Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B664_LEIMU

TriTrypDb:

LmxM.34.1870

Length:

738

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B664

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B664

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	229	233	PF00656	0.518
CLV_C14_Caspase3-7	436	440	PF00656	0.593
CLV_NRD_NRD_1	294	296	PF00675	0.514
CLV_NRD_NRD_1	443	445	PF00675	0.617
CLV_NRD_NRD_1	542	544	PF00675	0.480
CLV_NRD_NRD_1	561	563	PF00675	0.632
CLV_NRD_NRD_1	638	640	PF00675	0.638
CLV_NRD_NRD_1	702	704	PF00675	0.344
CLV_NRD_NRD_1	728	730	PF00675	0.465
CLV_PCSK_KEX2_1	294	296	PF00082	0.514
CLV_PCSK_KEX2_1	33	35	PF00082	0.597
CLV_PCSK_KEX2_1	443	445	PF00082	0.613
CLV_PCSK_KEX2_1	561	563	PF00082	0.627
CLV_PCSK_KEX2_1	571	573	PF00082	0.612
CLV_PCSK_KEX2_1	638	640	PF00082	0.638
CLV_PCSK_KEX2_1	728	730	PF00082	0.465
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.597
CLV_PCSK_PC1ET2_1	571	573	PF00082	0.597
CLV_PCSK_PC7_1	567	573	PF00082	0.646
CLV_PCSK_SKI1_1	455	459	PF00082	0.535
CLV_PCSK_SKI1_1	516	520	PF00082	0.420
CLV_PCSK_SKI1_1	572	576	PF00082	0.533
CLV_PCSK_SKI1_1	608	612	PF00082	0.626
CLV_PCSK_SKI1_1	619	623	PF00082	0.632
CLV_PCSK_SKI1_1	82	86	PF00082	0.612
CLV_PCSK_SKI1_1	91	95	PF00082	0.640
DEG_APCC_DBOX_1	515	523	PF00400	0.447
DEG_Nend_Nbox_1	1	3	PF02207	0.535
DEG_SPOP_SBC_1	26	30	PF00917	0.410
DEG_SPOP_SBC_1	72	76	PF00917	0.642
DOC_CDC14_PxL_1	330	338	PF14671	0.375
DOC_CDC14_PxL_1	52	60	PF14671	0.599
DOC_CKS1_1	262	267	PF01111	0.636
DOC_CKS1_1	281	286	PF01111	0.645
DOC_MAPK_gen_1	513	522	PF00069	0.562
DOC_MAPK_gen_1	703	711	PF00069	0.431
DOC_MAPK_HePTP_8	510	522	PF00069	0.556
DOC_MAPK_MEF2A_6	513	522	PF00069	0.562
DOC_PP1_RVXF_1	519	525	PF00149	0.453
DOC_PP2B_LxvP_1	98	101	PF13499	0.660
DOC_SPAK_OSR1_1	491	495	PF12202	0.410
DOC_USP7_MATH_1	105	109	PF00917	0.401
DOC_USP7_MATH_1	301	305	PF00917	0.502
DOC_USP7_MATH_1	348	352	PF00917	0.662
DOC_USP7_MATH_1	353	357	PF00917	0.606
DOC_USP7_MATH_1	47	51	PF00917	0.731
DOC_USP7_MATH_1	548	552	PF00917	0.583
DOC_USP7_MATH_1	592	596	PF00917	0.653
DOC_USP7_MATH_1	623	627	PF00917	0.615
DOC_USP7_MATH_1	633	637	PF00917	0.623
DOC_USP7_MATH_1	655	659	PF00917	0.565
DOC_USP7_MATH_1	89	93	PF00917	0.580
DOC_WW_Pin1_4	163	168	PF00397	0.644
DOC_WW_Pin1_4	241	246	PF00397	0.679
DOC_WW_Pin1_4	261	266	PF00397	0.601
DOC_WW_Pin1_4	280	285	PF00397	0.743
DOC_WW_Pin1_4	522	527	PF00397	0.582
DOC_WW_Pin1_4	629	634	PF00397	0.493
LIG_14-3-3_CanoR_1	170	176	PF00244	0.625
LIG_14-3-3_CanoR_1	300	310	PF00244	0.547
LIG_14-3-3_CanoR_1	543	550	PF00244	0.484
LIG_14-3-3_CanoR_1	567	574	PF00244	0.579
LIG_14-3-3_CanoR_1	627	633	PF00244	0.587
LIG_14-3-3_CanoR_1	683	691	PF00244	0.510
LIG_Actin_WH2_2	305	321	PF00022	0.452
LIG_Actin_WH2_2	394	412	PF00022	0.523
LIG_APCC_ABBA_1	492	497	PF00400	0.388
LIG_APCC_ABBAyCdc20_2	491	497	PF00400	0.396
LIG_CaM_IQ_9	721	736	PF13499	0.459
LIG_CSL_BTD_1	523	526	PF09270	0.469
LIG_EH1_1	15	23	PF00400	0.509
LIG_eIF4E_1	403	409	PF01652	0.591
LIG_eIF4E_1	514	520	PF01652	0.399
LIG_FHA_1	170	176	PF00498	0.562
LIG_FHA_1	214	220	PF00498	0.630
LIG_FHA_1	242	248	PF00498	0.733
LIG_FHA_1	291	297	PF00498	0.562
LIG_FHA_1	33	39	PF00498	0.649
LIG_FHA_1	388	394	PF00498	0.441
LIG_FHA_1	706	712	PF00498	0.490
LIG_FHA_2	434	440	PF00498	0.684
LIG_FHA_2	454	460	PF00498	0.528
LIG_FHA_2	481	487	PF00498	0.536
LIG_FHA_2	673	679	PF00498	0.426
LIG_FHA_2	682	688	PF00498	0.445
LIG_FHA_2	691	697	PF00498	0.465
LIG_LIR_Gen_1	136	145	PF02991	0.465
LIG_LIR_Gen_1	308	318	PF02991	0.365
LIG_LIR_Nem_3	136	141	PF02991	0.462
LIG_LIR_Nem_3	308	313	PF02991	0.373
LIG_LIR_Nem_3	459	464	PF02991	0.498
LIG_PDZ_Class_1	733	738	PF00595	0.472
LIG_Pex14_2	12	16	PF04695	0.455
LIG_SH2_CRK	461	465	PF00017	0.356
LIG_SH2_PTP2	138	141	PF00017	0.498
LIG_SH2_STAP1	514	518	PF00017	0.513
LIG_SH2_STAT3	514	517	PF00017	0.520
LIG_SH2_STAT3	698	701	PF00017	0.351
LIG_SH2_STAT5	138	141	PF00017	0.444
LIG_SH2_STAT5	535	538	PF00017	0.687
LIG_SH2_STAT5	673	676	PF00017	0.418
LIG_SH3_2	556	561	PF14604	0.489
LIG_SH3_3	252	258	PF00018	0.675
LIG_SH3_3	278	284	PF00018	0.729
LIG_SH3_3	461	467	PF00018	0.409
LIG_SH3_3	484	490	PF00018	0.559
LIG_SH3_3	50	56	PF00018	0.755
LIG_SH3_3	553	559	PF00018	0.489
LIG_SH3_3	595	601	PF00018	0.616
LIG_Sin3_3	310	317	PF02671	0.357
LIG_SUMO_SIM_anti_2	706	713	PF11976	0.507
LIG_SUMO_SIM_par_1	706	713	PF11976	0.513
LIG_WRC_WIRS_1	306	311	PF05994	0.368
MOD_CDC14_SPxK_1	632	635	PF00782	0.493
MOD_CDK_SPK_2	261	266	PF00069	0.599
MOD_CDK_SPxK_1	629	635	PF00069	0.494
MOD_CDK_SPxxK_3	163	170	PF00069	0.655
MOD_CK1_1	108	114	PF00069	0.502
MOD_CK1_1	177	183	PF00069	0.679
MOD_CK1_1	28	34	PF00069	0.721
MOD_CK1_1	308	314	PF00069	0.445
MOD_CK1_1	379	385	PF00069	0.521
MOD_CK1_1	404	410	PF00069	0.530
MOD_CK1_1	450	456	PF00069	0.687
MOD_CK1_1	527	533	PF00069	0.519
MOD_CK1_1	566	572	PF00069	0.615
MOD_CK2_1	672	678	PF00069	0.426
MOD_CK2_1	681	687	PF00069	0.445
MOD_CK2_1	690	696	PF00069	0.459
MOD_Cter_Amidation	141	144	PF01082	0.503
MOD_Cter_Amidation	441	444	PF01082	0.524
MOD_Cter_Amidation	559	562	PF01082	0.492
MOD_DYRK1A_RPxSP_1	280	284	PF00069	0.657
MOD_GlcNHglycan	161	164	PF01048	0.547
MOD_GlcNHglycan	210	213	PF01048	0.650
MOD_GlcNHglycan	228	231	PF01048	0.556
MOD_GlcNHglycan	284	287	PF01048	0.675
MOD_GlcNHglycan	288	291	PF01048	0.602
MOD_GlcNHglycan	323	326	PF01048	0.454
MOD_GlcNHglycan	355	358	PF01048	0.608
MOD_GlcNHglycan	360	363	PF01048	0.579
MOD_GlcNHglycan	416	419	PF01048	0.640
MOD_GlcNHglycan	423	426	PF01048	0.750
MOD_GlcNHglycan	448	452	PF01048	0.606
MOD_GlcNHglycan	48	52	PF01048	0.582
MOD_GlcNHglycan	501	504	PF01048	0.352
MOD_GlcNHglycan	529	532	PF01048	0.537
MOD_GlcNHglycan	544	547	PF01048	0.541
MOD_GlcNHglycan	584	587	PF01048	0.656
MOD_GlcNHglycan	594	597	PF01048	0.514
MOD_GlcNHglycan	645	648	PF01048	0.523
MOD_GlcNHglycan	657	660	PF01048	0.538
MOD_GlcNHglycan	735	738	PF01048	0.476
MOD_GSK3_1	159	166	PF00069	0.663
MOD_GSK3_1	170	177	PF00069	0.607
MOD_GSK3_1	203	210	PF00069	0.685
MOD_GSK3_1	237	244	PF00069	0.714
MOD_GSK3_1	25	32	PF00069	0.594
MOD_GSK3_1	276	283	PF00069	0.642
MOD_GSK3_1	286	293	PF00069	0.537
MOD_GSK3_1	301	308	PF00069	0.467
MOD_GSK3_1	349	356	PF00069	0.549
MOD_GSK3_1	379	386	PF00069	0.445
MOD_GSK3_1	387	394	PF00069	0.434
MOD_GSK3_1	446	453	PF00069	0.696
MOD_GSK3_1	563	570	PF00069	0.733
MOD_GSK3_1	604	611	PF00069	0.600
MOD_GSK3_1	623	630	PF00069	0.509
MOD_GSK3_1	672	679	PF00069	0.439
MOD_GSK3_1	681	688	PF00069	0.497
MOD_N-GLC_1	145	150	PF02516	0.488
MOD_N-GLC_1	446	451	PF02516	0.503
MOD_N-GLC_1	477	482	PF02516	0.305
MOD_N-GLC_1	582	587	PF02516	0.483
MOD_N-GLC_1	730	735	PF02516	0.439
MOD_NEK2_1	27	32	PF00069	0.420
MOD_NEK2_1	318	323	PF00069	0.455
MOD_NEK2_1	485	490	PF00069	0.516
MOD_NEK2_1	542	547	PF00069	0.577
MOD_NEK2_1	606	611	PF00069	0.666
MOD_NEK2_1	628	633	PF00069	0.583
MOD_NEK2_2	490	495	PF00069	0.410
MOD_NEK2_2	633	638	PF00069	0.481
MOD_PIKK_1	184	190	PF00454	0.665
MOD_PIKK_1	370	376	PF00454	0.450
MOD_PK_1	34	40	PF00069	0.615
MOD_PKA_2	169	175	PF00069	0.623
MOD_PKA_2	177	183	PF00069	0.660
MOD_PKA_2	274	280	PF00069	0.551
MOD_PKA_2	318	324	PF00069	0.413
MOD_PKA_2	490	496	PF00069	0.400
MOD_PKA_2	542	548	PF00069	0.480
MOD_PKA_2	566	572	PF00069	0.585
MOD_PKA_2	575	581	PF00069	0.515
MOD_PKB_1	444	452	PF00069	0.609
MOD_Plk_1	105	111	PF00069	0.485
MOD_Plk_1	145	151	PF00069	0.494
MOD_Plk_1	404	410	PF00069	0.530
MOD_Plk_1	47	53	PF00069	0.601
MOD_Plk_1	705	711	PF00069	0.515
MOD_Plk_1	717	723	PF00069	0.440
MOD_Plk_1	730	736	PF00069	0.436
MOD_Plk_1	89	95	PF00069	0.510
MOD_Plk_4	305	311	PF00069	0.418
MOD_Plk_4	388	394	PF00069	0.503
MOD_Plk_4	404	410	PF00069	0.441
MOD_Plk_4	608	614	PF00069	0.581
MOD_Plk_4	676	682	PF00069	0.425
MOD_Plk_4	690	696	PF00069	0.459
MOD_ProDKin_1	163	169	PF00069	0.643
MOD_ProDKin_1	241	247	PF00069	0.680
MOD_ProDKin_1	261	267	PF00069	0.601
MOD_ProDKin_1	280	286	PF00069	0.738
MOD_ProDKin_1	522	528	PF00069	0.581
MOD_ProDKin_1	629	635	PF00069	0.494
MOD_SUMO_rev_2	707	716	PF00179	0.444
TRG_DiLeu_BaEn_1	48	53	PF01217	0.603
TRG_DiLeu_BaEn_1	515	520	PF01217	0.397
TRG_DiLeu_BaEn_1	707	712	PF01217	0.448
TRG_DiLeu_BaLyEn_6	171	176	PF01217	0.628
TRG_DiLeu_BaLyEn_6	569	574	PF01217	0.476
TRG_ENDOCYTIC_2	138	141	PF00928	0.460
TRG_ENDOCYTIC_2	461	464	PF00928	0.396
TRG_ER_diArg_1	294	296	PF00400	0.486
TRG_ER_diArg_1	443	446	PF00400	0.662
TRG_ER_diArg_1	638	640	PF00400	0.599
TRG_NES_CRM1_1	305	315	PF08389	0.375
TRG_Pf-PMV_PEXEL_1	266	271	PF00026	0.716
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	443	448	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	455	459	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	683	687	PF00026	0.514
TRG_Pf-PMV_PEXEL_1	717	722	PF00026	0.323

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIY4	Leptomonas seymouri	37%	91%
A0A3Q8II80	Leishmania donovani	85%	100%
A4HMK8	Leishmania braziliensis	68%	100%
A4IB87	Leishmania infantum	85%	100%
E9AF08	Leishmania major	84%	100%