24%	100%
A0A3Q8IG88	Leishmania donovani	91%	99%
A0A3S7WX05	Leishmania donovani	31%	78%
A0A422MZ05	Trypanosoma rangeli	57%	100%
A0A422NEF2	Trypanosoma rangeli	36%	69%
A0A422NEQ8	Trypanosoma rangeli	26%	92%
A4HAQ7	Leishmania braziliensis	27%	100%
A4HMM9	Leishmania braziliensis	75%	99%
A4HND6	Leishmania braziliensis	25%	100%
A4HZT3	Leishmania infantum	31%	78%
A4I562	Leishmania infantum	24%	100%
A4IBA7	Leishmania infantum	91%	99%
C9ZU98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	85%
C9ZVT5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	68%
C9ZZN5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AF32	Leishmania major	87%	100%
E9B0F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
Q4QBU1	Leishmania major	31%	78%
Q6FXI5	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	24%	70%
Q8J1G1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	25%	100%
V5B8X9	Trypanosoma cruzi	57%	98%
V5D733	Trypanosoma cruzi	26%	92%
V5DFA7	Trypanosoma cruzi	29%	100%