LeishMANIAdb
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RNA-dependent RNA polymerase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
RNA-dependent RNA polymerase
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B660_LEIMU
TriTrypDb:
LmxM.34.1830 *
Length:
739

Annotations

LeishMANIAdb annotations

Almost certainly non-TM

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B660
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B660

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 210 212 PF00675 0.403
CLV_NRD_NRD_1 320 322 PF00675 0.406
CLV_NRD_NRD_1 488 490 PF00675 0.374
CLV_NRD_NRD_1 502 504 PF00675 0.438
CLV_NRD_NRD_1 647 649 PF00675 0.341
CLV_PCSK_KEX2_1 488 490 PF00082 0.402
CLV_PCSK_KEX2_1 502 504 PF00082 0.402
CLV_PCSK_KEX2_1 647 649 PF00082 0.341
CLV_PCSK_SKI1_1 250 254 PF00082 0.339
CLV_PCSK_SKI1_1 336 340 PF00082 0.438
CLV_PCSK_SKI1_1 427 431 PF00082 0.322
CLV_PCSK_SKI1_1 440 444 PF00082 0.309
CLV_PCSK_SKI1_1 569 573 PF00082 0.329
CLV_PCSK_SKI1_1 649 653 PF00082 0.519
CLV_PCSK_SKI1_1 708 712 PF00082 0.352
DOC_CKS1_1 661 666 PF01111 0.477
DOC_CYCLIN_RxL_1 284 295 PF00134 0.366
DOC_CYCLIN_RxL_1 424 432 PF00134 0.346
DOC_CYCLIN_yCln2_LP_2 625 631 PF00134 0.293
DOC_MAPK_gen_1 437 444 PF00069 0.330
DOC_MAPK_RevD_3 526 540 PF00069 0.411
DOC_PP1_RVXF_1 285 292 PF00149 0.361
DOC_PP1_RVXF_1 438 445 PF00149 0.291
DOC_PP1_SILK_1 332 337 PF00149 0.402
DOC_PP4_FxxP_1 421 424 PF00568 0.312
DOC_PP4_FxxP_1 661 664 PF00568 0.469
DOC_USP7_MATH_1 135 139 PF00917 0.407
DOC_USP7_MATH_1 2 6 PF00917 0.559
DOC_USP7_MATH_1 234 238 PF00917 0.497
DOC_USP7_MATH_1 280 284 PF00917 0.554
DOC_USP7_MATH_1 337 341 PF00917 0.441
DOC_USP7_UBL2_3 339 343 PF12436 0.489
DOC_WW_Pin1_4 111 116 PF00397 0.307
DOC_WW_Pin1_4 420 425 PF00397 0.298
DOC_WW_Pin1_4 660 665 PF00397 0.431
LIG_14-3-3_CanoR_1 143 151 PF00244 0.393
LIG_14-3-3_CanoR_1 232 242 PF00244 0.433
LIG_14-3-3_CanoR_1 321 325 PF00244 0.375
LIG_14-3-3_CanoR_1 327 335 PF00244 0.338
LIG_14-3-3_CanoR_1 336 342 PF00244 0.331
LIG_14-3-3_CanoR_1 391 395 PF00244 0.483
LIG_14-3-3_CanoR_1 569 575 PF00244 0.341
LIG_14-3-3_CanoR_1 619 627 PF00244 0.314
LIG_14-3-3_CanoR_1 648 654 PF00244 0.463
LIG_14-3-3_CanoR_1 80 88 PF00244 0.434
LIG_Actin_WH2_2 195 213 PF00022 0.428
LIG_Actin_WH2_2 66 82 PF00022 0.357
LIG_APCC_ABBA_1 220 225 PF00400 0.352
LIG_BRCT_BRCA1_1 671 675 PF00533 0.457
LIG_BRCT_BRCA1_1 73 77 PF00533 0.336
LIG_Clathr_ClatBox_1 133 137 PF01394 0.314
LIG_deltaCOP1_diTrp_1 688 695 PF00928 0.304
LIG_EH_1 30 34 PF12763 0.454
LIG_eIF4E_1 611 617 PF01652 0.351
LIG_FHA_1 143 149 PF00498 0.462
LIG_FHA_1 329 335 PF00498 0.486
LIG_FHA_1 372 378 PF00498 0.564
LIG_FHA_1 466 472 PF00498 0.332
LIG_FHA_1 54 60 PF00498 0.500
LIG_FHA_1 548 554 PF00498 0.417
LIG_FHA_1 630 636 PF00498 0.349
LIG_FHA_2 321 327 PF00498 0.474
LIG_FHA_2 593 599 PF00498 0.433
LIG_FHA_2 635 641 PF00498 0.336
LIG_FHA_2 697 703 PF00498 0.371
LIG_IBAR_NPY_1 602 604 PF08397 0.376
LIG_LIR_Apic_2 418 424 PF02991 0.308
LIG_LIR_Gen_1 122 130 PF02991 0.456
LIG_LIR_Gen_1 228 235 PF02991 0.511
LIG_LIR_Gen_1 398 407 PF02991 0.362
LIG_LIR_Gen_1 482 490 PF02991 0.358
LIG_LIR_Nem_3 122 126 PF02991 0.469
LIG_LIR_Nem_3 214 219 PF02991 0.375
LIG_LIR_Nem_3 228 233 PF02991 0.387
LIG_LIR_Nem_3 251 256 PF02991 0.293
LIG_LIR_Nem_3 305 309 PF02991 0.406
LIG_LIR_Nem_3 374 379 PF02991 0.548
LIG_LIR_Nem_3 398 402 PF02991 0.288
LIG_LIR_Nem_3 448 454 PF02991 0.433
LIG_LIR_Nem_3 482 487 PF02991 0.375
LIG_LIR_Nem_3 510 515 PF02991 0.291
LIG_LIR_Nem_3 584 588 PF02991 0.336
LIG_LIR_Nem_3 626 630 PF02991 0.361
LIG_LIR_Nem_3 705 710 PF02991 0.326
LIG_NRBOX 425 431 PF00104 0.285
LIG_NRBOX 527 533 PF00104 0.342
LIG_Pex14_2 249 253 PF04695 0.445
LIG_Pex14_2 417 421 PF04695 0.430
LIG_Pex14_2 623 627 PF04695 0.304
LIG_PTB_Apo_2 141 148 PF02174 0.431
LIG_PTB_Apo_2 505 512 PF02174 0.323
LIG_PTB_Phospho_1 141 147 PF10480 0.434
LIG_REV1ctd_RIR_1 441 450 PF16727 0.336
LIG_REV1ctd_RIR_1 708 715 PF16727 0.377
LIG_SH2_CRK 230 234 PF00017 0.443
LIG_SH2_CRK 399 403 PF00017 0.286
LIG_SH2_CRK 484 488 PF00017 0.383
LIG_SH2_GRB2like 506 509 PF00017 0.333
LIG_SH2_NCK_1 230 234 PF00017 0.443
LIG_SH2_NCK_1 45 49 PF00017 0.497
LIG_SH2_PTP2 123 126 PF00017 0.463
LIG_SH2_PTP2 376 379 PF00017 0.547
LIG_SH2_SRC 185 188 PF00017 0.444
LIG_SH2_SRC 484 487 PF00017 0.461
LIG_SH2_SRC 506 509 PF00017 0.381
LIG_SH2_SRC 604 607 PF00017 0.330
LIG_SH2_STAP1 230 234 PF00017 0.424
LIG_SH2_STAP1 245 249 PF00017 0.352
LIG_SH2_STAT3 312 315 PF00017 0.465
LIG_SH2_STAT3 392 395 PF00017 0.404
LIG_SH2_STAT5 123 126 PF00017 0.334
LIG_SH2_STAT5 147 150 PF00017 0.430
LIG_SH2_STAT5 185 188 PF00017 0.444
LIG_SH2_STAT5 22 25 PF00017 0.465
LIG_SH2_STAT5 230 233 PF00017 0.413
LIG_SH2_STAT5 307 310 PF00017 0.418
LIG_SH2_STAT5 351 354 PF00017 0.342
LIG_SH2_STAT5 376 379 PF00017 0.420
LIG_SH2_STAT5 392 395 PF00017 0.314
LIG_SH2_STAT5 420 423 PF00017 0.305
LIG_SH2_STAT5 45 48 PF00017 0.320
LIG_SH2_STAT5 486 489 PF00017 0.375
LIG_SH2_STAT5 506 509 PF00017 0.186
LIG_SH2_STAT5 604 607 PF00017 0.330
LIG_SH2_STAT5 734 737 PF00017 0.365
LIG_SH3_2 716 721 PF14604 0.398
LIG_SH3_3 184 190 PF00018 0.406
LIG_SH3_3 365 371 PF00018 0.432
LIG_SH3_3 651 657 PF00018 0.450
LIG_SH3_3 713 719 PF00018 0.363
LIG_SUMO_SIM_anti_2 114 120 PF11976 0.320
LIG_SUMO_SIM_par_1 109 114 PF11976 0.303
LIG_SUMO_SIM_par_1 117 122 PF11976 0.299
LIG_SUMO_SIM_par_1 549 557 PF11976 0.382
LIG_TRAF2_1 642 645 PF00917 0.334
LIG_TYR_ITIM 121 126 PF00017 0.461
LIG_TYR_ITIM 183 188 PF00017 0.437
LIG_TYR_ITSM 372 379 PF00017 0.450
LIG_UBA3_1 531 540 PF00899 0.409
LIG_WRC_WIRS_1 451 456 PF05994 0.392
LIG_WRC_WIRS_1 466 471 PF05994 0.263
MOD_CDK_SPxxK_3 420 427 PF00069 0.300
MOD_CK1_1 267 273 PF00069 0.370
MOD_CK1_1 329 335 PF00069 0.497
MOD_CK1_1 453 459 PF00069 0.406
MOD_CK1_1 81 87 PF00069 0.309
MOD_CK2_1 280 286 PF00069 0.573
MOD_CK2_1 308 314 PF00069 0.455
MOD_CK2_1 592 598 PF00069 0.443
MOD_CK2_1 634 640 PF00069 0.343
MOD_CK2_1 696 702 PF00069 0.327
MOD_GlcNHglycan 195 198 PF01048 0.395
MOD_GlcNHglycan 236 239 PF01048 0.449
MOD_GlcNHglycan 281 285 PF01048 0.589
MOD_GlcNHglycan 339 342 PF01048 0.498
MOD_GlcNHglycan 402 405 PF01048 0.287
MOD_GlcNHglycan 532 535 PF01048 0.444
MOD_GlcNHglycan 671 674 PF01048 0.438
MOD_GlcNHglycan 680 683 PF01048 0.388
MOD_GSK3_1 142 149 PF00069 0.565
MOD_GSK3_1 18 25 PF00069 0.440
MOD_GSK3_1 189 196 PF00069 0.369
MOD_GSK3_1 316 323 PF00069 0.446
MOD_GSK3_1 326 333 PF00069 0.420
MOD_GSK3_1 425 432 PF00069 0.326
MOD_GSK3_1 680 687 PF00069 0.388
MOD_N-GLC_1 507 512 PF02516 0.398
MOD_N-GLC_1 547 552 PF02516 0.389
MOD_NEK2_1 320 325 PF00069 0.379
MOD_NEK2_1 429 434 PF00069 0.342
MOD_NEK2_1 547 552 PF00069 0.482
MOD_NEK2_1 78 83 PF00069 0.320
MOD_NEK2_2 2 7 PF00069 0.550
MOD_PIKK_1 453 459 PF00454 0.334
MOD_PIKK_1 81 87 PF00454 0.309
MOD_PKA_1 211 217 PF00069 0.502
MOD_PKA_2 142 148 PF00069 0.468
MOD_PKA_2 320 326 PF00069 0.381
MOD_PKA_2 390 396 PF00069 0.470
MOD_PKA_2 40 46 PF00069 0.384
MOD_PKA_2 618 624 PF00069 0.325
MOD_PKA_2 684 690 PF00069 0.429
MOD_PKA_2 79 85 PF00069 0.443
MOD_Plk_1 297 303 PF00069 0.357
MOD_Plk_1 507 513 PF00069 0.320
MOD_Plk_2-3 305 311 PF00069 0.309
MOD_Plk_4 256 262 PF00069 0.447
MOD_Plk_4 330 336 PF00069 0.424
MOD_Plk_4 347 353 PF00069 0.203
MOD_Plk_4 372 378 PF00069 0.551
MOD_Plk_4 425 431 PF00069 0.326
MOD_Plk_4 450 456 PF00069 0.430
MOD_Plk_4 507 513 PF00069 0.298
MOD_Plk_4 527 533 PF00069 0.184
MOD_ProDKin_1 111 117 PF00069 0.302
MOD_ProDKin_1 420 426 PF00069 0.296
MOD_ProDKin_1 660 666 PF00069 0.432
MOD_SUMO_rev_2 364 374 PF00179 0.385
TRG_DiLeu_BaEn_1 198 203 PF01217 0.347
TRG_DiLeu_BaEn_1 384 389 PF01217 0.427
TRG_DiLeu_BaEn_1 527 532 PF01217 0.337
TRG_DiLeu_BaLyEn_6 147 152 PF01217 0.348
TRG_DiLeu_BaLyEn_6 158 163 PF01217 0.368
TRG_DiLeu_BaLyEn_6 268 273 PF01217 0.406
TRG_DiLeu_BaLyEn_6 542 547 PF01217 0.378
TRG_ENDOCYTIC_2 123 126 PF00928 0.463
TRG_ENDOCYTIC_2 185 188 PF00928 0.444
TRG_ENDOCYTIC_2 216 219 PF00928 0.364
TRG_ENDOCYTIC_2 230 233 PF00928 0.373
TRG_ENDOCYTIC_2 376 379 PF00928 0.547
TRG_ENDOCYTIC_2 399 402 PF00928 0.285
TRG_ENDOCYTIC_2 451 454 PF00928 0.438
TRG_ENDOCYTIC_2 484 487 PF00928 0.376
TRG_ENDOCYTIC_2 707 710 PF00928 0.343
TRG_ER_diArg_1 487 489 PF00400 0.370
TRG_ER_diArg_1 646 648 PF00400 0.344
TRG_NES_CRM1_1 294 305 PF08389 0.350

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I4C7 Leptomonas seymouri 84% 100%
A0A0S4ILQ1 Bodo saltans 59% 99%
A0A1X0P5V8 Trypanosomatidae 65% 100%
A0A3Q8IHX6 Leishmania donovani 98% 100%
A0A422NNY1 Trypanosoma rangeli 67% 100%
A4HMK4 Leishmania braziliensis 93% 100%
A4IB83 Leishmania infantum 99% 100%
C9ZZK8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 55% 100%
E9AF04 Leishmania major 98% 100%
V5D9G0 Trypanosoma cruzi 66% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS