Pru domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome complex subunit Rpn13 ubiquitin receptor, putative

Species:

Leishmania mexicana

UniProt:

E9B654_LEIMU

TriTrypDb:

LmxM.34.1760

Length:

246

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	14
GO:0005737	cytoplasm	2	15
GO:0043226	organelle	2	15
GO:0043227	membrane-bounded organelle	3	14
GO:0043229	intracellular organelle	3	15
GO:0043231	intracellular membrane-bounded organelle	4	14
GO:0110165	cellular anatomical entity	1	15
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0008541	proteasome regulatory particle, lid subcomplex	2	1
GO:0032991	protein-containing complex	1	7
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0000502	proteasome complex	3	6
GO:0140535	intracellular protein-containing complex	2	6
GO:1902494	catalytic complex	2	6
GO:1905368	peptidase complex	3	6
GO:1905369	endopeptidase complex	4	6

Expansion

Sequence features

E9B654

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B654

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008047	enzyme activator activity	3	1
GO:0016504	peptidase activator activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1
GO:0044877	protein-containing complex binding	2	1
GO:0061133	endopeptidase activator activity	5	1
GO:0061134	peptidase regulator activity	3	1
GO:0061135	endopeptidase regulator activity	4	1
GO:0070628	proteasome binding	3	1
GO:0098772	molecular function regulator activity	1	1
GO:0140677	molecular function activator activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.466
CLV_NRD_NRD_1	31	33	PF00675	0.278
CLV_PCSK_KEX2_1	31	33	PF00082	0.276
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.318
CLV_PCSK_SKI1_1	135	139	PF00082	0.539
CLV_PCSK_SKI1_1	146	150	PF00082	0.479
CLV_PCSK_SKI1_1	78	82	PF00082	0.247
DEG_APCC_DBOX_1	77	85	PF00400	0.483
DEG_SPOP_SBC_1	153	157	PF00917	0.569
DOC_CYCLIN_RxL_1	75	86	PF00134	0.480
DOC_CYCLIN_yCln2_LP_2	208	214	PF00134	0.490
DOC_MAPK_gen_1	124	131	PF00069	0.637
DOC_MAPK_gen_1	143	150	PF00069	0.569
DOC_MAPK_gen_1	31	38	PF00069	0.470
DOC_MAPK_gen_1	63	70	PF00069	0.512
DOC_PP1_RVXF_1	76	83	PF00149	0.461
DOC_PP4_FxxP_1	221	224	PF00568	0.560
DOC_PP4_FxxP_1	7	10	PF00568	0.541
DOC_PP4_MxPP_1	1	4	PF00568	0.592
DOC_USP7_MATH_1	139	143	PF00917	0.605
DOC_USP7_MATH_1	195	199	PF00917	0.490
DOC_USP7_MATH_1	40	44	PF00917	0.547
DOC_USP7_MATH_1	50	54	PF00917	0.534
DOC_USP7_UBL2_3	100	104	PF12436	0.531
DOC_USP7_UBL2_3	145	149	PF12436	0.633
DOC_WW_Pin1_4	53	58	PF00397	0.340
LIG_14-3-3_CanoR_1	124	130	PF00244	0.691
LIG_14-3-3_CanoR_1	63	69	PF00244	0.507
LIG_eIF4E_1	169	175	PF01652	0.508
LIG_EVH1_2	3	7	PF00568	0.563
LIG_FHA_1	126	132	PF00498	0.637
LIG_FHA_1	149	155	PF00498	0.525
LIG_FHA_1	158	164	PF00498	0.483
LIG_FHA_1	199	205	PF00498	0.528
LIG_FHA_1	74	80	PF00498	0.471
LIG_LIR_Apic_2	219	224	PF02991	0.582
LIG_LIR_Nem_3	132	137	PF02991	0.549
LIG_LIR_Nem_3	213	217	PF02991	0.431
LIG_SH2_CRK	214	218	PF00017	0.502
LIG_SH2_STAT5	108	111	PF00017	0.312
LIG_SH2_STAT5	177	180	PF00017	0.581
LIG_SH2_STAT5	22	25	PF00017	0.548
LIG_SH2_STAT5	35	38	PF00017	0.521
LIG_SH2_STAT5	93	96	PF00017	0.528
LIG_SH3_3	189	195	PF00018	0.510
LIG_Sin3_3	200	207	PF02671	0.499
LIG_WRC_WIRS_1	35	40	PF05994	0.518
MOD_CK1_1	157	163	PF00069	0.521
MOD_CK1_1	198	204	PF00069	0.523
MOD_CK1_1	41	47	PF00069	0.501
MOD_CK1_1	53	59	PF00069	0.500
MOD_CK1_1	69	75	PF00069	0.347
MOD_CK2_1	40	46	PF00069	0.488
MOD_CK2_1	48	54	PF00069	0.450
MOD_Cter_Amidation	88	91	PF01082	0.140
MOD_GlcNHglycan	105	108	PF01048	0.525
MOD_GlcNHglycan	40	43	PF01048	0.314
MOD_GSK3_1	137	144	PF00069	0.561
MOD_GSK3_1	148	155	PF00069	0.439
MOD_GSK3_1	157	164	PF00069	0.490
MOD_GSK3_1	34	41	PF00069	0.532
MOD_GSK3_1	69	76	PF00069	0.521
MOD_NEK2_1	154	159	PF00069	0.499
MOD_NEK2_1	20	25	PF00069	0.533
MOD_NEK2_1	38	43	PF00069	0.489
MOD_NEK2_2	34	39	PF00069	0.502
MOD_PIKK_1	187	193	PF00454	0.536
MOD_PIKK_1	195	201	PF00454	0.509
MOD_PIKK_1	69	75	PF00454	0.514
MOD_Plk_4	111	117	PF00069	0.498
MOD_Plk_4	154	160	PF00069	0.512
MOD_Plk_4	216	222	PF00069	0.531
MOD_Plk_4	34	40	PF00069	0.465
MOD_Plk_4	66	72	PF00069	0.511
MOD_ProDKin_1	53	59	PF00069	0.340
MOD_SUMO_rev_2	132	137	PF00179	0.614
MOD_SUMO_rev_2	142	151	PF00179	0.628
MOD_SUMO_rev_2	99	106	PF00179	0.539
TRG_ENDOCYTIC_2	214	217	PF00928	0.465
TRG_ENDOCYTIC_2	35	38	PF00928	0.538
TRG_Pf-PMV_PEXEL_1	78	83	PF00026	0.277

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1T1	Leptomonas seymouri	67%	99%
A0A0S4KJ38	Bodo saltans	34%	98%
A0A1X0P5X9	Trypanosomatidae	29%	89%
A0A1X0P6U7	Trypanosomatidae	41%	100%
A0A3Q8IIY1	Leishmania donovani	96%	100%
A0A3R7K022	Trypanosoma rangeli	31%	92%
A0A422MVV1	Trypanosoma rangeli	41%	100%
A4HMJ8	Leishmania braziliensis	88%	100%
A4IB77	Leishmania infantum	96%	100%
C9ZZD7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	88%
C9ZZK1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	97%
E9AEZ8	Leishmania major	96%	100%
Q556N5	Dictyostelium discoideum	23%	86%
V5ATF0	Trypanosoma cruzi	36%	100%