Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B671_LEIMU

TriTrypDb:

LmxM.34.1940

Length:

449

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B671

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B671

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.696
CLV_NRD_NRD_1	438	440	PF00675	0.672
CLV_PCSK_FUR_1	108	112	PF00082	0.633
CLV_PCSK_KEX2_1	110	112	PF00082	0.696
CLV_Separin_Metazoa	187	191	PF03568	0.470
CLV_Separin_Metazoa	317	321	PF03568	0.503
DEG_APCC_KENBOX_2	409	413	PF00400	0.643
DEG_SPOP_SBC_1	83	87	PF00917	0.415
DOC_PP2B_LxvP_1	135	138	PF13499	0.664
DOC_PP2B_LxvP_1	97	100	PF13499	0.634
DOC_PP4_FxxP_1	271	274	PF00568	0.503
DOC_PP4_FxxP_1	341	344	PF00568	0.514
DOC_PP4_FxxP_1	346	349	PF00568	0.469
DOC_USP7_MATH_1	152	156	PF00917	0.506
DOC_USP7_MATH_1	162	166	PF00917	0.433
DOC_USP7_MATH_1	243	247	PF00917	0.758
DOC_USP7_MATH_1	249	253	PF00917	0.668
DOC_USP7_MATH_1	263	267	PF00917	0.675
DOC_USP7_MATH_1	296	300	PF00917	0.585
DOC_USP7_MATH_1	385	389	PF00917	0.381
DOC_USP7_MATH_1	59	63	PF00917	0.553
DOC_USP7_MATH_1	83	87	PF00917	0.642
DOC_USP7_MATH_1	88	92	PF00917	0.624
DOC_WW_Pin1_4	125	130	PF00397	0.636
DOC_WW_Pin1_4	141	146	PF00397	0.727
DOC_WW_Pin1_4	148	153	PF00397	0.609
DOC_WW_Pin1_4	156	161	PF00397	0.443
DOC_WW_Pin1_4	245	250	PF00397	0.666
DOC_WW_Pin1_4	26	31	PF00397	0.487
DOC_WW_Pin1_4	272	277	PF00397	0.756
DOC_WW_Pin1_4	281	286	PF00397	0.645
DOC_WW_Pin1_4	365	370	PF00397	0.449
LIG_14-3-3_CanoR_1	381	385	PF00244	0.497
LIG_14-3-3_CanoR_1	63	73	PF00244	0.521
LIG_BIR_II_1	1	5	PF00653	0.578
LIG_BIR_III_4	58	62	PF00653	0.543
LIG_BRCT_BRCA1_1	413	417	PF00533	0.534
LIG_deltaCOP1_diTrp_1	328	334	PF00928	0.396
LIG_FHA_1	10	16	PF00498	0.611
LIG_FHA_1	381	387	PF00498	0.409
LIG_FHA_1	432	438	PF00498	0.576
LIG_FHA_1	94	100	PF00498	0.745
LIG_FHA_2	113	119	PF00498	0.602
LIG_FHA_2	27	33	PF00498	0.461
LIG_LIR_Apic_2	270	274	PF02991	0.501
LIG_LIR_Apic_2	398	403	PF02991	0.592
LIG_LIR_Gen_1	76	84	PF02991	0.499
LIG_LIR_Nem_3	171	177	PF02991	0.481
LIG_LIR_Nem_3	245	250	PF02991	0.619
LIG_LIR_Nem_3	328	333	PF02991	0.449
LIG_LIR_Nem_3	76	82	PF02991	0.483
LIG_MAD2	424	432	PF02301	0.564
LIG_PDZ_Class_2	444	449	PF00595	0.663
LIG_Pex14_1	330	334	PF04695	0.397
LIG_Pex14_2	206	210	PF04695	0.437
LIG_PTB_Apo_2	188	195	PF02174	0.475
LIG_SH2_CRK	247	251	PF00017	0.622
LIG_SH2_CRK	322	326	PF00017	0.390
LIG_SH2_GRB2like	73	76	PF00017	0.576
LIG_SH2_NCK_1	79	83	PF00017	0.570
LIG_SH2_SRC	79	82	PF00017	0.506
LIG_SH2_STAP1	73	77	PF00017	0.492
LIG_SH2_STAP1	79	83	PF00017	0.496
LIG_SH2_STAT3	333	336	PF00017	0.401
LIG_SH2_STAT5	114	117	PF00017	0.691
LIG_SH2_STAT5	177	180	PF00017	0.461
LIG_SH2_STAT5	333	336	PF00017	0.401
LIG_SH2_STAT5	377	380	PF00017	0.439
LIG_SH2_STAT5	39	42	PF00017	0.461
LIG_SH3_3	140	146	PF00018	0.689
LIG_SH3_3	271	277	PF00018	0.668
LIG_SH3_3	282	288	PF00018	0.634
LIG_SH3_3	387	393	PF00018	0.399
LIG_TRAF2_1	237	240	PF00917	0.627
LIG_WRC_WIRS_1	5	10	PF05994	0.577
MOD_CDC14_SPxK_1	248	251	PF00782	0.667
MOD_CDK_SPxK_1	245	251	PF00069	0.677
MOD_CK1_1	139	145	PF00069	0.687
MOD_CK1_1	148	154	PF00069	0.587
MOD_CK1_1	216	222	PF00069	0.360
MOD_CK1_1	245	251	PF00069	0.535
MOD_CK1_1	254	260	PF00069	0.502
MOD_CK1_1	3	9	PF00069	0.474
MOD_CK2_1	112	118	PF00069	0.597
MOD_GlcNHglycan	103	106	PF01048	0.748
MOD_GlcNHglycan	138	141	PF01048	0.686
MOD_GlcNHglycan	164	167	PF01048	0.543
MOD_GlcNHglycan	218	221	PF01048	0.420
MOD_GlcNHglycan	253	256	PF01048	0.652
MOD_GlcNHglycan	299	302	PF01048	0.494
MOD_GlcNHglycan	31	36	PF01048	0.724
MOD_GlcNHglycan	359	362	PF01048	0.636
MOD_GlcNHglycan	387	390	PF01048	0.383
MOD_GlcNHglycan	9	12	PF01048	0.469
MOD_GlcNHglycan	90	93	PF01048	0.635
MOD_GSK3_1	141	148	PF00069	0.698
MOD_GSK3_1	152	159	PF00069	0.513
MOD_GSK3_1	194	201	PF00069	0.483
MOD_GSK3_1	245	252	PF00069	0.616
MOD_GSK3_1	263	270	PF00069	0.573
MOD_GSK3_1	277	284	PF00069	0.664
MOD_GSK3_1	3	10	PF00069	0.522
MOD_GSK3_1	83	90	PF00069	0.627
MOD_N-GLC_1	194	199	PF02516	0.477
MOD_N-GLC_1	297	302	PF02516	0.455
MOD_N-GLC_1	411	416	PF02516	0.554
MOD_NEK2_1	1	6	PF00069	0.576
MOD_NEK2_1	194	199	PF00069	0.477
MOD_NEK2_1	297	302	PF00069	0.600
MOD_NEK2_1	379	384	PF00069	0.571
MOD_PKA_1	439	445	PF00069	0.658
MOD_PKA_2	213	219	PF00069	0.437
MOD_PKA_2	380	386	PF00069	0.484
MOD_Plk_1	194	200	PF00069	0.497
MOD_Plk_1	202	208	PF00069	0.441
MOD_Plk_4	152	158	PF00069	0.604
MOD_Plk_4	213	219	PF00069	0.475
MOD_Plk_4	267	273	PF00069	0.517
MOD_Plk_4	431	437	PF00069	0.650
MOD_ProDKin_1	125	131	PF00069	0.633
MOD_ProDKin_1	141	147	PF00069	0.725
MOD_ProDKin_1	148	154	PF00069	0.609
MOD_ProDKin_1	156	162	PF00069	0.433
MOD_ProDKin_1	245	251	PF00069	0.667
MOD_ProDKin_1	26	32	PF00069	0.484
MOD_ProDKin_1	272	278	PF00069	0.755
MOD_ProDKin_1	281	287	PF00069	0.644
MOD_ProDKin_1	365	371	PF00069	0.443
MOD_SUMO_for_1	258	261	PF00179	0.628
TRG_DiLeu_BaEn_4	239	245	PF01217	0.634
TRG_DiLeu_BaLyEn_6	404	409	PF01217	0.641
TRG_ENDOCYTIC_2	247	250	PF00928	0.620
TRG_ENDOCYTIC_2	322	325	PF00928	0.395
TRG_ENDOCYTIC_2	79	82	PF00928	0.569
TRG_ER_diArg_1	108	111	PF00400	0.782

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZQ4	Leptomonas seymouri	49%	98%
A0A3S5H7Z2	Leishmania donovani	91%	100%
A4HML4	Leishmania braziliensis	78%	100%
A4IB91	Leishmania infantum	91%	100%
E9AF15	Leishmania major	90%	100%