SH3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Variant SH3 domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B684_LEIMU

TriTrypDb:

LmxM.34.2060

Length:

482

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B684

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B684

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.730
CLV_C14_Caspase3-7	400	404	PF00656	0.711
CLV_C14_Caspase3-7	438	442	PF00656	0.767
CLV_NRD_NRD_1	302	304	PF00675	0.341
CLV_NRD_NRD_1	316	318	PF00675	0.344
CLV_NRD_NRD_1	446	448	PF00675	0.736
CLV_NRD_NRD_1	451	453	PF00675	0.766
CLV_NRD_NRD_1	5	7	PF00675	0.813
CLV_NRD_NRD_1	8	10	PF00675	0.762
CLV_PCSK_FUR_1	314	318	PF00082	0.333
CLV_PCSK_FUR_1	6	10	PF00082	0.714
CLV_PCSK_KEX2_1	302	304	PF00082	0.357
CLV_PCSK_KEX2_1	316	318	PF00082	0.357
CLV_PCSK_KEX2_1	446	448	PF00082	0.797
CLV_PCSK_KEX2_1	450	452	PF00082	0.785
CLV_PCSK_KEX2_1	5	7	PF00082	0.762
CLV_PCSK_KEX2_1	8	10	PF00082	0.762
CLV_PCSK_PC7_1	446	452	PF00082	0.736
CLV_PCSK_SKI1_1	140	144	PF00082	0.475
CLV_PCSK_SKI1_1	317	321	PF00082	0.357
CLV_PCSK_SKI1_1	425	429	PF00082	0.778
DEG_Nend_UBRbox_3	1	3	PF02207	0.523
DOC_CKS1_1	392	397	PF01111	0.699
DOC_CKS1_1	99	104	PF01111	0.587
DOC_PP2B_LxvP_1	129	132	PF13499	0.502
DOC_PP4_FxxP_1	222	225	PF00568	0.736
DOC_USP7_MATH_1	115	119	PF00917	0.763
DOC_USP7_MATH_1	125	129	PF00917	0.668
DOC_USP7_MATH_1	228	232	PF00917	0.795
DOC_USP7_MATH_1	460	464	PF00917	0.723
DOC_USP7_MATH_2	395	401	PF00917	0.711
DOC_WW_Pin1_4	121	126	PF00397	0.711
DOC_WW_Pin1_4	18	23	PF00397	0.521
DOC_WW_Pin1_4	194	199	PF00397	0.391
DOC_WW_Pin1_4	391	396	PF00397	0.692
DOC_WW_Pin1_4	98	103	PF00397	0.570
LIG_14-3-3_CanoR_1	153	159	PF00244	0.678
LIG_14-3-3_CanoR_1	16	22	PF00244	0.529
LIG_14-3-3_CanoR_1	193	198	PF00244	0.357
LIG_14-3-3_CanoR_1	340	345	PF00244	0.573
LIG_14-3-3_CanoR_1	413	418	PF00244	0.747
LIG_14-3-3_CanoR_1	429	435	PF00244	0.722
LIG_14-3-3_CanoR_1	461	465	PF00244	0.741
LIG_BIR_III_2	245	249	PF00653	0.625
LIG_BRCT_BRCA1_1	346	350	PF00533	0.594
LIG_FHA_1	137	143	PF00498	0.571
LIG_FHA_1	266	272	PF00498	0.561
LIG_FHA_1	377	383	PF00498	0.611
LIG_FHA_1	426	432	PF00498	0.726
LIG_FHA_1	468	474	PF00498	0.439
LIG_FHA_1	47	53	PF00498	0.610
LIG_FHA_2	378	384	PF00498	0.630
LIG_FHA_2	392	398	PF00498	0.615
LIG_FHA_2	436	442	PF00498	0.787
LIG_FHA_2	464	470	PF00498	0.748
LIG_Integrin_RGD_1	452	454	PF01839	0.533
LIG_LIR_Apic_2	322	327	PF02991	0.556
LIG_LIR_Gen_1	383	392	PF02991	0.597
LIG_LIR_Gen_1	66	75	PF02991	0.438
LIG_LIR_Nem_3	383	388	PF02991	0.597
LIG_LIR_Nem_3	66	70	PF02991	0.399
LIG_LIR_Nem_3	92	98	PF02991	0.497
LIG_Pex14_2	266	270	PF04695	0.619
LIG_SH2_CRK	324	328	PF00017	0.561
LIG_SH2_NCK_1	324	328	PF00017	0.561
LIG_SH2_STAP1	171	175	PF00017	0.391
LIG_SH2_STAP1	345	349	PF00017	0.634
LIG_SH2_STAP1	351	355	PF00017	0.528
LIG_SH2_STAT3	161	164	PF00017	0.662
LIG_SH2_STAT3	171	174	PF00017	0.438
LIG_SH2_STAT5	324	327	PF00017	0.612
LIG_SH2_STAT5	374	377	PF00017	0.627
LIG_SH2_STAT5	98	101	PF00017	0.558
LIG_SH3_3	96	102	PF00018	0.494
LIG_TRAF2_1	247	250	PF00917	0.530
LIG_TYR_ITIM	65	70	PF00017	0.438
MOD_CK1_1	119	125	PF00069	0.757
MOD_CK1_1	18	24	PF00069	0.548
MOD_CK1_1	231	237	PF00069	0.743
MOD_CK1_1	322	328	PF00069	0.555
MOD_CK1_1	396	402	PF00069	0.758
MOD_CK1_1	455	461	PF00069	0.804
MOD_CK1_1	463	469	PF00069	0.634
MOD_CK2_1	174	180	PF00069	0.228
MOD_CK2_1	391	397	PF00069	0.774
MOD_CK2_1	4	10	PF00069	0.598
MOD_Cter_Amidation	314	317	PF01082	0.369
MOD_GlcNHglycan	125	128	PF01048	0.744
MOD_GlcNHglycan	206	209	PF01048	0.380
MOD_GlcNHglycan	22	25	PF01048	0.698
MOD_GlcNHglycan	230	234	PF01048	0.797
MOD_GlcNHglycan	351	354	PF01048	0.407
MOD_GlcNHglycan	399	402	PF01048	0.710
MOD_GlcNHglycan	91	94	PF01048	0.562
MOD_GSK3_1	115	122	PF00069	0.675
MOD_GSK3_1	12	19	PF00069	0.808
MOD_GSK3_1	265	272	PF00069	0.570
MOD_GSK3_1	340	347	PF00069	0.579
MOD_GSK3_1	349	356	PF00069	0.526
MOD_GSK3_1	393	400	PF00069	0.744
MOD_GSK3_1	42	49	PF00069	0.694
MOD_GSK3_1	421	428	PF00069	0.689
MOD_GSK3_1	430	437	PF00069	0.661
MOD_GSK3_1	463	470	PF00069	0.462
MOD_GSK3_1	51	58	PF00069	0.638
MOD_GSK3_1	83	90	PF00069	0.379
MOD_N-GLC_1	278	283	PF02516	0.456
MOD_N-GLC_1	322	327	PF02516	0.530
MOD_N-GLC_1	83	88	PF02516	0.438
MOD_NEK2_1	147	152	PF00069	0.545
MOD_NEK2_1	154	159	PF00069	0.602
MOD_NEK2_1	4	9	PF00069	0.721
MOD_NEK2_1	412	417	PF00069	0.755
MOD_NEK2_2	309	314	PF00069	0.391
MOD_NEK2_2	345	350	PF00069	0.506
MOD_PKA_2	136	142	PF00069	0.694
MOD_PKA_2	15	21	PF00069	0.590
MOD_PKA_2	192	198	PF00069	0.357
MOD_PKA_2	237	243	PF00069	0.794
MOD_PKA_2	4	10	PF00069	0.714
MOD_PKA_2	412	418	PF00069	0.793
MOD_PKA_2	455	461	PF00069	0.785
MOD_PKB_1	450	458	PF00069	0.529
MOD_Plk_1	116	122	PF00069	0.486
MOD_Plk_1	179	185	PF00069	0.438
MOD_Plk_1	278	284	PF00069	0.415
MOD_Plk_1	322	328	PF00069	0.528
MOD_Plk_1	404	410	PF00069	0.774
MOD_Plk_1	73	79	PF00069	0.389
MOD_Plk_4	345	351	PF00069	0.632
MOD_Plk_4	430	436	PF00069	0.691
MOD_Plk_4	460	466	PF00069	0.731
MOD_ProDKin_1	121	127	PF00069	0.713
MOD_ProDKin_1	18	24	PF00069	0.519
MOD_ProDKin_1	194	200	PF00069	0.391
MOD_ProDKin_1	391	397	PF00069	0.696
MOD_ProDKin_1	98	104	PF00069	0.580
MOD_SUMO_rev_2	50	58	PF00179	0.691
TRG_ENDOCYTIC_2	67	70	PF00928	0.438
TRG_ER_diArg_1	302	304	PF00400	0.358
TRG_ER_diArg_1	313	316	PF00400	0.360
TRG_ER_diArg_1	4	6	PF00400	0.809
TRG_ER_diArg_1	446	448	PF00400	0.794
TRG_ER_diArg_1	450	452	PF00400	0.774
TRG_NES_CRM1_1	381	391	PF08389	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZT1	Leptomonas seymouri	53%	100%
A0A0S4JH24	Bodo saltans	36%	100%
A0A3Q8IJ10	Leishmania donovani	89%	100%
A0A422NNS8	Trypanosoma rangeli	43%	100%
A4HMM6	Leishmania braziliensis	70%	99%
A4IBA4	Leishmania infantum	89%	100%
E9AF28	Leishmania major	86%	100%