U3 small nucleolar RNA-associated protein 6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U3 small nucleolar RNA-associated protein 6, putative

Species:

Leishmania mexicana

UniProt:

E9B677_LEIMU

TriTrypDb:

LmxM.34.1990

Length:

1059

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043231	intracellular membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	7
GO:0005737	cytoplasm	2	1
GO:0030684	preribosome	3	1
GO:0032040	small-subunit processome	4	1
GO:0032991	protein-containing complex	1	1
GO:0034388	Pwp2p-containing subcomplex of 90S preribosome	3	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9B677

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B677

Function

Biological processes
Term	Name	Level	Count
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006364	rRNA processing	8	7
GO:0006396	RNA processing	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0016072	rRNA metabolic process	7	7
GO:0030490	maturation of SSU-rRNA	9	7
GO:0034470	ncRNA processing	7	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0034660	ncRNA metabolic process	6	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0030515	snoRNA binding	5	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	662	666	PF00656	0.567
CLV_NRD_NRD_1	1043	1045	PF00675	0.402
CLV_NRD_NRD_1	141	143	PF00675	0.388
CLV_NRD_NRD_1	207	209	PF00675	0.446
CLV_NRD_NRD_1	210	212	PF00675	0.476
CLV_NRD_NRD_1	402	404	PF00675	0.606
CLV_NRD_NRD_1	425	427	PF00675	0.431
CLV_NRD_NRD_1	467	469	PF00675	0.509
CLV_NRD_NRD_1	475	477	PF00675	0.416
CLV_NRD_NRD_1	514	516	PF00675	0.740
CLV_NRD_NRD_1	677	679	PF00675	0.377
CLV_NRD_NRD_1	868	870	PF00675	0.401
CLV_PCSK_FUR_1	674	678	PF00082	0.452
CLV_PCSK_KEX2_1	1043	1045	PF00082	0.402
CLV_PCSK_KEX2_1	141	143	PF00082	0.388
CLV_PCSK_KEX2_1	212	214	PF00082	0.556
CLV_PCSK_KEX2_1	401	403	PF00082	0.610
CLV_PCSK_KEX2_1	424	426	PF00082	0.629
CLV_PCSK_KEX2_1	461	463	PF00082	0.618
CLV_PCSK_KEX2_1	467	469	PF00082	0.504
CLV_PCSK_KEX2_1	475	477	PF00082	0.388
CLV_PCSK_KEX2_1	514	516	PF00082	0.644
CLV_PCSK_KEX2_1	676	678	PF00082	0.384
CLV_PCSK_KEX2_1	68	70	PF00082	0.299
CLV_PCSK_KEX2_1	708	710	PF00082	0.586
CLV_PCSK_KEX2_1	868	870	PF00082	0.401
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.521
CLV_PCSK_PC1ET2_1	401	403	PF00082	0.696
CLV_PCSK_PC1ET2_1	461	463	PF00082	0.574
CLV_PCSK_PC1ET2_1	514	516	PF00082	0.644
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.299
CLV_PCSK_PC1ET2_1	708	710	PF00082	0.527
CLV_PCSK_PC7_1	208	214	PF00082	0.537
CLV_PCSK_SKI1_1	1030	1034	PF00082	0.394
CLV_PCSK_SKI1_1	213	217	PF00082	0.532
CLV_PCSK_SKI1_1	467	471	PF00082	0.527
CLV_PCSK_SKI1_1	476	480	PF00082	0.517
CLV_PCSK_SKI1_1	49	53	PF00082	0.299
CLV_PCSK_SKI1_1	561	565	PF00082	0.451
CLV_PCSK_SKI1_1	608	612	PF00082	0.592
CLV_PCSK_SKI1_1	709	713	PF00082	0.493
DEG_APCC_DBOX_1	185	193	PF00400	0.360
DEG_APCC_DBOX_1	675	683	PF00400	0.410
DEG_SCF_FBW7_2	416	422	PF00400	0.501
DEG_SPOP_SBC_1	504	508	PF00917	0.631
DOC_CKS1_1	416	421	PF01111	0.548
DOC_CKS1_1	493	498	PF01111	0.612
DOC_CYCLIN_RxL_1	45	55	PF00134	0.299
DOC_CYCLIN_yCln2_LP_2	493	499	PF00134	0.523
DOC_MAPK_gen_1	141	147	PF00069	0.369
DOC_MAPK_gen_1	674	684	PF00069	0.397
DOC_MAPK_MEF2A_6	1044	1053	PF00069	0.431
DOC_MAPK_MEF2A_6	296	303	PF00069	0.380
DOC_MAPK_MEF2A_6	45	54	PF00069	0.299
DOC_PP1_RVXF_1	642	649	PF00149	0.376
DOC_PP4_FxxP_1	272	275	PF00568	0.384
DOC_PP4_MxPP_1	569	572	PF00568	0.661
DOC_SPAK_OSR1_1	644	648	PF12202	0.445
DOC_USP7_MATH_1	140	144	PF00917	0.389
DOC_USP7_MATH_1	333	337	PF00917	0.560
DOC_USP7_MATH_1	412	416	PF00917	0.538
DOC_USP7_MATH_1	431	435	PF00917	0.486
DOC_USP7_MATH_1	478	482	PF00917	0.466
DOC_USP7_MATH_1	499	503	PF00917	0.642
DOC_USP7_MATH_1	510	514	PF00917	0.541
DOC_USP7_MATH_1	572	576	PF00917	0.730
DOC_USP7_MATH_1	782	786	PF00917	0.651
DOC_USP7_MATH_1	814	818	PF00917	0.601
DOC_USP7_UBL2_3	212	216	PF12436	0.496
DOC_USP7_UBL2_3	512	516	PF12436	0.566
DOC_USP7_UBL2_3	96	100	PF12436	0.368
DOC_WW_Pin1_4	271	276	PF00397	0.392
DOC_WW_Pin1_4	415	420	PF00397	0.565
DOC_WW_Pin1_4	438	443	PF00397	0.667
DOC_WW_Pin1_4	492	497	PF00397	0.594
DOC_WW_Pin1_4	626	631	PF00397	0.687
DOC_WW_Pin1_4	929	934	PF00397	0.381
DOC_WW_Pin1_4	995	1000	PF00397	0.432
LIG_14-3-3_CanoR_1	1043	1048	PF00244	0.343
LIG_14-3-3_CanoR_1	141	147	PF00244	0.369
LIG_14-3-3_CanoR_1	158	166	PF00244	0.395
LIG_14-3-3_CanoR_1	331	339	PF00244	0.565
LIG_14-3-3_CanoR_1	377	383	PF00244	0.441
LIG_14-3-3_CanoR_1	475	481	PF00244	0.457
LIG_14-3-3_CanoR_1	519	527	PF00244	0.708
LIG_14-3-3_CanoR_1	57	63	PF00244	0.264
LIG_14-3-3_CanoR_1	735	743	PF00244	0.646
LIG_14-3-3_CanoR_1	752	758	PF00244	0.373
LIG_14-3-3_CanoR_1	759	767	PF00244	0.326
LIG_14-3-3_CanoR_1	822	827	PF00244	0.315
LIG_14-3-3_CanoR_1	861	866	PF00244	0.404
LIG_14-3-3_CanoR_1	910	920	PF00244	0.320
LIG_14-3-3_CanoR_1	942	947	PF00244	0.441
LIG_Actin_WH2_2	618	634	PF00022	0.483
LIG_APCC_ABBA_1	917	922	PF00400	0.322
LIG_BRCT_BRCA1_1	999	1003	PF00533	0.511
LIG_Clathr_ClatBox_1	51	55	PF01394	0.299
LIG_deltaCOP1_diTrp_1	1016	1024	PF00928	0.332
LIG_deltaCOP1_diTrp_1	144	152	PF00928	0.357
LIG_DLG_GKlike_1	124	131	PF00625	0.369
LIG_FHA_1	1005	1011	PF00498	0.394
LIG_FHA_1	238	244	PF00498	0.473
LIG_FHA_1	277	283	PF00498	0.311
LIG_FHA_1	30	36	PF00498	0.326
LIG_FHA_1	377	383	PF00498	0.424
LIG_FHA_1	384	390	PF00498	0.367
LIG_FHA_1	441	447	PF00498	0.449
LIG_FHA_1	554	560	PF00498	0.533
LIG_FHA_1	59	65	PF00498	0.278
LIG_FHA_1	591	597	PF00498	0.629
LIG_FHA_1	637	643	PF00498	0.378
LIG_FHA_1	853	859	PF00498	0.333
LIG_FHA_1	912	918	PF00498	0.336
LIG_FHA_1	986	992	PF00498	0.392
LIG_FHA_1	996	1002	PF00498	0.517
LIG_FHA_2	230	236	PF00498	0.595
LIG_FHA_2	26	32	PF00498	0.299
LIG_FHA_2	264	270	PF00498	0.414
LIG_FHA_2	416	422	PF00498	0.574
LIG_FHA_2	521	527	PF00498	0.527
LIG_FHA_2	636	642	PF00498	0.395
LIG_FHA_2	7	13	PF00498	0.388
LIG_FHA_2	873	879	PF00498	0.401
LIG_LIR_Apic_2	269	275	PF02991	0.387
LIG_LIR_Gen_1	593	602	PF02991	0.626
LIG_LIR_Gen_1	845	854	PF02991	0.367
LIG_LIR_Gen_1	960	969	PF02991	0.413
LIG_LIR_Nem_3	1016	1021	PF02991	0.337
LIG_LIR_Nem_3	129	135	PF02991	0.496
LIG_LIR_Nem_3	151	155	PF02991	0.432
LIG_LIR_Nem_3	361	367	PF02991	0.486
LIG_LIR_Nem_3	43	47	PF02991	0.340
LIG_LIR_Nem_3	460	466	PF02991	0.507
LIG_LIR_Nem_3	593	597	PF02991	0.626
LIG_LIR_Nem_3	72	76	PF02991	0.403
LIG_LIR_Nem_3	756	761	PF02991	0.344
LIG_LIR_Nem_3	845	851	PF02991	0.384
LIG_LIR_Nem_3	960	965	PF02991	0.485
LIG_LIR_Nem_3	976	981	PF02991	0.285
LIG_MYND_3	918	922	PF01753	0.320
LIG_NRBOX	195	201	PF00104	0.443
LIG_NRBOX	281	287	PF00104	0.429
LIG_NRBOX	894	900	PF00104	0.289
LIG_PCNA_yPIPBox_3	120	132	PF02747	0.373
LIG_PCNA_yPIPBox_3	186	200	PF02747	0.349
LIG_PCNA_yPIPBox_3	246	258	PF02747	0.410
LIG_PDZ_Class_1	1054	1059	PF00595	0.302
LIG_Pex14_2	118	122	PF04695	0.358
LIG_Pex14_2	645	649	PF04695	0.371
LIG_RPA_C_Fungi	199	211	PF08784	0.453
LIG_SH2_CRK	628	632	PF00017	0.545
LIG_SH2_CRK	76	80	PF00017	0.358
LIG_SH2_SRC	813	816	PF00017	0.537
LIG_SH2_STAP1	378	382	PF00017	0.422
LIG_SH2_STAP1	962	966	PF00017	0.404
LIG_SH2_STAT5	1021	1024	PF00017	0.324
LIG_SH2_STAT5	22	25	PF00017	0.299
LIG_SH2_STAT5	367	370	PF00017	0.419
LIG_SH2_STAT5	378	381	PF00017	0.337
LIG_SH2_STAT5	388	391	PF00017	0.360
LIG_SH2_STAT5	73	76	PF00017	0.299
LIG_SH3_2	627	632	PF14604	0.601
LIG_SH3_3	134	140	PF00018	0.393
LIG_SH3_3	44	50	PF00018	0.343
LIG_SH3_3	546	552	PF00018	0.450
LIG_SH3_3	624	630	PF00018	0.783
LIG_SH3_3	691	697	PF00018	0.547
LIG_SH3_3	941	947	PF00018	0.518
LIG_Sin3_3	1035	1042	PF02671	0.272
LIG_SUMO_SIM_anti_2	134	139	PF11976	0.452
LIG_SUMO_SIM_par_1	277	283	PF11976	0.296
LIG_SUMO_SIM_par_1	30	36	PF11976	0.299
LIG_SUMO_SIM_par_1	49	55	PF11976	0.299
LIG_TRAF2_1	233	236	PF00917	0.735
LIG_TRAF2_1	28	31	PF00917	0.299
LIG_TRAF2_1	419	422	PF00917	0.406
LIG_TRAF2_1	843	846	PF00917	0.485
LIG_UBA3_1	1023	1030	PF00899	0.258
LIG_UBA3_1	258	265	PF00899	0.365
LIG_UBA3_1	965	973	PF00899	0.381
LIG_WRC_WIRS_1	823	828	PF05994	0.349
MOD_CDC14_SPxK_1	629	632	PF00782	0.542
MOD_CDK_SPxK_1	626	632	PF00069	0.599
MOD_CK1_1	274	280	PF00069	0.399
MOD_CK1_1	334	340	PF00069	0.541
MOD_CK1_1	359	365	PF00069	0.440
MOD_CK1_1	415	421	PF00069	0.515
MOD_CK1_1	506	512	PF00069	0.642
MOD_CK1_1	817	823	PF00069	0.474
MOD_CK1_1	840	846	PF00069	0.477
MOD_CK1_1	929	935	PF00069	0.352
MOD_CK1_1	938	944	PF00069	0.444
MOD_CK2_1	1003	1009	PF00069	0.483
MOD_CK2_1	229	235	PF00069	0.710
MOD_CK2_1	25	31	PF00069	0.299
MOD_CK2_1	263	269	PF00069	0.410
MOD_CK2_1	415	421	PF00069	0.464
MOD_CK2_1	6	12	PF00069	0.387
MOD_CK2_1	759	765	PF00069	0.345
MOD_CK2_1	840	846	PF00069	0.477
MOD_CK2_1	872	878	PF00069	0.401
MOD_Cter_Amidation	866	869	PF01082	0.381
MOD_GlcNHglycan	1056	1059	PF01048	0.335
MOD_GlcNHglycan	23	26	PF01048	0.315
MOD_GlcNHglycan	240	243	PF01048	0.558
MOD_GlcNHglycan	276	279	PF01048	0.389
MOD_GlcNHglycan	314	317	PF01048	0.491
MOD_GlcNHglycan	333	336	PF01048	0.464
MOD_GlcNHglycan	393	396	PF01048	0.582
MOD_GlcNHglycan	443	446	PF01048	0.509
MOD_GlcNHglycan	448	452	PF01048	0.517
MOD_GlcNHglycan	480	483	PF01048	0.485
MOD_GlcNHglycan	564	567	PF01048	0.666
MOD_GlcNHglycan	665	668	PF01048	0.517
MOD_GlcNHglycan	698	701	PF01048	0.596
MOD_GlcNHglycan	704	707	PF01048	0.643
MOD_GlcNHglycan	736	739	PF01048	0.490
MOD_GlcNHglycan	761	764	PF01048	0.345
MOD_GlcNHglycan	786	789	PF01048	0.804
MOD_GlcNHglycan	801	805	PF01048	0.525
MOD_GlcNHglycan	834	837	PF01048	0.347
MOD_GlcNHglycan	928	931	PF01048	0.388
MOD_GlcNHglycan	937	940	PF01048	0.533
MOD_GSK3_1	153	160	PF00069	0.369
MOD_GSK3_1	21	28	PF00069	0.315
MOD_GSK3_1	29	36	PF00069	0.355
MOD_GSK3_1	314	321	PF00069	0.493
MOD_GSK3_1	331	338	PF00069	0.711
MOD_GSK3_1	391	398	PF00069	0.479
MOD_GSK3_1	408	415	PF00069	0.585
MOD_GSK3_1	436	443	PF00069	0.415
MOD_GSK3_1	495	502	PF00069	0.530
MOD_GSK3_1	506	513	PF00069	0.666
MOD_GSK3_1	626	633	PF00069	0.734
MOD_GSK3_1	714	721	PF00069	0.505
MOD_GSK3_1	814	821	PF00069	0.708
MOD_GSK3_1	872	879	PF00069	0.402
MOD_GSK3_1	938	945	PF00069	0.544
MOD_N-GLC_1	124	129	PF02516	0.363
MOD_N-GLC_1	510	515	PF02516	0.637
MOD_N-GLC_1	733	738	PF02516	0.409
MOD_N-GLC_1	789	794	PF02516	0.558
MOD_N-GLC_1	799	804	PF02516	0.509
MOD_N-GLC_1	942	947	PF02516	0.548
MOD_NEK2_1	1003	1008	PF00069	0.450
MOD_NEK2_1	263	268	PF00069	0.404
MOD_NEK2_1	301	306	PF00069	0.530
MOD_NEK2_1	436	441	PF00069	0.511
MOD_NEK2_1	592	597	PF00069	0.555
MOD_NEK2_1	670	675	PF00069	0.483
MOD_NEK2_1	733	738	PF00069	0.409
MOD_NEK2_1	832	837	PF00069	0.345
MOD_NEK2_1	911	916	PF00069	0.543
MOD_NEK2_1	926	931	PF00069	0.296
MOD_PIKK_1	153	159	PF00454	0.403
MOD_PIKK_1	349	355	PF00454	0.604
MOD_PIKK_1	768	774	PF00454	0.530
MOD_PIKK_1	942	948	PF00454	0.423
MOD_PKA_1	1043	1049	PF00069	0.401
MOD_PKA_1	701	707	PF00069	0.498
MOD_PKA_2	1043	1049	PF00069	0.365
MOD_PKA_2	140	146	PF00069	0.374
MOD_PKA_2	157	163	PF00069	0.401
MOD_PKA_2	356	362	PF00069	0.490
MOD_PKA_2	376	382	PF00069	0.324
MOD_PKA_2	518	524	PF00069	0.760
MOD_PKA_2	734	740	PF00069	0.587
MOD_PKA_2	821	827	PF00069	0.337
MOD_PKA_2	872	878	PF00069	0.436
MOD_PKB_1	859	867	PF00069	0.338
MOD_Plk_1	29	35	PF00069	0.324
MOD_Plk_1	318	324	PF00069	0.565
MOD_Plk_1	383	389	PF00069	0.411
MOD_Plk_2-3	718	724	PF00069	0.476
MOD_Plk_4	263	269	PF00069	0.369
MOD_Plk_4	276	282	PF00069	0.458
MOD_Plk_4	359	365	PF00069	0.528
MOD_Plk_4	412	418	PF00069	0.726
MOD_Plk_4	431	437	PF00069	0.396
MOD_Plk_4	753	759	PF00069	0.416
MOD_Plk_4	853	859	PF00069	0.333
MOD_Plk_4	974	980	PF00069	0.374
MOD_ProDKin_1	271	277	PF00069	0.390
MOD_ProDKin_1	415	421	PF00069	0.557
MOD_ProDKin_1	438	444	PF00069	0.673
MOD_ProDKin_1	492	498	PF00069	0.601
MOD_ProDKin_1	626	632	PF00069	0.688
MOD_ProDKin_1	929	935	PF00069	0.395
MOD_ProDKin_1	995	1001	PF00069	0.428
TRG_DiLeu_BaEn_2	113	119	PF01217	0.356
TRG_DiLeu_BaEn_4	651	657	PF01217	0.398
TRG_DiLeu_BaEn_4	846	852	PF01217	0.426
TRG_DiLeu_BaLyEn_6	191	196	PF01217	0.352
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.299
TRG_DiLeu_BaLyEn_6	555	560	PF01217	0.533
TRG_ENDOCYTIC_2	1021	1024	PF00928	0.324
TRG_ENDOCYTIC_2	132	135	PF00928	0.545
TRG_ENDOCYTIC_2	367	370	PF00928	0.419
TRG_ENDOCYTIC_2	628	631	PF00928	0.544
TRG_ENDOCYTIC_2	76	79	PF00928	0.363
TRG_ENDOCYTIC_2	962	965	PF00928	0.405
TRG_ER_diArg_1	140	142	PF00400	0.399
TRG_ER_diArg_1	348	351	PF00400	0.559
TRG_ER_diArg_1	354	357	PF00400	0.533
TRG_ER_diArg_1	424	426	PF00400	0.438
TRG_ER_diArg_1	466	468	PF00400	0.507
TRG_ER_diArg_1	474	476	PF00400	0.419
TRG_ER_diArg_1	674	677	PF00400	0.396
TRG_ER_diArg_1	858	861	PF00400	0.324
TRG_ER_diArg_1	868	870	PF00400	0.401
TRG_NLS_MonoExtC_3	207	212	PF00514	0.444
TRG_NLS_MonoExtN_4	208	215	PF00514	0.503
TRG_Pf-PMV_PEXEL_1	164	168	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	558	562	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.358

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHB0	Leptomonas seymouri	55%	100%
A0A3Q8II91	Leishmania donovani	89%	100%
A4HML9	Leishmania braziliensis	79%	100%
A4IB97	Leishmania infantum	89%	100%
E9AF21	Leishmania major	89%	100%