rRNA processing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic rRNA processing protein EBP2, putative

Species:

Leishmania mexicana

UniProt:

E9B659_LEIMU

TriTrypDb:

LmxM.34.1820

Length:

273

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0030684	preribosome	3	1
GO:0030687	preribosome, large subunit precursor	4	1
GO:0032991	protein-containing complex	1	1
GO:0034399	nuclear periphery	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9B659

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B659

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	11
GO:0022613	ribonucleoprotein complex biogenesis	4	11
GO:0042254	ribosome biogenesis	5	10
GO:0044085	cellular component biogenesis	3	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0042273	ribosomal large subunit biogenesis	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	46	50	PF00656	0.646
CLV_NRD_NRD_1	17	19	PF00675	0.454
CLV_NRD_NRD_1	184	186	PF00675	0.240
CLV_NRD_NRD_1	219	221	PF00675	0.258
CLV_NRD_NRD_1	223	225	PF00675	0.233
CLV_NRD_NRD_1	8	10	PF00675	0.454
CLV_PCSK_FUR_1	220	224	PF00082	0.236
CLV_PCSK_KEX2_1	10	12	PF00082	0.442
CLV_PCSK_KEX2_1	120	122	PF00082	0.240
CLV_PCSK_KEX2_1	148	150	PF00082	0.240
CLV_PCSK_KEX2_1	16	18	PF00082	0.458
CLV_PCSK_KEX2_1	184	186	PF00082	0.240
CLV_PCSK_KEX2_1	209	211	PF00082	0.281
CLV_PCSK_KEX2_1	222	224	PF00082	0.252
CLV_PCSK_KEX2_1	244	246	PF00082	0.373
CLV_PCSK_KEX2_1	263	265	PF00082	0.247
CLV_PCSK_KEX2_1	270	272	PF00082	0.542
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.442
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.240
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.258
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.240
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.240
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.301
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.260
CLV_PCSK_PC7_1	205	211	PF00082	0.240
CLV_PCSK_SKI1_1	100	104	PF00082	0.268
CLV_PCSK_SKI1_1	185	189	PF00082	0.286
CLV_PCSK_SKI1_1	241	245	PF00082	0.373
CLV_Separin_Metazoa	200	204	PF03568	0.240
DEG_SPOP_SBC_1	102	106	PF00917	0.258
DOC_CKS1_1	249	254	PF01111	0.373
DOC_PP1_RVXF_1	86	92	PF00149	0.373
DOC_PP4_FxxP_1	91	94	PF00568	0.240
DOC_USP7_MATH_1	102	106	PF00917	0.242
DOC_USP7_MATH_1	243	247	PF00917	0.306
DOC_USP7_MATH_1	65	69	PF00917	0.706
DOC_USP7_MATH_1	76	80	PF00917	0.572
DOC_USP7_UBL2_3	188	192	PF12436	0.240
DOC_USP7_UBL2_3	263	267	PF12436	0.318
DOC_WW_Pin1_4	248	253	PF00397	0.353
DOC_WW_Pin1_4	29	34	PF00397	0.726
LIG_14-3-3_CanoR_1	100	110	PF00244	0.253
LIG_14-3-3_CanoR_1	135	140	PF00244	0.282
LIG_14-3-3_CanoR_1	184	188	PF00244	0.393
LIG_FHA_1	104	110	PF00498	0.258
LIG_FHA_1	132	138	PF00498	0.351
LIG_FHA_2	85	91	PF00498	0.337
LIG_LIR_Apic_2	90	94	PF02991	0.260
LIG_LIR_Gen_1	151	162	PF02991	0.290
LIG_NRP_CendR_1	270	273	PF00754	0.599
LIG_PCNA_yPIPBox_3	220	233	PF02747	0.301
LIG_SH2_NCK_1	4	8	PF00017	0.472
LIG_SH2_SRC	4	7	PF00017	0.568
LIG_SH2_SRC	47	50	PF00017	0.604
LIG_SH2_STAP1	154	158	PF00017	0.252
LIG_SH2_STAP1	4	8	PF00017	0.408
LIG_SH2_STAT5	47	50	PF00017	0.604
LIG_SUMO_SIM_par_1	129	134	PF11976	0.293
LIG_TRAF2_1	50	53	PF00917	0.763
MOD_CDK_SPK_2	248	253	PF00069	0.318
MOD_CDK_SPxxK_3	248	255	PF00069	0.318
MOD_CK1_1	105	111	PF00069	0.261
MOD_CK1_1	79	85	PF00069	0.334
MOD_CK2_1	135	141	PF00069	0.258
MOD_CK2_1	183	189	PF00069	0.342
MOD_CK2_1	29	35	PF00069	0.674
MOD_CK2_1	47	53	PF00069	0.492
MOD_CK2_1	84	90	PF00069	0.314
MOD_GlcNHglycan	78	81	PF01048	0.460
MOD_GSK3_1	101	108	PF00069	0.285
MOD_GSK3_1	131	138	PF00069	0.351
MOD_N-GLC_1	225	230	PF02516	0.440
MOD_NEK2_1	101	106	PF00069	0.240
MOD_NEK2_1	131	136	PF00069	0.297
MOD_NEK2_1	171	176	PF00069	0.282
MOD_NEK2_1	212	217	PF00069	0.373
MOD_PKA_2	183	189	PF00069	0.373
MOD_Plk_4	126	132	PF00069	0.261
MOD_ProDKin_1	248	254	PF00069	0.353
MOD_ProDKin_1	29	35	PF00069	0.725
MOD_SUMO_for_1	119	122	PF00179	0.240
MOD_SUMO_rev_2	21	30	PF00179	0.612
MOD_SUMO_rev_2	236	246	PF00179	0.299
TRG_ENDOCYTIC_2	154	157	PF00928	0.252
TRG_ER_diArg_1	15	18	PF00400	0.588
TRG_ER_diArg_1	202	205	PF00400	0.270
TRG_ER_diArg_1	252	255	PF00400	0.373
TRG_ER_diArg_1	270	273	PF00400	0.568
TRG_NLS_Bipartite_1	209	226	PF00514	0.240
TRG_NLS_MonoCore_2	219	224	PF00514	0.242
TRG_NLS_MonoExtC_3	219	224	PF00514	0.262
TRG_NLS_MonoExtN_4	220	226	PF00514	0.240
TRG_NLS_MonoExtN_4	241	248	PF00514	0.301
TRG_Pf-PMV_PEXEL_1	107	112	PF00026	0.318

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I326	Leptomonas seymouri	73%	100%
A0A0S4IQU9	Bodo saltans	59%	100%
A0A1X0P5U9	Trypanosomatidae	57%	100%
A0A3Q8IPE1	Leishmania donovani	94%	100%
A0A3R7KIH6	Trypanosoma rangeli	62%	100%
A4HMK3	Leishmania braziliensis	86%	100%
A4IB82	Leishmania infantum	94%	100%
C9ZZK7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9AF03	Leishmania major	95%	100%
Q9D903	Mus musculus	29%	89%
Q9I8J6	Xenopus laevis	30%	88%
Q9LUJ5	Arabidopsis thaliana	33%	93%