Protein kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase-like protein

Species:

Leishmania mexicana

UniProt:

E9B663_LEIMU

TriTrypDb:

LmxM.34.1860

Length:

575

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B663

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B663

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016310	phosphorylation	5	8
GO:0019538	protein metabolic process	3	8
GO:0036211	protein modification process	4	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018107	peptidyl-threonine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0018210	peptidyl-threonine modification	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0004672	protein kinase activity	3	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0016301	kinase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:0140096	catalytic activity, acting on a protein	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0004713	protein tyrosine kinase activity	4	1
GO:0004712	protein serine/threonine/tyrosine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.506
CLV_C14_Caspase3-7	566	570	PF00656	0.732
CLV_NRD_NRD_1	315	317	PF00675	0.455
CLV_NRD_NRD_1	481	483	PF00675	0.348
CLV_PCSK_KEX2_1	315	317	PF00082	0.194
CLV_PCSK_KEX2_1	481	483	PF00082	0.401
CLV_PCSK_KEX2_1	499	501	PF00082	0.193
CLV_PCSK_PC1ET2_1	499	501	PF00082	0.401
CLV_PCSK_SKI1_1	184	188	PF00082	0.587
CLV_PCSK_SKI1_1	272	276	PF00082	0.328
CLV_PCSK_SKI1_1	408	412	PF00082	0.401
CLV_PCSK_SKI1_1	511	515	PF00082	0.394
DEG_SCF_FBW7_1	146	151	PF00400	0.796
DOC_CKS1_1	162	167	PF01111	0.682
DOC_MAPK_DCC_7	195	203	PF00069	0.507
DOC_MAPK_gen_1	264	273	PF00069	0.352
DOC_MAPK_gen_1	315	322	PF00069	0.488
DOC_MAPK_gen_1	417	426	PF00069	0.348
DOC_MAPK_gen_1	508	516	PF00069	0.394
DOC_MAPK_HePTP_8	261	273	PF00069	0.401
DOC_MAPK_HePTP_8	414	426	PF00069	0.348
DOC_MAPK_MEF2A_6	195	203	PF00069	0.507
DOC_MAPK_MEF2A_6	264	273	PF00069	0.315
DOC_MAPK_MEF2A_6	417	426	PF00069	0.348
DOC_PP1_RVXF_1	394	401	PF00149	0.348
DOC_PP2B_LxvP_1	426	429	PF13499	0.348
DOC_PP4_MxPP_1	83	86	PF00568	0.653
DOC_USP7_MATH_1	454	458	PF00917	0.325
DOC_USP7_MATH_1	5	9	PF00917	0.674
DOC_USP7_MATH_1	52	56	PF00917	0.723
DOC_USP7_MATH_1	67	71	PF00917	0.741
DOC_WW_Pin1_4	144	149	PF00397	0.732
DOC_WW_Pin1_4	161	166	PF00397	0.516
DOC_WW_Pin1_4	174	179	PF00397	0.555
DOC_WW_Pin1_4	375	380	PF00397	0.271
DOC_WW_Pin1_4	501	506	PF00397	0.336
DOC_WW_Pin1_4	539	544	PF00397	0.348
LIG_14-3-3_CanoR_1	107	114	PF00244	0.706
LIG_14-3-3_CanoR_1	184	190	PF00244	0.428
LIG_14-3-3_CanoR_1	339	347	PF00244	0.407
LIG_14-3-3_CanoR_1	408	414	PF00244	0.401
LIG_BRCT_BRCA1_1	181	185	PF00533	0.653
LIG_BRCT_BRCA1_1	199	203	PF00533	0.566
LIG_BRCT_BRCA1_1	310	314	PF00533	0.401
LIG_BRCT_BRCA1_1	341	345	PF00533	0.401
LIG_BRCT_BRCA1_1	389	393	PF00533	0.443
LIG_CtBP_PxDLS_1	180	184	PF00389	0.661
LIG_deltaCOP1_diTrp_1	435	439	PF00928	0.401
LIG_deltaCOP1_diTrp_1	548	555	PF00928	0.401
LIG_FHA_1	145	151	PF00498	0.793
LIG_FHA_1	162	168	PF00498	0.527
LIG_FHA_1	251	257	PF00498	0.377
LIG_FHA_1	288	294	PF00498	0.401
LIG_FHA_1	353	359	PF00498	0.364
LIG_FHA_1	429	435	PF00498	0.348
LIG_FHA_1	55	61	PF00498	0.778
LIG_FHA_1	562	568	PF00498	0.712
LIG_FHA_1	95	101	PF00498	0.443
LIG_FHA_2	115	121	PF00498	0.659
LIG_FHA_2	185	191	PF00498	0.560
LIG_FHA_2	430	436	PF00498	0.401
LIG_LIR_Apic_2	416	422	PF02991	0.348
LIG_LIR_Apic_2	78	84	PF02991	0.785
LIG_LIR_Gen_1	327	338	PF02991	0.401
LIG_LIR_Gen_1	522	533	PF02991	0.385
LIG_LIR_Nem_3	117	121	PF02991	0.694
LIG_LIR_Nem_3	171	176	PF02991	0.733
LIG_LIR_Nem_3	253	257	PF02991	0.348
LIG_LIR_Nem_3	327	333	PF02991	0.401
LIG_LIR_Nem_3	438	442	PF02991	0.401
LIG_LIR_Nem_3	467	472	PF02991	0.350
LIG_LIR_Nem_3	522	528	PF02991	0.385
LIG_LIR_Nem_3	548	554	PF02991	0.401
LIG_MLH1_MIPbox_1	199	203	PF16413	0.566
LIG_MYND_1	148	152	PF01753	0.712
LIG_SH2_CRK	173	177	PF00017	0.620
LIG_SH2_CRK	231	235	PF00017	0.395
LIG_SH2_CRK	330	334	PF00017	0.401
LIG_SH2_CRK	81	85	PF00017	0.705
LIG_SH2_NCK_1	330	334	PF00017	0.401
LIG_SH2_NCK_1	81	85	PF00017	0.693
LIG_SH2_PTP2	318	321	PF00017	0.469
LIG_SH2_SRC	197	200	PF00017	0.554
LIG_SH2_SRC	224	227	PF00017	0.275
LIG_SH2_SRC	330	333	PF00017	0.469
LIG_SH2_STAP1	280	284	PF00017	0.348
LIG_SH2_STAP1	430	434	PF00017	0.348
LIG_SH2_STAT3	280	283	PF00017	0.401
LIG_SH2_STAT5	173	176	PF00017	0.706
LIG_SH2_STAT5	197	200	PF00017	0.563
LIG_SH2_STAT5	202	205	PF00017	0.426
LIG_SH2_STAT5	280	283	PF00017	0.401
LIG_SH2_STAT5	318	321	PF00017	0.401
LIG_SH2_STAT5	413	416	PF00017	0.352
LIG_SH2_STAT5	430	433	PF00017	0.380
LIG_SH2_STAT5	468	471	PF00017	0.348
LIG_SH2_STAT5	475	478	PF00017	0.348
LIG_SH3_1	499	505	PF00018	0.405
LIG_SH3_1	81	87	PF00018	0.781
LIG_SH3_3	159	165	PF00018	0.694
LIG_SH3_3	175	181	PF00018	0.644
LIG_SH3_3	448	454	PF00018	0.348
LIG_SH3_3	499	505	PF00018	0.374
LIG_SH3_3	61	67	PF00018	0.787
LIG_SH3_3	81	87	PF00018	0.456
LIG_SUMO_SIM_anti_2	290	295	PF11976	0.445
LIG_TRAF2_1	188	191	PF00917	0.463
LIG_TRAF2_1	284	287	PF00917	0.401
LIG_TRAF2_1	403	406	PF00917	0.401
LIG_TRAF2_1	519	522	PF00917	0.194
LIG_TRFH_1	322	326	PF08558	0.401
LIG_WRC_WIRS_1	436	441	PF05994	0.401
MOD_CDK_SPK_2	375	380	PF00069	0.194
MOD_CDK_SPxxK_3	501	508	PF00069	0.194
MOD_CK1_1	388	394	PF00069	0.406
MOD_CK1_1	504	510	PF00069	0.257
MOD_CK1_1	561	567	PF00069	0.646
MOD_CK2_1	114	120	PF00069	0.660
MOD_CK2_1	184	190	PF00069	0.520
MOD_CK2_1	201	207	PF00069	0.481
MOD_CK2_1	36	42	PF00069	0.503
MOD_CK2_1	399	405	PF00069	0.349
MOD_CK2_1	454	460	PF00069	0.325
MOD_CK2_1	516	522	PF00069	0.194
MOD_Cter_Amidation	479	482	PF01082	0.390
MOD_Cter_Amidation	496	499	PF01082	0.390
MOD_GlcNHglycan	102	105	PF01048	0.754
MOD_GlcNHglycan	109	112	PF01048	0.723
MOD_GlcNHglycan	203	206	PF01048	0.256
MOD_GlcNHglycan	401	404	PF01048	0.391
MOD_GlcNHglycan	50	53	PF01048	0.777
MOD_GlcNHglycan	560	563	PF01048	0.524
MOD_GlcNHglycan	69	72	PF01048	0.610
MOD_GlcNHglycan	7	10	PF01048	0.701
MOD_GSK3_1	142	149	PF00069	0.749
MOD_GSK3_1	17	24	PF00069	0.616
MOD_GSK3_1	197	204	PF00069	0.288
MOD_GSK3_1	381	388	PF00069	0.414
MOD_GSK3_1	409	416	PF00069	0.348
MOD_GSK3_1	48	55	PF00069	0.714
MOD_GSK3_1	5	12	PF00069	0.786
MOD_GSK3_1	557	564	PF00069	0.646
MOD_GSK3_1	565	572	PF00069	0.589
MOD_GSK3_1	62	69	PF00069	0.807
MOD_GSK3_1	75	82	PF00069	0.669
MOD_N-GLC_1	17	22	PF02516	0.668
MOD_N-GLC_1	278	283	PF02516	0.401
MOD_N-GLC_1	36	41	PF02516	0.702
MOD_N-GLC_1	5	10	PF02516	0.696
MOD_N-GLC_1	94	99	PF02516	0.481
MOD_N-GLC_2	158	160	PF02516	0.716
MOD_NEK2_1	100	105	PF00069	0.610
MOD_NEK2_1	308	313	PF00069	0.401
MOD_NEK2_1	567	572	PF00069	0.734
MOD_PIKK_1	54	60	PF00454	0.717
MOD_PKA_2	114	120	PF00069	0.660
MOD_PKA_2	215	221	PF00069	0.539
MOD_PKA_2	555	561	PF00069	0.613
MOD_Plk_1	36	42	PF00069	0.703
MOD_Plk_1	391	397	PF00069	0.401
MOD_Plk_1	45	51	PF00069	0.602
MOD_Plk_2-3	287	293	PF00069	0.469
MOD_Plk_2-3	563	569	PF00069	0.446
MOD_Plk_4	197	203	PF00069	0.568
MOD_Plk_4	36	42	PF00069	0.553
MOD_Plk_4	471	477	PF00069	0.386
MOD_Plk_4	94	100	PF00069	0.522
MOD_ProDKin_1	144	150	PF00069	0.734
MOD_ProDKin_1	161	167	PF00069	0.511
MOD_ProDKin_1	174	180	PF00069	0.547
MOD_ProDKin_1	375	381	PF00069	0.271
MOD_ProDKin_1	501	507	PF00069	0.336
MOD_ProDKin_1	539	545	PF00069	0.348
MOD_SUMO_for_1	370	373	PF00179	0.348
MOD_SUMO_rev_2	131	140	PF00179	0.672
MOD_SUMO_rev_2	286	291	PF00179	0.382
TRG_DiLeu_BaEn_4	286	292	PF01217	0.401
TRG_DiLeu_BaLyEn_6	162	167	PF01217	0.474
TRG_DiLeu_BaLyEn_6	304	309	PF01217	0.469
TRG_ENDOCYTIC_2	118	121	PF00928	0.715
TRG_ENDOCYTIC_2	173	176	PF00928	0.622
TRG_ENDOCYTIC_2	231	234	PF00928	0.390
TRG_ENDOCYTIC_2	243	246	PF00928	0.271
TRG_ENDOCYTIC_2	318	321	PF00928	0.385
TRG_ENDOCYTIC_2	330	333	PF00928	0.401
TRG_ENDOCYTIC_2	450	453	PF00928	0.348
TRG_ER_diArg_1	314	316	PF00400	0.194
TRG_ER_diArg_1	538	541	PF00400	0.469
TRG_NLS_Bipartite_1	481	502	PF00514	0.401
TRG_NLS_MonoExtC_3	497	502	PF00514	0.401
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.706

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4D6	Leptomonas seymouri	59%	80%
A0A0S4IL53	Bodo saltans	26%	85%
A0A0S4IUF2	Bodo saltans	40%	100%
A0A3Q8IB74	Leishmania donovani	27%	100%
A0A3Q8IC55	Leishmania donovani	28%	100%
A0A3Q8ITZ9	Leishmania donovani	30%	100%
A0A3Q8IVR8	Leishmania donovani	33%	100%
A0A3S5H6C8	Leishmania donovani	27%	100%
A0A3S5H7N7	Leishmania donovani	27%	100%
A0A3S7WQK7	Leishmania donovani	27%	100%
A0A3S7WR45	Leishmania donovani	25%	100%
A0A3S7X9D1	Leishmania donovani	93%	100%
A0A3S7XA45	Leishmania donovani	31%	100%
A0A422NSR4	Trypanosoma rangeli	25%	66%
A0A451EJH2	Leishmania donovani	26%	100%
A4H5L7	Leishmania braziliensis	26%	100%
A4H641	Leishmania braziliensis	26%	100%
A4H7F4	Leishmania braziliensis	25%	100%
A4H9X5	Leishmania braziliensis	28%	100%
A4HC27	Leishmania braziliensis	30%	100%
A4HD79	Leishmania braziliensis	24%	100%
A4HIM5	Leishmania braziliensis	28%	100%
A4HMK7	Leishmania braziliensis	82%	100%
A4HNG3	Leishmania braziliensis	30%	100%
A4HNT2	Leishmania braziliensis	33%	100%
A4HRN3	Leishmania infantum	26%	100%
A4HTV4	Leishmania infantum	27%	100%
A4HTV5	Leishmania infantum	27%	100%
A4HUG1	Leishmania infantum	25%	100%
A4HZH0	Leishmania infantum	28%	100%
A4I5X0	Leishmania infantum	27%	100%
A4I910	Leishmania infantum	30%	100%
A4IB86	Leishmania infantum	92%	100%
A4IC54	Leishmania infantum	31%	100%
A4ICR2	Leishmania infantum	33%	100%
A8WJR8	Caenorhabditis briggsae	39%	71%
C9ZRX8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	68%
E8NHK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9ACB1	Leishmania major	26%	100%
E9AF07	Leishmania major	92%	100%
E9AFX4	Leishmania major	31%	100%
E9AGS0	Leishmania infantum	27%	100%
E9AJJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AMP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AN59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9ARW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9ASJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AVG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AWL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B164	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B3X5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B727	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
O43781	Homo sapiens	37%	98%
P83102	Drosophila melanogaster	38%	69%
Q07538	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
Q09815	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	69%
Q45FA5	Physarum polycephalum	27%	100%
Q4Q204	Leishmania major	34%	100%
Q4Q449	Leishmania major	30%	100%
Q4Q701	Leishmania major	27%	100%
Q4QC19	Leishmania major	28%	100%
Q4QDK3	Leishmania major	27%	100%
Q4QFG6	Leishmania major	35%	100%
Q4QHG6	Leishmania major	25%	100%
Q4QHY3	Leishmania major	27%	100%
Q4QHY4	Leishmania major	27%	100%
Q4R6S5	Macaca fascicularis	37%	100%
Q4V8A3	Rattus norvegicus	37%	98%
Q5U4C9	Mus musculus	40%	96%
Q5ZIU3	Gallus gallus	39%	100%
Q922Y0	Mus musculus	37%	98%
Q92630	Homo sapiens	39%	96%
Q9V3D5	Drosophila melanogaster	38%	80%
Q9XTF3	Caenorhabditis elegans	39%	70%
V5DIC3	Trypanosoma cruzi	32%	95%