Dynein-associated roadblock protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dynein-associated roadblock protein-like protein

Species:

Leishmania mexicana

UniProt:

E9B652_LEIMU

TriTrypDb:

LmxM.34.1750

Length:

150

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0005868	cytoplasmic dynein complex	4	6
GO:0005874	microtubule	6	5
GO:0005875	microtubule associated complex	2	6
GO:0005930	axoneme	2	2
GO:0030286	dynein complex	3	6
GO:0032991	protein-containing complex	1	6
GO:0099080	supramolecular complex	2	5
GO:0099081	supramolecular polymer	3	5
GO:0099512	supramolecular fiber	4	5
GO:0099513	polymeric cytoskeletal fiber	5	5
GO:0110165	cellular anatomical entity	1	6
GO:1902494	catalytic complex	2	6
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

E9B652

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B652

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	6
GO:0007018	microtubule-based movement	3	6
GO:0009987	cellular process	1	6

Molecular functions
Term	Name	Level	Count
GO:0003774	cytoskeletal motor activity	1	1
GO:0003777	microtubule motor activity	2	1
GO:0005488	binding	1	6
GO:0005515	protein binding	2	6
GO:0045505	dynein intermediate chain binding	3	6
GO:0140657	ATP-dependent activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_Nend_UBRbox_4	1	3	PF02207	0.446
DOC_CYCLIN_yClb1_LxF_4	117	123	PF00134	0.359
DOC_MAPK_gen_1	126	134	PF00069	0.428
DOC_MAPK_MEF2A_6	138	145	PF00069	0.359
DOC_USP7_MATH_1	6	10	PF00917	0.425
DOC_USP7_MATH_1	82	86	PF00917	0.359
DOC_WW_Pin1_4	78	83	PF00397	0.359
LIG_14-3-3_CanoR_1	44	48	PF00244	0.516
LIG_14-3-3_CanoR_1	51	61	PF00244	0.465
LIG_14-3-3_CanoR_1	63	70	PF00244	0.458
LIG_FHA_1	115	121	PF00498	0.338
LIG_FHA_1	69	75	PF00498	0.298
LIG_FHA_2	84	90	PF00498	0.359
LIG_LIR_Apic_2	9	15	PF02991	0.482
LIG_LIR_Gen_1	137	148	PF02991	0.529
LIG_LIR_Gen_1	59	68	PF02991	0.385
LIG_LIR_Nem_3	119	125	PF02991	0.376
LIG_LIR_Nem_3	13	17	PF02991	0.434
LIG_LIR_Nem_3	137	143	PF02991	0.385
LIG_LIR_Nem_3	59	64	PF02991	0.385
LIG_Pex14_2	31	35	PF04695	0.386
LIG_SH2_CRK	12	16	PF00017	0.438
LIG_SH2_STAP1	96	100	PF00017	0.529
LIG_SUMO_SIM_anti_2	139	145	PF11976	0.359
LIG_SUMO_SIM_anti_2	71	77	PF11976	0.329
LIG_SUMO_SIM_par_1	71	77	PF11976	0.358
LIG_UBA3_1	99	106	PF00899	0.529
MOD_CDK_SPxK_1	78	84	PF00069	0.359
MOD_CK1_1	13	19	PF00069	0.428
MOD_CK1_1	46	52	PF00069	0.497
MOD_CK2_1	82	88	PF00069	0.521
MOD_GSK3_1	15	22	PF00069	0.428
MOD_GSK3_1	38	45	PF00069	0.516
MOD_GSK3_1	6	13	PF00069	0.468
MOD_GSK3_1	78	85	PF00069	0.317
MOD_N-GLC_1	68	73	PF02516	0.329
MOD_NEK2_1	10	15	PF00069	0.439
MOD_NEK2_1	4	9	PF00069	0.422
MOD_NEK2_1	47	52	PF00069	0.530
MOD_NEK2_1	99	104	PF00069	0.495
MOD_PIKK_1	62	68	PF00454	0.359
MOD_PKA_2	38	44	PF00069	0.517
MOD_PKA_2	62	68	PF00069	0.529
MOD_PKA_2	83	89	PF00069	0.529
MOD_Plk_1	87	93	PF00069	0.359
MOD_Plk_4	43	49	PF00069	0.446
MOD_Plk_4	6	12	PF00069	0.447
MOD_ProDKin_1	78	84	PF00069	0.359
TRG_ENDOCYTIC_2	96	99	PF00928	0.529
TRG_ER_diArg_1	123	126	PF00400	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IJB4	Leishmania donovani	96%	100%
A0A3Q8IJQ7	Leishmania donovani	37%	100%
A4H9K8	Leishmania braziliensis	35%	100%
A4HXX4	Leishmania infantum	37%	100%
A4IB75	Leishmania infantum	96%	100%
E9AEZ6	Leishmania major	96%	100%
E9ARN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
Q4QDU1	Leishmania major	37%	100%