DUF4205 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4205), putative

Species:

Leishmania mexicana

UniProt:

E9B685_LEIMU

TriTrypDb:

LmxM.34.2070

Length:

706

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B685

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B685

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004843	cysteine-type deubiquitinase activity	5	7
GO:0008233	peptidase activity	3	7
GO:0008234	cysteine-type peptidase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0019783	ubiquitin-like protein peptidase activity	4	7
GO:0101005	deubiquitinase activity	5	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1990380	K48-linked deubiquitinase activity	6	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	210	214	PF00656	0.618
CLV_C14_Caspase3-7	228	232	PF00656	0.677
CLV_C14_Caspase3-7	247	251	PF00656	0.543
CLV_C14_Caspase3-7	296	300	PF00656	0.706
CLV_C14_Caspase3-7	509	513	PF00656	0.464
CLV_NRD_NRD_1	138	140	PF00675	0.675
CLV_NRD_NRD_1	172	174	PF00675	0.612
CLV_NRD_NRD_1	37	39	PF00675	0.522
CLV_NRD_NRD_1	97	99	PF00675	0.567
CLV_PCSK_KEX2_1	172	174	PF00082	0.719
CLV_PCSK_KEX2_1	291	293	PF00082	0.553
CLV_PCSK_KEX2_1	37	39	PF00082	0.522
CLV_PCSK_KEX2_1	397	399	PF00082	0.436
CLV_PCSK_KEX2_1	97	99	PF00082	0.567
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.553
CLV_PCSK_PC1ET2_1	397	399	PF00082	0.436
CLV_PCSK_SKI1_1	180	184	PF00082	0.660
CLV_PCSK_SKI1_1	346	350	PF00082	0.513
CLV_PCSK_SKI1_1	38	42	PF00082	0.635
CLV_PCSK_SKI1_1	4	8	PF00082	0.678
CLV_PCSK_SKI1_1	420	424	PF00082	0.411
CLV_PCSK_SKI1_1	476	480	PF00082	0.472
CLV_PCSK_SKI1_1	538	542	PF00082	0.436
CLV_PCSK_SKI1_1	620	624	PF00082	0.411
CLV_Separin_Metazoa	465	469	PF03568	0.389
DEG_APCC_DBOX_1	37	45	PF00400	0.632
DEG_APCC_DBOX_1	524	532	PF00400	0.513
DEG_SPOP_SBC_1	149	153	PF00917	0.547
DEG_SPOP_SBC_1	583	587	PF00917	0.383
DOC_ANK_TNKS_1	76	83	PF00023	0.571
DOC_CDC14_PxL_1	9	17	PF14671	0.682
DOC_MAPK_gen_1	190	199	PF00069	0.514
DOC_MAPK_gen_1	479	488	PF00069	0.347
DOC_MAPK_MEF2A_6	515	522	PF00069	0.436
DOC_PP1_RVXF_1	536	543	PF00149	0.389
DOC_PP1_RVXF_1	654	661	PF00149	0.436
DOC_PP2B_LxvP_1	518	521	PF13499	0.513
DOC_USP7_MATH_1	147	151	PF00917	0.643
DOC_USP7_MATH_1	243	247	PF00917	0.798
DOC_USP7_MATH_1	301	305	PF00917	0.733
DOC_USP7_MATH_1	391	395	PF00917	0.332
DOC_USP7_MATH_1	579	583	PF00917	0.428
DOC_USP7_MATH_1	62	66	PF00917	0.641
DOC_USP7_MATH_1	684	688	PF00917	0.411
DOC_USP7_MATH_1	690	694	PF00917	0.411
DOC_USP7_UBL2_3	140	144	PF12436	0.699
DOC_WW_Pin1_4	162	167	PF00397	0.580
DOC_WW_Pin1_4	258	263	PF00397	0.799
DOC_WW_Pin1_4	584	589	PF00397	0.411
LIG_14-3-3_CanoR_1	139	147	PF00244	0.714
LIG_14-3-3_CanoR_1	180	185	PF00244	0.831
LIG_14-3-3_CanoR_1	257	262	PF00244	0.648
LIG_14-3-3_CanoR_1	525	529	PF00244	0.433
LIG_14-3-3_CanoR_1	61	70	PF00244	0.650
LIG_14-3-3_CanoR_1	675	681	PF00244	0.524
LIG_Actin_WH2_2	2	18	PF00022	0.646
LIG_Actin_WH2_2	453	470	PF00022	0.436
LIG_BRCT_BRCA1_1	330	334	PF00533	0.379
LIG_BRCT_BRCA1_1	486	490	PF00533	0.513
LIG_BRCT_BRCA1_1	656	660	PF00533	0.513
LIG_FHA_1	163	169	PF00498	0.545
LIG_FHA_1	462	468	PF00498	0.492
LIG_FHA_1	525	531	PF00498	0.353
LIG_FHA_1	534	540	PF00498	0.353
LIG_FHA_1	617	623	PF00498	0.411
LIG_FHA_1	650	656	PF00498	0.515
LIG_FHA_1	99	105	PF00498	0.601
LIG_FHA_2	151	157	PF00498	0.547
LIG_FHA_2	196	202	PF00498	0.697
LIG_FHA_2	352	358	PF00498	0.389
LIG_FHA_2	407	413	PF00498	0.411
LIG_FHA_2	642	648	PF00498	0.411
LIG_FHA_2	83	89	PF00498	0.510
LIG_GBD_Chelix_1	403	411	PF00786	0.513
LIG_Integrin_isoDGR_2	513	515	PF01839	0.222
LIG_LIR_Apic_2	474	480	PF02991	0.411
LIG_LIR_Gen_1	331	340	PF02991	0.360
LIG_LIR_Gen_1	451	460	PF02991	0.411
LIG_LIR_Gen_1	487	498	PF02991	0.513
LIG_LIR_Gen_1	608	615	PF02991	0.513
LIG_LIR_Nem_3	331	337	PF02991	0.351
LIG_LIR_Nem_3	487	493	PF02991	0.513
LIG_LIR_Nem_3	495	500	PF02991	0.364
LIG_LIR_Nem_3	608	613	PF02991	0.513
LIG_NRBOX	488	494	PF00104	0.513
LIG_REV1ctd_RIR_1	539	547	PF16727	0.513
LIG_SH2_GRB2like	591	594	PF00017	0.513
LIG_SH2_NCK_1	591	595	PF00017	0.478
LIG_SH2_STAP1	387	391	PF00017	0.411
LIG_SH2_STAP1	555	559	PF00017	0.411
LIG_SH2_STAT5	392	395	PF00017	0.411
LIG_SH2_STAT5	437	440	PF00017	0.436
LIG_SH2_STAT5	591	594	PF00017	0.387
LIG_SH3_3	110	116	PF00018	0.673
LIG_SH3_3	260	266	PF00018	0.639
LIG_SH3_3	371	377	PF00018	0.411
LIG_SH3_3	594	600	PF00018	0.342
LIG_SUMO_SIM_anti_2	181	186	PF11976	0.538
LIG_SUMO_SIM_anti_2	634	639	PF11976	0.513
LIG_SUMO_SIM_par_1	420	426	PF11976	0.367
LIG_SUMO_SIM_par_1	644	654	PF11976	0.396
LIG_TRAF2_1	18	21	PF00917	0.541
LIG_TRAF2_1	459	462	PF00917	0.389
LIG_WRC_WIRS_1	485	490	PF05994	0.513
MOD_CK1_1	150	156	PF00069	0.547
MOD_CK1_1	186	192	PF00069	0.822
MOD_CK1_1	206	212	PF00069	0.737
MOD_CK1_1	229	235	PF00069	0.739
MOD_CK1_1	246	252	PF00069	0.603
MOD_CK1_1	255	261	PF00069	0.622
MOD_CK1_1	277	283	PF00069	0.675
MOD_CK1_1	320	326	PF00069	0.368
MOD_CK1_1	435	441	PF00069	0.490
MOD_CK1_1	582	588	PF00069	0.375
MOD_CK2_1	215	221	PF00069	0.734
MOD_CK2_1	291	297	PF00069	0.770
MOD_CK2_1	406	412	PF00069	0.411
MOD_CK2_1	456	462	PF00069	0.377
MOD_CK2_1	641	647	PF00069	0.457
MOD_CK2_1	82	88	PF00069	0.524
MOD_CMANNOS	602	605	PF00535	0.513
MOD_GlcNHglycan	185	188	PF01048	0.807
MOD_GlcNHglycan	241	244	PF01048	0.833
MOD_GlcNHglycan	246	249	PF01048	0.697
MOD_GlcNHglycan	282	285	PF01048	0.560
MOD_GlcNHglycan	319	322	PF01048	0.606
MOD_GlcNHglycan	330	333	PF01048	0.373
MOD_GlcNHglycan	522	525	PF01048	0.351
MOD_GlcNHglycan	567	570	PF01048	0.409
MOD_GlcNHglycan	581	584	PF01048	0.418
MOD_GlcNHglycan	631	634	PF01048	0.272
MOD_GlcNHglycan	663	666	PF01048	0.413
MOD_GlcNHglycan	692	695	PF01048	0.411
MOD_GSK3_1	135	142	PF00069	0.555
MOD_GSK3_1	147	154	PF00069	0.734
MOD_GSK3_1	202	209	PF00069	0.730
MOD_GSK3_1	211	218	PF00069	0.750
MOD_GSK3_1	225	232	PF00069	0.723
MOD_GSK3_1	235	242	PF00069	0.790
MOD_GSK3_1	251	258	PF00069	0.598
MOD_GSK3_1	276	283	PF00069	0.547
MOD_GSK3_1	423	430	PF00069	0.424
MOD_GSK3_1	448	455	PF00069	0.323
MOD_GSK3_1	484	491	PF00069	0.515
MOD_GSK3_1	503	510	PF00069	0.411
MOD_GSK3_1	520	527	PF00069	0.220
MOD_GSK3_1	579	586	PF00069	0.442
MOD_GSK3_1	676	683	PF00069	0.411
MOD_N-GLC_1	168	173	PF02516	0.663
MOD_N-GLC_1	211	216	PF02516	0.561
MOD_N-GLC_1	544	549	PF02516	0.222
MOD_N-GLC_1	592	597	PF02516	0.499
MOD_NEK2_1	168	173	PF00069	0.592
MOD_NEK2_1	202	207	PF00069	0.701
MOD_NEK2_1	253	258	PF00069	0.816
MOD_NEK2_1	317	322	PF00069	0.395
MOD_NEK2_1	340	345	PF00069	0.515
MOD_NEK2_1	40	45	PF00069	0.534
MOD_NEK2_1	423	428	PF00069	0.507
MOD_NEK2_1	467	472	PF00069	0.389
MOD_NEK2_1	488	493	PF00069	0.411
MOD_NEK2_1	533	538	PF00069	0.499
MOD_NEK2_1	589	594	PF00069	0.420
MOD_NEK2_1	629	634	PF00069	0.323
MOD_NEK2_1	651	656	PF00069	0.410
MOD_NEK2_1	680	685	PF00069	0.411
MOD_PKA_1	139	145	PF00069	0.704
MOD_PKA_1	291	297	PF00069	0.556
MOD_PKA_2	135	141	PF00069	0.551
MOD_PKA_2	291	297	PF00069	0.770
MOD_PKA_2	435	441	PF00069	0.383
MOD_PKA_2	467	473	PF00069	0.411
MOD_PKA_2	514	520	PF00069	0.399
MOD_PKA_2	524	530	PF00069	0.351
MOD_PKA_2	606	612	PF00069	0.513
MOD_PKA_2	674	680	PF00069	0.222
MOD_PKB_1	450	458	PF00069	0.323
MOD_Plk_2-3	641	647	PF00069	0.411
MOD_Plk_4	180	186	PF00069	0.542
MOD_Plk_4	423	429	PF00069	0.436
MOD_Plk_4	467	473	PF00069	0.411
MOD_Plk_4	484	490	PF00069	0.411
MOD_Plk_4	514	520	PF00069	0.416
MOD_Plk_4	598	604	PF00069	0.362
MOD_Plk_4	676	682	PF00069	0.411
MOD_Plk_4	82	88	PF00069	0.524
MOD_ProDKin_1	162	168	PF00069	0.580
MOD_ProDKin_1	258	264	PF00069	0.799
MOD_ProDKin_1	584	590	PF00069	0.411
MOD_SUMO_for_1	78	81	PF00179	0.574
MOD_SUMO_rev_2	152	162	PF00179	0.549
TRG_DiLeu_BaEn_1	100	105	PF01217	0.610
TRG_DiLeu_BaEn_1	21	26	PF01217	0.520
TRG_ENDOCYTIC_2	119	122	PF00928	0.626
TRG_ER_diArg_1	172	175	PF00400	0.551
TRG_ER_diArg_1	449	452	PF00400	0.443
TRG_ER_diArg_1	97	99	PF00400	0.567
TRG_NES_CRM1_1	84	96	PF08389	0.521
TRG_Pf-PMV_PEXEL_1	61	66	PF00026	0.642
TRG_Pf-PMV_PEXEL_1	620	624	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	97	102	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILT4	Leptomonas seymouri	53%	100%
A0A3S7X9A6	Leishmania donovani	89%	100%
A4HMM7	Leishmania braziliensis	77%	99%
A4IBA5	Leishmania infantum	88%	100%
E9AF29	Leishmania major	89%	99%