LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B678_LEIMU
TriTrypDb:
LmxM.34.2000
Length:
914

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B678
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B678

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 621 625 PF00656 0.595
CLV_NRD_NRD_1 15 17 PF00675 0.566
CLV_NRD_NRD_1 217 219 PF00675 0.601
CLV_NRD_NRD_1 3 5 PF00675 0.555
CLV_NRD_NRD_1 354 356 PF00675 0.358
CLV_NRD_NRD_1 436 438 PF00675 0.697
CLV_NRD_NRD_1 565 567 PF00675 0.683
CLV_NRD_NRD_1 643 645 PF00675 0.543
CLV_NRD_NRD_1 658 660 PF00675 0.542
CLV_NRD_NRD_1 777 779 PF00675 0.521
CLV_NRD_NRD_1 871 873 PF00675 0.576
CLV_PCSK_FUR_1 352 356 PF00082 0.538
CLV_PCSK_FUR_1 434 438 PF00082 0.686
CLV_PCSK_KEX2_1 15 17 PF00082 0.628
CLV_PCSK_KEX2_1 217 219 PF00082 0.596
CLV_PCSK_KEX2_1 3 5 PF00082 0.489
CLV_PCSK_KEX2_1 354 356 PF00082 0.545
CLV_PCSK_KEX2_1 436 438 PF00082 0.694
CLV_PCSK_KEX2_1 565 567 PF00082 0.635
CLV_PCSK_KEX2_1 585 587 PF00082 0.507
CLV_PCSK_KEX2_1 658 660 PF00082 0.535
CLV_PCSK_KEX2_1 776 778 PF00082 0.524
CLV_PCSK_KEX2_1 871 873 PF00082 0.576
CLV_PCSK_PC1ET2_1 585 587 PF00082 0.602
CLV_PCSK_PC7_1 773 779 PF00082 0.599
CLV_PCSK_SKI1_1 18 22 PF00082 0.635
CLV_PCSK_SKI1_1 241 245 PF00082 0.529
CLV_PCSK_SKI1_1 256 260 PF00082 0.440
CLV_PCSK_SKI1_1 565 569 PF00082 0.680
CLV_PCSK_SKI1_1 589 593 PF00082 0.551
CLV_PCSK_SKI1_1 685 689 PF00082 0.494
CLV_PCSK_SKI1_1 851 855 PF00082 0.633
CLV_PCSK_SKI1_1 87 91 PF00082 0.807
CLV_PCSK_SKI1_1 97 101 PF00082 0.568
DEG_APCC_DBOX_1 684 692 PF00400 0.496
DEG_COP1_1 442 452 PF00400 0.545
DEG_Nend_Nbox_1 1 3 PF02207 0.564
DEG_SCF_FBW7_2 88 94 PF00400 0.639
DEG_SPOP_SBC_1 43 47 PF00917 0.498
DEG_SPOP_SBC_1 573 577 PF00917 0.678
DEG_SPOP_SBC_1 743 747 PF00917 0.695
DOC_ANK_TNKS_1 802 809 PF00023 0.566
DOC_CDC14_PxL_1 717 725 PF14671 0.494
DOC_CKS1_1 736 741 PF01111 0.571
DOC_CKS1_1 88 93 PF01111 0.688
DOC_CYCLIN_yClb3_PxF_3 322 328 PF00134 0.583
DOC_MAPK_gen_1 644 652 PF00069 0.570
DOC_MAPK_gen_1 668 676 PF00069 0.549
DOC_MAPK_gen_1 773 781 PF00069 0.603
DOC_MAPK_MEF2A_6 230 239 PF00069 0.577
DOC_MAPK_MEF2A_6 304 313 PF00069 0.469
DOC_MAPK_MEF2A_6 644 652 PF00069 0.601
DOC_MAPK_MEF2A_6 698 707 PF00069 0.516
DOC_MAPK_NFAT4_5 645 653 PF00069 0.605
DOC_PP1_RVXF_1 352 359 PF00149 0.530
DOC_PP2B_LxvP_1 547 550 PF13499 0.630
DOC_PP2B_LxvP_1 74 77 PF13499 0.610
DOC_USP7_MATH_1 122 126 PF00917 0.434
DOC_USP7_MATH_1 160 164 PF00917 0.644
DOC_USP7_MATH_1 228 232 PF00917 0.565
DOC_USP7_MATH_1 263 267 PF00917 0.575
DOC_USP7_MATH_1 282 286 PF00917 0.373
DOC_USP7_MATH_1 288 292 PF00917 0.447
DOC_USP7_MATH_1 43 47 PF00917 0.627
DOC_USP7_MATH_1 48 52 PF00917 0.595
DOC_USP7_MATH_1 573 577 PF00917 0.628
DOC_USP7_MATH_1 604 608 PF00917 0.660
DOC_USP7_MATH_1 75 79 PF00917 0.656
DOC_USP7_MATH_1 852 856 PF00917 0.562
DOC_USP7_UBL2_3 585 589 PF12436 0.664
DOC_WW_Pin1_4 151 156 PF00397 0.468
DOC_WW_Pin1_4 203 208 PF00397 0.516
DOC_WW_Pin1_4 24 29 PF00397 0.627
DOC_WW_Pin1_4 333 338 PF00397 0.620
DOC_WW_Pin1_4 439 444 PF00397 0.576
DOC_WW_Pin1_4 52 57 PF00397 0.581
DOC_WW_Pin1_4 66 71 PF00397 0.587
DOC_WW_Pin1_4 735 740 PF00397 0.701
DOC_WW_Pin1_4 792 797 PF00397 0.545
DOC_WW_Pin1_4 833 838 PF00397 0.673
DOC_WW_Pin1_4 87 92 PF00397 0.691
LIG_14-3-3_CanoR_1 180 184 PF00244 0.613
LIG_14-3-3_CanoR_1 209 216 PF00244 0.557
LIG_14-3-3_CanoR_1 230 235 PF00244 0.564
LIG_14-3-3_CanoR_1 267 271 PF00244 0.533
LIG_14-3-3_CanoR_1 354 359 PF00244 0.450
LIG_14-3-3_CanoR_1 644 649 PF00244 0.507
LIG_14-3-3_CanoR_1 716 721 PF00244 0.539
LIG_14-3-3_CanoR_1 851 857 PF00244 0.569
LIG_Actin_WH2_2 194 211 PF00022 0.605
LIG_Actin_WH2_2 495 512 PF00022 0.567
LIG_Actin_WH2_2 669 687 PF00022 0.550
LIG_Actin_WH2_2 895 910 PF00022 0.475
LIG_BIR_III_4 271 275 PF00653 0.446
LIG_BRCT_BRCA1_1 162 166 PF00533 0.550
LIG_BRCT_BRCA1_1 444 448 PF00533 0.560
LIG_CaM_NSCaTE_8 242 249 PF13499 0.326
LIG_CaM_NSCaTE_8 342 349 PF13499 0.480
LIG_CtBP_PxDLS_1 704 709 PF00389 0.575
LIG_deltaCOP1_diTrp_1 157 161 PF00928 0.647
LIG_deltaCOP1_diTrp_1 305 312 PF00928 0.458
LIG_eIF4E_1 717 723 PF01652 0.496
LIG_FHA_1 209 215 PF00498 0.417
LIG_FHA_1 304 310 PF00498 0.609
LIG_FHA_1 389 395 PF00498 0.529
LIG_FHA_1 551 557 PF00498 0.787
LIG_FHA_1 633 639 PF00498 0.466
LIG_FHA_1 717 723 PF00498 0.528
LIG_FHA_1 828 834 PF00498 0.643
LIG_FHA_1 859 865 PF00498 0.614
LIG_FHA_1 907 913 PF00498 0.550
LIG_FHA_2 396 402 PF00498 0.409
LIG_FHA_2 45 51 PF00498 0.493
LIG_FHA_2 517 523 PF00498 0.603
LIG_FHA_2 553 559 PF00498 0.497
LIG_FHA_2 596 602 PF00498 0.418
LIG_FHA_2 762 768 PF00498 0.565
LIG_FHA_2 816 822 PF00498 0.689
LIG_GBD_Chelix_1 420 428 PF00786 0.492
LIG_LIR_Gen_1 305 315 PF02991 0.462
LIG_LIR_Gen_1 725 734 PF02991 0.523
LIG_LIR_Nem_3 104 109 PF02991 0.525
LIG_LIR_Nem_3 305 311 PF02991 0.461
LIG_LIR_Nem_3 477 482 PF02991 0.491
LIG_LIR_Nem_3 714 720 PF02991 0.504
LIG_LIR_Nem_3 725 730 PF02991 0.503
LIG_MYND_1 323 327 PF01753 0.556
LIG_MYND_1 38 42 PF01753 0.489
LIG_NRBOX 126 132 PF00104 0.585
LIG_NRBOX 462 468 PF00104 0.485
LIG_NRBOX 485 491 PF00104 0.401
LIG_NRBOX 633 639 PF00104 0.487
LIG_NRBOX 687 693 PF00104 0.508
LIG_PAM2_1 785 797 PF00658 0.484
LIG_SH2_CRK 718 722 PF00017 0.500
LIG_SH2_NCK_1 496 500 PF00017 0.532
LIG_SH2_NCK_1 859 863 PF00017 0.571
LIG_SH2_STAP1 459 463 PF00017 0.397
LIG_SH2_STAP1 496 500 PF00017 0.532
LIG_SH2_STAT5 465 468 PF00017 0.404
LIG_SH2_STAT5 479 482 PF00017 0.447
LIG_SH2_STAT5 696 699 PF00017 0.622
LIG_SH2_STAT5 718 721 PF00017 0.504
LIG_SH2_STAT5 727 730 PF00017 0.511
LIG_SH3_1 85 91 PF00018 0.633
LIG_SH3_3 201 207 PF00018 0.415
LIG_SH3_3 23 29 PF00018 0.568
LIG_SH3_3 232 238 PF00018 0.599
LIG_SH3_3 320 326 PF00018 0.608
LIG_SH3_3 432 438 PF00018 0.625
LIG_SH3_3 649 655 PF00018 0.598
LIG_SH3_3 727 733 PF00018 0.666
LIG_SH3_3 752 758 PF00018 0.557
LIG_SH3_3 811 817 PF00018 0.704
LIG_SH3_3 831 837 PF00018 0.582
LIG_SH3_3 85 91 PF00018 0.646
LIG_SH3_3 899 905 PF00018 0.668
LIG_SUMO_SIM_anti_2 485 491 PF11976 0.292
LIG_SUMO_SIM_anti_2 60 69 PF11976 0.636
LIG_SUMO_SIM_par_1 635 643 PF11976 0.508
LIG_SUMO_SIM_par_1 880 886 PF11976 0.682
LIG_TRAF2_1 91 94 PF00917 0.637
LIG_TYR_ITIM 715 720 PF00017 0.503
LIG_UBA3_1 637 645 PF00899 0.522
MOD_CDC14_SPxK_1 206 209 PF00782 0.573
MOD_CDC14_SPxK_1 795 798 PF00782 0.497
MOD_CDK_SPxK_1 203 209 PF00069 0.589
MOD_CDK_SPxK_1 792 798 PF00069 0.497
MOD_CDK_SPxxK_3 833 840 PF00069 0.586
MOD_CK1_1 254 260 PF00069 0.542
MOD_CK1_1 266 272 PF00069 0.354
MOD_CK1_1 27 33 PF00069 0.629
MOD_CK1_1 442 448 PF00069 0.575
MOD_CK1_1 475 481 PF00069 0.588
MOD_CK1_1 491 497 PF00069 0.353
MOD_CK1_1 66 72 PF00069 0.653
MOD_CK1_1 745 751 PF00069 0.683
MOD_CK1_1 822 828 PF00069 0.798
MOD_CK1_1 855 861 PF00069 0.612
MOD_CK2_1 120 126 PF00069 0.552
MOD_CK2_1 129 135 PF00069 0.532
MOD_CK2_1 395 401 PF00069 0.418
MOD_CK2_1 44 50 PF00069 0.532
MOD_CK2_1 516 522 PF00069 0.710
MOD_CK2_1 535 541 PF00069 0.377
MOD_CK2_1 552 558 PF00069 0.493
MOD_CK2_1 595 601 PF00069 0.418
MOD_CK2_1 633 639 PF00069 0.502
MOD_CK2_1 761 767 PF00069 0.578
MOD_CK2_1 801 807 PF00069 0.561
MOD_CMANNOS 158 161 PF00535 0.472
MOD_Cter_Amidation 583 586 PF01082 0.619
MOD_GlcNHglycan 162 165 PF01048 0.555
MOD_GlcNHglycan 230 233 PF01048 0.677
MOD_GlcNHglycan 318 321 PF01048 0.526
MOD_GlcNHglycan 343 346 PF01048 0.598
MOD_GlcNHglycan 347 350 PF01048 0.668
MOD_GlcNHglycan 370 373 PF01048 0.609
MOD_GlcNHglycan 439 442 PF01048 0.688
MOD_GlcNHglycan 469 472 PF01048 0.484
MOD_GlcNHglycan 752 755 PF01048 0.711
MOD_GlcNHglycan 77 80 PF01048 0.656
MOD_GlcNHglycan 785 790 PF01048 0.486
MOD_GlcNHglycan 803 806 PF01048 0.651
MOD_GlcNHglycan 823 827 PF01048 0.687
MOD_GlcNHglycan 885 888 PF01048 0.686
MOD_GSK3_1 24 31 PF00069 0.661
MOD_GSK3_1 280 287 PF00069 0.607
MOD_GSK3_1 303 310 PF00069 0.503
MOD_GSK3_1 341 348 PF00069 0.517
MOD_GSK3_1 44 51 PF00069 0.628
MOD_GSK3_1 444 451 PF00069 0.628
MOD_GSK3_1 484 491 PF00069 0.471
MOD_GSK3_1 550 557 PF00069 0.636
MOD_GSK3_1 640 647 PF00069 0.545
MOD_GSK3_1 742 749 PF00069 0.711
MOD_GSK3_1 815 822 PF00069 0.779
MOD_GSK3_1 847 854 PF00069 0.555
MOD_GSK3_1 883 890 PF00069 0.634
MOD_GSK3_1 906 913 PF00069 0.514
MOD_N-GLC_2 606 608 PF02516 0.433
MOD_NEK2_1 166 171 PF00069 0.512
MOD_NEK2_1 208 213 PF00069 0.561
MOD_NEK2_1 280 285 PF00069 0.514
MOD_NEK2_1 313 318 PF00069 0.498
MOD_NEK2_1 395 400 PF00069 0.451
MOD_NEK2_1 402 407 PF00069 0.390
MOD_NEK2_1 466 471 PF00069 0.421
MOD_NEK2_1 488 493 PF00069 0.445
MOD_NEK2_1 498 503 PF00069 0.486
MOD_NEK2_1 574 579 PF00069 0.523
MOD_NEK2_1 633 638 PF00069 0.506
MOD_NEK2_1 640 645 PF00069 0.564
MOD_NEK2_1 703 708 PF00069 0.482
MOD_NEK2_1 722 727 PF00069 0.505
MOD_NEK2_1 787 792 PF00069 0.555
MOD_NEK2_1 847 852 PF00069 0.518
MOD_NEK2_2 92 97 PF00069 0.532
MOD_OFUCOSY 602 608 PF10250 0.426
MOD_PIKK_1 222 228 PF00454 0.601
MOD_PIKK_1 313 319 PF00454 0.510
MOD_PIKK_1 395 401 PF00454 0.418
MOD_PIKK_1 488 494 PF00454 0.474
MOD_PIKK_1 698 704 PF00454 0.502
MOD_PKA_1 354 360 PF00069 0.524
MOD_PKA_1 644 650 PF00069 0.565
MOD_PKA_2 179 185 PF00069 0.479
MOD_PKA_2 208 214 PF00069 0.612
MOD_PKA_2 266 272 PF00069 0.475
MOD_PKA_2 303 309 PF00069 0.600
MOD_PKA_2 354 360 PF00069 0.443
MOD_PKA_2 380 386 PF00069 0.478
MOD_PKA_2 475 481 PF00069 0.540
MOD_PKB_1 16 24 PF00069 0.660
MOD_PKB_1 352 360 PF00069 0.337
MOD_Plk_1 263 269 PF00069 0.538
MOD_Plk_1 484 490 PF00069 0.447
MOD_Plk_1 595 601 PF00069 0.431
MOD_Plk_1 662 668 PF00069 0.553
MOD_Plk_2-3 595 601 PF00069 0.431
MOD_Plk_2-3 618 624 PF00069 0.597
MOD_Plk_2-3 761 767 PF00069 0.578
MOD_Plk_4 115 121 PF00069 0.426
MOD_Plk_4 241 247 PF00069 0.528
MOD_Plk_4 303 309 PF00069 0.488
MOD_Plk_4 444 450 PF00069 0.586
MOD_Plk_4 475 481 PF00069 0.551
MOD_Plk_4 484 490 PF00069 0.457
MOD_Plk_4 491 497 PF00069 0.388
MOD_Plk_4 498 504 PF00069 0.414
MOD_Plk_4 595 601 PF00069 0.431
MOD_Plk_4 633 639 PF00069 0.487
MOD_Plk_4 687 693 PF00069 0.508
MOD_Plk_4 703 709 PF00069 0.497
MOD_Plk_4 722 728 PF00069 0.491
MOD_ProDKin_1 151 157 PF00069 0.469
MOD_ProDKin_1 203 209 PF00069 0.509
MOD_ProDKin_1 24 30 PF00069 0.628
MOD_ProDKin_1 333 339 PF00069 0.619
MOD_ProDKin_1 439 445 PF00069 0.573
MOD_ProDKin_1 52 58 PF00069 0.581
MOD_ProDKin_1 66 72 PF00069 0.589
MOD_ProDKin_1 735 741 PF00069 0.704
MOD_ProDKin_1 792 798 PF00069 0.547
MOD_ProDKin_1 833 839 PF00069 0.668
MOD_ProDKin_1 87 93 PF00069 0.691
MOD_SUMO_for_1 591 594 PF00179 0.430
MOD_SUMO_rev_2 836 842 PF00179 0.464
TRG_DiLeu_BaEn_1 126 131 PF01217 0.513
TRG_DiLeu_BaEn_4 595 601 PF01217 0.556
TRG_DiLeu_BaLyEn_6 235 240 PF01217 0.491
TRG_DiLeu_BaLyEn_6 371 376 PF01217 0.421
TRG_DiLeu_BaLyEn_6 718 723 PF01217 0.493
TRG_DiLeu_LyEn_5 126 131 PF01217 0.585
TRG_ENDOCYTIC_2 106 109 PF00928 0.654
TRG_ENDOCYTIC_2 459 462 PF00928 0.398
TRG_ENDOCYTIC_2 717 720 PF00928 0.501
TRG_ENDOCYTIC_2 727 730 PF00928 0.511
TRG_ER_diArg_1 15 18 PF00400 0.551
TRG_ER_diArg_1 2 4 PF00400 0.574
TRG_ER_diArg_1 216 218 PF00400 0.595
TRG_ER_diArg_1 354 356 PF00400 0.358
TRG_ER_diArg_1 434 437 PF00400 0.684
TRG_ER_diArg_1 657 659 PF00400 0.553
TRG_ER_diArg_1 775 778 PF00400 0.523
TRG_ER_diArg_1 871 873 PF00400 0.574
TRG_Pf-PMV_PEXEL_1 659 663 PF00026 0.538

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PA60 Leptomonas seymouri 48% 99%
A0A3Q8IV80 Leishmania donovani 91% 100%
A4HMM0 Leishmania braziliensis 75% 100%
A4IB98 Leishmania infantum 91% 100%
E9AF22 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS