PPIase cyclophilin-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclophilin 14, putative

Species:

Leishmania mexicana

UniProt:

E9B649_LEIMU

TriTrypDb:

LmxM.34.1720

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9B649

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B649

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0018193	peptidyl-amino acid modification	5	11
GO:0018208	peptidyl-proline modification	6	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	11
GO:0003824	catalytic activity	1	11
GO:0016853	isomerase activity	2	11
GO:0016859	cis-trans isomerase activity	3	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0005488	binding	1	1
GO:0016018	cyclosporin A binding	4	1
GO:0033218	amide binding	2	1
GO:0042277	peptide binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	76	80	PF00656	0.678
CLV_MEL_PAP_1	8	14	PF00089	0.504
CLV_NRD_NRD_1	137	139	PF00675	0.513
CLV_NRD_NRD_1	253	255	PF00675	0.482
CLV_NRD_NRD_1	436	438	PF00675	0.727
CLV_NRD_NRD_1	48	50	PF00675	0.371
CLV_PCSK_FUR_1	135	139	PF00082	0.440
CLV_PCSK_KEX2_1	137	139	PF00082	0.442
CLV_PCSK_KEX2_1	253	255	PF00082	0.482
CLV_PCSK_KEX2_1	366	368	PF00082	0.586
CLV_PCSK_KEX2_1	438	440	PF00082	0.713
CLV_PCSK_KEX2_1	48	50	PF00082	0.371
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.586
CLV_PCSK_PC1ET2_1	438	440	PF00082	0.713
CLV_PCSK_SKI1_1	152	156	PF00082	0.393
CLV_PCSK_SKI1_1	310	314	PF00082	0.482
CLV_PCSK_SKI1_1	49	53	PF00082	0.372
DEG_APCC_DBOX_1	137	145	PF00400	0.635
DEG_APCC_DBOX_1	309	317	PF00400	0.282
DEG_Kelch_Keap1_1	71	76	PF01344	0.687
DEG_Nend_Nbox_1	1	3	PF02207	0.778
DEG_ODPH_VHL_1	385	398	PF01847	0.501
DOC_CYCLIN_RxL_1	134	145	PF00134	0.634
DOC_MAPK_DCC_7	20	30	PF00069	0.711
DOC_MAPK_gen_1	135	143	PF00069	0.651
DOC_MAPK_gen_1	20	30	PF00069	0.657
DOC_MAPK_gen_1	48	54	PF00069	0.674
DOC_MAPK_MEF2A_6	135	143	PF00069	0.638
DOC_MAPK_MEF2A_6	152	161	PF00069	0.579
DOC_MAPK_MEF2A_6	180	189	PF00069	0.392
DOC_MAPK_MEF2A_6	23	30	PF00069	0.747
DOC_SPAK_OSR1_1	18	22	PF12202	0.629
DOC_USP7_MATH_1	24	28	PF00917	0.748
DOC_USP7_MATH_1	312	316	PF00917	0.280
DOC_USP7_MATH_1	365	369	PF00917	0.200
DOC_USP7_MATH_1	85	89	PF00917	0.601
DOC_USP7_MATH_2	300	306	PF00917	0.362
DOC_WW_Pin1_4	321	326	PF00397	0.271
DOC_WW_Pin1_4	38	43	PF00397	0.770
LIG_14-3-3_CanoR_1	138	144	PF00244	0.631
LIG_14-3-3_CanoR_1	152	161	PF00244	0.549
LIG_14-3-3_CanoR_1	310	320	PF00244	0.282
LIG_14-3-3_CanoR_1	408	414	PF00244	0.504
LIG_14-3-3_CanoR_1	48	54	PF00244	0.779
LIG_Actin_WH2_2	201	218	PF00022	0.365
LIG_BRCT_BRCA1_1	323	327	PF00533	0.282
LIG_FHA_1	299	305	PF00498	0.338
LIG_FHA_1	38	44	PF00498	0.745
LIG_FHA_2	140	146	PF00498	0.659
LIG_FHA_2	153	159	PF00498	0.577
LIG_LIR_Nem_3	219	225	PF02991	0.311
LIG_SH2_NCK_1	348	352	PF00017	0.362
LIG_SH2_NCK_1	393	397	PF00017	0.474
LIG_SH2_STAP1	172	176	PF00017	0.355
LIG_SH2_STAT3	336	339	PF00017	0.282
LIG_SH2_STAT5	192	195	PF00017	0.420
LIG_SH2_STAT5	222	225	PF00017	0.309
LIG_SH2_STAT5	247	250	PF00017	0.271
LIG_SH2_STAT5	298	301	PF00017	0.282
LIG_SH2_STAT5	369	372	PF00017	0.362
LIG_SH3_3	144	150	PF00018	0.625
LIG_SH3_3	18	24	PF00018	0.719
LIG_SUMO_SIM_anti_2	155	161	PF11976	0.568
LIG_SUMO_SIM_par_1	139	146	PF11976	0.644
LIG_TYR_ITIM	220	225	PF00017	0.308
LIG_ULM_U2AF65_1	437	442	PF00076	0.512
LIG_WRC_WIRS_1	33	38	PF05994	0.715
MOD_CK1_1	29	35	PF00069	0.772
MOD_CK1_1	58	64	PF00069	0.745
MOD_CK1_1	88	94	PF00069	0.696
MOD_CK2_1	139	145	PF00069	0.658
MOD_CK2_1	152	158	PF00069	0.585
MOD_GlcNHglycan	332	335	PF01048	0.475
MOD_GlcNHglycan	409	412	PF01048	0.690
MOD_GlcNHglycan	432	435	PF01048	0.760
MOD_GlcNHglycan	49	52	PF01048	0.548
MOD_GlcNHglycan	70	73	PF01048	0.524
MOD_GlcNHglycan	81	84	PF01048	0.594
MOD_GlcNHglycan	94	97	PF01048	0.546
MOD_GSK3_1	194	201	PF00069	0.338
MOD_GSK3_1	223	230	PF00069	0.404
MOD_GSK3_1	298	305	PF00069	0.347
MOD_GSK3_1	32	39	PF00069	0.743
MOD_GSK3_1	376	383	PF00069	0.414
MOD_GSK3_1	88	95	PF00069	0.764
MOD_N-GLC_1	227	232	PF02516	0.562
MOD_NEK2_1	1	6	PF00069	0.750
MOD_NEK2_1	174	179	PF00069	0.480
MOD_NEK2_1	194	199	PF00069	0.344
MOD_NEK2_1	36	41	PF00069	0.723
MOD_NEK2_1	380	385	PF00069	0.423
MOD_NEK2_1	392	397	PF00069	0.417
MOD_NEK2_1	47	52	PF00069	0.699
MOD_PIKK_1	424	430	PF00454	0.575
MOD_PK_1	216	222	PF00069	0.327
MOD_PKA_1	253	259	PF00069	0.282
MOD_PKA_2	253	259	PF00069	0.282
MOD_PKA_2	407	413	PF00069	0.515
MOD_PKA_2	47	53	PF00069	0.780
MOD_PKA_2	68	74	PF00069	0.753
MOD_Plk_2-3	55	61	PF00069	0.577
MOD_Plk_4	139	145	PF00069	0.633
MOD_Plk_4	216	222	PF00069	0.328
MOD_ProDKin_1	321	327	PF00069	0.271
MOD_ProDKin_1	38	44	PF00069	0.771
MOD_SUMO_for_1	125	128	PF00179	0.726
MOD_SUMO_rev_2	332	338	PF00179	0.386
MOD_SUMO_rev_2	397	405	PF00179	0.435
MOD_SUMO_rev_2	55	64	PF00179	0.641
TRG_DiLeu_BaEn_2	127	133	PF01217	0.512
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.770
TRG_ENDOCYTIC_2	172	175	PF00928	0.335
TRG_ENDOCYTIC_2	222	225	PF00928	0.309
TRG_ENDOCYTIC_2	348	351	PF00928	0.362
TRG_ENDOCYTIC_2	393	396	PF00928	0.432
TRG_ER_diArg_1	135	138	PF00400	0.715
TRG_ER_diArg_1	47	49	PF00400	0.676
TRG_NES_CRM1_1	151	166	PF08389	0.656
TRG_NLS_MonoCore_2	436	441	PF00514	0.517
TRG_NLS_MonoExtN_4	437	442	PF00514	0.512
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJJ3	Leptomonas seymouri	69%	98%
A0A1X0P6T5	Trypanosomatidae	72%	100%
A0A3S7X941	Leishmania donovani	93%	100%
A0A422NQ98	Trypanosoma rangeli	72%	100%
A4HMJ2	Leishmania braziliensis	83%	100%
A4IB72	Leishmania infantum	93%	100%
C9ZZI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9AEZ3	Leishmania major	93%	100%
V5BP10	Trypanosoma cruzi	71%	100%