| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 11 |
| NetGPI | no | yes: 0, no: 11 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005730 | nucleolus | 5 | 12 |
| GO:0043226 | organelle | 2 | 12 |
| GO:0043228 | non-membrane-bounded organelle | 3 | 12 |
| GO:0043229 | intracellular organelle | 3 | 12 |
| GO:0043232 | intracellular non-membrane-bounded organelle | 4 | 12 |
| GO:0110165 | cellular anatomical entity | 1 | 12 |
| GO:0005737 | cytoplasm | 2 | 1 |
Related structures:
AlphaFold database: E9B648
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006139 | nucleobase-containing compound metabolic process | 3 | 12 |
| GO:0006396 | RNA processing | 6 | 12 |
| GO:0006725 | cellular aromatic compound metabolic process | 3 | 12 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 12 |
| GO:0008152 | metabolic process | 1 | 12 |
| GO:0009987 | cellular process | 1 | 12 |
| GO:0016070 | RNA metabolic process | 5 | 12 |
| GO:0022613 | ribonucleoprotein complex biogenesis | 4 | 11 |
| GO:0034641 | cellular nitrogen compound metabolic process | 3 | 12 |
| GO:0042254 | ribosome biogenesis | 5 | 11 |
| GO:0043170 | macromolecule metabolic process | 3 | 12 |
| GO:0044085 | cellular component biogenesis | 3 | 11 |
| GO:0044237 | cellular metabolic process | 2 | 12 |
| GO:0044238 | primary metabolic process | 2 | 12 |
| GO:0046483 | heterocycle metabolic process | 3 | 12 |
| GO:0071704 | organic substance metabolic process | 2 | 12 |
| GO:0071840 | cellular component organization or biogenesis | 2 | 11 |
| GO:0090304 | nucleic acid metabolic process | 4 | 12 |
| GO:1901360 | organic cyclic compound metabolic process | 3 | 12 |
| GO:0000469 | cleavage involved in rRNA processing | 7 | 1 |
| GO:0000478 | endonucleolytic cleavage involved in rRNA processing | 8 | 1 |
| GO:0000479 | endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 9 | 1 |
| GO:0036260 | RNA capping | 7 | 1 |
| GO:0090305 | nucleic acid phosphodiester bond hydrolysis | 5 | 1 |
| GO:0090501 | RNA phosphodiester bond hydrolysis | 6 | 1 |
| GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic | 7 | 1 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003824 | catalytic activity | 1 | 12 |
| GO:0003963 | RNA-3'-phosphate cyclase activity | 3 | 5 |
| GO:0009975 | cyclase activity | 2 | 5 |
| GO:0016874 | ligase activity | 2 | 5 |
| GO:0016886 | ligase activity, forming phosphoric ester bonds | 3 | 5 |
| GO:0140098 | catalytic activity, acting on RNA | 3 | 6 |
| GO:0140640 | catalytic activity, acting on a nucleic acid | 2 | 6 |
| GO:0004484 | mRNA guanylyltransferase activity | 5 | 2 |
| GO:0004518 | nuclease activity | 4 | 1 |
| GO:0004519 | endonuclease activity | 5 | 1 |
| GO:0004521 | RNA endonuclease activity | 5 | 1 |
| GO:0004540 | RNA nuclease activity | 4 | 1 |
| GO:0008192 | RNA guanylyltransferase activity | 4 | 2 |
| GO:0016301 | kinase activity | 4 | 1 |
| GO:0016740 | transferase activity | 2 | 2 |
| GO:0016772 | transferase activity, transferring phosphorus-containing groups | 3 | 2 |
| GO:0016779 | nucleotidyltransferase activity | 4 | 2 |
| GO:0016787 | hydrolase activity | 2 | 1 |
| GO:0016788 | hydrolase activity, acting on ester bonds | 3 | 1 |
| GO:0019205 | nucleobase-containing compound kinase activity | 5 | 1 |
| GO:0070568 | guanylyltransferase activity | 5 | 2 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_C14_Caspase3-7 | 218 | 222 | PF00656 | 0.434 |
| CLV_NRD_NRD_1 | 147 | 149 | PF00675 | 0.245 |
| CLV_NRD_NRD_1 | 166 | 168 | PF00675 | 0.245 |
| CLV_NRD_NRD_1 | 180 | 182 | PF00675 | 0.237 |
| CLV_PCSK_FUR_1 | 178 | 182 | PF00082 | 0.223 |
| CLV_PCSK_KEX2_1 | 147 | 149 | PF00082 | 0.245 |
| CLV_PCSK_KEX2_1 | 166 | 168 | PF00082 | 0.245 |
| CLV_PCSK_KEX2_1 | 180 | 182 | PF00082 | 0.226 |
| CLV_PCSK_KEX2_1 | 266 | 268 | PF00082 | 0.234 |
| CLV_PCSK_PC1ET2_1 | 266 | 268 | PF00082 | 0.234 |
| CLV_PCSK_PC7_1 | 176 | 182 | PF00082 | 0.223 |
| CLV_PCSK_SKI1_1 | 127 | 131 | PF00082 | 0.234 |
| CLV_PCSK_SKI1_1 | 166 | 170 | PF00082 | 0.245 |
| CLV_PCSK_SKI1_1 | 198 | 202 | PF00082 | 0.224 |
| CLV_PCSK_SKI1_1 | 87 | 91 | PF00082 | 0.259 |
| DEG_Nend_Nbox_1 | 1 | 3 | PF02207 | 0.346 |
| DEG_SPOP_SBC_1 | 240 | 244 | PF00917 | 0.434 |
| DOC_ANK_TNKS_1 | 147 | 154 | PF00023 | 0.524 |
| DOC_CKS1_1 | 68 | 73 | PF01111 | 0.529 |
| DOC_CYCLIN_yClb1_LxF_4 | 43 | 49 | PF00134 | 0.423 |
| DOC_MAPK_gen_1 | 178 | 187 | PF00069 | 0.434 |
| DOC_MAPK_gen_1 | 266 | 273 | PF00069 | 0.434 |
| DOC_PP1_RVXF_1 | 106 | 112 | PF00149 | 0.490 |
| DOC_PP1_RVXF_1 | 181 | 188 | PF00149 | 0.434 |
| DOC_PP2B_LxvP_1 | 98 | 101 | PF13499 | 0.423 |
| DOC_PP4_FxxP_1 | 336 | 339 | PF00568 | 0.571 |
| DOC_USP7_MATH_1 | 186 | 190 | PF00917 | 0.528 |
| DOC_USP7_MATH_1 | 332 | 336 | PF00917 | 0.526 |
| DOC_WW_Pin1_4 | 257 | 262 | PF00397 | 0.488 |
| DOC_WW_Pin1_4 | 294 | 299 | PF00397 | 0.430 |
| DOC_WW_Pin1_4 | 67 | 72 | PF00397 | 0.535 |
| LIG_14-3-3_CanoR_1 | 108 | 112 | PF00244 | 0.463 |
| LIG_14-3-3_CanoR_1 | 127 | 132 | PF00244 | 0.339 |
| LIG_14-3-3_CanoR_1 | 198 | 207 | PF00244 | 0.483 |
| LIG_14-3-3_CanoR_1 | 51 | 58 | PF00244 | 0.449 |
| LIG_14-3-3_CanoR_1 | 87 | 92 | PF00244 | 0.429 |
| LIG_Clathr_ClatBox_1 | 317 | 321 | PF01394 | 0.490 |
| LIG_EH1_1 | 12 | 20 | PF00400 | 0.423 |
| LIG_EH1_1 | 285 | 293 | PF00400 | 0.423 |
| LIG_FHA_1 | 241 | 247 | PF00498 | 0.511 |
| LIG_FHA_1 | 342 | 348 | PF00498 | 0.370 |
| LIG_FHA_1 | 88 | 94 | PF00498 | 0.490 |
| LIG_FHA_2 | 113 | 119 | PF00498 | 0.423 |
| LIG_FHA_2 | 170 | 176 | PF00498 | 0.473 |
| LIG_FHA_2 | 189 | 195 | PF00498 | 0.512 |
| LIG_FHA_2 | 216 | 222 | PF00498 | 0.436 |
| LIG_LIR_Apic_2 | 333 | 339 | PF02991 | 0.547 |
| LIG_LIR_Gen_1 | 130 | 139 | PF02991 | 0.423 |
| LIG_LIR_Gen_1 | 42 | 52 | PF02991 | 0.423 |
| LIG_LIR_Nem_3 | 130 | 136 | PF02991 | 0.423 |
| LIG_LIR_Nem_3 | 232 | 237 | PF02991 | 0.425 |
| LIG_LIR_Nem_3 | 303 | 309 | PF02991 | 0.448 |
| LIG_LIR_Nem_3 | 321 | 326 | PF02991 | 0.360 |
| LIG_LIR_Nem_3 | 42 | 48 | PF02991 | 0.423 |
| LIG_MYND_1 | 339 | 343 | PF01753 | 0.518 |
| LIG_NRBOX | 288 | 294 | PF00104 | 0.434 |
| LIG_Pex14_1 | 133 | 137 | PF04695 | 0.423 |
| LIG_SH2_CRK | 234 | 238 | PF00017 | 0.423 |
| LIG_SH2_STAT5 | 215 | 218 | PF00017 | 0.423 |
| LIG_SH2_STAT5 | 323 | 326 | PF00017 | 0.434 |
| LIG_SH2_STAT5 | 91 | 94 | PF00017 | 0.423 |
| LIG_SH3_3 | 251 | 257 | PF00018 | 0.456 |
| LIG_SH3_3 | 336 | 342 | PF00018 | 0.511 |
| LIG_Sin3_3 | 96 | 103 | PF02671 | 0.448 |
| LIG_SUMO_SIM_anti_2 | 315 | 322 | PF11976 | 0.423 |
| LIG_SUMO_SIM_par_1 | 235 | 244 | PF11976 | 0.423 |
| LIG_UBA3_1 | 97 | 104 | PF00899 | 0.466 |
| MOD_CK1_1 | 107 | 113 | PF00069 | 0.451 |
| MOD_CK1_1 | 122 | 128 | PF00069 | 0.377 |
| MOD_CK1_1 | 17 | 23 | PF00069 | 0.423 |
| MOD_CK1_1 | 250 | 256 | PF00069 | 0.451 |
| MOD_CK1_1 | 312 | 318 | PF00069 | 0.441 |
| MOD_CK1_1 | 54 | 60 | PF00069 | 0.527 |
| MOD_CK2_1 | 112 | 118 | PF00069 | 0.434 |
| MOD_CK2_1 | 169 | 175 | PF00069 | 0.494 |
| MOD_CK2_1 | 294 | 300 | PF00069 | 0.434 |
| MOD_Cter_Amidation | 264 | 267 | PF01082 | 0.234 |
| MOD_GlcNHglycan | 231 | 234 | PF01048 | 0.223 |
| MOD_GlcNHglycan | 309 | 312 | PF01048 | 0.234 |
| MOD_GlcNHglycan | 314 | 317 | PF01048 | 0.213 |
| MOD_GlcNHglycan | 53 | 56 | PF01048 | 0.266 |
| MOD_GSK3_1 | 341 | 348 | PF00069 | 0.351 |
| MOD_GSK3_1 | 50 | 57 | PF00069 | 0.442 |
| MOD_GSK3_1 | 58 | 65 | PF00069 | 0.402 |
| MOD_N-GLC_1 | 63 | 68 | PF02516 | 0.259 |
| MOD_NEK2_1 | 168 | 173 | PF00069 | 0.393 |
| MOD_NEK2_1 | 309 | 314 | PF00069 | 0.479 |
| MOD_NEK2_1 | 319 | 324 | PF00069 | 0.430 |
| MOD_NEK2_1 | 4 | 9 | PF00069 | 0.434 |
| MOD_NEK2_1 | 75 | 80 | PF00069 | 0.467 |
| MOD_PIKK_1 | 112 | 118 | PF00454 | 0.423 |
| MOD_PIKK_1 | 247 | 253 | PF00454 | 0.423 |
| MOD_PIKK_1 | 82 | 88 | PF00454 | 0.524 |
| MOD_PKA_1 | 166 | 172 | PF00069 | 0.463 |
| MOD_PKA_2 | 107 | 113 | PF00069 | 0.466 |
| MOD_PKA_2 | 166 | 172 | PF00069 | 0.486 |
| MOD_PKA_2 | 229 | 235 | PF00069 | 0.496 |
| MOD_PKA_2 | 24 | 30 | PF00069 | 0.466 |
| MOD_PKA_2 | 50 | 56 | PF00069 | 0.423 |
| MOD_Plk_1 | 119 | 125 | PF00069 | 0.408 |
| MOD_Plk_1 | 299 | 305 | PF00069 | 0.429 |
| MOD_Plk_1 | 63 | 69 | PF00069 | 0.473 |
| MOD_Plk_4 | 14 | 20 | PF00069 | 0.428 |
| MOD_Plk_4 | 319 | 325 | PF00069 | 0.488 |
| MOD_Plk_4 | 342 | 348 | PF00069 | 0.328 |
| MOD_Plk_4 | 5 | 11 | PF00069 | 0.424 |
| MOD_Plk_4 | 75 | 81 | PF00069 | 0.402 |
| MOD_Plk_4 | 87 | 93 | PF00069 | 0.417 |
| MOD_ProDKin_1 | 257 | 263 | PF00069 | 0.488 |
| MOD_ProDKin_1 | 294 | 300 | PF00069 | 0.430 |
| MOD_ProDKin_1 | 67 | 73 | PF00069 | 0.535 |
| MOD_SUMO_for_1 | 203 | 206 | PF00179 | 0.524 |
| MOD_SUMO_rev_2 | 159 | 165 | PF00179 | 0.524 |
| TRG_DiLeu_BaEn_1 | 206 | 211 | PF01217 | 0.524 |
| TRG_DiLeu_BaEn_1 | 5 | 10 | PF01217 | 0.524 |
| TRG_DiLeu_BaEn_1 | 94 | 99 | PF01217 | 0.423 |
| TRG_ENDOCYTIC_2 | 234 | 237 | PF00928 | 0.423 |
| TRG_ENDOCYTIC_2 | 323 | 326 | PF00928 | 0.434 |
| TRG_ER_diArg_1 | 146 | 148 | PF00400 | 0.423 |
| TRG_ER_diArg_1 | 165 | 167 | PF00400 | 0.423 |
| TRG_ER_diArg_1 | 176 | 179 | PF00400 | 0.391 |
| TRG_ER_diArg_1 | 180 | 183 | PF00400 | 0.439 |
| TRG_ER_diLys_1 | 359 | 362 | PF00400 | 0.426 |
| TRG_NES_CRM1_1 | 287 | 300 | PF08389 | 0.423 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1I4D4 | Leptomonas seymouri | 91% | 100% |
| A0A0S4KLE5 | Bodo saltans | 68% | 100% |
| A0A1X0P619 | Trypanosomatidae | 71% | 100% |
| A0A3R7KQG1 | Trypanosoma rangeli | 72% | 100% |
| A0A3S7X948 | Leishmania donovani | 97% | 100% |
| A0B532 | Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) | 26% | 100% |
| A1RSJ7 | Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3) | 27% | 100% |
| A2BN21 | Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5) | 28% | 100% |
| A3DN24 | Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1) | 25% | 100% |
| A3MXQ7 | Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1) | 27% | 100% |
| A4HMJ1 | Leishmania braziliensis | 94% | 100% |
| A4IB71 | Leishmania infantum | 97% | 100% |
| A4XRJ0 | Pseudomonas mendocina (strain ymp) | 25% | 100% |
| A4YEC3 | Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) | 25% | 100% |
| A8A9W2 | Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125) | 26% | 100% |
| A8MAV7 | Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167) | 26% | 100% |
| B1L6E9 | Korarchaeum cryptofilum (strain OPF8) | 25% | 100% |
| B1YDJ1 | Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta) | 26% | 100% |
| B2IWJ8 | Nostoc punctiforme (strain ATCC 29133 / PCC 73102) | 26% | 100% |
| B6YSJ5 | Thermococcus onnurineus (strain NA1) | 24% | 100% |
| B7KCF3 | Gloeothece citriformis (strain PCC 7424) | 24% | 100% |
| B8D680 | Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n) | 22% | 100% |
| C3MKC1 | Sulfolobus islandicus (strain L.S.2.15 / Lassen #1) | 24% | 100% |
| C3MU91 | Sulfolobus islandicus (strain M.14.25 / Kamchatka #1) | 24% | 100% |
| C3N179 | Sulfolobus islandicus (strain M.16.27) | 24% | 100% |
| C3N969 | Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1) | 24% | 100% |
| C3NMT8 | Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2) | 24% | 100% |
| C4KKE6 | Sulfolobus islandicus (strain M.16.4 / Kamchatka #3) | 24% | 100% |
| C5A2A3 | Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3) | 23% | 100% |
| C6A4N4 | Thermococcus sibiricus (strain DSM 12597 / MM 739) | 20% | 100% |
| C9ZZI0 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 73% | 100% |
| E9AEZ2 | Leishmania major | 97% | 100% |
| O00442 | Homo sapiens | 25% | 99% |
| O15746 | Dictyostelium discoideum | 21% | 84% |
| O27937 | Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) | 25% | 100% |
| O28837 | Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) | 25% | 100% |
| O59198 | Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) | 28% | 100% |
| O66884 | Aquifex aeolicus (strain VF5) | 23% | 100% |
| O77264 | Drosophila melanogaster | 25% | 100% |
| P56175 | Drosophila melanogaster | 33% | 94% |
| Q08096 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 29% | 99% |
| Q09870 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 34% | 100% |
| Q12V70 | Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M) | 23% | 100% |
| Q23400 | Caenorhabditis elegans | 32% | 96% |
| Q2HJ88 | Bos taurus | 25% | 99% |
| Q2KHX8 | Bos taurus | 34% | 97% |
| Q2Y720 | Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71) | 23% | 100% |
| Q3M6L1 | Trichormus variabilis (strain ATCC 29413 / PCC 7937) | 28% | 100% |
| Q46DV9 | Methanosarcina barkeri (strain Fusaro / DSM 804) | 24% | 100% |
| Q4JB78 | Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) | 25% | 100% |
| Q4R3J0 | Macaca fascicularis | 24% | 99% |
| Q54S38 | Dictyostelium discoideum | 37% | 98% |
| Q5JIQ0 | Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) | 23% | 100% |
| Q5R7P3 | Pongo abelii | 24% | 99% |
| Q60335 | Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) | 23% | 100% |
| Q609M1 | Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath) | 25% | 100% |
| Q8PXC4 | Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) | 22% | 100% |
| Q8TH85 | Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) | 23% | 100% |
| Q8TZC9 | Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) | 24% | 100% |
| Q8U0N7 | Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) | 25% | 100% |
| Q8YVS3 | Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576) | 27% | 100% |
| Q8ZST4 | Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2) | 29% | 100% |
| Q974U1 | Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) | 26% | 100% |
| Q97W04 | Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) | 23% | 100% |
| Q9C578 | Arabidopsis thaliana | 36% | 97% |
| Q9D7H3 | Mus musculus | 25% | 99% |
| Q9JJT0 | Mus musculus | 35% | 97% |
| Q9V0Z6 | Pyrococcus abyssi (strain GE5 / Orsay) | 26% | 100% |
| Q9Y2P8 | Homo sapiens | 34% | 97% |
| Q9YES0 | Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) | 24% | 100% |
| V5DKG4 | Trypanosoma cruzi | 71% | 100% |