Serine protease

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Serine protease

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B676_LEIMU

TriTrypDb:

LmxM.34.1980

Length:

588

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B676

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B676

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	437	441	PF00656	0.615
CLV_NRD_NRD_1	3	5	PF00675	0.720
CLV_NRD_NRD_1	303	305	PF00675	0.580
CLV_NRD_NRD_1	34	36	PF00675	0.426
CLV_NRD_NRD_1	401	403	PF00675	0.648
CLV_NRD_NRD_1	450	452	PF00675	0.601
CLV_NRD_NRD_1	548	550	PF00675	0.605
CLV_NRD_NRD_1	554	556	PF00675	0.548
CLV_NRD_NRD_1	567	569	PF00675	0.574
CLV_PCSK_FUR_1	32	36	PF00082	0.451
CLV_PCSK_FUR_1	549	553	PF00082	0.619
CLV_PCSK_KEX2_1	142	144	PF00082	0.530
CLV_PCSK_KEX2_1	3	5	PF00082	0.720
CLV_PCSK_KEX2_1	302	304	PF00082	0.593
CLV_PCSK_KEX2_1	34	36	PF00082	0.426
CLV_PCSK_KEX2_1	551	553	PF00082	0.565
CLV_PCSK_KEX2_1	554	556	PF00082	0.567
CLV_PCSK_KEX2_1	566	568	PF00082	0.528
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.549
CLV_PCSK_PC1ET2_1	551	553	PF00082	0.588
CLV_PCSK_PC7_1	298	304	PF00082	0.726
CLV_PCSK_SKI1_1	114	118	PF00082	0.495
CLV_PCSK_SKI1_1	283	287	PF00082	0.538
CLV_PCSK_SKI1_1	339	343	PF00082	0.589
CLV_PCSK_SKI1_1	432	436	PF00082	0.586
DEG_APCC_DBOX_1	128	136	PF00400	0.437
DEG_APCC_DBOX_1	450	458	PF00400	0.592
DEG_Nend_Nbox_1	1	3	PF02207	0.682
DOC_ANK_TNKS_1	301	308	PF00023	0.675
DOC_CKS1_1	71	76	PF01111	0.495
DOC_MAPK_DCC_7	325	333	PF00069	0.612
DOC_MAPK_gen_1	3	9	PF00069	0.638
DOC_MAPK_gen_1	322	331	PF00069	0.612
DOC_MAPK_MEF2A_6	322	331	PF00069	0.621
DOC_PP2B_LxvP_1	196	199	PF13499	0.504
DOC_PP4_FxxP_1	80	83	PF00568	0.404
DOC_USP7_MATH_1	182	186	PF00917	0.482
DOC_USP7_MATH_1	290	294	PF00917	0.732
DOC_USP7_MATH_1	480	484	PF00917	0.645
DOC_USP7_MATH_1	542	546	PF00917	0.721
DOC_USP7_UBL2_3	24	28	PF12436	0.518
DOC_WW_Pin1_4	403	408	PF00397	0.635
DOC_WW_Pin1_4	496	501	PF00397	0.647
DOC_WW_Pin1_4	529	534	PF00397	0.822
DOC_WW_Pin1_4	70	75	PF00397	0.476
LIG_14-3-3_CanoR_1	103	108	PF00244	0.449
LIG_14-3-3_CanoR_1	205	210	PF00244	0.399
LIG_14-3-3_CanoR_1	291	299	PF00244	0.751
LIG_14-3-3_CanoR_1	3	8	PF00244	0.694
LIG_14-3-3_CanoR_1	451	455	PF00244	0.593
LIG_14-3-3_CanoR_1	88	95	PF00244	0.520
LIG_Actin_WH2_2	127	144	PF00022	0.518
LIG_AP_GAE_1	475	481	PF02883	0.545
LIG_BRCT_BRCA1_1	271	275	PF00533	0.434
LIG_BRCT_BRCA1_1	348	352	PF00533	0.604
LIG_BRCT_BRCA1_1	354	358	PF00533	0.624
LIG_Clathr_ClatBox_1	278	282	PF01394	0.447
LIG_FHA_1	166	172	PF00498	0.557
LIG_FHA_1	216	222	PF00498	0.450
LIG_FHA_1	248	254	PF00498	0.436
LIG_FHA_1	61	67	PF00498	0.436
LIG_FHA_1	85	91	PF00498	0.522
LIG_FHA_2	250	256	PF00498	0.473
LIG_FHA_2	295	301	PF00498	0.670
LIG_FHA_2	340	346	PF00498	0.571
LIG_FHA_2	374	380	PF00498	0.680
LIG_FHA_2	71	77	PF00498	0.469
LIG_FHA_2	92	98	PF00498	0.487
LIG_LIR_Apic_2	73	78	PF02991	0.530
LIG_LIR_Gen_1	272	281	PF02991	0.421
LIG_LIR_Gen_1	59	69	PF02991	0.475
LIG_LIR_Nem_3	272	278	PF02991	0.414
LIG_LIR_Nem_3	30	36	PF02991	0.490
LIG_LIR_Nem_3	475	481	PF02991	0.681
LIG_LIR_Nem_3	483	487	PF02991	0.547
LIG_LIR_Nem_3	76	80	PF02991	0.493
LIG_NRP_CendR_1	587	588	PF00754	0.591
LIG_Pex14_2	42	46	PF04695	0.504
LIG_PTB_Apo_2	151	158	PF02174	0.521
LIG_PTB_Phospho_1	151	157	PF10480	0.546
LIG_SH2_GRB2like	346	349	PF00017	0.702
LIG_SH2_GRB2like	411	414	PF00017	0.756
LIG_SH2_NCK_1	411	415	PF00017	0.683
LIG_SH2_NCK_1	515	519	PF00017	0.683
LIG_SH2_SRC	411	414	PF00017	0.630
LIG_SH2_STAP1	15	19	PF00017	0.474
LIG_SH2_STAP1	270	274	PF00017	0.406
LIG_SH2_STAP1	515	519	PF00017	0.683
LIG_SH2_STAT3	81	84	PF00017	0.700
LIG_SH2_STAT5	157	160	PF00017	0.518
LIG_SH3_2	83	88	PF14604	0.600
LIG_SH3_3	131	137	PF00018	0.441
LIG_SH3_3	534	540	PF00018	0.736
LIG_SH3_3	68	74	PF00018	0.390
LIG_SH3_3	80	86	PF00018	0.539
LIG_SH3_4	395	402	PF00018	0.672
LIG_SUMO_SIM_par_1	194	200	PF11976	0.486
LIG_SUMO_SIM_par_1	276	282	PF11976	0.448
LIG_TRAF2_1	293	296	PF00917	0.688
LIG_TRFH_1	157	161	PF08558	0.457
LIG_UBA3_1	274	283	PF00899	0.494
LIG_WRC_WIRS_1	384	389	PF05994	0.793
MOD_CK1_1	373	379	PF00069	0.574
MOD_CK1_1	386	392	PF00069	0.733
MOD_CK1_1	532	538	PF00069	0.760
MOD_CK1_1	91	97	PF00069	0.503
MOD_CK2_1	178	184	PF00069	0.413
MOD_CK2_1	249	255	PF00069	0.448
MOD_CK2_1	290	296	PF00069	0.707
MOD_GlcNHglycan	143	146	PF01048	0.526
MOD_GlcNHglycan	180	183	PF01048	0.581
MOD_GlcNHglycan	348	351	PF01048	0.610
MOD_GlcNHglycan	354	357	PF01048	0.609
MOD_GlcNHglycan	364	367	PF01048	0.554
MOD_GlcNHglycan	372	375	PF01048	0.544
MOD_GlcNHglycan	475	478	PF01048	0.705
MOD_GlcNHglycan	489	492	PF01048	0.664
MOD_GlcNHglycan	503	506	PF01048	0.625
MOD_GlcNHglycan	58	61	PF01048	0.575
MOD_GSK3_1	178	185	PF00069	0.436
MOD_GSK3_1	262	269	PF00069	0.434
MOD_GSK3_1	290	297	PF00069	0.686
MOD_GSK3_1	383	390	PF00069	0.765
MOD_GSK3_1	426	433	PF00069	0.575
MOD_GSK3_1	529	536	PF00069	0.796
MOD_GSK3_1	56	63	PF00069	0.538
MOD_GSK3_1	84	91	PF00069	0.531
MOD_N-GLC_1	165	170	PF02516	0.548
MOD_N-GLC_1	425	430	PF02516	0.583
MOD_N-GLC_1	435	440	PF02516	0.614
MOD_N-GLC_1	471	476	PF02516	0.728
MOD_N-GLC_1	496	501	PF02516	0.670
MOD_N-GLC_1	542	547	PF02516	0.750
MOD_NEK2_1	123	128	PF00069	0.533
MOD_NEK2_1	2	7	PF00069	0.706
MOD_NEK2_1	215	220	PF00069	0.439
MOD_NEK2_1	234	239	PF00069	0.397
MOD_NEK2_1	249	254	PF00069	0.433
MOD_NEK2_1	262	267	PF00069	0.396
MOD_NEK2_1	318	323	PF00069	0.607
MOD_NEK2_1	352	357	PF00069	0.629
MOD_NEK2_1	37	42	PF00069	0.385
MOD_NEK2_1	387	392	PF00069	0.780
MOD_NEK2_1	466	471	PF00069	0.613
MOD_NEK2_1	47	52	PF00069	0.535
MOD_NEK2_1	95	100	PF00069	0.474
MOD_NEK2_2	182	187	PF00069	0.489
MOD_PIKK_1	290	296	PF00454	0.779
MOD_PIKK_1	359	365	PF00454	0.584
MOD_PIKK_1	97	103	PF00454	0.408
MOD_PK_1	205	211	PF00069	0.293
MOD_PK_1	3	9	PF00069	0.638
MOD_PKA_1	3	9	PF00069	0.638
MOD_PKA_2	2	8	PF00069	0.696
MOD_PKA_2	290	296	PF00069	0.757
MOD_PKA_2	450	456	PF00069	0.594
MOD_PKB_1	203	211	PF00069	0.507
MOD_Plk_1	165	171	PF00069	0.544
MOD_Plk_1	294	300	PF00069	0.623
MOD_Plk_1	37	43	PF00069	0.406
MOD_Plk_1	435	441	PF00069	0.637
MOD_Plk_1	542	548	PF00069	0.748
MOD_Plk_4	182	188	PF00069	0.494
MOD_Plk_4	234	240	PF00069	0.415
MOD_Plk_4	3	9	PF00069	0.706
MOD_Plk_4	329	335	PF00069	0.595
MOD_Plk_4	383	389	PF00069	0.717
MOD_Plk_4	466	472	PF00069	0.645
MOD_Plk_4	542	548	PF00069	0.720
MOD_ProDKin_1	403	409	PF00069	0.633
MOD_ProDKin_1	496	502	PF00069	0.649
MOD_ProDKin_1	529	535	PF00069	0.822
MOD_ProDKin_1	70	76	PF00069	0.490
MOD_SUMO_rev_2	144	150	PF00179	0.511
MOD_SUMO_rev_2	184	193	PF00179	0.551
MOD_SUMO_rev_2	255	262	PF00179	0.573
MOD_SUMO_rev_2	332	341	PF00179	0.543
MOD_SUMO_rev_2	437	444	PF00179	0.601
TRG_ENDOCYTIC_2	113	116	PF00928	0.518
TRG_ENDOCYTIC_2	77	80	PF00928	0.385
TRG_ER_diArg_1	159	162	PF00400	0.488
TRG_ER_diArg_1	2	4	PF00400	0.655
TRG_ER_diArg_1	202	205	PF00400	0.477
TRG_ER_diArg_1	227	230	PF00400	0.587
TRG_ER_diArg_1	302	304	PF00400	0.616
TRG_ER_diArg_1	33	35	PF00400	0.448
TRG_ER_diArg_1	565	568	PF00400	0.612
TRG_NES_CRM1_1	97	108	PF08389	0.497
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	432	437	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P326	Leptomonas seymouri	79%	97%
A0A0S4JIC7	Bodo saltans	56%	100%
A0A1X0P7C6	Trypanosomatidae	68%	100%
A0A3Q8IM74	Leishmania donovani	96%	100%
A4HML8	Leishmania braziliensis	91%	100%
A4IB96	Leishmania infantum	95%	100%
C9ZZM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
E9AF20	Leishmania major	96%	100%
V5ATF8	Trypanosoma cruzi	67%	100%